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BMC Medicine

Issue 1/2024

Content (608 Articles)

NHS Health Check attendance is associated with reduced multiorgan disease risk: a matched cohort study in the UK Biobank

  • Open Access
  • Research article

Celeste McCracken, Zahra Raisi-Estabragh, Liliana Szabo, John Robson, Betty Raman, Anya Topiwala, Adriana Roca-Fernández, Masud Husain, Steffen E. Petersen, Stefan Neubauer, Thomas E. Nichols

Interpregnancy interval and early infant neurodevelopment: the role of maternal–fetal glucose metabolism

  • Open Access
  • Research article

Ruirui Ma, Peng Wang, Qiaolan Yang, Yuanyuan Zhu, Lei Zhang, Yuhong Wang, Lijun Sun, Wenxiang Li, Jinfang Ge, Peng Zhu

Randomized controlled trial demonstrates novel tools to assess patient outcomes of Indigenous cultural safety training

  • Open Access
  • Research article

Janet Smylie, Michael A. Rotondi, Sam Filipenko, William T. L. Cox, Diane Smylie, Cheryl Ward, Kristina Klopfer, Aisha K. Lofters, Braden O’Neill, Melissa Graham, Linda Weber, Ali N. Damji, Patricia G. Devine, Jane Collins, Billie-Jo Hardy

Effects of acetazolamide combined with remote ischemic preconditioning on risk of acute mountain sickness: a randomized clinical trial

Moqi Liu, Xueqiao Jiao, Rui Li, Jialu Li, Lu Wang, Liyan Wang, Yishu Wang, Chunmei Lv, Dan Huang, Ran Wei, Liming Wang, Xunming Ji, Xiuhai Guo

Development of prescribing indicators related to opioid-related harm in patients with chronic pain in primary care—a modified e-Delphi study

  • Open Access
  • Opioids
  • Research article

Neetu Bansal, Stephen M. Campbell, Chiu-Yi Lin, Darren M. Ashcroft, Li-Chia Chen

Genetic proxies for antihypertensive drugs and mental disorders: Mendelian randomization study in European and East Asian populations

Bohan Fan, Jie V. Zhao

Supporting youth mental health with arts-based strategies: a global perspective

  • Open Access
  • Opinion

Tasha L. Golden, Richard W. Ordway, Susan Magsamen, Aanchal Mohanty, Yifan Chen, T. W. Cherry Ng

Effects of glucagon-like peptide-1 receptor agonists on liver-related and cardiovascular mortality in patients with type 2 diabetes

Fu-Shun Yen, Ming-Chih Hou, James Cheng-Chung Wei, Ying-Hsiu Shih, Chii-Min Hwu, Chih-Cheng Hsu

Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status

Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, Marjanka K. Schmidt

Maternal pre-pregnancy body mass index and risk of preterm birth: a collaboration using large routine health datasets

R. P. Cornish, M. C. Magnus, S. K. Urhoj, G. Santorelli, L. G. Smithers, D. Odd, A. Fraser, S. E. Håberg, A. M. Nybo Andersen, K. Birnie, J. W. Lynch, K. Tilling, D. A. Lawlor

Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy

Mengxia Fu, Xiumeng Hua, Songren Shu, Xinjie Xu, Hang Zhang, Zhiming Peng, Han Mo, Yanyun Liu, Xiao Chen, Yicheng Yang, Ningning Zhang, Xiaohu Wang, Zirui Liu, Guangxin Yue, Shengshou Hu, Jiangping Song

First trans-diagnostic experiences with a novel micro-choice based concentrated group rehabilitation for patients with low back pain, long COVID, and type 2 diabetes: a pilot study

Gerd Kvale, Eirik Søfteland, Marte Jürgensen, Ane Wilhelmsen-Langeland, Anne Haugstvedt, Sigurd William Hystad, Øystein Theodor Ødegaard-Olsen, Bernt Bøgvald Aarli, Sidsel Rykken, Bente Frisk

A network meta-analysis of efficacy and safety for first-line and second/further-line therapies in postmenopausal women with hormone receptor-positive, HER2-negative, advanced breast cancer

Hanqiao Shao, Mingye Zhao, Ai-Jia Guan, Taihang Shao, Dachuang Zhou, Guo Yu, Wenxi Tang

Risks of digestive diseases in long COVID: evidence from a population-based cohort study

Yuying Ma, Lijun Zhang, Rui Wei, Weiyu Dai, Ruijie Zeng, Dongling Luo, Rui Jiang, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W Leung, Chongyang Duan, Weihong Sha, Hao Chen

Exposure to residential green and blue space and the natural environment is associated with a lower incidence of psychiatric disorders in middle-aged and older adults: findings from the UK Biobank

  • Open Access
  • Research article

Bao-Peng Liu, Rachel R. Huxley, Tamara Schikowski, Ke-Jia Hu, Qi Zhao, Cun-Xian Jia

Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants

Jia Li, Liangle Yang, Yuxin Yao, Pei Gu, Yujia Xie, Haoyu Yin, Mingyue Xue, Yu Jiang, Jianghong Dai, Jixuan Ma

Human lifespan and sex-specific patterns of resilience to disease: a retrospective population-wide cohort study

  • Open Access
  • Research article

Joaquim Sol, Marta Ortega-Bravo, Manuel Portero-Otín, Gerard Piñol-Ripoll, Vicent Ribas-Ripoll, Eva Artigues-Barberà, Miquel Butí, Reinald Pamplona, Mariona Jové

Benefits and challenges experienced by participants on long-term methadone maintenance treatment in China: a qualitative study

Xijia Tang, Wenxue Xiong, Wen Chen, Chijie Wang, Hexuan Wang, Boyu Li, Zirong Zhang, Li Ling

LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

Hongjin Shi, Zhiyong Tan, Bowen Duan, Chunming Guo, Chong Li, Ting Luan, Ning Li, Yinglong Huang, Shi Chen, Jixian Gao, Wei Feng, Haole Xu, Jiansong Wang, Shi Fu, Haifeng Wang

Trajectories of health conditions and their associations with the risk of cognitive impairment among older adults: insights from a national prospective cohort study

  • Open Access
  • Research article

Min Du, Liyuan Tao, Min Liu, Jue Liu

Evolution in key indicators of maternal and child health across the wealth gradient in 41 sub-Saharan African countries, 1986–2019

Yeeun Lee, Sarah Bolongaita, Ryoko Sato, Jesse B. Bump, Stéphane Verguet

The quality of care delivered to residents in long-term care in Australia: an indicator-based review of resident records (CareTrack Aged study)

  • Open Access
  • Research article

Peter D. Hibbert, Charlotte J. Molloy, Ian D. Cameron, Leonard C. Gray, Richard L. Reed, Louise K. Wiles, Johanna Westbrook, Gaston Arnolda, Rebecca Bilton, Ruby Ash, Andrew Georgiou, Alison Kitson, Clifford F. Hughes, Susan J. Gordon, Rebecca J. Mitchell, Frances Rapport, Carole Estabrooks, Gregory L. Alexander, Charles Vincent, Adrian Edwards, Andrew Carson-Stevens, Cordula Wagner, Brendan McCormack, Jeffrey Braithwaite

Self- and interviewer-reported cognitive problems in relation to cognitive decline and dementia: results from two prospective studies

Yuhui Huang, Hui Chen, Mengyan Gao, Xiaozhen Lv, Ting Pang, Shuang Rong, Xin Xu, Changzheng Yuan

Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma

Wenqiong Chen, Yi He, Guowei Zhou, Xiang Chen, Youqiong Ye, Guanxiong Zhang, Hong Liu

Experiences of hospital care for people with multiple long-term conditions: a scoping review of qualitative research

Sue Bellass, Thomas Scharf, Linda Errington, Kelly Bowden Davies, Sian Robinson, Adam Runacres, Jodi Ventre, Miles D. Witham, Avan A. Sayer, Rachel Cooper

Gut and bladder fermentation syndromes: a narrative review

Kenichi Tamama, Katherine M. Kruckenberg, Andrea F. DiMartini

Effects of 6-month customized home-based exercise on motor development, bone strength, and parental stress in children with simple congenital heart disease: a single-blinded randomized clinical trial

Qing Du, Xin Li, Zhaoxi Wang, Sun Chen, Xi Zhang, Juping Liang, Haibin Guo, Nan Chen, Hong Yu, Xiaoqing Zhu, Xuan Zhou, Kun Sun

Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial

Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li, Ji-Guang Wang

Interpretable artificial intelligence-based app assists inexperienced radiologists in diagnosing biliary atresia from sonographic gallbladder images

Wenying Zhou, Zejun Ye, Guangliang Huang, Xiaoer Zhang, Ming Xu, Baoxian Liu, Bowen Zhuang, Zijian Tang, Shan Wang, Dan Chen, Yunxiang Pan, Xiaoyan Xie, Ruixuan Wang, Luyao Zhou

Identifying the most at-risk age-group and longitudinal trends of drug allergy labeling amongst 7.3 million individuals in Hong Kong

Valerie Chiang, Andy Ka Chun Kan, Chinmoy Saha, Elaine Y. L. Au, Philip H. Li

Geospatial analysis of Plasmodium falciparum serological indicators: school versus community sampling in a low-transmission malaria setting

  • Open Access
  • Malaria
  • Research article

Alicia Jaramillo-Underwood, Camelia Herman, Samuel E. Jean, Doug Nace, E. Scott Elder, Keri Robinson, Alaine Knipes, Caitlin M. Worrell, LeAnne M. Fox, Luccene Desir, Carl Fayette, Alain Javel, Franck Monestime, Kimberly E. Mace, Venkatachalam Udhayakumar, Kimberly Y. Won, Michelle A. Chang, Jean F. Lemoine, Eric Rogier

Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes

Maria Carolina Borges, Gemma L. Clayton, Rachel M. Freathy, Janine F. Felix, Alba Fernández-Sanlés, Ana Gonçalves Soares, Fanny Kilpi, Qian Yang, Rosemary R. C. McEachan, Rebecca C. Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T. Hattersley, Barbara Bodinier, Denise M. Scholtens, Ellen A. Nohr, Tom A. Bond, M. Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard, Mario Murcia, Mariona Bustamante, Marc Chadeau-Hyam, Marjo-Riitta Jarvelin, Martine Vrijheid, Patrice Perron, Per Magnus, Romy Gaillard, Vincent W. V. Jaddoe, William L. Lowe Jr, Bjarke Feenstra, Marie-France Hivert, Thorkild I. A. Sørensen, Siri E. Håberg, Sylvain Serbert, Maria Magnus, Deborah A. Lawlor

Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms

Stefano Comai, Nicolas Nunez, Tobias Atkin, Maykel F. Ghabrash, Rita Zakarian, Allan Fielding, Marie Saint-Laurent, Nancy Low, Garrett Sauber, Eugenio Ragazzi, Cecilia J. Hillard, Gabriella Gobbi

Proteomics for heart failure risk stratification: a systematic review

Kayode O. Kuku, Rebecca Oyetoro, Maryam Hashemian, Alicia A. Livinski, Joseph J. Shearer, Jungnam Joo, Bruce M. Psaty, Daniel Levy, Peter Ganz, Véronique L. Roger

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus

Predicting cognitive scores from wearable-based digital physiological features using machine learning: data from a clinical trial in mild cognitive impairment

Yuri G. Rykov, Michael D. Patterson, Bikram A. Gangwar, Syaheed B. Jabar, Jacklyn Leonardo, Kok Pin Ng, Nagaendran Kandiah

Impact of socioeconomic status on chronic control and complications of type 1 diabetes mellitus in users of glucose flash systems: a follow-up study

Fernando Sebastian-Valles, Julia Martínez-Alfonso, Jose Alfonso Arranz Martin, Jessica Jiménez-Díaz, Iñigo Hernando Alday, Victor Navas-Moreno, Teresa Armenta Joya, Maria del Mar Fandiño García, Gisela Liz Román Gómez, Jon Garai Hierro, Luis Eduardo Lander Lobariñas, Purificación Martínez de Icaya, Miguel Antonio Sampedro-Nuñez, Vicente Martínez-Vizcaíno, Mónica Marazuela

Mapping heterogeneity in family planning indicators in Burkina Faso, Kenya, and Nigeria, 2000–2020

Doori Oh, Rebecca M. Cogen, Erin C. Mullany, Susan McLaughlin, Olumide Abiodun, Lawan Hassan Adamu, Abiola Victor Adepoju, Miracle Ayomikun Adesina, Daniel Adedayo Adeyinka, Aanuoluwapo Adeyimika Afolabi, Olufemi Ajumobi, Dickson A. Amugsi, Olivia Angelino, Tesleem Kayode Babalola, Manaseh A. Bocha, Isaac Sunday Chukwu, Michael Ekholuenetale, Adeniyi Francis Fagbamigbe, Prof Morenike Oluwatoyin Folayan, Prof Muktar A. Gadanya, Augustine Mwangi Gatotoh, Annie Haakenstad, Prof Simon I. Hay, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Kenneth Chukwuemeka Iregbu, Charity Ehimwenma Joshua, Gbenga A. Kayode, Peter M. Macharia, Shafiu Mohammed, Aggrey Gisiora Mokaya, Prof Christopher J. L. Murray, Josephine W. Ngunjiri, Julius Nyerere Odhiambo, Oluwakemi Ololade Odukoya, Onome Bright Oghenetega, Abiola Ogunkoya, Akinkunmi Paul Okekunle, Patrick Godwin Okwute, Andrew T. Olagunju, Babayemi Oluwaseun Olakunde, Isaac Iyinoluwa Olufadewa, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Prof Obinna E. Onwujekwe, Prof Mayowa O. Owolabi, Mu’awiyyah Babale Sufiyan, Shehu Salihu Umar, Chukwuma David Umeokonkwo, Yohannes Dibaba Wado, Hadiza Yusuf, Laura Dwyer-Lindgren

Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years

Jaz Lyons-Reid, José G. B. Derraik, Timothy Kenealy, Benjamin B. Albert, J. Manuel Ramos Nieves, Cathriona R. Monnard, Phil Titcombe, Heidi Nield, Sheila J. Barton, Sarah El-Heis, Elizabeth Tham, Keith M. Godfrey, Shiao-Yng Chan, Wayne S. Cutfield, Ryan Carvalho, Julie Ann Castro, Mary Cavanagh, Hsin Fang Chang, Yap Seng Chong, Paula Costello, Vanessa Cox, Sevasti Galani, Judith Hammond, Nicholas C. Harvey, Soo Min Han, Mrunalini Jagtap, Chiara Nembrini, Justin M. O’Sullivan, Judith Ong, Irma Silva-Zolezzi, Wendy Sim, Vicky Tay, Mya-Thway Tint, Mark Vickers, Jui-Tsung Wong, Gladys Woon, Wen Lun Yuan

The experience of albinism in France: a qualitative study on dyads of parents and their adult child with albinism

  • Open Access
  • Research article

Hugo Fournier, Marie Hasdenteufel, Constance Garrouteigt, Mathieu Perie, Antoine Gliksohn, Béatrice Jouanne, Smail Hadj-Rabia, Benoit Arveiler, Fanny Morice-Picard, Bruno Quintard

Mosquito odour-baited mass trapping reduced malaria transmission intensity: a result from a controlled before-and-after intervention study

  • Open Access
  • Malaria
  • Research article

Yared Debebe, Habte Tekie, Sisay Dugassa, Richard J. Hopkins, Sharon Rose Hill, Rickard Ignell

Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma

Xu Yang, Baofeng Lian, Nan Zhang, Junyu Long, Yiran Li, Jingnan Xue, Xiangqi Chen, Yunchao Wang, Yanyu Wang, Ziyu Xun, Mingjian Piao, Chenpei Zhu, Shanshan Wang, Huishan Sun, Zhijian Song, Leilei Lu, Xiaowei Dong, Aodi Wang, Wenjin Liu, Jie Pan, Xiaorong Hou, Mei Guan, Li Huo, Jie Shi, Haohai Zhang, Jinxue Zhou, Zhenhui Lu, Yilei Mao, Xinting Sang, Liqun Wu, Xiaobo Yang, Kai Wang, Haitao Zhao

Isolating the effect of confounding from the observed survival benefit of screening participants — a methodological approach illustrated by data from the German mammography screening programme

Laura Buschmann, Ina Wellmann, Nadine Bonberg, Jürgen Wellmann, Hans-Werner Hense, André Karch, Heike Minnerup

Immune checkpoint inhibitors in cancer: the increased risk of atherosclerotic cardiovascular disease events and progression of coronary artery calcium

Bingxin Gong, Yusheng Guo, Yi Li, Jing Wang, Guofeng Zhou, Yong-hao Chen, Tong Nie, Ming Yang, Kun Luo, Chuansheng Zheng, Feng Pan, Bo Liang, Lian Yang

Is the price right? Paying for value today to get more value tomorrow

  • Open Access
  • Opinion

Sreeram V. Ramagopalan, Jose Diaz, Grace Mitchell, Louis P. Garrison Jr., Peter Kolchinsky

Substantial health and economic burden of COVID-19 during the year after acute illness among US adults at high risk of severe COVID-19

Amie Scott, Wajeeha Ansari, Farid Khan, Richard Chambers, Michael Benigno, Manuela Di Fusco, Leah McGrath, Deepa Malhotra, Florin Draica, Jennifer Nguyen, Joanna Atkinson, Jessica E. Atwell

Substantial health and economic burden of COVID-19 during the year after acute illness among US adults not at high risk of severe COVID-19

Amie Scott, Wajeeha Ansari, Richard Chambers, Maya Reimbaeva, Tomasz Mikolajczyk, Michael Benigno, Florin Draica, Joanna Atkinson

Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID)

Ekaterina Pazukhina, Mikhail Rumyantsev, Dina Baimukhambetova, Elena Bondarenko, Nadezhda Markina, Yasmin El-Taravi, Polina Petrova, Anastasia Ezhova, Margarita Andreeva, Ekaterina Iakovleva, Polina Bobkova, Maria Pikuza, Anastasia Trefilova, Elina Abdeeva, Aysylu Galiautdinova, Yulia Filippova, Anastasiia Bairashevskaia, Aleksandr Zolotarev, Nikolay Bulanov, Audrey DunnGalvin, Anastasia Chernyavskaya, Elena Kondrikova, Anastasia Kolotilina, Svetlana Gadetskaya, Yulia V. Ivanova, Irina Turina, Alina Eremeeva, Ludmila A. Fedorova, Pasquale Comberiati, Diego G. Peroni, Nikita Nekliudov, Jon Genuneit, Luis Felipe Reyes, Caroline L. H. Brackel, Lyudmila Mazankova, Alexandra Miroshina, Elmira Samitova, Svetlana Borzakova, Gail Carson, Louise Sigfrid, Janet T. Scott, Sammie McFarland, Matthew Greenhawt, Danilo Buonsenso, Malcolm G. Semple, John O. Warner, Piero Olliaro, Ismail M. Osmanov, Anatoliy A. Korsunskiy, Daniel Munblit, Khazhar Aktulaeva, Islamudin Aldanov, Nikol Alekseeva, Ramina Assanova, Asmik Avagyan, Irina Babkova, Lusine Baziyants, Anna Berbenyuk, Tatiana Bezbabicheva, Julia Chayka, Iuliia Cherdantseva, Yana Chervyakova, Tamara Chitanava, Alexander Chubukov, Natalia Degtiareva, Gleb Demyanov, Semen Demyanov, Salima Deunezhewa, Aleksandr Dubinin, Anastasia Dymchishina, Murad Dzhavadov, Leila Edilgireeva, Veronika Filippova, Yuliia Frumkina, Anastasia Gorina, Cyrill Gorlenko, Marat Gripp, Mariia Grosheva, Eliza Gudratova, Elena Iakimenko, Margarita Kalinina, Ekaterina Kharchenko, Anna Kholstinina, Bogdan Kirillov, Herman Kiseljow, Natalya Kogut, Polina Kondrashova, Irina Konova, Mariia Korgunova, Anastasia Kotelnikova, Alexandra Krupina, Anna Kuznetsova, Anastasia Kuznetsova, Anna S. Kuznetsova, Anastasia Laevskaya, Veronika Laukhina, Baina Lavginova, Yulia Levina, Elza Lidjieva, Anastasia Butorina, Juliya Lyaginskaya, Ekaterina Lyubimova, Shamil Magomedov, Daria Mamchich, Rezeda Minazetdinova, Artemii Mingazov, Aigun Mursalova, Daria Nikolaeva, Alexandra Nikolenko, Viacheslav Novikov, Georgiy Novoselov, Ulyana Ovchinnikova, Veronika Palchikova, Kira Papko, Mariia Pavlova, Alexandra Pecherkina, Sofya Permyakova, Erika Porubayeva, Kristina Presnyakova, Maksim Privalov, Alesia Prutkogliadova, Anna Pushkareva, Arina Redya, Anastasia Romanenko, Filipp Roshchin, Diana Salakhova, Maria Sankova, Ilona Sarukhanyan, Viktoriia Savina, Ekaterina Semeniako, Valeriia Seregina, Anna Shapovalova, Khivit Sharbetova, Nataliya Shishkina, Anastasia Shvedova, Valeriia Stener, Valeria Ustyan, Yana Valieva, Maria Varaksina, Katerina Varaksina, Ekaterina Varlamova, Natalia Vlasova, Margarita Yegiyan, Nadezhda Ziskina, Daniella Zolochevskaya, Elena Zuykova

Daily routine disruptions and psychiatric symptoms amid COVID-19: a systematic review and meta-analysis of data from 0.9 million individuals in 32 countries

Huinan Liu, Tiffany Junchen Tao, Selina Kit Yi Chan, Jeremy Chi Him Ma, Abby Yan Tung Lau, Ernest Tsun Fung Yeung, Stevan E. Hobfoll, Wai Kai Hou

Maternal smoking, nutritional factors at different life stage, and the risk of incident type 2 diabetes: a prospective study of the UK Biobank

Wenbo Jiang, Yiwei Tang, Ruiming Yang, Yujia Long, Changhao Sun, Tianshu Han, Wei Wei

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Tracey Smythe, Nathaniel Scherer, Carol Nanyunja, Cally J. Tann, Bolajoko O. Olusanya

Real-world nudging, pricing, and mobile physical activity coaching was insufficient to improve lifestyle behaviours and cardiometabolic health: the Supreme Nudge parallel cluster-randomised controlled supermarket trial

  • Open Access
  • Research article

Josine M. Stuber, Joreintje D. Mackenbach, Gert-Jan de Bruijn, Marleen Gillebaart, Jody C. Hoenink, Cédric N. H. Middel, Denise T. D. de Ridder, Yvonne T. van der Schouw, Edith G. Smit, Elizabeth Velema, Anne L. Vos, Wilma E. Waterlander, Jeroen Lakerveld, Joline W. J. Beulens, Femke Rutters, Stephanie Blom, Femke E. de Boer, Michel C.A. Klein, Jacqueline E. W. Broerse, Tjerk-Jan Schuitmaker-Warnaar, Ivonne Sluijs, Marjolein C. Harbers

Association between drinking water quality and mental health and the modifying role of diet: a prospective cohort study

