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Medulloblastoma 

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  1. Open Access 01-12-2024 | Medulloblastoma | Letter

    Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study

    Constitutional heterozygous pathogenic variants in genes coding for some components of the Fanconi anemia-BRCA signaling pathway, which repairs DNA interstrand crosslinks, represent risk factors for common cancers, including breast, ovarian …

  2. Open Access 01-12-2024 | Medulloblastoma | OriginalPaper

    LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes

    Medulloblastomas (MBs) are one of the most common malignant brain tumor types in children [ 1 ]. Although the 5-year overall survival from MB has been improved to 70% ~ 80% [ 2 – 4 ], approximately one-third of patients surviving the primary tumor …

  3. Open Access 20-04-2024 | Medulloblastoma | Online First

    Radiomic- and dosiomic-based clustering development for radio-induced neurotoxicity in pediatric medulloblastoma

    Medulloblastoma (MB) is the most common brain malignancy in pediatric patients, which accounts for 20–25% of pediatric central nervous system neoplasms [ 1 , 2 ]. Despite the increase in survival rates in recent years, prognosis of MB patients …

  4. 25-04-2024 | Medulloblastoma | Online First

    PUMC-MB1 is a novel group 3 medulloblastoma preclinical model, sensitive to PI3K/mTOR dual inhibitor

    Medulloblastoma (MB), a common malignant tumor in the posterior fossa of children, constitutes about 20% of all pediatric central nervous system tumors [ 1 , 2 ]. MB is molecularly classified into four subgroups: sonic hedgehog (SHH), wingless …

  5. 19-12-2023 | ReviewPaper

    Evolution of neurosurgical advances and nuances in medulloblastoma therapy

    Medulloblastoma, the most common malignant brain tumor in children, presents a complex treatment challenge due to its propensity for infiltrative growth within the posterior fossa and its potential attachment to critical anatomical structures.

  6. 02-04-2024 | Medulloblastoma | Online First

    Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States

    Medulloblastoma is a malignant brain tumor that is the most common pediatric central nervous system (CNS) tumor, constituting up to 20% of them [ 1 ]. Although prognosis is variable depending on molecular subtype, surgery and adjuvant therapy …

  7. 01-12-2024 | Medulloblastoma | OriginalPaper

    Development and validation of a 23-gene expression signature for molecular subtyping of medulloblastoma in a long-term Chinese cohort

    Medulloblastoma (MB) is the most common malignant pediatric brain tumor, accounting for ~ 12% of childhood cancer deaths worldwide [ 22 ]. Approximately 80% of medulloblastomas occur in children under the age of 15. In adults, medulloblastomas are …

  8. Open Access 01-12-2024 | Medulloblastoma | OriginalPaper

    Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma

    Medulloblastoma (MB) is the most common intracerebellar pediatric brain tumor, accounting for approximately 20% of all childhood brain tumors and over 60% of embryonal brain tumors. Standard-of-care treatment for MB consists of surgery, radiation …

  9. 12-09-2023 | Medulloblastoma | OriginalPaper

    Late effects of medulloblastoma treatment: multidisciplinary approach of survivors

    Medulloblastoma is the most common malignant brain tumor in childhood [ 1 ]. In the 1950s, there was a significant improvement in overall survival of patients with the use of postsurgical radiotherapy in treatment of the disease. In previous …

  10. Open Access 09-11-2023 | Medulloblastoma | Review

    Recent Advances in Pediatric Medulloblastoma

    Medulloblastomas are the most common malignant brain tumors in children. Advances in understanding their etiology, biology, radiology, and management are discussed.

  11. Open Access 07-01-2024 | Medulloblastoma | OriginalPaper

    Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells

    Medulloblastoma (MB) is an embryonal brain tumor occurring in children and young adults. The clinical outcome of patients with MB is strongly dependent on the molecular subgroup (WNT, SHH, Group 3 and Group 4) [ 1 , 2 ]. Group 3 and Group 4 tumors …

  12. Open Access 01-12-2023 | Medulloblastoma | OriginalPaper

    Mitochondrial DNA mutations in Medulloblastoma

    To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to its division into four groups—WNT, SHH, group 3 (G3) and group 4 (G4). However, there is little …

  13. Open Access 01-12-2023 | Medulloblastoma | OriginalPaper

    miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4

    The prognosis of childhood medulloblastoma (MB) is often poor, and it usually requires aggressive therapy that adversely affects quality of life. microRNA-211 (miR-211) was previously identified as an important regulator of cells that descend from …

  14. Open Access 01-12-2023 | Medulloblastoma | OriginalPaper

    MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice

    Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes combined. While overexpression of MYC has previously been shown to drive …

  15. Open Access 01-12-2023 | Medulloblastoma | OriginalPaper

    Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma

    Chemotherapy resistance is considered one of the main causes of tumor relapse, still challenging researchers for the identification of the molecular mechanisms sustaining its emergence. Here, we setup and characterized chemotherapy-resistant …

  16. 23-11-2023 | Medulloblastoma | Online First

    Automatic image segmentation and online survival prediction model of medulloblastoma based on machine learning

    Medulloblastoma (MB) is a highly heterogeneous malignant tumor of the central nervous system in children, with varying prognoses [ 1 ]. Different risk levels of patients require different treatment methods [ 2 , 3 ]. However, the prognostic risk …

  17. Open Access 01-12-2023 | Medulloblastoma | OriginalPaper

    IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma

    Medulloblastoma (MB) is the most common pediatric brain malignancy and is divided into four molecularly distinct subgroups: WNT, Sonic Hedgehog (SHHp53mut and SHHp53wt), Group 3, and Group 4. Previous reports suggest that SHH MB features a unique …

  18. Open Access 01-12-2023 | Medulloblastoma | Letter

    A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma

  19. Open Access 01-12-2023 | Erratum

    Correction to: Dynamic profiling of medulloblastoma surfaceome

  20. Open Access 01-12-2023 | Medulloblastoma | OriginalPaper

    Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses

    Nowadays medulloblastoma (MB) tumors can be treated with risk-stratified approaches with up to 80% success rate. However, disease relapses occur in approximately 30% of patients and successful salvage treatment strategies at relapse remain scarce.

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