  • Open Access
  • Anxiety
  • Research article

Shuduo Zhou, Mintao Su, Peng Shen, Zongming Yang, Pengfei Chai, Shengzhi Sun, Hongbo Lin, Liming Shui, Na Zhang, Ming Xu, Zhi-Jie Zheng, Jianbing Wang, Zhenyu Zhang, Kun Chen

Ethnicity-specific blood pressure thresholds based on cardiovascular and renal complications: a prospective study in the UK Biobank

Donghan Su, Huanhuan Yang, Zekun Chen, Yuhao Kong, Xiaona Na, Queran Lin, Ai Zhao, Yan Zheng, Yanan Ma, Xiaoyu Li, Zhihui Li

PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study

  • Open Access
  • Triage
  • Research article

Dan Cao, Zhicong Yang, Shihua Dong, Yuhong Li, Zhanrui Mao, Qi Lu, Peng Xu, Minfang Shao, Lei Pan, Xu Han, Jiangjing Yuan, Qiong Fan, Lei Chen, Yanzhong Wang, Weipei Zhu, Wenqiang Yu, Yudong Wang

Artificial intelligence in the risk prediction models of cardiovascular disease and development of an independent validation screening tool: a systematic review

Yue Cai, Yu-Qing Cai, Li-Ying Tang, Yi-Han Wang, Mengchun Gong, Tian-Ci Jing, Hui-Jun Li, Jesse Li-Ling, Wei Hu, Zhihua Yin, Da-Xin Gong, Guang-Wei Zhang

Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth

Jiayi Wu, Chuanmei Qin, Fuju Tian, Xueqing Liu, Jianing Hu, Fan Wu, Cailian Chen, Yi Lin

Co-designing care for multimorbidity: a systematic review

  • Open Access
  • Research article

Jennifer Sumner, Celeste Wen Ting Ng, Kimberly Ee Lin Teo, Adena Li Tyin Peh, Yee Wei Lim

Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis

Shu Wen, Jianwei Zhu, Xin Han, Yuchen Li, Haowen Liu, Huazhen Yang, Can Hou, Shishi Xu, Junren Wang, Yao Hu, Yuanyuan Qu, Di Liu, Thor Aspelund, Fang Fang, Unnur A. Valdimarsdóttir, Huan Song

Diagnostic and progression biomarkers in cerebrospinal fluid of Alzheimer’s disease patients

Miyo K. Chatanaka, Ioannis Prassas, Eleftherios P. Diamandis

Healthcare exposures and associated risk of endocarditis after open-heart cardiac valve surgery

Timothy N. Kwan, David Brieger, Vincent Chow, Arnold Chin Tse Ng, Gemma Kwan, Karice Hyun, Raymond Sy, Leonard Kritharides, Austin Chin Chwan Ng

Comparison of long-term radial artery occlusion via distal vs. conventional transradial access (CONDITION): a randomized controlled trial

  • Open Access
  • Research article

Tao Chen, Lamei Li, Feng Li, Wei Lu, Ganwei Shi, Wenhua Li, Anni Yang, Hui Huang, Jianqiang Xiao, Qiuwei Zhang, Jun Gu, Sheliang Xue, Liuyan Zhang, Li Li, Lingxia Xu, Rongrong Ji, Haibo Wang, Gaojun Cai

Peripheral vertigo and subsequent risk of depression and anxiety disorders: a prospective cohort study using the UK Biobank

Xiaowan Chen, Dang Wei, Fang Fang, Huan Song, Li Yin, Magnus Kaijser, Tiril Pedersen Gurholt, Ole Andreas Andreassen, Unnur Valdimarsdóttir, Kejia Hu, Maoli Duan

Efficacy of virtual reality for pain relief in medical procedures: a systematic review and meta-analysis

  • Open Access
  • Research article

Jhia J. Teh, Dominic J. Pascoe, Safiya Hafeji, Rohini Parchure, Adam Koczoski, Michael P. Rimmer, Khalid S. Khan, Bassel H. Al Wattar

Exploration of the potential association between GLP-1 receptor agonists and suicidal or self-injurious behaviors: a pharmacovigilance study based on the FDA Adverse Event Reporting System database

Jianxing Zhou, You Zheng, Baohua Xu, Songjun Long, Li-e Zhu, Yunhui Liu, Chengliang Li, Yifan Zhang, Maobai Liu, Xuemei Wu

Association between pregnancy-related complications and development of type 2 diabetes and hypertension in women: an umbrella review

Steven Wambua, Megha Singh, Kelvin Okoth, Kym I. E. Snell, Richard D. Riley, Christopher Yau, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Francesca L. Crowe

Influence of light at night on allergic diseases: a systematic review and meta-analysis

Andy Deprato, Robert Maidstone, Anna Palomar Cros, Ana Adan, Prasun Haldar, Barbara N. Harding, Paige Lacy, Lyle Melenka, Saibal Moitra, José Francisco Navarro, Manolis Kogevinas, Hannah J Durrington, Subhabrata Moitra

Developing a practical neurodevelopmental prediction model for targeting high-risk very preterm infants during visit after NICU: a retrospective national longitudinal cohort study

  • Open Access
  • Research article

Hao Wei Chung, Ju-Chieh Chen, Hsiu-Lin Chen, Fang-Yu Ko, Shinn-Ying Ho, Jui-Hsing Chang, Kuo-Inn Tsou, Po-Nien Tsao, Shu-Chi Mu, Chyong-Hsin Hsu, Reyin Lien, Hung-Chih Lin, Chien-Chou Hsiao, Chao-Ching Huang, Chih-Cheng Chen

Higher-valency pneumococcal conjugate vaccines in older adults, taking into account indirect effects from childhood vaccination: a cost-effectiveness study for the Netherlands

Pieter T. de Boer, Cornelis H. van Werkhoven, Albert Jan van Hoek, Mirjam J. Knol, Elisabeth A. M. Sanders, Jacco Wallinga, Hester E. de Melker, Anneke Steens

Correction: Predicting drug response from single-cell expression profiles of tumours

  • Open Access
  • Correction

Simona Pellecchia, Gaetano Viscido, Melania Franchini, Gennaro Gambardella

Correction: Coronary microvascular function in male physicians with burnout and job stress: an observational study

Roland von Känel , Mary Princip, Sarah A. Holzgang, Chrysoula Garefa, Alexia Rossi, Dominik C. Benz, Andreas A. Giannopoulos, Philipp A. Kaufmann, Ronny R. Buechel, Claudia Zuccarella-Hackl, Aju P. Pazhenkottil

The effectiveness, implementation, and experiences of peer support approaches for mental health: a systematic umbrella review

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Ruth E. Cooper, Katherine R. K. Saunders, Anna Greenburgh, Prisha Shah, Rebecca Appleton, Karen Machin, Tamar Jeynes, Phoebe Barnett, Sophie M. Allan, Jessica Griffiths, Ruth Stuart, Lizzie Mitchell, Beverley Chipp, Stephen Jeffreys, Brynmor Lloyd-Evans, Alan Simpson, Sonia Johnson

Risk-based lung cancer screening in heavy smokers: a benefit–harm and cost-effectiveness modeling study

Yin Liu, Huifang Xu, Lihong Lv, Xiaoyang Wang, Ruihua Kang, Xiaoli Guo, Hong Wang, Liyang Zheng, Hongwei Liu, Lanwei Guo, Qiong Chen, Shuzheng Liu, Youlin Qiao, Shaokai Zhang

Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer

Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato, Razelle Kurzrock

Comparison of immune checkpoint inhibitors related to pulmonary adverse events: a retrospective analysis of clinical studies and network meta-analysis

Baohui Hong, Bin Du, Rong Chen, Caiyun Zheng, Ruping Ni, Maobai Liu, Jing Yang

Efficacy of interventions targeted at physician prescribers of opioids for chronic non-cancer pain: an overview of systematic reviews

  • Open Access
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Katya Peri, Lucy Honeycutt, Erica Wennberg, Sarah B. Windle, Kristian B. Filion, Genevieve Gore, Irina Kudrina, Elena Paraskevopoulos, Areesha Moiz, Marc O. Martel, Mark J. Eisenberg

Characteristics and clinical treatment outcomes of chronic hepatitis B children with coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg

Yingping Gu, Shuangjie Li, Zhenzhen Yao, Xin Lai, Meng Yang, Yi Xu, Songxu Peng

Immunogenicity and safety of RAZI recombinant spike protein vaccine (RCP) as a booster dose after priming with BBIBP-CorV: a parallel two groups, randomized, double blind trial

Saeed Erfanpoor, Seyed Reza Banihashemi, Ladan Mokhbaeralsafa, Saeed Kalantari, Ali Es-haghi, Mojtaba Nofeli, Ali Rezaei Mokarram, Fariba Sadeghi, Monireh Hajimoradi, Seyad Hossein Razaz, Maryam Taghdiri, Mohsen Lotfi, Akbar Khorasani, Akram Ansarifar, Safdar Masoumi, Arash Mohazzab, Sara Filsoof, Vahideh Mohseni, Masoumeh Shahsavan, Niloufar Gharavi, Seyed Amin Setarehdan, Mohammad Hasan Rabiee, Mohammad Hossein Fallah Mehrabadi, Masoud Solaymani-Dodaran

Novel insights from our special issue on maternal factors during pregnancy that influence maternal, fetal and childhood outcomes

Stephen Tong, Katrien Benhalima, Louis Muglia, Susan Ozanne

Safety, feasibility, and impact on the gut microbiome of kefir administration in critically ill adults

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Vinod K. Gupta, Sanu Rajendraprasad, Mahmut Ozkan, Dhanya Ramachandran, Sumera Ahmad, Johan S. Bakken, Krzysztof Laudanski, Ognjen Gajic, Brent Bauer, Simon Zec, David W. Freeman, Sahil Khanna, Aditya Shah, Joseph H. Skalski, Jaeyun Sung, Lioudmila V. Karnatovskaia

Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization

Loukas Zagkos, Héléne T. Cronjé, Benjamin Woolf, Roxane de La Harpe, Stephen Burgess, Christos S. Mantzoros, Paul Elliott, Shuai Yuan, Susanna C. Larsson, Ioanna Tzoulaki, Dipender Gill

Association between patient ethnicity and prostate cancer diagnosis following a prostate-specific antigen test: a cohort study of 730,000 men in primary care in the UK

Liz Down, Melissa Barlow, Sarah E. R. Bailey, Luke T. A. Mounce, Samuel W. D. Merriel, Jessica Watson, Tanimola Martins

Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials

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Chang Xu, Fengying Zhang, Suhail A. R. Doi, Luis Furuya-Kanamori, Lifeng Lin, Haitao Chu, Xi Yang, Sheyu Li, Liliane Zorzela, Su Golder, Yoon Loke, Sunita Vohra

Estrogen-modulating treatment among mid-life women and COVID-19 morbidity and mortality: a multiregister nationwide matched cohort study in Sweden

Evangelia Elenis, Helena Kopp Kallner, Maria A. Karalexi, David Hägg, Marie Linder, Katja Fall, Fotios C. Papadopoulos, Alkistis Skalkidou

Mesenchymal stromal cells plus basiliximab improve the response of steroid-refractory acute graft-versus-host disease as a second-line therapy: a multicentre, randomized, controlled trial

Haixia Fu, Xueyan Sun, Ren Lin, Yu Wang, Li Xuan, Han Yao, Yuanyuan Zhang, Xiaodong Mo, Meng lv, Fengmei Zheng, Jun Kong, Fengrong Wang, Chenhua Yan, Tingting Han, Huan Chen, Yao Chen, Feifei Tang, Yuqian Sun, Yuhong Chen, Lanping Xu, Kaiyan Liu, Xi Zhang, Qifa Liu, Xiaojun Huang, Xiaohui Zhang

Myocardial bridging in obstructive hypertrophic cardiomyopathy: a risk factor for myocardial fibrosis

Changpeng Song, Shengwei Wang, Xinli Guo, Manyun Huang, Xinxin Zheng, Jie Lu, Keshan Ji, Shihua Zhao, Jingang Cui, Shuiyun Wang, Xiaohong Huang

Supermarket interventions to improve dietary and lifestyle behaviours: what is the key to success?

  • Open Access
  • Commentary

Carmen Piernas

Mid- and long-term risk of atrial fibrillation among breast cancer surgery survivors

Yong-Moon Mark Park, Wonyoung Jung, Yohwan Yeo, Sang Hyun Park, Michael G. Fradley, Sindhu J. Malapati, Tushar Tarun, Vinay Raj, Hong Seok Lee, Tasneem Z. Naqvi, Ronda S. Henry-Tillman, Jawahar L. Mehta, Mario Schootman, Benjamin C. Amick III, Kyungdo Han, Dong Wook Shin

Specific dairy foods and risk of frailty in older women: a prospective cohort study

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Ellen A. Struijk, Teresa T. Fung, Fernando Rodriguez-Artalejo, Heike A. Bischoff-Ferrari, Walter C. Willett, Esther Lopez-Garcia

Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants

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Yaxin Chen, Yufang Xie, Hang Ci, Zhengpei Cheng, Yongjie Kuang, Shuqing Li, Gang Wang, Yawen Qi, Jun Tang, Dan Liu, Weimin Li, Yaohua Yang

Exploring the Smoking-Epilepsy Nexus: a systematic review and meta-analysis of observational studies

Yerin Kang, Sieun Kim, Yunah Jung, Dai Sik Ko, Hyun-Woo Kim, Jung-Pil Yoon, Sunghwan Cho, Tae-Jin Song, Kihun Kim, Eunjeong Son, Yun Hak Kim

Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit/hyperactivity disorder

Wanfang You, Qian Li, Lizhou Chen, Ning He, Yuanyuan Li, Fenghua Long, Yaxuan Wang, Yufei Chen, Robert K. McNamara, John A. Sweeney, Melissa P. DelBello, Qiyong Gong, Fei Li

The role of lifestyle in the association between long-term ambient air pollution exposure and cardiovascular disease: a national cohort study in China

Xiangming Hu, Luke D. Knibbs, Yingling Zhou, Yanqiu Ou, Guang-Hui Dong, Haojian Dong

Autoimmune diseases and adverse pregnancy outcomes: an umbrella review

Megha Singh, Steven Wambua, Siang Ing Lee, Kelvin Okoth, Zhaonan Wang, Fathima Fazla Ahamed Fayaz, Kelly-Ann Eastwood, Catherine Nelson-Piercy, John A. Reynolds, Krishnarajah Nirantharakumar, Francesca Crowe

Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure

Hozeifa Mohamed Hassan, Xi Liang, Jiaojiao Xin, Yingyan Lu, Qun Cai, Dongyan Shi, Keke Ren, Jun Li, Qi Chen, Jiang Li, Peng Li, Beibei Guo, Hui Yang, Jinjin Luo, Heng Yao, Xingping Zhou, Wen Hu, Jing Jiang, Jun Li

TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yong-Ping Chen

Carbohydrate quality, not quantity, linked to reduced colorectal cancer incidence and mortality in US populations: evidence from a prospective study

Yi Xiao, Ling Xiang, Yahui Jiang, Yunhao Tang, Haitao Gu, Yaxu Wang, Linglong Peng

Subsidized gestational diabetes mellitus screening and management program in rural China: a pragmatic multicenter, randomized controlled trial

Tingting Xu, Qing Xia, Xiaozhen Lai, Kun He, Dazhi Fan, Liangkun Ma, Hai Fang

Characterising smoking and nicotine use behaviours among women of reproductive age: a 10-year population study in England

Sarah E. Jackson, Jamie Brown, Caitlin Notley, Lion Shahab, Sharon Cox

A self-controlled case series study to measure the risk of SARS-CoV-2 infection associated with attendance at sporting and cultural events: the UK Events Research Programme events

Ian J. Douglas, Jerlyn Peh, Kathryn E. Mansfield, Anna Trelfa, Tom Fowler, Matthew Boulter, Paul Cleary, Jenifer Smith, W. John Edmunds

Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis

Limin Cao, Yu An, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu, Liangkai Chen, Yang Xia

Medication adherence in patients with type 2 diabetes after disability onset: a difference-in-differences analysis using nationwide data

Szu-Han Chen, Miaw-Chwen Lee, Christy Pu

Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination

Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamaria, Luis Izquierdo, Antoni Trilla, Anna Vilella, Sonia Barroso, Marta Tortajada, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño

Gut microbiome features and metabolites in non-alcoholic fatty liver disease among community-dwelling middle-aged and older adults

Fangfang Zeng, Xin Su, Xinxiu Liang, Minqi Liao, Haili Zhong, Jinjian Xu, Wanglong Gou, Xiangzhou Zhang, Luqi Shen, Ju-Sheng Zheng, Yu-ming Chen

Characterization and trajectories of hematological parameters prior to severe COVID-19 based on a large-scale prospective health checkup cohort in western China: a longitudinal study of 13-year follow-up

Yifei Lin, Yong Yang, Nanyan Xiang, Le Wang, Tao Zheng, Xuejun Zhuo, Rui Shi, Xiaoyi Su, Yan Liu, Ga Liao, Liang Du, Jin Huang

Breastfeeding is associated with enhanced intestinal gluconeogenesis in infants

  • Open Access
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Duan Ni, Jian Tan, Laurence Macia, Ralph Nanan

Camrelizumab plus gemcitabine and oxaliplatin for relapsed or refractory classical Hodgkin lymphoma: a phase II trial

Yanfei Liu, Lingyan Ping, Yuqin Song, Yongjing Tang, Wen Zheng, Weiping Liu, Zhitao Ying, Chen Zhang, Meng Wu, Feier Feng, Ningjing Lin, Meifeng Tu, Jun Zhu, Yan Xie

Degree of joint risk factor control and hazard of mortality in diabetes patients: a matched cohort study in UK Biobank

Jian Zhou, Xuan Wang, Rui Tang, Minghao Kou, Hao Ma, Xiang Li, Yoriko Heianza, Vivian Fonseca, Lu Qi

The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis

Seung Wan Suh, Eunji Lim, Suh-Yuhn Burm, Hyungji Lee, Jong Bin Bae, Ji Won Han, Ki Woong Kim

Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials

Liuting Zeng, Kailin Yang, Qi He, Xiaofei Zhu, Zhiyong Long, Yang Wu, Junpeng Chen, Yuwei Li, Jinsong Zeng, Ge Cui, Wang Xiang, Wensa Hao, Lingyun Sun

Malaria vaccination: hurdles to reach high-risk children

Floriano Amimo

Low awareness of the transitivity assumption in complex networks of interventions: a systematic survey from 721 network meta-analyses

  • Open Access
  • Research article

Loukia M. Spineli, Chrysostomos Kalyvas, Juan Jose Yepes-Nuñez, Andrés Mauricio García-Sierra, Diana C. Rivera-Pinzón, Svenja E. Seide, Katerina Papadimitropoulou

The optimal antithrombotic strategy for post-stroke patients with atrial fibrillation and extracranial artery stenosis—a nationwide cohort study

Chuan-Tsai Tsai, Yi-Hsin Chan, Jo-Nan Liao, Tzeng-Ji Chen, Gregory Y. H. Lip, Shih-Ann Chen, Tze-Fan Chao

Assessing the impact of type 2 diabetes on mortality and life expectancy according to the number of risk factor targets achieved: an observational study

Bin Wang, Yanqi Fu, Xiao Tan, Ningjian Wang, Lu Qi, Yingli Lu

Investigating the nexus of metabolic syndrome, serum uric acid, and dementia risk: a prospective cohort study

Tara SR Chen, Ning-Ning Mi, Hubert Yuenhei Lao, Chen-Yu Wang, Wai Leung Ambrose Lo, Yu-Rong Mao, Yan Tang, Zhong Pei, Jin-Qiu Yuan, Dong-Feng Huang

Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review

Chengchen Duan, Liu Liu, Tianyi Wang, Guanru Wang, Zhishen Jiang, Honglin Li, Gaowei Zhang, Li Ye, Chunjie Li, Yubin Cao

Paxlovid use is associated with lower risk of cardiovascular diseases in COVID-19 patients with autoimmune rheumatic diseases: a retrospective cohort study

Weijie Wang, Yu-Hsun Wang, Ching-Hua Huang, Tsung-Hsueh Hsieh, Gema Hernández Ibarburu, James Cheng-Chung Wei

The medication-based Rx-Risk Comorbidity Index and risk of hip fracture - a nationwide NOREPOS cohort study

Siri Marie Solbakken, Haakon Eduard Meyer, Cecilie Dahl, Trine Elisabeth Finnes, Vidar Hjellvik, Christopher Sivert Nielsen, Tone Kristin Omsland, Hein Stigum, Kristin Holvik

Safety and efficacy of sirolimus in recurrent intravenous leiomyomatosis, pulmonary benign metastatic leiomyomatosis, and leiomyomatosis peritonealis disseminata: a pilot study

Guorui Zhang, Rong Fan, Hua Yang, Hao Su, Xin Yu, Yutong Wang, Fengzhi Feng, Lan Zhu

Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks

Young Chan Lee, Sang-Hyuk Jung, Manu Shivakumar, Soojin Cha, Woong-Yang Park, Hong-Hee Won, Young-Gyu Eun, Penn Medicine Biobank, Dokyoon Kim

Improved emotion differentiation under reduced acoustic variability of speech in autism

Mathilde Marie Duville, Luz María Alonso-Valerdi, David I. Ibarra-Zarate

Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells

  • Open Access
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Dohee Yoon, Bongkun Choi, Ji-Eun Kim, Eun-Young Kim, Soo-Hyun Chung, Hyo-Jin Min, Yoolim Sung, Eun-Ju Chang, Jae-Kwan Song

Risk of encephalitis and meningitis after COVID-19 vaccination in South Korea: a self-controlled case series analysis

Ju Hwan Kim, Dongwon Yoon, Hwa Yeon Ko, Kyungyeon Jung, Jun-Sang Sunwoo, Won Chul Shin, Jung-Ick Byun, Ju-Young Shin

SARS-CoV-2 infection is detrimental to pregnancy outcomes after embryo transfer in IVF/ICSI: a prospective cohort study

Yuan Li, Qi Zhao, Shujuan Ma, Sha Tang, Guangxiu Lu, Ge Lin, Fei Gong

Incorporating social vulnerability in infectious disease mathematical modelling: a scoping review

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Megan Naidoo, Whitney Shephard, Innocensia Kambewe, Nokuthula Mtshali, Sky Cope, Felipe Alves Rubio, Davide Rasella

Comparing the clinical practice and prescribing safety of locum and permanent doctors: observational study of primary care consultations in England

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Christos Grigoroglou, Kieran Walshe, Evangelos Kontopantelis, Jane Ferguson, Gemma Stringer, Darren M. Ashcroft, Thomas Allen

Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: a 7-year longitudinal cohort study in a large population

Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Ugo Trama, Maria Virginia Manzi, Angela Lombardi, Roberto Piccinocchi, Paola Gallo, Giovanni Esposito, Gaetano Piccinocchi, Maria Lembo, Carmine Morisco, Francesco Rozza, Gaetano Santulli, Bruno Trimarco

Correction: Transient increased risk of influenza infection following RSV infection in South Africa: findings from the PHIRST study, South Africa, 2016–2018

Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen, Stefan Flasche

Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study

Catherine J. Wedderburn, Shunmay Yeung, Sivenesi Subramoney, Jean-Paul Fouche, Shantanu H. Joshi, Katherine L. Narr, Andrea M. Rehman, Annerine Roos, Diana M. Gibb, Heather J. Zar, Dan J. Stein, Kirsten A. Donald

Regional disparities and risk factors of mortality among patients at high risk of sudden cardiac death in emerging countries: a nonrandomized controlled trial

Shuang Zhao, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A. Rodriguez-Guerrero, Azlan Hussin, Young-Hoon Kim, Brian Van Dorn, Xiaohong Zhou, Balbir Singh, Shu Zhang

Progress with the Learning Health System 2.0: a rapid review of Learning Health Systems’ responses to pandemics and climate change

Carolynn L. Smith, Georgia Fisher, Putu Novi Arfirsta Dharmayani, Shalini Wijekulasuriya, Louise A. Ellis, Samantha Spanos, Genevieve Dammery, Yvonne Zurynski, Jeffrey Braithwaite

Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies

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Lu Gan, Bin Zhao, Maki Inoue-Choi, Linda M. Liao, Barry I. Graubard, Stephanie J. Weinstein, Demetrius Albanes, Jiaqi Huang

Sarcopenic obesity is part of obesity paradox in dementia development: evidence from a population-based cohort study

  • Open Access
  • Obesity
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Junhan Zhang, Xiaona Na, Zhihui Li, John S. Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi, Donghan Su, Huatang Zeng, Liqun Wu, Ai Zhao

Sleep alterations as a function of 88 health indicators

Péter Przemyslaw Ujma, Róbert Bódizs

Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses

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Ana Lucia Espinosa Dice, Rebecca B. Lawn, Andrew Ratanatharathorn, Andrea L. Roberts, Christy A. Denckla, Ariel H. Kim, Pedro A. de la Rosa, Yiwen Zhu, Tyler J. VanderWeele, Karestan C. Koenen

Medication non-adherence and self-inflicted violence behaviors among 185,800 patients with schizophrenia in the community: a 12-year cohort study

  • Open Access
  • Suicide
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Chuanlong Zuo, Xianmei Yang, Xiangrui Wu, Ruoxin Fan, Jun Liu, Hu Xiang, Yang Li, Xing Zhao, Xiang Liu, Yuanyuan Liu

Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations

Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang

Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s disease

Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu, Longfei Jia

Evaluation of a hospital-initiated tobacco dependence treatment service: uptake, smoking cessation, readmission and mortality

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John Robins, Irem Patel, Ann McNeill, John Moxham, Arran Woodhouse, Gareth Absalom, Buljana Shehu, Geraldine Bruce, Amy Dewar, Alanna Molloy, Stephanie Duckworth Porras, Michael Waring, Andrew Stock, Debbie Robson

Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity

  • Open Access
  • Obesity
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Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson, Jetro J. Tuulari

Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss

  • Open Access
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Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won, Dokyoon Kim

A phase II study of belumosudil for chronic graft-versus-host disease in patients who failed at least one line of systemic therapy in China

Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang, Ying Zhang

SARS-CoV-2, influenza A/B and respiratory syncytial virus positivity and association with influenza-like illness and self-reported symptoms, over the 2022/23 winter season in the UK: a longitudinal surveillance cohort

Elisabeth Dietz, Emma Pritchard, Koen Pouwels, Muhammad Ehsaan, Joshua Blake, Charlotte Gaughan, Eric Haduli, Hugh Boothe, Karina-Doris Vihta, Tim Peto, Nicole Stoesser, Philippa Matthews, Nick Taylor, Ian Diamond, Ruth Studley, Emma Rourke, Paul Birrell, Daniela De Angelis, Tom Fowler, Conall Watson, David Eyre, Thomas House, Ann Sarah Walker

A practical evidence-based approach to management of type 2 diabetes in children and young people (CYP): UK consensus

Billy White, S. M. Ng, J. C. Agwu, T. G. Barrett, N. Birchmore, M. Kershaw, J. Drew, F. Kavvoura, J. Law, C. Moudiotis, E. Procter, P. Paul, F. Regan, P. Reilly, P. Sachdev, R. Sakremath, C. Semple, K. Sharples, M. Skae, A. Timmis, E. Williams, N. Wright, A. Soni

Inpatient-level care at home delivered by virtual wards and hospital at home: a systematic review and meta-analysis of complex interventions and their components

  • Open Access
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Chunhu Shi, Jo Dumville, Fernando Rubinstein, Gill Norman, Akbar Ullah, Saima Bashir, Peter Bower, Emma R. L. C. Vardy

Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2

  • Open Access
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Xiao Zhang, Yuyanan Zhang, Hao Yan, Hao Yu, Dai Zhang, Venkata S. Mattay, Hao Yang Tan, Weihua Yue

Blood leukocytes as a non-invasive diagnostic tool for thyroid nodules: a prospective cohort study

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Feihang Wang, Danyang Zhao, Wang-yang Xu, Yiying Liu, Huiyi Sun, Shanshan Lu, Yuan Ji, Jingjing Jiang, Yi Chen, Qiye He, Chengxiang Gong, Rui Liu, Zhixi Su, Yi Dong, Zhiping Yan, Lingxiao Liu

Real-world performance of indobufen versus aspirin after percutaneous coronary intervention: insights from the ASPIRATION registry

Chunfeng Dai, Muyin Liu, Zheng Yang, Youran Li, You Zhou, Danbo Lu, Yan Xia, Ao Chen, Chenguang Li, Hao Lu, Yuxiang Dai, Jianying Ma, Zhangwei Chen, Juying Qian, Junbo Ge

Interventions on gender equity in the workplace: a scoping review

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Andrea C. Tricco, Amanda Parker, Paul A. Khan, Vera Nincic, Reid Robson, Heather MacDonald, Rachel Warren, Olga Cleary, Elaine Zibrowski, Nancy Baxter, Karen E. A. Burns, Doug Coyle, Ruth Ndjaboue, Jocalyn P. Clark, Etienne V. Langlois, Sofia B. Ahmed, Holly O. Witteman, Ian D. Graham, Wafa El-Adhami, Becky Skidmore, France Légaré, Janet Curran, Gillian Hawker, Jennifer Watt, Ivy Lynn Bourgeault, Jeanna Parsons Leigh, Karen Lawford, Alice Aiken, Christopher McCabe, Sasha Shepperd, Reena Pattani, Natalie Leon, Jamie Lundine, Évèhouénou Lionel Adisso, Santa Ono, Linda Rabeneck, Sharon E. Straus

Canadians’ use of cannabis for therapeutic purposes since legalization of recreational cannabis: a cross-sectional analysis by medical authorization status

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Lynda G. Balneaves, Ashleigh Brown, Matthew Green, Erin Prosk, Lucile Rapin, Max Monahan-Ellison, Eva McMillan, Jonathan Zaid, Michael Dworkind, Cody Z. Watling

Patterns of comorbidities in patients with atrial fibrillation and impact on management and long-term prognosis: an analysis from the Prospective Global GLORIA-AF Registry

Giulio Francesco Romiti, Bernadette Corica, Davide Antonio Mei, Arnaud Bisson, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip

Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases

Xiaohui Sun, Yu Qian, Weiqiu Cheng, Ding Ye, Bin Liu, Dan Zhou, Chengping Wen, Ole A. Andreassen, Yingying Mao

Cervical lymph node metastasis prediction from papillary thyroid carcinoma US videos: a prospective multicenter study

Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu, Jie Tian, Yu-Kun Luo, Kun Wang

PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer

Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu, Jianing Cao, Qin Zhu, Li Liang

Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study

Adrian Dahl Askelund, Robyn E. Wootton, Fartein A. Torvik, Rebecca B. Lawn, Helga Ask, Elizabeth C. Corfield, Maria C. Magnus, Ted Reichborn-Kjennerud, Per M. Magnus, Ole A. Andreassen, Camilla Stoltenberg, George Davey Smith, Neil M. Davies, Alexandra Havdahl, Laurie J. Hannigan

The effects of telehealth-delivered mindfulness meditation, cognitive therapy, and behavioral activation for chronic low back pain: a randomized clinical trial

Melissa A. Day, Marcia A. Ciol, M. Elena Mendoza, Jeffrey Borckardt, Dawn M. Ehde, Andrea K. Newman, Joy F. Chan, Sydney A. Drever, Janna L. Friedly, John Burns, Beverly E. Thorn, Mark P. Jensen

Identification and support of autistic individuals within the UK Criminal Justice System: a practical approach based upon professional consensus with input from lived experience

  • Open Access
  • Guideline

Emma Woodhouse, Jack Hollingdale, Lisa Davies, Zainab Al-Attar, Susan Young, Luke P. Vinter, Kwaku Agyemang, Carla Bartlett, Colleen Berryessa, Eddie Chaplin, Quinton Deeley, Ian Freckelton, Felicity Gerry, Gisli Gudjonsson, Katie Maras, Michelle Mattison, Jane McCarthy, Richard Mills, Peter Misch, David Murphy, Clare Allely

Olfactory bulb anomalies in KBG syndrome mouse model and patients

  • Open Access
  • Anosmia
  • Research article

Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E. S. Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh-Bergès, Karen J. Low, Anastassia Voronova

What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnography

Trisha Greenhalgh, Julie L. Darbyshire, Cassie Lee, Emma Ladds, Jenny Ceolta-Smith

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Wei Hu, Bao-Peng Liu, Cun-Xian Jia

Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

Xinghao Yu, Yiyin Chen, Jia Chen, Yi Fan, Huimin Lu, Depei Wu, Yang Xu

COVID-19 inequalities in England: a mathematical modelling study of transmission risk and clinical vulnerability by socioeconomic status

Lucy Goodfellow, Edwin van Leeuwen, Rosalind M. Eggo

Quantifying the impact of hospital catchment area definitions on hospital admissions forecasts: COVID-19 in England, September 2020–April 2021

Sophie Meakin, Sebastian Funk

Lipid metabolic reprogramming mediated by circulating Nrg4 alleviates metabolic dysfunction-associated steatotic liver disease during the early recovery phase after sleeve gastrectomy

Chengcan Yang, Dongzi Zhu, Chaofan Liu, Wenyue Wang, Yining He, Bing Wang, Meiyi Li

Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma

Meiyan Zhu, Meng Jin, Xiao Zhao, Shunli Shen, Yihan Chen, Han Xiao, Guangyan Wei, Qiang He, Bin Li, Zhenwei Peng

Prevalence and differences in the co-administration of drugs known to interact: an analysis of three distinct and large populations

Jon Sánchez-Valle, Rion Brattig Correia, Marta Camacho-Artacho, Rosalba Lepore, Mauro M. Mattos, Luis M. Rocha, Alfonso Valencia

Variability in the prevalence of depression among adults with chronic pain: UK Biobank analysis through clinical prediction models

Lingxiao Chen, Claire E Ashton-James, Baoyi Shi, Maja R Radojčić, David B Anderson, Yujie Chen, David B Preen, John L Hopper, Shuai Li, Minh Bui, Paula R Beckenkamp, Nigel K Arden, Paulo H Ferreira, Hengxing Zhou, Shiqing Feng, Manuela L Ferreira

Undiagnosed type 2 diabetes is common – intensified screening of established risk groups is imperative in Sweden: the SDPP cohort

Hrafnhildur Gudjonsdottir, Per Tynelius, Nouha Saleh Stattin, Diego Yacamán Méndez, Anton Lager, Boel Brynedal

Impact of COVID-19 pandemic on depression incidence and healthcare service use among patients with depression: an interrupted time-series analysis from a 9-year population-based study

Vivien Kin Yi Chan, Yi Chai, Sandra Sau Man Chan, Hao Luo, Mark Jit, Martin Knapp, David Makram Bishai, Michael Yuxuan Ni, Ian Chi Kei Wong, Xue Li

A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial

M. Alkema, M. J. Smit, C. Marin-Mogollon, K. Totté, K. Teelen, G. J. van Gemert, M. van de Vegte-Bolmer, B. G. Mordmüller, J. M. Reimer, K. L. Lövgren-Bengtsson, R. W. Sauerwein, T. Bousema, J. Plieskatt, M. Theisen, M. M. Jore, M. B. B. McCall

Impact of perioperative low-molecular-weight heparin therapy on clinical events of elderly patients with prior coronary stents implanted > 12 months undergoing non-cardiac surgery: a randomized, placebo-controlled trial

Bin Wang, Yanhui Su, Cong Ma, Lining Xu, Qunxia Mao, Wenjia Cheng, Qingming Lu, Ying Zhang, Rong Wang, Yan Lu, Jing He, Shihao Chen, Lei Chen, Tianzhi Li, Linggen Gao

Efficacy and safety of tislelizumab plus lenvatinib as first-line treatment in patients with unresectable hepatocellular carcinoma: a multicenter, single-arm, phase 2 trial

Li Xu, Jinzhang Chen, Chang Liu, Xiaoling Song, Yanqiao Zhang, Haitao Zhao, Sheng Yan, Weidong Jia, Zheng Wu, Yabing Guo, Jiayin Yang, Wei Gong, Yue Ma, Xiaobo Yang, Zhenzhen Gao, Nu Zhang, Xin Zheng, Mengyu Li, Dan Su, Minshan Chen

Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease: a cohort study

Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engström, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson, Olle Melander

Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer

Ruoshuang Han, Haoyue Guo, Jinpeng Shi, Sha Zhao, Yijun Jia, Xiaozhen Liu, Yiwei Liu, Lei Cheng, Chao Zhao, Xuefei Li, Caicun Zhou

Long-term assessment of the NHS hybrid closed-loop real-world study on glycaemic outcomes, time-in-range, and quality of life in children and young people with type 1 diabetes

Sze May Ng, Neil P. Wright, Diana Yardley, Fiona Campbell, Tabitha Randell, Nicola Trevelyan, Atrayee Ghatak, Peter C. Hindmarsh

Mini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial

Yu Wang, Qi-Fa Liu, De-Pei Wu, Zheng-Li Xu, Ting-Ting Han, Yu-Qian Sun, Fen Huang, Zhi-Ping Fan, Na Xu, Feng Chen, Ye Zhao, Yuan Kong, Xiao-Dong Mo, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang

The Healthy Start scheme in England “is a lifeline for families but many are missing out”: a rapid qualitative analysis

  • Open Access
  • Research article

Millie Barrett, Mark Spires, Christina Vogel

Correction: Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells

  • Open Access
  • Correction

Dohee Yoon, Bongkun Choi, Ji-Eun Kim, Eun-Young Kim, Soo-Hyun Chung, Hyo-Jin Min, Yoolim Sung, Eun-Ju Chang, Jae-Kwan Song

Correction: Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma

Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung, Shun He, Jinqiu Yuan, Wenbo Meng, Xun Li

Suicide mortality following the implementation of tobacco packaging and pricing policies in Korea: an interrupted time-series analysis

  • Open Access
  • Suicide
  • Research article

Taiyue Jin, Juhee Seo, Shinhee Ye, Seulbi Lee, Eun Young Park, Jin-Kyoung Oh, Changwoo Han, Byungmi Kim

First-trimester fetal size, accelerated growth in utero, and child neurodevelopment in a cohort study

  • Open Access
  • Research article

Xinmei Chen, Hongxiu Liu, Yuanyuan Li, Wenxin Zhang, Aifen Zhou, Wei Xia, Shunqing Xu

Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib

Oryan Agranyoni, Debpali Sur, Sivan Amidror, Nuphar Shidlovsky, Anastasia Bagaev, Nissan Yissachar, Albert Pinhasov, Shiri Navon-Venezia

Toward evidence-based communication on overweight body mass index and mortality

Maya B. Mathur, Vandana S. Mathur

The effectiveness of a standardized tobacco cessation program on psychophysiological parameters in patients with addiction undergoing long-term rehabilitation: a quasi-experimental pilot study

J. Fuchshuber, H. Schöber, M. Wohlmuth, H. Senra, C. Rominger, A. Schwerdtfeger, H. F. Unterrainer

A randomized controlled trial of an app-based intervention on physical activity and glycemic control in people with type 2 diabetes

Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim

Driving delivery and uptake of catch-up vaccination among adolescent and adult migrants in UK general practice: a mixed methods pilot study

Alison F. Crawshaw, Lucy P. Goldsmith, Anna Deal, Jessica Carter, Felicity Knights, Farah Seedat, Karen Lau, Sally E. Hayward, Joanna Yong, Desiree Fyle, Nathaniel Aspray, Michiyo Iwami, Yusuf Ciftci, Fatima Wurie, Azeem Majeed, Alice S. Forster, Sally Hargreaves

Histology-specific standardized incidence ratio improves the estimation of second primary lung cancer risk

Marian Eberl, Luana F. Tanaka, Klaus Kraywinkel, Stefanie J. Klug

Floods and cause-specific mortality in the UK: a nested case-control study

  • Open Access
  • Suicide
  • Research article

Yao Wu, Danijela Gasevic, Bo Wen, Zhengyu Yang, Pei Yu, Guowei Zhou, Yan Zhang, Jiangning Song, Hong Liu, Shanshan Li, Yuming Guo

Glucose competition between endothelial cells in the blood-spinal cord barrier and infiltrating regulatory T cells is linked to sleep restriction-induced hyperalgesia

  • Open Access
  • Research article

Yulin Huang, Rui Xu, Qi Liu, Xiao Zhang, Yanting Mao, Yan Yang, Xiaoping Gu, Yue Liu, Zhengliang Ma

A proposed simplified definition of metabolic syndrome in children and adolescents: a global perspective

Xin’nan Zong, Roya Kelishadi, Hae Soon Kim, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Peter H. Whincup, Lucia Pacifico, Abel López-Bermejo, Min Zhao, Miaobing Zheng, Bo Xi

Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium — positive effects on thyroid hormones, cardiovascular mortality, and quality of life

  • Open Access
  • Research article

Urban Alehagen, Jan Alexander, Jan O. Aaseth, Anders Larsson, Trine B. Opstad

Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank

Xiaofei Wang, Ziyan Shi, Yuhan Qiu, Dongren Sun, Hongyu Zhou

Deprescribing of antidepressants: development of indicators of high-risk and overprescribing using the RAND/UCLA Appropriateness Method

Vita Brisnik, Jochen Vukas, Caroline Jung-Sievers, Karoline Lukaschek, G Caleb Alexander, Ulrich Thiem, Petra Thürmann, Cornelius Schüle, Sebastian Fischer, Erika Baum, Michael Drey, Sebastian Harder, Wilhelm Niebling, Ulrike Janka, Olaf Krause, Jochen Gensichen, Tobias Dreischulte, Peter Falkai, Peter Henningsen, Markus Bühner, Helmut Krcmar, Gabriele Pitschel-Walz, Antonius Schneider, Katharina Biersack, Constantin Brand, Christopher Ebert, Julia Eder, Feyza Gökce, Carolin Haas, Lisa Hattenkofer, Lukas Kaupe, Jonas Raub, Philipp Reindl-Spanner, Hannah Schillok, Petra Schönweger, Clara Teusen, Marie Vogel, Victoria von Schrottenberg, Puya Younesi

Modifiable lifestyle factors and lifetime risk of atrial fibrillation: longitudinal data from the Korea NHIS-HealS and UK Biobank cohorts

Hanjin Park, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Dong-min Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Pil-Sung Yang, Boyoung Joung

Prevalence of diabetic cardiomyopathy in patients with type 2 diabetes in a large academic medical center

Iwona Swiatkiewicz, Neeja T. Patel, MaryAnn Villarreal-Gonzalez, Pam R. Taub

Impact of mHealth interventions on maternal, newborn, and child health from conception to 24 months postpartum in low- and middle-income countries: a systematic review

  • Open Access
  • Review

Marianne Ravn Knop, Michiko Nagashima-Hayashi, Ruixi Lin, Chan Hang Saing, Mengieng Ung, Sreymom Oy, Esabelle Lo Yan Yam, Marina Zahari, Siyan Yi

Rethinking causal assumptions about maternal BMI, gestational weight gain, and adverse pregnancy outcomes

  • Open Access
  • Obesity
  • Research article

Jodie M. Dodd, Jennie Louise, Andrea R. Deussen, Megan Mitchell, Lucilla Poston

Learning together for better health using an evidence-based Learning Health System framework: a case study in stroke

Helena Teede, Dominique A. Cadilhac, Tara Purvis, Monique F. Kilkenny, Bruce C.V. Campbell, Coralie English, Alison Johnson, Emily Callander, Rohan S. Grimley, Christopher Levi, Sandy Middleton, Kelvin Hill, Joanne Enticott

Exploratory biomarker analysis in the phase III L-MOCA study of olaparib maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer

Huayi Li, Zikun Peng, Jianqing Zhu, Weidong Zhao, Yi Huang, Ruifang An, Hong Zheng, Pengpeng Qu, Li Wang, Qi Zhou, Danbo Wang, Ge Lou, Jing Wang, Ke Wang, Beihua Kong, Xing Xie, Rutie Yin, John Low, Abdul Malik Rozita, Lim Chun Sen, Yong Chee Meng, Kho Swee Kiong, Jihong Liu, Zhiqing Liang, Weiguo Lv, Yaping Zhu, Weiguo Hu, Wei Sun, Jingya Su, Qiqi Wang, Rongyu Zang, Ding Ma, Qinglei Gao

Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma

Yun Liu, Mingwei He, Haijun Tang, Tianyu Xie, Yunhua Lin, Shangyu Liu, Jiming Liang, Feicui Li, Kai Luo, Mingxiu Yang, Hongcai Teng, Xiaoting Luo, Juliang He, Shijie Liao, Qian Huang, Wenyu Feng, Xinli Zhan, Qingjun Wei

Association of genetic variants related to combined lipid-lowering and antihypertensive therapies with risk of cardiovascular disease: 2 × 2 factorial Mendelian randomization analyses

Ying Li, Hongwei Liu, Chong Shen, Jianxin Li, Fangchao Liu, Keyong Huang, Dongfeng Gu, Yun Li, Xiangfeng Lu

Learning from sotorasib: risk of bias in confirmatory clinical studies of accelerated approved drugs and resolution strategies

  • Open Access
  • Commentary

Ning Jiang, Yanjie Han, Shuhang Wang, Ning Li

Association between being large for gestational age and cardiovascular metabolic health in children conceived from assisted reproductive technology: a prospective cohort study

  • Open Access
  • Obesity
  • Research article

Yiyuan Zhang, Kexin Dai, Xiaojing Chen, Linlin Cui, Zi-Jiang Chen

Ruxolitinib plus standard of care in severe hospitalized adults with severe fever with thrombocytopenia syndrome (SFTS): an exploratory, single-arm trial

Sai Wen, Nannan Xu, Lianhui Zhao, Lulu Yang, Hui Yang, Caiyun Chang, Shanshan Wang, Chunmei Qu, Li Song, Wenlu Zou, Yishan He, Gang Wang

Effectiveness of genetic feedback on alcohol metabolism to reduce alcohol consumption in young adults: an open-label randomized controlled trial

  • Open Access
  • Research article

Yukiko Owaki, Hisashi Yoshimoto, Go Saito, Shohei Dobashi, Satoshi Kushio, Akihiro Nakamura, Takahiro Goto, Yusuke Togo, Kazumasa Mori, Hideki Hokazono

ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang, Chuan Liu, Ting-Ting Gong, Qi-Jun Wu

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer

Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Jihui Zhu, Weihui Shi, Jinye Ding, Yao Ge, Chunhong Liu, Zhen Lu, Robert C. Bast Jr, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li, Rong Chen, Shupeng Liu, Huajun Jin, Binghui Zhao, Zhongping Cheng

Association of heavy menstrual bleeding with cardiovascular disease in US female hospitalizations

  • Open Access
  • Obesity
  • Research article

Pallavi Dubey, Sireesha Reddy, Vishwajeet Singh, Abdelrehman Yousif, Alok Kumar Dwivedi

Safety, tolerability, pharmacokinetics, and pharmacodynamics of TG103 injection in participants who are overweight or obese: a randomized, double-blind, placebo-controlled, multiple-dose phase 1b study

Diaozhu Lin, Huisheng Xiao, Kexu Yang, Juan Li, Suiwen Ye, Yanqiong Liu, Shan Jing, Yang Lin, Yuanxun Yang, Lei Huang, Jing Yuan, Ziyan Li, Jinlan Yang, Huanhuan Gao, Ying Xie, Mingtong Xu, Li Yan

Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Komodo Matta, Vivian Viallon, Edoardo Botteri, Giulia Peveri, Christina Dahm, Anne Østergaard Nannsen, Anja Olsen, Anne Tjønneland, Alexis Elbaz, Fanny Artaud, Chloé Marques, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Erand Llanaj, Giovanna Masala, Valeria Pala, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Jeroen W. G. Derksen, Therese Haugdahl Nøst, Torkjel M. Sandanger, Kristin Benjaminsen Borch, J. Ramón Quirós, Carlota Castro-Espin, Maria-José Sánchez, Amaia Aizpurua Atxega, Lluís Cirera, Marcela Guevara, Jonas Manjer, Sandar Tin Tin, Alicia Heath, Mathilde Touvier, Marcel Goldberg, Elisabete Weiderpass, Marc J. Gunter, Heinz Freisling, Elio Riboli, Pietro Ferrari

The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records

Alexandra C. Gillett, Saskia P. Hagenaars, Dale Handley, Francesco Casanova, Katherine G. Young, Harry Green, Cathryn M. Lewis, Jess Tyrrell

Information technology-supported integrated health service for older adults in long-term care settings

  • Open Access
  • Research article

Jung-Yeon Choi, Hongsoo Kim, Seungyeon Chun, Young-il Jung, Sooyoung Yoo, In-Hwan Oh, Gi-Soo Kim, Jin Young Ko, Jae-Young Lim, Minho Lee, Jongseon Lee, Kwang-il Kim

Associations between vaping and self-reported respiratory symptoms in young people in Canada, England and the US

  • Open Access
  • Research article

Leonie S. Brose, Jessica L. Reid, Debbie Robson, Ann McNeill, David Hammond

Diabetes and further risk of cancer: a nationwide population-based study

Wei-Chuan Chang, Tsung-Cheng Hsieh, Wen-Lin Hsu, Fang-Ling Chang, Hou-Ren Tsai, Ming-Shan He

The efficacy and safety of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor, in patients with advanced head and neck mucosal melanoma harboring CDK4 amplification

Chaoji Shi, Houyu Ju, Rong Zhou, Shengming Xu, Yunteng Wu, Ziyue Gu, Ying Wang, Wanling Chen, Xinyi Huang, Yong Han, Shuyang Sun, Chuwen Li, Min Wang, Guoyu Zhou, Zhiyuan Zhang, Jiang Li, Guoxin Ren

Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank

Renhao Luo, Dena Zeraatkar, Maria Glymour, Randall J. Ellis, Hossein Estiri, Chirag J. Patel

Personalized therapy in endometriosis — based on ERα or ERβ expression

Lei Zhan, Yunxia Cao

Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up

Yuan Gao, Shu Wang, Anni Wang, Shiying Fan, Yan Ge, Huimin Wang, Dongmei Gao, Jian Wang, Zhiqi Mao, Hulin Zhao, Hua Zhang, Lin Shi, Huanguang Liu, Guanyu Zhu, Anchao Yang, Yutong Bai, Xin Zhang, Chong Liu, Qiao Wang, Renpeng Li, Kun Liang, Kayla Giovanna Brown, Zhiqiang Cui, Chunlei Han, Jianguo Zhang, Fangang Meng

Clustering care pathways of people with alcohol dependence using a data linkage of routine data in Bremen, Germany

Justin Möckl, Jakob Manthey, Monika Murawski, Christina Lindemann, Bernd Schulte, Jens Reimer, Oliver Pogarell, Ludwig Kraus

Associations of prenatal blood pressure trajectory and variability with child neurodevelopment at 2 years old

  • Open Access
  • Research article

Luli Xu, Jiayi Cheng, Xiaohan Dong, Menglan Guo, Kai Chen, Xiaoxuan Fan, Xiaofeng Mu, Yuji Wang, Zhiguo Xia, Jun Li, Youjie Wang, Chao Xiong, Aifen Zhou

Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study

Ana-Lucia Mayén, Mirna Sabra, Elom K. Aglago, Gabriel Perlemuter, Cosmin Voican, Ines Ramos, Charlotte Debras, Jessica Blanco, Vivian Viallon, Pietro Ferrari, Anja Olsen, Anne Tjønneland, Fie Langmann, Christina C. Dahm, Joseph Rothwell, Nasser Laouali, Chloé Marques, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Domenico Palli, Alessandra Macciotta, Salvatore Panico, Rosario Tumino, Claudia Agnoli, Marta Farràs, Esther Molina-Montes, Pilar Amiano, María-Dolores Chirlaque, Jesús Castilla, Mårten Werner, Stina Bodén, Alicia K. Heath, Kostas Tsilidis, Dagfinn Aune, Elisabete Weiderpass, Heinz Freisling, Marc J. Gunter, Mazda Jenab

Virtual reality as an engaging and enjoyable method for delivering emergency clinical simulation training: a prospective, interventional study of medical undergraduates

  • Open Access
  • Research article

Risheka Walls, Priyanka Nageswaran, Adrian Cowell, Tunav Sehgal, Thomas White, James McVeigh, Stefan Staykov, Paul Basett, Daniel Mitelpunkt, Amir H. Sam

The neural and genetic underpinnings of different developmental trajectories of Attention-Deficit/Hyperactivity Symptoms in children and adolescents

Yanpei Wang, Leilei Ma, Jiali Wang, Yuyin Ding, Ningyu Liu, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong, Sha Tao

Adherence to a Mediterranean diet is associated with a lower risk of diabetic kidney disease among individuals with hyperglycemia: a prospective cohort study

Changbo Qu, Jinyu Zhao, Jicai Lai, Xinxiang Wu, Peng Huang, Ting Zhu, Yan Li, Taoli Liu, Jinqiu Yuan, Ning Wang, Maikel P Peppelenbosch, Hongda Chen, Bin Xia, Jian Qin

Association of depressive symptoms and sleep disturbances with survival among US adult cancer survivors

Ailin Lan, Han Li, Meiying Shen, Daxue Li, Dan Shu, Yang Liu, Haozheng Tang, Kang Li, Yang Peng, Shengchun Liu

Sex-specific associations of adolescent motherhood with cognitive function, behavioral problems, and autistic-like traits in offspring and the mediating roles of family conflict and altered brain structure

  • Open Access
  • Research article

Tai Ren, Lingli Zhang, Yongjie Liu, Qingli Zhang, Yunjun Sun, Wei Zhou, Like Huang, Ming Wang, Yiwei Pu, Runqi Huang, Jingyu Chen, Hua He, Tailin Zhu, Susu Wang, Weiran Chen, Qianlong Zhang, Wenchong Du, Qiang Luo, Fei Li

How effective is the BNT162b2 mRNA vaccine against SARS-CoV-2 transmission and infection? A national programme analysis in Monaco, July 2021 to September 2022

Thomas Althaus, Christopher E. Overton, Isabelle Devaux, Thomas House, Arnaud Lapouze, Alexa Troel, Bertrand Vanzo, Margaux Laroche, Alexandre Bordero, Pernille Jorgensen, Richard Pebody, Eric J. Voiglio

Are Dutch adults equally susceptible to nudging and pricing strategies? Secondary analyses of the Supreme Nudge parallel cluster-randomised controlled supermarket trial

  • Open Access
  • Research

Josine M. Stuber, Joline W. J. Beulens, Juul J. E. van Lierop, Esmee Schuurman, Jeroen Lakerveld, Joreintje D. Mackenbach, Jody C. Hoenink, Femke Rutters, Wilma E. Waterlander, Denise T. D. de Ridder, Marleen Gillebaart, Stephanie Blom, Femke E. de Boer, Gert-Jan de Bruijn, Anne L. Vos, Edith G. Smit, Michel C. A. Klein, Jacqueline E. W. Broerse, Tjerk-Jan Schuitmaker-Warnaar, Cédric N. H. Middel, Yvonne T. van der Schouw, Ivonne Sluijs, Marjolein C. Harbers, Elizabeth Velema

Dysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications

Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma, Jian-Huan Chen

How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank

  • Open Access
  • Obesity
  • Research article

Mengrong Zhang, Joey Ward, Rona J. Strawbridge, Carlos Celis-Morales, Jill P. Pell, Donald M. Lyall, Frederick K. Ho

Expanding community case management of malaria to all ages can improve universal access to malaria diagnosis and treatment: results from a cluster randomized trial in Madagascar

  • Open Access
  • Malaria
  • Research article

Andres Garchitorena, Aina Harimanana, Judickaelle Irinantenaina, Hobisoa Léa Razanadranaivo, Tsinjo Fehizoro Rasoanaivo, Dean Sayre, Julie R. Gutman, Reziky Tiandraza Mangahasimbola, Masiarivony Ravaoarimanga, Oméga Raobela, Lala Yvette Razafimaharo, Nicolas Ralemary, Mahefa Andrianasolomanana, Julie Pontarollo, Aline Mukerabirori, Walter Ochieng, Catherine M. Dentinger, Laurent Kapesa, Laura C. Steinhardt

Geriatric assessment with management for older patients with cancer receiving radiotherapy: a cluster-randomised controlled pilot study

Marit Slaaen, Inga Marie Røyset, Ingvild Saltvedt, Bjørn Henning Grønberg, Vidar Halsteinli, Øystein Døhl, Corinna Vossius, Øyvind Kirkevold, Sverre Bergh, Siri Rostoft, Line Oldervoll, Asta Bye, Line Melby, Tove Røsstad, Guro Falk Eriksen, May Ingvild Volungholen Sollid, Darryl Rolfson, Jūratė Šaltytė Benth

Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis

Achim Burrer, Stephan T. Egger, Tobias R. Spiller, Matthias Kirschner, Philipp Homan, Erich Seifritz, Stefan Vetter

Optimizing perioperative treatment for potentially resectable stage III squamous cell lung carcinoma: promising results of a condensed four-cycle regimen with tislelizumaband chemotherapy

Jianzhen Shan, Zhen Liu, Songan Chen, Chengli Du, Bing Li, Lingxiang Ruan, Mei Kong, Lingjie Wang, Miaoyan Du, Shuo Shi, Guoliang Qiao, Tian Tian, Zhengliang Tu

Understanding the causes of missingness in primary care: a realist review

  • Open Access
  • Research

Calum Lindsay, David Baruffati, Mhairi Mackenzie, David A. Ellis, Michelle Major, Catherine A. O’Donnell, Sharon A. Simpson, Andrea E. Williamson, Geoff Wong

Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care

  • Open Access
  • Research article

Ahmad Abbadi, Emmanouil Kokoroskos, Matthew Stamets, Davide L. Vetrano, Nicola Orsini, Sölve Elmståhl, Cecilia Fagerström, Anders Wimo, Anders Sköldunger, Johan Sanmartin Berglund, Christina B. Olsson, Caroline Wachtler, Laura Fratiglioni, Amaia Calderón-Larrañaga

Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England

Daniel Tzu-Hsuan Chen, Emma Copland, Jennifer A. Hirst, Emma Mi, Sharon Dixon, Carol Coupland, Julia Hippisley-Cox

Chronic pain in children and young people with cerebral palsy: a narrative review of challenges, advances, and future directions

Adrienne Harvey, Nadine Smith, Meredith Smith, Katarina Ostojic, Carolyn Berryman

Protein truncating variants in mitochondrial-related nuclear genes and the risk of chronic liver disease

Huangbo Yuan, Zhenqiu Liu, Mingyang Chen, Qiaoyi Xu, Yanfeng Jiang, Tiejun Zhang, Chen Suo, Xingdong Chen

Utility of shaking chills as a diagnostic sign for bacteremia in adults: a systematic review and meta-analysis

Tetsuro Aita, Hiroaki Nakagawa, Sei Takahashi, Toru Naganuma, Keisuke Anan, Masahiro Banno, Sugihiro Hamaguchi

Effectiveness of home treatment in children and adolescents with psychiatric disorders—systematic review and meta-analysis

Daniel Graf, Christine Sigrist, Isabel Boege, Marialuisa Cavelti, Julian Koenig, Michael Kaess

Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange

Enrique Alfaro, Elena Díaz-García, Sara García-Tovar, Raúl Galera, Raquel Casitas, María Torres-Vargas, Cristina López-Fernández, José M. Añón, Francisco García-Río, Carolina Cubillos-Zapata

“The dream is that there’s one place you go”: a qualitative study of women’s experiences seeking care from Long COVID clinics in the USA

Linnea I. Laestadius, Jeanine P. D. Guidry, Megan M. Wahl, Paul B. Perrin, Kellie E. Carlyle, Xiaobei Dong, Raouf Gharbo, Celeste Campos-Castillo

Minimally invasive surgeries for spontaneous hypertensive intracerebral hemorrhage (MISICH): a multicenter randomized controlled trial

Xinghua Xu, Huaping Zhang, Jiashu Zhang, Ming Luo, Qun Wang, Yining Zhao, Zhichao Gan, Bainan Xu, Xiaolei Chen

Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020

Qiang Qu, Qixin Guo, Jinjing Shi, Ziqi Chen, Jinyu Sun, Iokfai Cheang, Rongrong Gao, Yanli Zhou, Haifeng Zhang, Shengen Liao, Wenming Yao, Xinli Li

The occlusion rates after distal radial access: how to multiply your bullets

  • Open Access
  • Comment

Alexandru Achim, Zoltan Ruzsa

Distance-related functional reorganization predicts motor outcome in stroke patients

Wenjun Hong, Zaixing Liu, Xin Zhang, Ming Li, Zhixuan Yu, Yuxin Wang, Minmin Wang, Yanan Wu, Shengjie Fang, Bo Yang, Rong Xu, Zhiyong Zhao

Perceived barriers and facilitators for model-informed dosing in pregnancy: a qualitative study across healthcare practitioners and pregnant women

  • Open Access
  • Research article

Charlotte Koldeweij, Mirèse Kleuskens, Carlijn Litjens, Bryony Dean Franklin, Hubertina C. J. Scheepers, Saskia N. de Wildt

Associations of neighborhood sociodemographic environment with mortality and circulating metabolites among low-income black and white adults living in the southeastern United States

  • Open Access
  • Research article

Kui Deng, Meng Xu, Melis Sahinoz, Qiuyin Cai, Martha J. Shrubsole, Loren Lipworth, Deepak K. Gupta, Debra D. Dixon, Wei Zheng, Ravi Shah, Danxia Yu

Early discharge hospital at home as alternative to routine hospital care for older people: a systematic review and meta-analysis

  • Open Access
  • Research article

Lulu Lin, Mengyuan Cheng, Yawei Guo, Xiaowen Cao, Weiming Tang, Xin Xu, Weibin Cheng, Zhongzhi Xu

Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study

Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim

Taxane combined with lobaplatin or anthracycline for neoadjuvant chemotherapy of triple-negative breast cancer: a randomized, controlled, phase II study

Cheng Wang, Long Yuan, Xiujuan Wu, Yan Wang, Hao Tian, Guozhi Zhang, Andi Wan, Siyi Xiong, Chengfang Wang, Yuqin Zhou, Dandan Ma, Yangqiu Bao, Man Qu, Jun Jiang, Yi Zhang, Xiaowei Qi

Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study

Xingxing Li, Junyao Liu, Shuochi Wei, Chang Yu, Dongmei Wang, Yuchen Li, Jiaxin Li, Wenhao Zhuang, Rui-Chen-Xi Luo, Yanli Li, Zhiwang Liu, Yuqiu Su, Jimeng Liu, Yongming Xu, Jialin Fan, Guidong Zhu, Weiqian Xu, Yiping Tang, Hui Yan, Raymond Y. Cho, Thomas R. Kosten, Dongsheng Zhou, Xiangyang Zhang

Circulating small extracellular vesicles in Alzheimer’s disease: a case–control study of neuro-inflammation and synaptic dysfunction

Rishabh Singh, Sanskriti Rai, Prahalad Singh Bharti, Sadaqa Zehra, Priya Kumari Gorai, Gyan Prakash Modi, Neerja Rani, Kapil Dev, Krishna Kishore Inampudi, Vishnu V. Y., Prasun Chatterjee, Fredrik Nikolajeff, Saroj Kumar

Healthcare utilisation in people with long COVID: an OpenSAFELY cohort study

Liang-Yu Lin, Alasdair D. Henderson, Oliver Carlile, Iain Dillingham, Ben F. C. Butler-Cole, Michael Marks, Andrew Briggs, Mark Jit, Laurie A. Tomlinson, Chris Bates, John Parry, Sebastian C. J. Bacon, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Rosalind M. Eggo, Emily Herrett

Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study

Han Lv, Jing Sun, Tong Zhang, Ying Hui, Jing Li, Xinyu Zhao, Shuohua Chen, Wenjuan Liu, Xiaoshuai Li, Pengfei Zhao, Shouling Wu, Yanying Liu, Zhenchang Wang

EEG signatures of cognitive decline after mild SARS-CoV-2 infection: an age-dependent study

Yike Sun, Jingnan Sun, Xiaogang Chen, Yijun Wang, Xiaorong Gao

Impact of baseline cardiovascular risk on the outcomes of intensive blood pressure intervention: a post hoc analysis of the China rural hypertension control project

Guozhe Sun, Chang Wang, Ning Ye, Chuning Shi, Nanxiang Ouyang, Lixia Qiao, Guangxiao Li, Linlin Zhang, Yao Yu, Zhi Li, Ying Zhou, Zihan Chen, Shu Zhang, Pengyu Zhang, Danxi Geng, Wei Miao, Songyue Liu, Yingxian Sun

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers

Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boitard

Long-term health outcomes by cancer diagnosed age among adolescent and young adult: multinational representative database

  • Open Access
  • Research article

Sooyeon Kim, Dong Wook Shin, Su-Min Jeong, Danbee Kang, Juhee Cho

Sleep and liver function biomarkers in relation to risk of incident liver cancer: a nationwide prospective cohort study

Jiahao Song, Lieyang Fan, Da Shi, Xuefeng Lai, Hao Wang, Wei Liu, Linling Yu, Ruyi Liang, Yongfang Zhang, Shuhui Wan, Yueru Yang, Bin Wang

Lung cancer metabolomics: a pooled analysis in the Cancer Prevention Studies

Ziyin Tang, Donghai Liang, Emily L. Deubler, Jeremy A. Sarnat, Sabrina S. Chow, W. Ryan Diver, Ying Wang

Heterologous versus homologous COVID-19 booster vaccinations for adults: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials

Mark Aninakwah Asante, Martin Ekholm Michelsen, Mithuna Mille Balakumar, Buddheera Kumburegama, Amin Sharifan, Allan Randrup Thomsen, Steven Kwasi Korang, Christian Gluud, Sonia Menon

Global burden, risk factors, and temporal trends of ureteral cancer: a comprehensive analysis of cancer registries

  • Open Access
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Junjie Huang, Wing Sze Pang, Yat Ching Fung, Fung Yu Mak, Sze Chai Chan, Xianjing Liu, Lin Zhang, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Marco Moschini, Benjamin Pradere, Francesco Soria, Dmitry Enikeev, Morgan Roupret, Shahrokh Shariat, Anthony Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Martin C. S. Wong

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme

Anthony Martyr, Laura D. Gamble, Anna Hunt, Catherine Quinn, Robin G. Morris, Catherine Henderson, Louise Allan, Carol Opdebeeck, Catherine Charlwood, Roy W. Jones, Claire Pentecost, Michael D. Kopelman, Jeanette M. Thom, Fiona E. Matthews, Linda Clare

Benzodiazepine use in relation to long-term dementia risk and imaging markers of neurodegeneration: a population-based study

Ilse vom Hofe, Bruno H. Stricker, Meike W. Vernooij, M. Kamran Ikram, M. Arfan Ikram, Frank J. Wolters

Assessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines

Yanyan Tang, Lina Zhou, Fei Wang, Yao Huang, Jianwei Wang, Shijun Zhao, Linlin Qi, Li Liu, Min Liang, Donghui Hou, Zhijian Xu, Kai Zhang, Wei Tang, Ning Wu

Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019)

Shanquan Chen, Benjamin R. Underwood, Rudolf N. Cardinal, Xi Chen, Shu Chen, Jay Amin, Huajie Jin, Jing Huang, Christoph Mueller, Lijing L. Yan, Carol Brayne, Hannah Kuper

Metformin use correlated with lower risk of cardiometabolic diseases and related mortality among US cancer survivors: evidence from a nationally representative cohort study

Yukun Li, Xiaoying Liu, Wenhe Lv, Xuesi Wang, Zhuohang Du, Xinmeng Liu, Fanchao Meng, Shuqi Jin, Songnan Wen, Rong Bai, Nian Liu, Ribo Tang

Do iron homeostasis biomarkers mediate the associations of liability to type 2 diabetes and glycemic traits in liver steatosis and cirrhosis: a two-step Mendelian randomization study

Ying Liang, Shan Luo, Steven Bell, Jacky Man Yuen Mo, Baoting He, Yangzhong Zhou, Xiaoyin Bai, Shiu Lun Au Yeung

Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection

Yanyao Du, Cong Li, Wei Zhao, Jinyue Li, Linlin Zhao, Huili Guo, Yingjia Jiang, Weiyin Vivian Liu, Song Zeng, Huiting Zhang, Hu Guo, Xuan Ouyang, Jun Liu

Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis

  • Open Access
  • Research article

Xiao-Hong Yu, Xin-Ru Li, Zhi-Run Du, Yu Zhang, Yang Fei, Wen-Ping Tang, Xian-Wen Li, Qing Zhao

Long-term comparison of renal and metabolic outcomes after sodium–glucose co-transporter 2 inhibitor or glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes

Minji Sohn, Seoungyeon Nam, Michael A. Nauck, Soo Lim

Prolonged increase in psychotropic drug use among young women following the COVID-19 pandemic: a French nationwide retrospective study

Antoine Lamer, Chloé Saint-Dizier, Mathieu Levaillant, Jean-François Hamel-Broza, Eiya Ayed, Emmanuel Chazard, Maxime Bubrovszky, Fabien D’Hondt, Michael Génin, Mathilde Horn

Ethnicity and outcomes for patients with gastrointestinal disorders attending an emergency department serving a multi-ethnic population

  • Open Access
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Christopher A. Martin, Tim Coats, Manish Pareek, Kamlesh Khunti, Ruw Abeyratne, Nigel J. Brunskill

Acceptability of data linkage to identify women at risk of postnatal complication for the development of digital risk prediction tools and interventions to better optimise postnatal care, a qualitative descriptive study design

Siobhán O’Connor, George Tilston, Olivia Jones, Anita Sharma, Laura Ormesher, Bradley Quinn, Anthony Wilson, Jenny Myers, Niels Peek, Victoria Palin

Risk of emergency hospital admission related to adverse events after antibiotic treatment in adults with a common infection: impact of COVID-19 and derivation and validation of risk prediction models

Xiaomin Zhong, Victoria Palin, Darren M. Ashcroft, Ben Goldacre, Brian MacKenna, Amir Mehrkar, Sebastian C. J. Bacon, Jon Massey, Peter Inglesby, Kieran Hand, Alexander Pate, Tjeerd Pieter van Staa

Serum dithiothreitol-oxidizing capacity (DOC) is a promising biomarker for excluding significant liver fibrosis: a proof-of-concept study

Lumin Yang, Yafei Zhang, Xiaodan Hong, Ke Zhang, Bingyan Liu, Peixin Zhang, Qianqian Tang, Jian Yu, Xiao-Zhi Jin, Xin-Zhe Jin, Ni Zhang, Giovanni Targher, Christopher D. Byrne, Zhenhua Zhang, Ming-Hua Zheng, Jinsong Zhang

Retraction Note: DNA barcoding detects contamination and substitution in North American herbal products

  • Open Access
  • Retraction Note

A meta-ethnography of the factors that shape link workers’ experiences of social prescribing

  • Open Access
  • Research

Amadea Turk, Stephanie Tierney, Bernie Hogan, Kamal R. Mahtani, Catherine Pope

Effect of combined physical–cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial

Yolanda Castellote-Caballero, María del Carmen Carcelén Fraile, Agustín Aibar-Almazán, Diego Fernando Afanador-Restrepo, Ana María González-Martín

Mining the interpretable prognostic features from pathological image of intrahepatic cholangiocarcinoma using multi-modal deep learning

Guang-Yu Ding, Wei-Min Tan, You-Pei Lin, Yu Ling, Wen Huang, Shu Zhang, Jie-Yi Shi, Rong-Kui Luo, Yuan Ji, Xiao-Ying Wang, Jian Zhou, Jia Fan, Mu-Yan Cai, Bo Yan, Qiang Gao

Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain

Nicole Jimenez, Taylor Norton, Gurbeen Diadala, Emerald Bell, Michelle Valenti, Leslie V. Farland, Nichole Mahnert, Melissa M. Herbst-Kralovetz

A longitudinal multi-centric cohort study assessing infant neurodevelopment delay among women with persistent postpartum depression in Nepal

Ashish KC, Jaya Chandna, Ankit Acharya, Rejina Gurung, Carin Andrew, Alkistis Skalkidou

Global incidence and characteristics of spinal cord injury since 2000–2021: a systematic review and meta-analysis

  • Open Access
  • Research

Yubao Lu, Zhizhong Shang, Wei Zhang, Mao Pang, Xuchang Hu, Yu Dai, Ruoqi Shen, Yingjie Wu, Chenrui Liu, Ting Luo, Xin Wang, Bin Liu, Liangming Zhang, Limin Rong

Factors influencing the development, recruitment, integration, retention and career development of advanced practice providers in hospital health care teams: a scoping review

  • Open Access
  • Research

Yingxi Zhao, Wesley Quadros, Shobhana Nagraj, Geoff Wong, Mike English, Attakrit Leckcivilize

The relationship between community food environment around schools and student meal participation: the role of school CEP participation status

  • Open Access
  • Research article

Emily M. Melnick, Francesco Acciai, Michael J. Yedidia, Punam Ohri-Vachaspati

Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY

  • Open Access
  • Research article

Colm D. Andrews, Rohini Mathur, Jon Massey, Robin Park, Helen J. Curtis, Lisa Hopcroft, Amir Mehrkar, Seb Bacon, George Hickman, Rebecca Smith, David Evans, Tom Ward, Simon Davy, Peter Inglesby, Iain Dillingham, Steven Maude, Thomas O’Dwyer, Ben F. C. Butler-Cole, Lucy Bridges, Chris Bates, John Parry, Frank Hester, Sam Harper, Jonathan Cockburn, Ben Goldacre, Brian MacKenna, Laurie A. Tomlinson, Alex J. Walker, William J. Hulme

Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks

Ke Miao, Shunkai Liu, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li

Correction: Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020

  • Open Access
  • Correction

Qiang Qu, Qixin Guo, Jinjing Shi, Ziqi Chen, Jinyu Sun, Iokfai Cheang, Rongrong Gao, Yanli Zhou, Haifeng Zhang, Shengen Liao, Wenming Yao, Xinli Li

Correction: ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

  • Open Access
  • Correction

Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang, Chuan Liu, Ting-Ting Gong, Qi-Jun Wu

Correction: Olfactory bulb anomalies in KBG syndrome mouse model and patients

  • Open Access
  • Correction

Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E. S. Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh‑Berges, Karen J. Low, Anastassia Voronova

The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice

Dong Xu, Lin Sui, Chunquan Zhang, Jing Xiong, Vicky Yang Wang, Yahan Zhou, Xinying Zhu, Chen Chen, Yu Zhao, Yiting Xie, Weizhen Kong, Jincao Yao, Lei Xu, Yuxia Zhai, Liping Wang

Gut microbiome in endometriosis: a cohort study on 1000 individuals

Inmaculada Pérez-Prieto, Eva Vargas, Eduardo Salas-Espejo, Kreete Lüll, Analuce Canha-Gouveia, Laura Antequera Pérez, Juan Fontes, Andres Salumets, Reidar Andreson, Oliver Aasmets, Metspalu Mait, Metspalu Andres, Milani Lili, Esko Tõnu, Katrine Whiteson, Elin Org, Signe Altmäe

Foetal gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome

María de Lourdes Moreno, María González-Rovira, Cristina Martínez-Pancorbo, María Martín-Cameán, Ana María Nájar-Moyano, Mercedes Romero, Esther de la Hoz, Cristina López-Beltrán, Encarnación Mellado, José Luis Bartha, Petter Brodin, Alfonso Rodríguez-Herrera, José Antonio Sainz-Bueno, Carolina Sousa

Evaluation of artificial intelligence-powered screening for sexually transmitted infections-related skin lesions using clinical images and metadata

Nyi N. Soe, Zhen Yu, Phyu M. Latt, David Lee, Jason J. Ong, Zongyuan Ge, Christopher K. Fairley, Lei Zhang

Estimating the relative importance of epidemiological and behavioural parameters for epidemic mpox transmission: a modelling study

  • Open Access
  • Mpox
  • Research article

Madhav Chaturvedi, Isti Rodiah, Mirjam Kretzschmar, Stefan Scholz, Berit Lange, André Karch, Veronika K. Jaeger

Associations of sugar intake, high-sugar dietary pattern, and the risk of dementia: a prospective cohort study of 210,832 participants

Sirui Zhang, Yi Xiao, Yangfan Cheng, Yuanzheng Ma, Jiyong Liu, Chunyu Li, Huifang Shang

Is trofinetide a future treatment for Rett syndrome? A comprehensive systematic review and meta-analysis of randomized controlled trials

Hazem E. Mohammed, Zeyad Bady, Mohamed E. Haseeb, Heba Aboeldahab, Wessam E. Sharaf-Eldin, Maha S. Zaki

Early and long-term responses of intestinal microbiota and metabolites to 131I treatment in differentiated thyroid cancer patients

Ganghua Lu, Dingwei Gao, Yixian Liu, Xiaqing Yu, Wen Jiang, Zhongwei Lv

Unveiling the epigenetic impact of vegan vs. omnivorous diets on aging: insights from the Twins Nutrition Study (TwiNS)

Varun B. Dwaraka, Lucia Aronica, Natalia Carreras-Gallo, Jennifer L. Robinson, Tayler Hennings, Matthew M. Carter, Michael J. Corley, Aaron Lin, Logan Turner, Ryan Smith, Tavis L. Mendez, Hannah Went, Emily R. Ebel, Erica D. Sonnenburg, Justin L. Sonnenburg, Christopher D. Gardner

Unraveling the metabolomic architecture of autism in a large Danish population-based cohort

  • Open Access
  • Research article

Filip Ottosson, Francesco Russo, Anna Abrahamsson, Nadia MacSween, Julie Courraud, Kristin Skogstrand, Olle Melander, Ulrika Ericson, Marju Orho-Melander, Arieh S. Cohen, Jakob Grove, Preben Bo Mortensen, David M. Hougaard, Madeleine Ernst

Comparative analysis of atherosclerotic cardiovascular disease burden between ages 20–54 and over 55 years: insights from the Global Burden of Disease Study 2019

Ziyi Li, Yucheng Yang, Xuechen Wang, Na Yang, Liyun He, Jialu Wang, Fan Ping, Lingling Xu, Huabing Zhang, Wei Li, Yuxiu Li

The association between serum S100β levels and prognosis in acute stroke patients after intravenous thrombolysis: a multicenter prospective cohort study

  • Open Access
  • Research article

Yang Qu, Hang Jin, Reziya Abuduxukuer, Shuang Qi, Xiang-Kun Si, Peng Zhang, Ke-Jia Zhang, Si-Ji Wang, Xiang-Yu Zheng, Yu Zhang, Jian-Hua Gao, Xian-Kun Zhang, Xiao-Dong Liu, Chun-Ying Li, Guang-Cai Li, Junmin Wang, Huimin Jin, Ying He, Ligang Jiang, Liang Liu, Yongfei Jiang, Rui-Hong Teng, Yan Jia, Bai-Jing Zhang, Zhibo Chen, Yingbin Qi, Xiuping Liu, Song Li, Xin Sun, Thanh N. Nguyen, Yi Yang, Zhen-Ni Guo, Lijuan Wang, Yumei Chen, Yang Zheng, Zhi-Mei Yuan, Dongsheng Ju, Yun-Fei Ba, Jinhua Chen, Jiliang Gu, Anying Wang, Li-Li Zhao, Chen-Peng Dong, Li Liu, Zhong-Rui Pei, Shuang Yu, Xue Liu, Chun-Li Jiang, Ling He, Sun-Juan Zhang

Correction: “The dream is that there’s one place you go”: a qualitative study of women’s experiences seeking care from Long COVID clinics in the USA

Linnea I. Laestadius, Jeanine P. D. Guidry, Megan M. Wahl, Paul B. Perrin, Kellie E. Carlyle, Xiaobei Dong, Raouf Gharbo, Celeste Campos-Castillo

Short- and long-term impact of aspirin cessation in older adults: a target trial emulation

  • Open Access
  • Research article

Zhen Zhou, Katherine L. Webb, Mark R. Nelson, Robyn L. Woods, Michael E. Ernst, Anne M. Murray, Andrew T. Chan, Andrew Tonkin, Christopher M. Reid, Suzanne G. Orchard, Brenda Kirpach, Raj C. Shah, Nigel Stocks, Jonathan C. Broder, Rory Wolfe

An original study assessing biomarker success rate in breast cancer recurrence biomarker research

K-V. Savva, A. MacKenzie, R. C. Coombes, N. M. Zhifang, B. G. Hanna, C. J. Peters

Development and validation of a patient-level model to predict dementia across a network of observational databases

Luis H. John, Egill A. Fridgeirsson, Jan A. Kors, Jenna M. Reps, Ross D. Williams, Patrick B. Ryan, Peter R. Rijnbeek

Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases

M. Jazmin Taeubert, Thomas B. Kuipers, Jiayi Zhou, Chihua Li, Shuang Wang, Tian Wang, Elmar W. Tobi, Daniel W. Belsky, L. H. Lumey, Bastiaan T. Heijmans

Early detection of uterine corpus endometrial carcinoma utilizing plasma cfDNA fragmentomics

Jing Liu, Dan Hu, Yibin Lin, Xiaoxi Chen, Ruowei Yang, Li Li, Yanyan Zhan, Hua Bao, LeLe Zang, Mingxuan Zhu, Fei Zhu, Junrong Yan, Dongqin Zhu, Huiqi Zhang, Benhua Xu, Qin Xu

The impact of a digital guideline version on schizophrenia guideline knowledge: results from a multicenter cluster-randomized controlled trial

Theresa Halms, Gabriele Gaigl, Carolin Lorenz, Duygu Güler, Naiiri Khorikian-Ghazari, Astrid Röh, Angelika Burschinski, Wolfgang Gaebel, Marisa Flick, Charline Pielenz, Eva Salveridou-Hof, Thomas Schneider-Axmann, Marco Schneider, Elias Wagner, Peter Falkai, Susanne Lucae, Michael Rentrop, Peter Zwanzger, Florian Seemüller, Michael Landgrebe, Marion Ortner, Bertram Schneeweiß, Peter Brieger, Klemens Ajayi, Michael Schwarz, Stephan Heres, Nicolay Marstrander, Thomas Becker, Markus Jäger, Albert Putzhammer, Karel Frasch, Raimund Steber, Stefan Leucht, Alkomiet Hasan

The impact of the COVID-19 pandemic on tuberculosis treatment outcomes in 49 high burden countries

Vester Gunsaru, Marc Y. R. Henrion, C. Finn McQuaid

The associations of chronic pain and 24-h movement behaviors with incident mental disorders: evidence from a large-scale cohort study

  • Open Access
  • Anxiety
  • Research article

Jiade Chen, Xuanbi Fang, Fan Zhang, Jiaxin Shen, Yuanhang Liu, Peng Xu, Rongrong Ye, Qingguang Zhong, Guanren Chen, Zhehao Wang, Shentong Chen, Lixia Li, Ziqiang Lin, Yanhui Gao

Postoperative radiotherapy with docetaxel versus cisplatin for high-risk oral squamous cell carcinoma: a randomized phase II trial with exploratory analysis of ITGB1 as a potential predictive biomarker

Wen Jiang, Lan Chen, Rongrong Li, Jiang Li, Shengjin Dou, Lulu Ye, Yining He, Zhen Tian, Yanli Yao, Guopei Zhu

The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis

  • Open Access
  • Research article

Dhaneesha N. S. Senaratne, Bhushan Thakkar, Blair H. Smith, Tim G. Hales, Louise Marryat, Lesley A. Colvin

Correction: The impact of the COVID-19 pandemic on tuberculosis treatment outcomes in 49 high burden countries

Vester Gunsaru, Marc Y. R. Henrion, C. Finn McQuaid

The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) as a predictor of all-cause and cardiovascular mortality in US adults with diabetes or prediabetes: NHANES 1999–2018

Binyang Yu, Min Li, Zongliang Yu, Tao Zheng, Xue Feng, Anran Gao, Haoling Zhang, Rui Gao

All-cause mortality and hospital admissions for nursing home residents during the COVID-19 pandemic: a Norwegian register-based cohort study

Henning Øien, Jonas Gjesvik, Katrine Damgaard Skyrud, Torill Alise Rotevatn, Mari Grøsland

History of childhood maltreatment associated with hospitalization or death due to COVID-19: a cohort study

Yue Wang, Fenfen Ge, Thor Aspelund, Helga Ask, Arna Hauksdóttir, Kejia Hu, Jóhanna Jakobsdóttir, Helga Zoega, Qing Shen, Heather C. Whalley, Ole Birger Vesterager Pedersen, Kelli Lehto, Ole A. Andreassen, Fang Fang, Huan Song, Unnur A. Valdimarsdóttir

Predicting disease recurrence in patients with endometriosis: an observational study

Sarah J. Holdsworth-Carson, Jessica Chung, Dorothy A. Machalek, Rebecca Li, Byung Kyu Jun, Meaghan J. Griffiths, Molly Churchill, Tristan McCaughey, Debbie Nisbet, Uri Dior, Jacqueline F. Donoghue, Grant W. Montgomery, Charlotte Reddington, Jane E. Girling, Martin Healey, Peter A. W. Rogers

Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity

  • Open Access
  • Research

Ana M. Valdes, Panayiotis Louca, Alessia Visconti, Francesco Asnicar, Kate Bermingham, Ana Nogal, Kari Wong, Gregory A. Michelotti, Jonathan Wolf, Nicola Segata, Tim D. Spector, Sarah E. Berry, Mario Falchi, Cristina Menni

Dilemma of commercial organ transplant in the Middle East

  • Open Access
  • Debate

Reem M. Alameer, Ahmed A. Alhammadi, Yusri Taha, Talal Al Goufi, Reem S. Almaghrabi

Unraveling the causality between gastroesophageal reflux disease and increased cancer risk: evidence from the UK Biobank and GWAS consortia

Gujie Wu, Yaqiong Liu, Dong Ning, Mengnan Zhao, Xiaoqing Li, Lu Chang, Qili Hu, Yao Li, Lin Cheng, Yiwei Huang

One-year outcomes of a novel venous stent for symptomatic iliofemoral venous obstruction: prospective cohort study

Chang Sheng, Xin-Wu Lu, Hong-Tao Shi, Lei Zhang, Sheng-Yun Wan, Hong-Pu Li, Ke Li, Sen Shi, Zhen-Jie Liu, Yu-Xian Luo, Guo-Dong Chen, Mao-Rong Liu, You-Gen Kang, Bo Ye, Kai Yao, Pu Yang, Wei Wang

Discrepancies between general and central obesity in arterial stiffness: observational studies and Mendelian randomization study

Wuqing Huang, Zhaojing Gan, Ziting Gao, Qiaofen Lin, Xiaojiang Li, Wenhui Xie, Zesen Gao, Zhixian Zhou, Ziyi Qiu, Weihong Qiu, Shanshan Du, Liangwan Chen, Huashan Hong, Weimin Ye

Daytime napping and the incidence of Parkinson’s disease: a prospective cohort study with Mendelian randomization

Fabin Lin, Yisen Shi, Wenjing Song, Yanhong Weng, Xinyang Zou, Xuanjie Chen, Jiayi Zheng, Ke Chen, Qinyong Ye, Xilin Wu, Guoen Cai

Recent cervical cancer incidence, stage at diagnosis, and mortality trends in Puerto Rico, 2001–2019

Ana P. Ortiz, Carlos R. Torres-Cintrón, Eduardo J. Santiago-Rodríguez, Jeslie M. Ramos-Cartagena, Tonatiuh Suárez-Ramos, Haluk Damgacioglu, Vivian Colón-López, Karen J. Ortiz-Ortiz, Ashish A. Deshmukh

Influences of HPV disease perceptions, vaccine accessibility, and information exposure on social media on HPV vaccination uptake among 11,678 mothers with daughters aged 9–17 years in China: a cross-sectional study

Zian Lin, Siyu Chen, Lixian Su, Yuxue Liao, Hongbiao Chen, Zhiqing Hu, Zhuolin Chen, Yuan Fang, Xue Liang, Jianan Chen, Biyun Luo, Chuanan Wu, Zixin Wang

Differences in hypersensitivity reactions and gadolinium deposition disease/symptoms associated with gadolinium exposure to gadolinium-based contrast agents: new insights based on global databases VigiBase, FAERS, and IQVIA-MIDAS

Han Qu, Wenjing Li, Zhenghua Wu, Yuanyuan Wang, Tingting Feng, Nianyun Li, Chendong Qi, Xiang Li, Taishan Wei, Guorong Fan, Yuefen Lou

Vitamin B12 status and the risk of developing sepsis in patients with bacterial infection: a prospective observational cohort study

Andreas Pregernig, Ulrike Held, Martin Schläpfer, Beatrice Beck-Schimmer

Chronic kidney disease: detect, diagnose, disclose—a UK primary care perspective of barriers and enablers to effective kidney care

Stuart Stewart, Philip A. Kalra, Tom Blakeman, Evangelos Kontopantelis, Howard Cranmer-Gordon, Smeeta Sinha

Trait impulsivity is associated with an increased risk of type 2 diabetes incidence in adults over 8 years of follow-up: results from the NutriNet-Santé cohort

Carlos Gómez-Martínez, Pauline Paolassini-Guesnier, Léopold Fezeu, Bernard Srour, Serge Hercberg, Mathilde Touvier, Nancy Babio, Jordi Salas-Salvadó, Sandrine Péneau

Overall and cause-specific mortality among patients diagnosed with gastric precancerous lesions in Sweden between 1979 and 2014: an observational cohort study

Yawen Sun, Li Yin, Dariush Nasrollahzadeh Nesheli, Jingru Yu, Joar Franzén, Weimin Ye

Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank

Esther M. González-Gil, Laia Peruchet-Noray, Anja M. Sedlmeier, Sofia Christakoudi, Carine Biessy, Anne-Sophie Navionis, Yahya Mahamat-Saleh, Rola F. Jaafar, Hansjörg Baurecht, Marcela Guevara, Pilar Amiano Etxezarreta, W. M. Monique Verschuren, Jolanda M. A. Boer, Anja Olsen, Anne Tjønneland, Vittorio Simeon, Carlota Castro-Espin, Dagfinn Aune, Alicia K. Heath, Marc Gunter, Sandra M. Colorado-Yohar, Nuno R. Zilhão, Christina C. Dahm, Erand Llanaj, Matthias B. Schulze, Dafina Petrova, Sabina Sieri, Fulvio Ricceri, Giovanna Masala, Tim Key, Vivian Viallon, Sabina Rinaldi, Heinz Freisling, Laure Dossus

Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation

Ju Hyeon Kim, Soon Jun Hong, Jung-Joon Cha, Subin Lim, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Tae Hoon Ahn, Young-Hoon Jeong, Byeong-Keuk Kim, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Do-Sun Lim

A systematic review and meta-analysis of randomized trials of substituting soymilk for cow’s milk and intermediate cardiometabolic outcomes: understanding the impact of dairy alternatives in the transition to plant-based diets on cardiometabolic health

  • Open Access
  • Research article

M. N. Erlich, D. Ghidanac, S. Blanco Mejia, T. A. Khan, L. Chiavaroli, A. Zurbau, S. Ayoub-Charette, A. Almneni, M. Messina, L. A. Leiter, R. P. Bazinet, D. J. A. Jenkins, C. W. C. Kendall, J. L. Sievenpiper

No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks

Nathaniel M. Pearson, John Novembre

Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation

Sean W. D. Carter, Erin L. Fee, Haruo Usuda, Gokce Oguz, Adaikalavan Ramasamy, Zubair Amin, Biswas Agnihotri, Qin Wei, Liu Xiawen, Tsukasa Takahashi, Yuki Takahashi, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Masatoshi Saito, Citra Mattar, Mark I. Evans, Sebastián E. Illanes, Alan H. Jobe, Mahesh Choolani, Matthew W. Kemp

Pregnancy complications and autoimmune diseases in women: systematic review and meta-analysis

Megha Singh, Fathima Fazla Ahamed Fayaz, Jingya Wang, Steven Wambua, Anuradha Subramanian, John A. Reynolds, Krishnarajah Nirantharakumar, Francesca Crowe

The consumption of ultra-processed foods was associated with adiposity, but not with metabolic indicators in a prospective cohort study of Chilean preschool children

  • Open Access
  • Obesity
  • Research article

Camila Zancheta, Natalia Rebolledo, Lindsey Smith Taillie, Marcela Reyes, Camila Corvalán

Healthiness of food products promoted through placement strategies in Australian online supermarkets: a cross-sectional study

  • Open Access
  • Research article

Damian Maganja, Madeleine de Carle, Tazman Davies, Clara Gómez Donoso, Tailane Scapin, Adrian J. Cameron, Jimmy C. Y. Louie, Mark D. Huffman, Kathy Trieu, Jason H. Y. Wu

Multispectral fluorescence imaging of EGFR and PD-L1 for precision detection of oral squamous cell carcinoma: a preclinical and clinical study

Nenghao Jin, Yu An, Yu Tian, Zeyu Zhang, Kunshan He, Chongwei Chi, Wei Mu, Jie Tian, Yang Du

Association between social determinants of health and survival among the US cancer survivors population

  • Open Access
  • Research

Hongbo Huang, Tingting Wei, Ying Huang, Aijie Zhang, Heng Zhang, Ze Zhang, Yijing Xu, Haonan Pan, Lingquan Kong, Yunhai Li, Fan Li

Camrelizumab plus apatinib in patients with advanced or recurrent endometrial cancer after failure of at least one prior systemic therapy (CAP 04): a single-arm phase II trial

Wenjuan Tian, Yulan Ren, Jing Lu, Chuyu Jing, Wei Zhang, Haiming Li, Tingting Wang, Zhiguo Hou, Ting Yang, Wenqing Zhu, Yi Zhang, Boer Shan, Huijuan Yang, Xi Cheng, Huaying Wang

Adulthood weight changes, body mass index in youth, genetic susceptibility and risk of atrial fibrillation: a population-based cohort study

Yufeng Du, Lu Qi, Yan Borné, Emily Sonestedt

Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang, Christoph Schramm, Johannes Fuss

Patient-reported outcome measures for medication treatment satisfaction: a systematic review of measure development and measurement properties

Mengting Yang, Puwen Zhang, Jillian Halladay, Kun Zou, Imti Choonara, Xiaorui Ji, Shuya Zhang, Weiyi Yan, Liang Huang, Xiaoxi Lu, Huiqing Wang, Yuxin Jiang, Xinyu Liu, Linan Zeng, Lingli Zhang, Gordon H. Guyatt

Impact of a school-based water and hygiene intervention on child health and school attendance in Addis Ababa, Ethiopia: a cluster-randomised controlled trial

Sarah Bick, Alem Ezezew, Charles Opondo, Baptiste Leurent, Wossen Argaw, Erin C. Hunter, Oliver Cumming, Elizabeth Allen, Robert Dreibelbis

Implementation of health-promoting retail initiatives in the Healthier Choices in Supermarkets Study—qualitative perspectives from a feasibility study

  • Open Access
  • Research

Katrine Sidenius Duus, Tine Tjørnhøj-Thomsen, Rikke Fredenslund Krølner

Past trends and future projections of palliative care needs in Chile: analysis of routinely available death registry and population data

Javiera Leniz, Angélica Domínguez, Anna E. Bone, Simon Etkind, Pedro E. Perez-Cruz, Katherine E. Sleeman

NLRC5 exerts anti-endometriosis effects through inhibiting ERβ-mediated inflammatory response

Bao Guo, Haiqing Zhu, Chengwei Xiao, Jing Zhang, Xiaojing Liu, Yuan Fang, Bing Wei, Junhui Zhang, Yunxia Cao, Lei Zhan

Radiogenomic profiling of global DNA methylation associated with molecular phenotypes and immune features in glioma

Zhuokai Zhuang, Jinxin Lin, Zixiao Wan, Jingrong Weng, Ze Yuan, Yumo Xie, Zongchao Liu, Peiyi Xie, Siyue Mao, Zongming Wang, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

Cruciferous vegetables lower blood pressure in adults with mildly elevated blood pressure in a randomized, controlled, crossover trial: the VEgetableS for vaScular hEaLth (VESSEL) study

  • Open Access
  • Research article

Emma L. Connolly, Alex H. Liu, Simone Radavelli-Bagatini, Armaghan Shafaei, Mary C. Boyce, Lisa G. Wood, Lyn McCahon, Henrietta Koch, Marc Sim, Caroline R. Hill, Benjamin H. Parmenter, Nicola P. Bondonno, Amanda Devine, Kevin D. Croft, Richard Mithen, Seng Khee Gan, Carl J. Schultz, Richard J. Woodman, Catherine P. Bondonno, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst

Integrating machine learning and artificial intelligence in life-course epidemiology: pathways to innovative public health solutions

Shanquan Chen, Jiazhou Yu, Sarah Chamouni, Yuqi Wang, Yunfei Li

Sex disparity in the association between metabolic-anthropometric phenotypes and risk of obesity-related cancer: a prospective cohort study

  • Open Access
  • Obesity
  • Research article

Jianxiao Gong, Fubin Liu, Yu Peng, Peng Wang, Changyu Si, Xixuan Wang, Huijun Zhou, Jiale Gu, Ailing Qin, Fangfang Song

Advances and counterpoints in type 2 diabetes. What is ready for translation into real-world practice, ahead of the guidelines

Stanley S. Schwartz, Barbara E. Corkey, James R Gavin 3rd, Ralph A. DeFronzo, Mary E. Herman

A functional variant rs912304 for late-onset T1D risk contributes to islet dysfunction by regulating proinflammatory cytokine-responsive gene STXBP6 expression

Yu Qian, Shu Chen, Yan Wang, Yuyue Zhang, Jie Zhang, Liying Jiang, Hao Dai, Min Shen, Yunqiang He, Hemin Jiang, Tao Yang, Qi Fu, Kuanfeng Xu

Effects of fructan and gluten on gut microbiota in individuals with self-reported non-celiac gluten/wheat sensitivity—a randomised controlled crossover trial

Anne Mari Herfindal, Morten Nilsen, Trude E. Aspholm, Gry I. G. Schultz, Jørgen Valeur, Knut Rudi, Magne Thoresen, Knut E. A. Lundin, Christine Henriksen, Siv K. Bøhn

The association of psychological and trauma-related factors with biological and facial aging acceleration: evidence from the UK Biobank

  • Open Access
  • Research article

Junren Wang, Xin Han, Yao Yang, Yu Zeng, Yuanyuan Qu, Huazhen Yang, Jie Song, Changjian Qiu, Huan Song

New-onset obstructive airway disease following COVID-19: a multicenter retrospective cohort study

Min-Hsiang Chuang, Wei Hsu, Ya-Wen Tsai, Wan-Hsuan Hsu, Jheng-Yan Wu, Ting-Hui Liu, Po-Yu Huang, Chih-Cheng Lai

Hyperactivation of ATF4/TGF-β1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant

Baowei Zhang, Yizhang Wu, Chunjiang Zhou, Jiaxi Xie, Youming Zhang, Xingbo Yang, Jing Xiao, Dao Wu Wang, Congjia Shan, Xiujuan Zhou, Yaozu Xiang, Bing Yang

Time-restricted eating with or without a low-carbohydrate diet improved myocardial status and thyroid function in individuals with metabolic syndrome: secondary analysis of a randomized clinical trial

  • Open Access
  • DBS
  • Research article

Yixuan Zheng, Jingya Wang, Mengmeng Liu, Xingchen Zhou, Xiaoying Lin, Qian Liang, Jing Yang, Meng Zhang, Ziyi Chen, Meng Li, Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Bingyin Shi, Mingqian He

Cancer incidence (2000–2020) among individuals under 35: an emerging sex disparity in oncology

Alessandro Cavazzani, Claudia Angelini, Dario Gregori, Luca Cardone

The spatiotemporal associations between esophageal and gastric cancers provide evidence for its joint endoscopic screening in China: a population-based study

Peng Li, Xin Qi, Ruhai Bai, Mei Yang, Jing Jing, Ruyi Xia, Jizhao Wang, Guangjian Zhang, Guihua Zhuang

Phase 1b study of first-line fuzuloparib combined with modified FOLFIRINOX followed by fuzuloparib maintenance monotherapy in pancreatic adenocarcinoma

Miaoyan Wei, Rujiao Liu, Yunyun Xu, Xiaobing Chen, Chao Liu, Xueli Bai, Xiaochen Zhang, Shuiping Gao, Jialin Li, Zhen Sheng, Jianpo Lian, Wenliang Wang, Jian Zhang, Si Shi, Jin Xu, Xianjun Yu

Effect of salt substitution on fracture—a secondary analysis of the Salt Substitute and Stroke Study (SSaSS)

Faxuan Wang, Yangyang Pi, Yi Zhao, Yuhong Zhang, Bo Zhou, Zhifang Li, Jixin Sun, Yan Yu, Maoyi Tian, Minghui Yang, Liping Huang, Hongyi Song, Bruce Neal, Katrina R. Kissock

Association of lifestyle with valvular heart disease progression and life expectancy among elderly people from different socioeconomic backgrounds

Yanxia Wei, Dawei Sun, Sanjay Jaiswal, Yuxin He, Xianbao Liu, Jian’an Wang

Cardiovascular health and cancer mortality: evidence from US NHANES and UK Biobank cohort studies

  • Open Access
  • Research article

Lijin Lin, Yulian Hu, Fang Lei, Xuewei Huang, Xingyuan Zhang, Tao Sun, Weifang Liu, Ru Li, Xiao-Jing Zhang, Jingjing Cai, Zhi-Gang She, Guoping Wang, Hongliang Li

Has multimorbidity and frailty in adult hospital admissions changed over the last 15 years? A retrospective study of 107 million admissions in England

  • Open Access
  • Research

Puji Faitna, Alex Bottle, Bob Klaber, Paul P. Aylin

Air pollution and risk of 32 health conditions: outcome-wide analyses in a population-based prospective cohort in Southwest China

Hanwen Zhou, Feng Hong, Lele Wang, Xuewei Tang, Bing Guo, Yuying Luo, Hui Yu, Deqiang Mao, Ting Liu, Yuemei Feng, Yangji Baima, Juying Zhang, Xing Zhao

Socioeconomic and ethnic disparities in preterm births in an English maternity setting: a population-based study of 1.3 million births

G. Kayode, A. Howell, C. Burden, R. Margelyte, V. Cheng, M. Viner, J. Sandall, J. Carter, L. Brigante, C. Winter, F. Carroll, B. Thilaganathan, D. Anumba, A. Judge, E. Lenguerrand

Trends in the healthiness and nutrient composition of packaged products sold by major food and beverage companies in New Zealand 2015 to 2019

  • Open Access
  • Research article

Leanne Young, Bruce Kidd, Stephanie Shen, Yannan Jiang, Helen Eyles, Josephine Marshall, Sally Schultz, Jasmine Chan, Gary Sacks, Cliona Ni Mhurchu

Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort

  • Open Access
  • Obesity
  • Research article

Anat Yaskolka Meir, Guoying Wang, Xiumei Hong, Frank B. Hu, Xiaobin Wang, Liming Liang

Addressing the credibility crisis in Mendelian randomization

  • Open Access
  • Review

Stephen Burgess, Benjamin Woolf, Amy M. Mason, Mika Ala-Korpela, Dipender Gill

A deep learning model for differentiating paediatric intracranial germ cell tumour subtypes and predicting survival with MRI: a multicentre prospective study

Yanong Li, Zhizheng Zhuo, Jinyuan Weng, Sven Haller, Harrison X. Bai, Bo Li, Xing Liu, Mingwang Zhu, Zheng Wang, Jane Li, Xiaoguang Qiu, Yaou Liu

IL-17A exacerbates corpus cavernosum fibrosis and neurogenic erectile dysfunction by inducing CSMC senescence via the mTORC2-ACACA pathway

Wende Yang, Jiafeng Fang, Jiancheng Zhai, Chen Qiu, Zhenkang Liang, Qianhui Liu, Hongbo Wei

Development and validation of machine-learning models of diet management for hyperphenylalaninemia: a multicenter retrospective study

Yajie Su, Yaqiong Wang, Jinfeng He, Huijun Wang, Xian A, Haili Jiang, Wei Lu, Wenhao Zhou, Long Li

Potential deprescribing indications for antidepressants between 2012 and 2019: repeated cross-sectional analysis in two Scottish health boards

Vita Brisnik, Marietta Rottenkolber, Jochen Vukas, Miriam Schechner, Karoline Lukaschek, Caroline Jung-Sievers, Jochen Gensichen, Ulrich Thiem, Michael Drey, Nils Krüger, Alpana Mair, Bruce Guthrie, Sebastian Fischer, Tobias Dreischulte, Peter Falkai, Peter Henningsen, Markus Bühner, Helmut Krcmar, Gabriele Pitschel-Walz, Antonius Schneider, Kirsten Lochbuhler, Barbara Prommegger, Andrea Schmitt, Katharina Biersack, Constantin Brand, Christopher Ebert, Julia Eder, Feyza Gökce, Carolin Haas, Lisa Pfeiffer, Lukas Kaupe, Jonas Raub, Philipp Reindl-Spanner, Hannah Schillok, Petra Schönweger, Clara Teusen, Marie Vogel, Victoria von Schrottenberg, Puya Younesi

Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity, in Danish children and adolescents

Sigri Kløve, Sara E. Stinson, Fie O. Romme, Julia Butt, Katrine B. Graversen, Morten A. V. Lund, Cilius E. Fonvig, Tim Waterboer, Guillermo I. Perez-Perez, Torben Hansen, Jens-Christian Holm, Sandra B. Andersen

Global acute malnutrition is associated with geography, season and malaria incidence in the conflict-affected regions of Ouham and Ouham Pendé prefectures, Central African Republic

Nicola Stambach, Helen Lambert, Katie Eves, Blaise Alenwi Nfornuh, Emily Bowler, Peter Williams, Marcel Lama, Pascal Bakamba, Richard Allan

Integration of clinical and blood parameters in risk prognostication for patients receiving immunochemotherapy for extensive stage small cell lung cancer: real-world data from two centers

  • Open Access
  • SCLC
  • Research

Xiaomi Li, Li Tong, Shan Wang, Jiaqi Yu, Baohua Lu, Qunhui Wang, Mingming Hu, Jinxiang Wu, Jing Yu, Baolan Li, Tongmei Zhang

Between faces: childhood adversity is associated with reduced threat-safety discrimination during facial expression processing in adolescence

Celine Samaey, Stephanie Van der Donck, Aleksandra Lecei, Sofie Vettori, Zhiling Qiao, Ruud van Winkel, Bart Boets

Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children

Lingdu Meng, Yifan Yang, Shiwei He, Huifen Chen, Yong Zhan, Ran Yang, Zifeng Li, Jiajie Zhu, Jin Zhou, Yi Li, Lulu Xie, Gong Chen, Shan Zheng, Xiaoying Yao, Rui Dong

Evaluating the impact of extended dosing intervals on mRNA COVID-19 vaccine effectiveness in adolescents

Tim K. Tsang, Sheena G. Sullivan, Yu Meng, Francisco Tsz Tsun Lai, Min Fan, Xiaotong Huang, Yun Lin, Liping Peng, Chengyao Zhang, Bingyi Yang, Kylie E. C. Ainslie, Benjamin J. Cowling

Replacement of sedentary behavior with various physical activities and the risk of all-cause and cause-specific mortality

  • Open Access
  • Research

Qinyu Chang, Yiqun Zhu, Zhichen Liu, Jun Cheng, Huaying Liang, Fengyu Lin, Dianwu Li, Juan Peng, Pinhua Pan, Yan Zhang

Association of depressive symptoms with incidence and mortality rates of COVID-19 over 2 years among healthcare workers in 20 countries: multi-country serial cross-sectional study

Hiroki Asaoka, Kazuhiro Watanabe, Yuki Miyamoto, Alexandra Restrepo-Henao, Els van der Ven, Maria Francesca Moro, Lubna A. Alnasser, Olatunde Ayinde, Arin A. Balalian, Armando Basagoitia, Sol Durand-Arias, Mehmet Eskin, Eduardo Fernández-Jiménez, Freytes Frey Marcela Ines, Luis Giménez, Hans W. Hoek, Rodrigo Ezequiel Jaldo, Jutta Lindert, Humberto Maldonado, Gonzalo Martínez-Alés, Roberto Mediavilla, Clare McCormack, Javier Narvaez, Uta Ouali, Aida Barrera-Perez, Erwin Calgua-Guerra, Jorge Ramírez, Ana María Rodríguez, Dominika Seblova, Andrea Tenorio Correia da Silva, Linda Valeri, Oye Gureje, Dinarte Ballester, Mauro Giovanni Carta, Anna Isahakyan, Amira Jamoussi, Jana Seblova, Maria Teresa Solis-Soto, Ruben Alvarado, Ezra Susser, Franco Mascayano, Daisuke Nishi

The impact of an exercise and sport intervention on cognitive function and pain among forcibly displaced individuals at risk for PTSD: a secondary analysis of the SALEEM randomized controlled trial

Florian Knappe, Konstantinia Filippou, Antonis Hatzigeorgiadis, Ioannis D. Morres, Sebastian Ludyga, Harald Seelig, Emmanouil Tzormpatzakis, Elsa Havas, Yannis Theodorakis, Roland von Känel, Uwe Pühse, Markus Gerber

A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children

  • Open Access
  • Malaria
  • Research article

Isobel S. Walker, Saber Dini, Elizabeth H. Aitken, Timon Damelang, Wina Hasang, Agersew Alemu, Anja T. R. Jensen, Janavi S. Rambhatla, D. Herbert Opi, Michael F. Duffy, Eizo Takashima, Visopo Harawa, Takafumi Tsuboi, Julie A. Simpson, Wilson Mandala, Terrie E. Taylor, Karl B. Seydel, Amy W. Chung, Stephen J. Rogerson

Efficacy of respiratory support therapies during pulmonary rehabilitation exercise training in chronic obstructive pulmonary disease patients: a systematic review and network meta-analysis

Xinrong Chen, Ling Xu, Shuqin Li, Cui Yang, Xiaoling Wu, Mei Feng, Ying Wu, Jing Zhu

Sleep patterns, physical activity, genetic susceptibility, and incident rheumatoid arthritis: a prospective cohort study

Jing Ni, Qiang Zhou, Shi-Ying Meng, Ting-Dong Zhou, Tian Tian, Hai-Feng Pan

Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK

Joshua A. Bell, David Carslake, Amanda Hughes, Kate Tilling, James W. Dodd, James C. Doidge, David A. Harrison, Kathryn M. Rowan, George Davey Smith

Interactive effect of air pollution and genetic risk of depression on processing speed by resting-state functional connectivity of occipitoparietal network

  • Open Access
  • Research

Yuyanan Zhang, Zhe Lu, Yaoyao Sun, Liangkun Guo, Xiao Zhang, Yundan Liao, Zhewei Kang, Xiaoyang Feng, Guorui Zhao, Junyuan Sun, Yang Yang, Hao Yan, Dai Zhang, Weihua Yue

Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms

Chloe Love, Luba Sominsky, Martin O’Hely, Michael Berk, Peter Vuillermin, Samantha L. Dawson

Real-world impact of acupuncture on analgesics and healthcare resource utilization in breast cancer survivors with pain

Ding Quan Ng, Sanghoon Lee, Richard T. Lee, Yun Wang, Alexandre Chan

A novel intrauterine estrogen-releasing system for preventing the postoperative recurrence of intrauterine adhesion: a multicenter randomized controlled study

Limin Feng, Yun Sun, Songying Zhang, Yonghong Qian, Suping Fang, Baojun Yang, Lizhen Xu, Jinghua Li, Yichao Niu, Shengpeng Zhang, Luping Zhang, Jianmin Chen

Risk of suicide after hospitalizations due to acute physical health conditions—a cohort study of the Norwegian population

Andreas Asheim, Sara Marie Nilsen, Ellen Rabben Svedahl, Silje L. Kaspersen, Ottar Bjerkeset, Imre Janszky, Johan Håkon Bjørngaard

Impact of propofol versus desflurane anesthesia on postoperative hepatic and renal functions in infants with living-related liver transplantation: a randomized controlled trial

Wei Liu, Min Du, Mingman Zhang, Xiaoke Dai, Haoming Wang, Ying Le, Shenshen Zhi, Lin Bo, Junjun Quan

Accelerometer-derived moderate-to-vigorous physical activity and incident nonalcoholic fatty liver disease

Mengyi Liu, Ziliang Ye, Yuanyuan Zhang, Panpan He, Chun Zhou, Sisi Yang, Yanjun Zhang, Xiaoqin Gan, Xianhui Qin

Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank

Michael J. Stein, Hansjörg Baurecht, Patricia Bohmann, Béatrice Fervers, Emma Fontvieille, Heinz Freisling, Christine M. Friedenreich, Julian Konzok, Laia Peruchet-Noray, Anja M. Sedlmeier, Michael F. Leitzmann, Andrea Weber

Mesothelin- and nucleolin-specific T cells from combined short peptides effectively kill triple-negative breast cancer cells

Suyanee Thongchot, Krittaya Aksonnam, Jaturawitt Prasopsiri, Malee Warnnissorn, Doonyapat Sa-nguanraksa, Pornchai O-Charoenrat, Peti Thuwajit, Pa-thai Yenchitsomanus, Chanitra Thuwajit

Nine months of bedaquiline, linezolid, levofloxacin, clofazimine, and cycloserine chemotherapy for rifampicin/multidrug-resistant tuberculosis: a multicenter, randomized, open-label non-inferiority trial in China

Yanhua Song, Wei Shu, Yi Pei, Juan Du, Guihui Wu, Hua Wang, Fengling Mi, Fangchao Liu, Liping Ma, Li Xie, Zhongshun Kong, Xiaoguang Wu, Rongmei Liu, Hongmei Chen, Hua Li, Qiping Ge, Lihui Nie, Zizheng Lv, Xuerui Huang, Mingwu Li, Mingying Jiang, Xiaohong Chen, Qingshan Cai, Wei Chen, Yanmei Liu, Yanfang Miao, Yan Tang, Yu Chen, Shujun Geng, Quanying Zhou, Yuhong Liu, Yu Pang, Mengqiu Gao

Prepackaged foods healthiness ranking index: developing front-of-pack labeling to facilitate the assessment and validation of healthiness rankings of prepackaged foods in China

  • Open Access
  • Research

Feiyan Wu, Yulong Qin, Dan Hou, Sasa Xie, Guanchao Zhang, Dexing Zhang, Min Yang

A guided single session intervention to reduce intrusive memories of work-related trauma: a randomised controlled trial with healthcare workers in the COVID-19 pandemic

Marie Kanstrup, Laura Singh, Elisabeth Johanna Leehr, Katarina E. Göransson, Sara Ahmed Pihlgren, Lalitha Iyadurai, Oili Dahl, Ann-Charlotte Falk, Veronica Lindström, Nermin Hadziosmanovic, Katja Gabrysch, Michelle L. Moulds, Emily A. Holmes

From conceptualising to modelling structural determinants and interventions in HIV transmission dynamics models: a scoping review and methodological framework for evidence-based analyses

James Stannah, Jorge Luis Flores Anato, Michael Pickles, Joseph Larmarange, Kate M. Mitchell, Adelina Artenie, Kostyantyn Dumchev, Serge Niangoran, Lucy Platt, Fern Terris-Prestholt, Aditya Singh, Jack Stone, Peter Vickerman, Andrew Phillips, Leigh Johnson, Mathieu Maheu-Giroux, Marie-Claude Boily

Correction: Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer

Ruoshuang Han, Haoyue Guo, Jinpeng Shi, Sha Zhao, Yijun Jia, Xiaozhen Liu, Yiwei Liu, Lei Cheng, Chao Zhao, Xuefei Li, Caicun Zhou

YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice

Chaopeng Ou, Kun Zhang, Yanyu Mu, Zhenzhen Huang, Xile Li, Wan Huang, Yan Wang, Weian Zeng, Handong Ouyang

An integrated machine learning model enhances delayed graft function prediction in pediatric renal transplantation from deceased donors

Xiao-You Liu, Run-Tao Feng, Wen-Xiang Feng, Wei-Wei Jiang, Jian-An Chen, Guang-Li Zhong, Chao-Wei Chen, Zi-Jian Li, Jia-Dong Zeng, Ding Liu, Song Zhou, Jian-Min Hu, Guo-Rong Liao, Jun Liao, Ze-Feng Guo, Yu-Zhu Li, Si-Qiang Yang, Shi-Chao Li, Hua Chen, Ying Guo, Min Li, Li-Pei Fan, Hong-Yan Yan, Jian-Rong Chen, Liu-Yang Li, Yong-Guang Liu

Effect of electronic alerts on the care and outcomes in patients with acute kidney injury: a meta-analysis and trial sequential analysis

Zhangning Fu, Xiuzhen Hao, Yangfan Lv, Quan Hong, Zhe Feng, Chao Liu

Correction: Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation

  • Open Access
  • Correction

Sean W. D. Carter, Erin L. Fee, Haruo Usuda, Gokce Oguz, Adaikalavan Ramasamy, Zubair Amin, Biswas Agnihotri, Qin Wei, Liu Xiawen, Tsukasa Takahashi, Yuki Takahashi, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Masatoshi Saito, Citra Mattar, Mark I. Evans, Sebastián E. Illanes, Alan H. Jobe, Mahesh Choolani, Matthew W. Kemp

Bivalirudin versus heparin in patients with or without bail-out GPI use: a pre-specified subgroup analysis from the BRIGHT-4 trial

Jia Liao, Miaohan Qiu, Xiaojian Feng, Kui Chen, Dingbao Zhang, Yuncheng Zou, Xiaohui Zheng, Gang Zhao, Nailiang Tian, Zeqi Zheng, Xiaoping Peng, Qing Yang, Zhenyang Liang, Yi Li, Yaling Han, Gregg W. Stone

Estimated glucose disposal rate for predicting cardiovascular events and mortality in patients with non-diabetic chronic kidney disease: a prospective cohort study

Juan Peng, Yan Zhang, Yiqun Zhu, Weilin Chen, Li Chen, Fangyu Ma, Bin Yi, Zhijun Huang

Strategies to improve the implementation of preventive care in primary care: a systematic review and meta-analysis

  • Open Access
  • Obesity
  • Research article

Laura Heath, Richard Stevens, Brian D. Nicholson, Joseph Wherton, Min Gao, Caitriona Callan, Simona Haasova, Paul Aveyard

Unleashing the full potential of digital outcome measures in clinical trials: eight questions that need attention

Mia S. Tackney, James R. Carpenter, Sofía S. Villar

Effectiveness of comprehensive geriatric assessment adapted to primary care when provided by a nurse or a general practitioner: the CEpiA cluster-randomised trial

Veronique Orcel, Leon Banh, Sylvie Bastuji-Garin, Vincent Renard, Emmanuelle Boutin, Amel Gouja, Philippe Caillet, Elena Paillaud, Etienne Audureau, Emilie Ferrat

Identifying psychosocial and contextual markers considered by physicians to personalize care

  • Open Access
  • Research

Paul Domenach, Karolin R. Krause, Alexandre Malmartel, Philippe Ravaud, Viet-Thi Tran

Parental migration, socioeconomic deprivation and hospital admissions in preschool children in England: national birth cohort study, 2008 to 2014

  • Open Access
  • Research article

Kate M. Lewis, Rachel Burns, Mario Cortina-Borja, Anja Heilmann, Alison Macfarlane, Selina Nath, Sarah M. Salway, Sonia Saxena, Nazmy Villarroel-Williams, Russell Viner, Pia Hardelid

A qualitative reflexive thematic analysis of innovation and regulation in hearing health care

  • Open Access
  • Research

Isabelle Boisvert, Samantha Cruz Rivera, Jennifer Smith-Merry, Barbara Molony-Oates, Emily Kecman, Sarah E. Hughes

Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis

Hannah Gordon, Noor Salim, Stephen Tong, Susan Walker, Manarangi De Silva, Catherine Cluver, Parinaz Mehdipour, Richard Hiscock, Lauren Sutherland, Ann Doust, Lina Bergman, Anna-Karin Wikström, Anthea Lindquist, Susanne Hesselman, Roxanne Hastie

Estimating pneumococcal carriage dynamics in adults living with HIV in a mature infant pneumococcal conjugate vaccine programme in Malawi, a modelling study

Joseph Phiri, Lusako Sibale, Lukerensia Mlongoti, Ndaona Mitole, Alice Kusakala, Mercy Khwiya, Thokozani Kayembe, Edwin Lisimba, Prosperina Kapwata, Ken Malisita, Chrispin Chaguza, Daniela M. Ferreira, Deus Thindwa, Kondwani Jambo

Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies

Hong Luo, Agnese Petrera, Stefanie M. Hauck, Wolfgang Rathmann, Christian Herder, Christian Gieger, Annika Hoyer, Annette Peters, Barbara Thorand

Post-marketing surveillance framework of cell and gene therapy products in the European Union, the United States, Japan, South Korea and China: a comparative study

Yuxin Cai, Lijuan Sui, Jingjing Wang, Weilin Qian, Yeheng Peng, Luyao Gong, Weijia Wu, Yuan Gao

Age- and ethnic-driven molecular and clinical disparity of East Asian breast cancers

Ji Yoon Lee, Ji Won Lee, Min Sung Chung, Jong Gwon Choi, Sung Hoon Sim, Hyo Jeong Kim, Jeong Eun Kim, Kyoung Eun Lee, Yeon Hee Park, Myoung Joo Kang, Mi Sun Ahn, Yee Soo Chae, Ji Hyun Park, Jee Hyun Kim, Gun Min Kim, Jae Ho Byun, Keon Uk Park, Ju Won Kim, Seung Pil Jung, Jung Hyun Lee, Jung Seok An, Byunghyun Jang, Dayoung Yoon, Jiwon Kim, Jisoo Hong, Harim Koo, Kyu Ran Cho, Cheol Yong Kim, Jason K. Sa, Kyong Hwa Park

Effects of physical and psychological multimorbidity on the risk of dementia: multinational prospective cohorts and a meta-analysis

Min Du, Min Liu, Jue Liu

The effectiveness of reduction in alcohol consumption achieved by the provision of non-alcoholic beverages associates with Alcohol Use Disorders Identification Test scores: a secondary analysis of a randomized controlled trial

  • Open Access
  • Research

Shohei Dobashi, Kyoko Kawaida, Go Saito, Yukiko Owaki, Hisashi Yoshimoto

Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank

Zirong Ye, Haoxiang Lang, Zishan Xie, Siyu Duan, Bihao Peng, Xiaochun Chen, Ya Fang, Jiawei Xin

Trends in non-daily cigarette smoking in England, 2006–2024

Sarah E. Jackson, Jamie Brown, Lion Shahab, Sharon Cox

Time-varying exposure to food retailers and cardiovascular disease hospitalization and mortality in the netherlands: a nationwide prospective cohort study

Maria Gabriela M. Pinho, Yvonne Koop, Joreintje D. Mackenbach, Jeroen Lakerveld, Mariana Simões, Roel Vermeulen, Alfred J. Wagtendonk, Ilonca Vaartjes, Joline W. J. Beulens

Updated overall survival and ctDNA analysis in patients with EGFR T790M-positive advanced non-small cell lung cancer treated with lazertinib in the phase 1/2 LASER201 study

  • Open Access
  • NSCLC
  • Research article

Ji-Youn Han, Myung-Ju Ahn, Ki Hyeong Lee, Yun-Gyoo Lee, Dong-Wan Kim, Young Joo Min, Sang-We Kim, Eun Kyung Cho, Joo-Hang Kim, Gyeong-Won Lee, Sung Sook Lee, Na Mi Lee, Hyun Woo Jang, Heewon Han, Hyejoo Park, Jieon Lee, Byoung Chul Cho

The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood

Zhenxian Jia, Feng Qiu, Yujie He, Huan Chen, Chenhui Yang, Hongxiu Liu, Tongzhang Zheng, Shunqing Xu, Shiqiong Wang, Yuanyuan Li

Surgical interventions for degenerative lumbar spinal stenosis: a systematic review with network meta-analysis

Lingxiao Chen, Bin Guan, David B. Anderson, Paulo H. Ferreira, Ralph Stanford, Paula R. Beckenkamp, James M. Van Gelder, Munkh-erdene Bayartai, Maja R. Radojčić, Jeremy C. T. Fairbank, Shiqing Feng, Hengxing Zhou, Manuela L. Ferreira

Cortical morphological changes and associated transcriptional signatures in post-traumatic stress disorder and psychological resilience

Minlan Yuan, Lun Li, Hongru Zhu, Bo Zheng, Su Lui, Wei Zhang

C/EBPδ deficiency delays infection-induced preterm birth

Wen-Jia Lei, Fan Zhang, Meng-Die Li, Fan Pan, Li-Jun Ling, Jiang-Wen Lu, Leslie Myatt, Kang Sun, Wang-Sheng Wang

Linking the reversal of gestational insulin resistance to postpartum depression

Minoli Vinoda Abeysekera, Duan Ni, Leah Gilbert, Emily Hibbert, Ralph Nanan

Medical student perceptions of gender and pain: a systematic review of the literature

  • Open Access
  • Research

Maia Patrick-Smith, Stephanie Bull

Measuring internalized health-related stigma across health conditions: development and validation of the I-HEARTS Scale

Rebecca L. Pearl, Yulin Li, Laurie C. Groshon, Marian Hernandez, Danielle Saunders, Miriam Sheynblyum, Kimberly A. Driscoll, Joel M. Gelfand, Preeti Manavalan, Marjorie Montanez-Wiscovich, Deidre B. Pereira, Rebecca M. Puhl, Thomas A. Wadden, Lori B. Waxenberg, Sarah C. Westen, Xiang-Yang Lou

Evaluation of a plasma cell-free DNA methylation test for colorectal cancer diagnosis: a multicenter clinical study

Zhijie Wang, Zixuan He, Rong Lin, Zhijie Feng, Xiuling Li, Xiangyu Sui, Lun Gu, Tian Xia, Dihan Zhou, Bali Zhao, Yanqing Li, Zhaoshen Li, Yu Bai

Slow and steady—small, but insufficient, changes in food and drink availability after four years of implementing a healthy food policy in New Zealand hospitals

Sally Mackay, Magda Rosin, Bruce Kidd, Sarah Gerritsen, Stephanie Shen, Yannan Jiang, Lisa Te Morenga, Cliona Ni Mhurchu

Association of weight change with all-cause and cause-specific mortality: an age-stratified analysis

  • Open Access
  • Research

Qing-Mei Huang, Dong Shen, Jian Gao, Huan Chen, Jia-Hao Xie, Hao-Yu Yan, Bin Wu, Zhi-Hao Li, Gang Liu, Chen Mao

ABLE-SCORE, a simplified risk score for major adverse cardiovascular outcomes in left ventricular hypertrabeculation: a multicenter longitudinal cohort study

Limin Liu, Rui Zeng, Ligang Ding, Simin Cai, Aiyue Chen, Yuchen Dong, Likun Zhou, Mengtong Xu, Yuanwei Xu, Le Li, Zhenhao Zhang, Zhao Hu, Zhuxin Zhang, Yulong Xiong, Zhicheng Hu, Yongqing Li, Minjie Lu, Lingmin Wu, Lihui Zheng, Xiaohan Fan, Tan Li, Yan Yao

The efficacy of different biomarkers and endpoints to refine referrals for suspected prostate cancer: the TARGET study (Tiered integrAted tests for eaRly diaGnosis of clinically significant ProstatE Tumours)

Artitaya Lophatananon, Kenneth R. Muir, Vincent J. Gnanapragasam

Enhancing radiologist's detection: an imaging-based grading system for differentiating Crohn's disease from ulcerative colitis

Ziman Xiong, Yan Zhang, Peili Wu, Jun Chen, Yaqi Shen, Ihab Kamel, Xianying Zheng, Bing Wu, Zhen Li

Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer

Philipp Zimmer, Tobias Esser, Diana Lueftner, Florian Schuetz, Freerk T. Baumann, Achim Rody, Andreas Schneeweiss, Andreas D. Hartkopf, Thomas Decker, Christoph Uleer, Oliver J. Stoetzer, Frank Foerster, Marcus Schmidt, Christoph Mundhenke, Karen Steindorf, Hans Tesch, Christian Jackisch, Thomas Fischer, Sven Hanson, Julia Kreuzeder, Gernot Guderian, Peter A. Fasching, Wilhelm Bloch

HLA diversity unveils susceptibility and organ-specific occurrence of second primary cancers: a prospective cohort study

  • Open Access
  • Research

Zi-Xuan Rong, Wei Wei, Qin Zeng, Xiao-Ting Cai, Yuan-Yuan Wang, Jian Wang, He-San Luo, Lu-Shan Xiao, Jia-Run Lin, Xue Bai, Yan-Pei Zhang, Duan-Duan Han, Zhong-Yi Dong, Wei Wang, De-Hua Wu, Si-Cong Ma

Integrative bioinformatics analysis for identifying the mitochondrial-related gene signature associated with immune infiltration in premature ovarian insufficiency

  • Open Access
  • Research

Minjun Lu, Wenxin Li, Jiamin Zhou, Junyu Shang, Li Lin, Yueqin Liu, Xiaolan Zhu

SSRI use during acute COVID-19 and risk of Long COVID among patients with depression

Zachary Butzin-Dozier, Yunwen Ji, Sarang Deshpande, Eric Hurwitz, A. Jerrod Anzalone, Jeremy Coyle, Junming Shi, Andrew Mertens, Mark J. van der Laan, John M. Colford Jr, Rena C. Patel, Alan E. Hubbard

Sex-specific differences of cardiopulmonary fitness and pulmonary function in exercise-based rehabilitation of patients with long-term post-COVID-19 syndrome

  • Open Access
  • Fatigue
  • Research article

René Garbsch, Hendrik Schäfer, Mona Kotewitsch, Johanna M. Mooren, Melina Waranski, Marc Teschler, Katalin Vereckei, Gereon Böll, Frank C. Mooren, Boris Schmitz

Correction: The effects of telehealth-delivered mindfulness meditation, cognitive therapy, and behavioral activation for chronic low back pain: a randomized clinical trial

Melissa A. Day, Marcia A. Ciol, M. Elena Mendoza, Jeffrey Borckardt, Dawn M. Ehde, Andrea K. Newman, Joy F. Chan, Sydney A. Drever, Janna L. Friedly, John Burns, Beverly E. Thorn, Mark P. Jensen

Correction: Gut microbiome in endometriosis: a cohort study on 1000 individuals

Inmaculada Pérez-Prieto, Eva Vargas, Eduardo Salas-Espejo, Kreete Lüll, Analuce Canha-Gouveia, Laura Antequera Pérez, Juan Fontes, Andres Salumets, Reidar Andreson, Oliver Aasmets, Katrine Whiteson, Elin Org, Signe Altmäe

Microbiome-derived metabolites in early to mid-pregnancy and risk of gestational diabetes: a metabolome-wide association study

Sita Manasa Susarla, Oliver Fiehn, Ines Thiele, Amanda L. Ngo, Dinesh K. Barupal, Rana F. Chehab, Assiamira Ferrara, Yeyi Zhu

Harm effects in non-registered versus registered randomized controlled trials of medications: a retrospective cohort study of clinical trials

  • Open Access
  • Research article

Chang Xu, Shiqi Fan, Luis Furuya-Kanamori, Sheyu Li, Lifeng Lin, Haitao Chu, Su Golder, Yoon Loke, Sunita Vohra

Risk of suicide in patients with atrial fibrillation receiving different oral anticoagulants: a nationwide analysis using target trial emulation framework

Brian Meng-Hsun Li, Avery Shuei-He Yang, Michael Chun-Yuan Cheng, Huei-Kai Huang, Edward Chia-Cheng Lai

Representation of multimorbidity and frailty in the development and validation of kidney failure prognostic prediction models: a systematic review

Heather Walker, Scott Day, Christopher H. Grant, Catrin Jones, Robert Ker, Michael K. Sullivan, Bhautesh Dinesh Jani, Katie Gallacher, Patrick B. Mark

Potential impact of rotavirus vaccine introduction in India’s Universal Immunisation Programme on private sector vaccine utilisation: an interrupted time series analysis

  • Open Access
  • Research article

Habib Hasan Farooqui, Anup Karan, Aashna Mehta, Giridhara Rathnaiah Babu, Onno C. P. van Schayck

Adverse pregnancy outcomes and multiple cancers risk in both mother and offspring: an umbrella review of systematic reviews with meta-analyses of observational studies

Na Liu, Rui-Han Bao, Yu-Jiao Chang, Fang-Hua Liu, Lang Wu, Jia-Yi Wang, Zi-Ping Niu, Shuai Ma, Yi-Xuan Men, Ke-Xin Liu, Dong-Hui Huang, Qian Xiao, Song Gao, Yue-Yang Zhao, Jian-Hua Fu, Qi-Jun Wu, Ting-Ting Gong

Dissecting shared genetic architecture between depression and body mass index

Hengyu Zhang, Rui Zheng, Binhe Yu, Yuefeng Yu, Xiaomin Luo, Shujuan Yin, Yingjun Zheng, Jie Shi, Sizhi Ai

Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits

Caibo Ning, Meng Jin, Yimin Cai, Linyun Fan, Kexin Hu, Zequn Lu, Ming Zhang, Can Chen, Yanmin Li, Naifan Hu, Donghui Zhang, Yizhuo Liu, Shuoni Chen, Yuan Jiang, Chunyi He, Zhuo Wang, Zilong Cao, Hanting Li, Gaoyuan Li, Qianying Ma, Hui Geng, Wen Tian, Heng Zhang, Xiaojun Yang, Chaoqun Huang, Yongchang Wei, Bin Li, Ying Zhu, Xiangpan Li, Xiaoping Miao, Jianbo Tian

Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial

Shahnaz Amani Tirani, Fariborz Khorvash, Parvane Saneei, Zahra Moradmand, Gholamreza Askari

Serum lipidome reveals lipid metabolic dysregulation in severe fever with thrombocytopenia syndrome

Shuai Guo, Yunjun Yan, Jingyao Zhang, Zhangong Yang, Lirui Tu, Chunjuan Wang, Ziqing Kong, Shuhua Wang, Baojie Wang, Danqing Qin, Jie Zhou, Wenjin Wang, Yumei Hao, Shougang Guo

Ultra-processed food consumption and renal cell carcinoma incidence and mortality: results from a large prospective cohort

Ya-Dong Li, Yong-Xin Fu, Le-Lan Gong, Ting Xie, Wei Tan, Hao Huang, Sheng-Jie Zeng, Chuan Liu, Zheng-Ju Ren

Surgical removal of tonsils and risk of COVID-19: a nested case–control study using data from UK Biobank and AMORIS Cohort

Yanping Yang, Kejia Hu, Karin Modig, Maria Feychting, Imre Janszky, Niklas Hammar, Fang Fang, Zhe Zhang, Dang Wei

Association of COVID-19 with acute and post-acute risk of multiple different complications and mortality in patients infected with omicron variant stratified by initial disease severity: a cohort study in Hong Kong

Eric Yuk Fai Wan, Ran Zhang, Sukriti Mathur, Vincent Ka Chun Yan, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Esther Wai Yin Chan, Chak Sing Lau, Ian Chi Kei Wong

Altered metabolic profiles in male offspring conceived from intracytoplasmic sperm injection

  • Open Access
  • ICSI
  • Research article

Bingqian Zhang, Miaomiao Ban, Xiaojing Chen, Jingmei Hu, Linlin Cui, Zi-Jiang Chen

Obesity and survival in advanced non-small cell lung cancer patients treated with chemotherapy, immunotherapy, or chemoimmunotherapy: a multicenter cohort study

  • Open Access
  • NSCLC
  • Research

Wei Nie, Jun Lu, Jie Qian, Shu-Yuan Wang, Lei Cheng, Liang Zheng, Guang-Yu Tao, Xue-Yan Zhang, Tian-Qing Chu, Bao-Hui Han, Hua Zhong

Combined associations of physical activity, diet quality and their changes over time with mortality: findings from the EPIC-Norfolk study, United Kingdom

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Shayan Aryannezhad, Alexander Mok, Fumiaki Imamura, Nicholas J. Wareham, Soren Brage, Nita G. Forouhi

Correction: Nine months of bedaquiline, linezolid, levofloxacin, clofazimine, and cycloserine chemotherapy for rifampicin/multidrug-resistant tuberculosis: a multicenter, randomized, open-label non-inferiority trial in China

Yanhua Song, Wei Shu, Yi Pei, Juan Du, Guihui Wu, Hua Wang, Fengling Mi, Fangchao Liu, Liping Ma, Li Xie, Zhongshun Kong, Xiaoguang Wu, Rongmei Liu, Hongmei Chen, Hua Li, Qiping Ge, Lihui Nie, Zizheng Lv, Xuerui Huang, Mingwu Li, Mingying Jiang, Xiaohong Chen, Qingshan Cai, Wei Chen, Yanmei Liu, Yanfang Miao, Yan Tang, Yu Chen, Shujun Geng, Quanying Zhou, Yuhong Liu, Yu Pang, Mengqiu Gao

Effects of a mobile health intervention based on a multitheoretical model of health behavior change on anxiety and depression, fear of cancer progression, and quality of life in patients with differentiated thyroid cancer: A randomized controlled trial

Xiangju Sun, Yang Jiang, Jing Wang, Siyuan Fan, Xinghua Fu, Zhi An, Xiaomei Zhu, Yibo Wu

Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis

Lisa K. Akison, Nicole Hayes, Chelsea Vanderpeet, Jayden Logan, Zachary Munn, Philippa Middleton, Karen M. Moritz, Natasha Reid, Storm Anderson, Diana Barnett, Andi Crawford, Robyn Doney, Elizabeth Elliott, Rowena Friend, Sarah Goldsbury, Matthew Gullo, Sophie Harrington, Katrina Harris, Nicole Hewlett, Delyse Hutchinson, Fiona Kay, Natalie Kippin, Raewyn Mutch, Max Naglazas, Seema Padencheri, Carmela Pestell, Doug Shelton, Kelly Skorka, James Stewart, Haydn Till, Prue Walker

Exploratory analysis of the potential impact of violence on HIV among female sex workers in Mombasa, Kenya: a mathematical modelling study

Michael Pickles, Elisa Mountain, Parinita Bhattacharjee, Japheth Kioko, Janet Musimbi, Helgar Musyoki, Peter Gichangi, James Stannah, Mathieu Maheu-Giroux, Marissa Becker, Marie-Claude Boily

Effectiveness of bivalent HPV vaccination against genital HPV DNA-positivity of a catch-up campaign at age 13–16 years compared to routine vaccination at age 12 years: a biennial repeated cross-sectional study

Johannes M. A. Kusters, Maarten F. Schim van der Loeff, Birgit H. B. van Benthem, Audrey J. King, Helmie van der Meijden, Karlijn Kampman, Elske Hoornenborg, Annet Bak, Marga Smit, Harriette van Buel, Ferna Neienhuijsen, Marlot Ippel, Dianne Schriemer, Inez Swart, Denise Twisk, Hester E. de Melker, Titia Heijman, Janneke C. M. Heijne

The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis

Guo-Bin Zhang, Jia-Mei Lv, Wei-Jie Yu, Hao-Yi Li, Lei Wu, Shao-Lan Zhang, Guang-Zhi Shi, Hua-Wei Huang

Correction: Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease

  • Open Access
  • Correction

Jinchao Jia, Mengyan Wang, Yuning Ma, Jianfen Meng, Dehao Zhu, Xia Chen, Hui Shi, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Tingting Liu, Zhuochao Zhou, Fan Wang, Longfang Chen, Da Yi, Yu Xiao, Chengde Yang, Jialin Teng, Qiongyi Hu

Individualised computerised cognitive training (iCCT) for community-dwelling people with mild cognitive impairment (MCI): results on cognition in the 6-month intervention period of a randomised controlled trial (MCI-CCT study)

Elmar Graessel, Michael Jank, Petra Scheerbaum, Julia-Sophia Scheuermann, Anna Pendergrass

Common pitfalls in drug target Mendelian randomization and how to avoid them

  • Open Access
  • Review

Dipender Gill, Marie-Joe Dib, Héléne T. Cronjé, Ville Karhunen, Benjamin Woolf, Eloi Gagnon, Iyas Daghlas, Michael Nyberg, Donald Drakeman, Stephen Burgess

Correction: Enhancing radiologist's detection: an imaging-based grading system for differentiating Crohn's disease from ulcerative colitis

Ziman Xiong, Yan Zhang, Peili Wu, Jun Chen, Yaqi Shen, Ihab Kamel, Xianying Zheng, Bing Wu, Zhen Li

Sex disparities in the prevalence, incidence, and management of diabetes mellitus: an Australian retrospective primary healthcare study involving 668,891 individuals

George Mnatzaganian, Crystal Man Ying Lee, Gill Cowen, James H. Boyd, Richard J. Varhol, Sean Randall, Suzanne Robinson

Global epidemiology of T2DM in patients with NAFLD or MAFLD: the real situation may be even more serious

Yinglan Ji, Qikai Wang, Yong Jiang, Binghua Liu

Correction: Risk of suicide after hospitalizations due to acute physical health conditions—a cohort study of the Norwegian population

Andreas Asheim, Sara Marie Nilsen, Ellen Rabben Svedahl, Silje L. Kaspersen, Ottar Bjerkeset, Imre Janszky, Johan Håkon Bjørngaard

Effectiveness and efficiency of immunisation strategies to prevent RSV among infants and older adults in Germany: a modelling study

Fabienne Krauer, Felix Guenther, Marina Treskova-Schwarzbach, Viktoria Schoenfeld, Mihaly Koltai, Mark Jit, David Hodgson, Udo Schneider, Ole Wichmann, Thomas Harder, Frank G. Sandmann, Stefan Flasche

Chronic disease diagnoses and health service use among people who died of illicit drug toxicity in British Columbia, Canada

Heather Palis, Kevin Hu, Andrew Tu, Frank Scheuermeyer, John A. Staples, Jessica Moe, Beth Haywood, Roshni Desai, Chloé G. Xavier, Jessica C. Xavier, Alexis Crabtree, Amanda Slaunwhite

Reducing rehospitalization in cardiac patients: a randomized, controlled trial of a cardiac care management program (“Cardiolotse”) in Germany

  • Open Access
  • Research

Wiebke Schüttig, Harald Darius, Katrin C. Reber, Marie Coors, Amelie Flothow, Alfred Holzgreve, Sebastian Karmann, Anica Stürtz, Rebecca Zöller, Saskia Kropp, Petra Riesner, Leonie Sundmacher

Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study

Jasmine I-Shin Su, Yao-rui Yeo, Mellesia Jeetoo, Neo K. Morojele, Joel M. Francis, Sheela Shenoi, R. Scott Braithwaite

Organic food consumption during pregnancy and symptoms of neurodevelopmental disorders at 8 years of age in the offspring: the Norwegian Mother, Father and Child Cohort Study (MoBa)

Johanne T. Instanes, Berit S. Solberg, Liv G. Kvalvik, Kari Klungsøyr, Maj-Britt R. Posserud, Catharina A. Hartman, Jan Haavik

Non-fermented and fermented milk intake in relation to risk of ischemic heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants

Karl Michaëlsson, Eva Warensjö Lemming, Susanna C. Larsson, Jonas Höijer, Håkan Melhus, Bodil Svennblad, John A. Baron, Alicja Wolk, Liisa Byberg

The impact of contextual effects in exercise therapy for low back pain: a systematic review and meta-analysis

Aaltje de Roode, Martijn W. Heymans, Wim van Lankveld, J. Bart Staal

Unhealthy plant-based diet is associated with a higher cardiovascular disease risk in patients with prediabetes and diabetes: a large-scale population-based study

Pan Zhuang, Fenglei Wang, Jianxin Yao, Xiaohui Liu, Yin Li, Yang Ao, Hao Ye, Xuzhi Wan, Yu Zhang, Jingjing Jiao

Loss to follow-up of patients after antiviral treatment as an additional barrier to HCV elimination

Dorota Zarębska-Michaluk, Michał Brzdęk, Olga Tronina, Justyna Janocha-Litwin, Marek Sitko, Anna Piekarska, Jakub Klapaczyński, Anna Parfieniuk-Kowerda, Barbara Sobala-Szczygieł, Magdalena Tudrujek-Zdunek, Łukasz Laurans, Robert Flisiak

Synthesizing regulatory guidance for demonstrating preclinical efficacy and translating promising cell therapies to early phase clinical trials: a scoping review

  • Open Access
  • Registered report

Matthew S. Jeffers, Cheng En Xi, Raj Bapuji, Hannah Wotherspoon, Jonathan Kimmelman, Patrick Bedford, Daniel I. McIsaac, Manoj M. Lalu, Dean A. Fergusson

Use of renin-angiotensin system blockers and posttraumatic stress disorder risk in the UK Biobank: a retrospective cohort study

Sunghyuk Kang, Jimin Kim, Ji Su Yang, Ye Jin Jeon, Hyeok-Hee Lee, Shakira F. Suglia, Alexander C. Tsai, Jee In Kang, Sun Jae Jung

Association of systemic corticosteroid use with prognosis of patients with acute exacerbations of chronic obstructive pulmonary disease in the intensive care unit: a propensity score-matched cohort study

  • Open Access
  • Research

Le Bai, Pengfei Zhu, Tingyu Pan, Yuanjie Liu, Yong Xu, Hailang He, Xianmei Zhou

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

Saskia Weber-Stiehl, Jan Taubenheim, Lea Järke, Christoph Röcken, Stefan Schreiber, Konrad Aden, Christoph Kaleta, Philip Rosenstiel, Felix Sommer

Structure–function coupling changes in first-episode, treatment-naïve schizophrenia correlate with cell type-specific transcriptional signature

Guanqun Yao, Jingjing Pan, Ting Zou, Jing Li, Juan Li, Xiao He, Fuquan Zhang, Yong Xu

Optimal fluid resuscitation targets in septic patients with acutely decompensated heart failure

Jie Weng, Zhe Xu, Jiaze Song, Chen Liu, Haijuan Jin, Qianhui Cheng, Xiaoming Zhou, Dongyuan He, Jingwen Yang, Jiaying Lin, Liang Wang, Chan Chen, Zhiyi Wang

Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases

Nathalie Rohmann, Theresa Geese, Samantha Nestel, Kristina Schlicht, Corinna Geisler, Kathrin Türk, Fynn Brix, Julia Jensen-Kroll, Tobias Demetrowitsch, Corinna Bang, Andre Franke, Wolfgang Lieb, Dominik M. Schulte, Karin Schwarz, Anne-Kathrin Ruß, Arunabh Sharma, Stefan Schreiber, Astrid Dempfle, Matthias Laudes

Assessment of inverse publication bias in safety outcomes: an empirical analysis

  • Open Access
  • Research article

Xing Xing, Jianan Zhu, Linyu Shi, Chang Xu, Lifeng Lin

Accelerating adverse pregnancy outcomes research amidst rising medication use: parallel retrospective cohort analyses for signal prioritization

Yeon Mi Hwang, Samantha N. Piekos, Alison G. Paquette, Qi Wei, Nathan D. Price, Leroy Hood, Jennifer J. Hadlock

Efficacy and safety of nanoparticle albumin-bound paclitaxel plus carboplatin as neoadjuvant chemotherapy for stages III–IV, unresectable ovarian cancer: a single-arm, open-label, phase Ib/II study

Lina Yin, Wei Jiang, Shuai Liu, Yi Fu, Lin Zhou, Xuan Pei, Shuang Ye, Wenbin Shen, Huijuan Yang, Boer Shan

Health Catch-UP!: a realist evaluation of an innovative multi-disease screening and vaccination tool in UK primary care for at-risk migrant patients

Jessica Carter, Lucy P. Goldsmith, Felicity Knights, Anna Deal, Subash Jayakumar, Alison F. Crawshaw, Farah Seedat, Nathaniel Aspray, Dominik Zenner, Philippa Harris, Yusuf Ciftci, Fatima Wurie, Azeem Majeed, Tess Harris, Philippa Matthews, Rebecca Hall, Ana Requena-Mendez, Sally Hargreaves

Developing a gender measure and examining its association with cardiovascular diseases incidence: a 28-year prospective cohort study

  • Open Access
  • Research article

Mahée Gilbert-Ouimet, Azita Zahiriharsini, Caty Blanchette, Denis Talbot, Xavier Trudel, Alain Milot, Chantal Brisson, Peter Smith

Associations of periconception dietary glycemic index and load with fertility in women and men: a study among couples in the general population

Mireille C. Schipper, Aline J. Boxem, Sophia M. Blaauwendraad, Annemarie G. M. G. J. Mulders, Vincent W. V. Jaddoe, Romy Gaillard

Use, perceptions, and effectiveness of e-cigarettes for smoking cessation among older adults in England: a population study, 2014–2024

Sarah E. Jackson, Jamie Brown, Lion Shahab, Sharon Cox

A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies

Md Hamidul Huque, Scherazad Kootar, Kim M. Kiely, Craig S. Anderson, Martin van Boxtel, Henry Brodaty, Perminder S. Sachdev, Michelle Carlson, Annette L. Fitzpatrick, Rachel A. Whitmer, Miia Kivipelto, Louisa Jorm, Sebastian Köhler, Nicola T. Lautenschlager, Oscar L. Lopez, Jonathan E. Shaw, Fiona E. Matthews, Ruth Peters, Kaarin J. Anstey

TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy

Juan Xiao, Zhenwang Zhao, Fengqiao Zhou, Jinsong Xiong, Zean Yang, Baoxian Gong, Lei Xiang, Mingming Liu, Fengsheng Cao, Hong Xiao, Huabo Chen, Anbing Zhang, Ke Wang

Prevalence and uptake of vaping among people who have quit smoking: a population study in England, 2013-2024

  • Open Access
  • Research

Sarah E. Jackson, Jamie Brown, Loren Kock, Lion Shahab

Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder

Lili Fan, Qi Li, Yaxin Shi, Xiang Li, Yutong Liu, Jiaqi Chen, Yaqi Sun, Anjie Chen, Yuan Yang, Xirui Zhang, Jia Wang, Lijie Wu

General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial

Anthony G. B. Walters, Greg D. Gamble, Caroline A. Crowther, Stuart R. Dalziel, Carl L. Eagleton, Christopher J. D. McKinlay, Barry J. Milne, Jane E. Harding

Mortality from external causes in late adolescence and early adulthood by gestational age and sex: a population-based cohort study in four Nordic countries

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Josephine Funck Bilsteen, Signe Opdahl, Anna Pulakka, Per Ivar Finseth, Weiyao Yin, Kristine Pape, Jorun Schei, Johanna Metsälä, Anne-Marie Nybo Andersen, Sven Sandin, Eero Kajantie, Kari Risnes

Identification of sensitive periods of weight status transition over the lifespan in Chinese population

Chaonan Gao, Xin Meng, Wei Liu, Qianjin Qi, Yinkun Yan

How does surgery influence female sexuality in patients with endometriosis compared to those with other benign gynecological conditions?

Alexandra Perricos, Manuela Gstoettner, Sahra Iklil, Florian Heinzl, Lejla Sandrieser, Jana Heine, Heinrich Husslein, Lorenz Kuessel, Christine Bekos, René Wenzl

Twenty-year trend in the prevalence of increased cardiometabolic risk, measured by abdominal obesity, among Spanish children and adolescents across body mass index categories

Helmut Schröder, Charlotte Juton, Michael I. Goran, Julia Wärnberg, Maddi Osés, Marcela Gonzalez-Gross, Narcis Gusi, Susana Aznar, Elena Marín-Cascales, Miguel González-Valeiro, Estefanía Herrera-Ramos, Nicolás Terrados, Josep A. Tur, Marta Segú, Montserrat Fitó, Lourdes Ribas-Barba, Inmaculada Bautista-Castaño, Luis Peña-Quintana, Paula Berruezo, Juan Carlos Benavente-Marín, Idoia Labayen, Augusto G. Zapico, Jesús Sánchez-Gómez, Fabio Jiménez-Zazo, Pedro E. Alcaraz, Marta Sevilla-Sanchez, Susana Pulgar, Cristina Bouzas, Lluis Serra-Majem, Santiago F. Gómez

BMI trajectories from birth to young adulthood associate with distinct cardiometabolic profiles

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Gang Wang, Dang Wei, Simon Kebede Merid, Sandra Ekström, Susanna Klevebro, Natalia Hernandez-Pacheco, Sophia Björkander, Petter Ljungman, Inger Kull, Jochen M. Schwenk, Anna Bergström, Erik Melén

METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus

Yu Liu, Xiaohua Wang, Mingcheng Huang, Ailing Luo, Shanshan Liu, Mansi Cai, Weinian Li, Shiwen Yuan, Zhihua Zheng, Xiaoping Liu, Chun Tang

Sex-specific dietary habits and their association with weight change in healthy adults

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  • Obesity
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Michal Rein, Matan Elkan, Anastasia Godneva, Noa Cohen Dolev, Eran Segal

Western diet promotes endometriotic lesion growth in mice and induces depletion of Akkermansia muciniphila in intestinal microbiota

Guillaume Parpex, Benoît Chassaing, Mathilde Bourdon, Pietro Santulli, Ludivine Doridot, Marine Thomas, Frédéric Batteux, Sandrine Chouzenoux, Charles Chapron, Carole Nicco, Louis Marcellin

“If government is saying the regulations are important, they should be putting in funding to back it up.”- An in-depth analysis of local authority officers’ perspectives of the Food (Promotion and Placement) (England) Regulations 2021

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Preeti Dhuria, Sarah Muir, Sarah Jenner, Emma Roe, Wendy Lawrence, Janis Baird, Christina Vogel

Correction: The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study

Lina Zhao, Fuhong Su, Nannan Zhang, Hening Wu, Yuehao Shen, Haiying Liu, Xuguang Li, Yun Li, Keliang Xie

Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial

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  • Malaria
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Roisin Connon, Peter Olupot-Olupot, Arthur M. A. Pistorius, William Okiror, Tonny Ssenyondo, Rita Muhindo, Sophie Uyoga, Ayub Mpoya, Thomas N. Williams, Diana M. Gibb, A. Sarah Walker, Rob ter Heine, Elizabeth C. George, Kathryn Maitland

Lost in translation: the lack of agreement between surgeons and scientists regarding biomaterials research and innovation for treating bone defects

Markus Laubach, Stephen Whyte, Ho Fai Chan, Tina Frankenbach-Désor, Susanne Mayer-Wagner, Frank Hildebrand, Boris M. Holzapfel, Ulrich Kneser, Uwe Dulleck, Dietmar W. Hutmacher

A comprehensive evaluation on the associations between hearing and vision impairments and risk of all-cause and cause-specific dementia: results from cohort study, meta-analysis and Mendelian randomization study

Fan Jiang, Qiuyue Dong, Sijia Wu, Xinhui Liu, Alimu Dayimu, Yingying Liu, Hanbing Ji, Le Wang, Tiemei Liu, Na Li, Xiaofei Li, Peipei Fu, Qi Jing, Chengchao Zhou, Hongkai Li, Lei Xu, Shanquan Chen, Haibo Wang

Measuring characteristics of wild and cultivated food environments: a scoping review

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Penny Farrell, Erica Reeve, Ellen Johnson, Anna K. Farmery, Dori Patay, Anne Marie Thow, Jonathan Wu, Jessica R. Bogard

Predicting post-COVID-19 condition in children and young people up to 24 months after a positive SARS-CoV-2 PCR-test: the CLoCk study

Manjula D. Nugawela, Terence Stephenson, Roz Shafran, Trudie Chalder, Emma Dalrymple, Tamsin Ford, Lana Fox-Smith, Anthony Harnden, Isobel Heyman, Shamez N. Ladhani, Kelsey McOwat, Ruth Simmons, Olivia Swann, Elizabeth Whittaker, Bianca De Stavola, Esther Crawley, Kishan Sharma, Marta Buszewicz, Michael Levin, Shruti Garg, Vanessa Poustie, Snehal M. Pinto Pereira

ANXA4 restricts HBV replication by inhibiting autophagic degradation of MCM2 in chronic hepatitis B

Luo Yang, Xianzhi Liu, Limin Zhen, Ying Liu, Lina Wu, Wenxiong Xu, Liang Peng, Chan Xie

Postoperative tumor bed radiation versus T-shaped field radiation in the treatment of locally advanced thoracic esophageal squamous cell carcinoma: a phase IIb multicenter randomized controlled trial

Ya Zeng, Jiancheng Li, Jingjun Ye, Gaohua Han, Wenguang Luo, Chaoyang Wu, Songbing Qin, Wendong Gu, Shengguang Zhao, Yufei Zhao, Bing Xia, Zhengfei Zhu, Xianghui Du, Yuan Liu, Jun Liu, Hongxuan Li, Jiaming Wang, Jindong Guo, Wen Yu, Qin Zhang, Changlu Wang, Wentao Fang, Zhigang Li, Xiaolong Fu, Xuwei Cai

rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l’essai proches)

Conall H. Watson, Pierre-Stéphane Gsell, Yper Hall, Anton Camacho, Ximena Riveros, Godwin Enwere, Andrea Vicari, Séverine Danmadji Nadlaou, Alhassane Toure, Ismaila M. Sani, Abdourahamane Diallo, Cece Kolie, Sophie Duraffour, Kékoura Ifono, Andre Maomou, Kassie Dore, Honora A. Djidonou, Aminata Bagayoko, Philos P. Damey, Mabetty Nancy Camara, Fatoumata Battouly Diallo, Fofana Thierno Oumar, Kalidou Toure, Mohamed Lamine Diaby, Lansana Sylla, Doussou Conde, Ibrahima Lansana Kaba, Tom Tipton, Rosalind M. Eggo, Michael Marks, Chrissy H. Roberts, Thomas Strecker, Stephan Günther, Sakoba Keita, W. John Edmunds, Miles W. Carroll, Ana Maria Henao-Restrepo

Correction: Loss to follow-up of patients after antiviral treatment as an additional barrier to HCV elimination

Dorota Zarębska-Michaluk, Michał Brzdęk, Olga Tronina, Justyna Janocha-Litwin, Marek Sitko, Anna Piekarska, Jakub Klapaczyński, Anna Parfieniuk-Kowerda, Barbara Sobala-Szczygieł, Magdalena Tudrujek-Zdunek, Łukasz Laurans, Robert Flisiak

Breaking barriers: why including boys and men is key to HPV prevention

Damian Naidoo, Kaymarlin Govender, Joanne E. Mantell

Relationship between timing of coffee and tea consumption with mortality (total, cardiovascular disease and diabetes) in people with diabetes: the U.S. National Health and Nutrition Examination Survey, 2003–2014

Ruiming Yang, Qianqian Lei, Zijie Liu, Xinyu Shan, Sijia Han, Yiwei Tang, Fengru Niu, Hui Liu, Wenbo Jiang, Wei Wei, Tianshu Han

Association between within-target risk factors and life expectancy free from cardiovascular disease, cancer, and dementia in individuals with type 2 diabetes in New Zealand between 1994 and 2018: a multi-ethnic cohort study

Dahai Yu, Zhanzheng Zhao, Karen Pickering, John Baker, Richard Cutfield, Brandon J. Orr-Walker, Gerhard Sundborn, Zheng Wang, Yamei Cai, Hang Fu, Chengzeng Wang, David Simmons

In utero, childhood, and adolescence tobacco smoke exposure, physical activity, and chronic kidney disease incidence in adulthood: evidence from a large prospective cohort study

Bingxin Shang, Yuxin Yao, Haoyu Yin, Yujia Xie, Shiyu Yang, Xiaojie You, Haoxiang Liu, Miao Wang, Jixuan Ma

Effects of different types of intermittent fasting on metabolic outcomes: an umbrella review and network meta-analysis

Yu-En Chen, Hui-Li Tsai, Yu-Kang Tu, Ling-Wei Chen

Comparison of MRI artificial intelligence-guided cognitive fusion-targeted biopsy versus routine cognitive fusion-targeted prostate biopsy in prostate cancer diagnosis: a randomized controlled trial

Ruiyi Deng, Yi Liu, Kexin Wang, Mingjian Ruan, Derun Li, Jingyun Wu, Jianhui Qiu, Pengsheng Wu, Peidong Tian, Chaojian Yu, Jiaheng Shang, Zihou Zhao, Jingcheng Zhou, Lin Cai, Xiaoying Wang, Kan Gong

Histological, histochemical, and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering

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Olimpia Ortiz-Arrabal, Cristina Blanco-Elices, Carmen González-Gallardo, David Sánchez-Porras, Miguel Etayo-Escanilla, Paula Ávila Fernández, Jesús Chato-Astrain, Óscar-Darío García-García, Ingrid Garzón, Miguel Alaminos

Symptom profile, case and symptom clustering, clinical and demographic characteristics of a multicentre cohort of 1297 patients evaluated for Long-COVID

Marco Floridia, Marina Giuliano, Liliana Elena Weimer, Maria Rosa Ciardi, Piergiuseppe Agostoni, Paolo Palange, Patrizia Rovere Querini, Silvia Zucco, Matteo Tosato, Aldo Lo Forte, Paolo Bonfanti, Donato Lacedonia, Emanuela Barisione, Stefano Figliozzi, Paola Andreozzi, Cecilia Damiano, Flavia Pricci, Graziano Onder, Tiziana Grisetti, Tiziana Grassi, Dorina Tiple, Marika Villa, Cosimo Polizzi, Fabio Galati, Patrizia Pasculli, Francesca Colazzo, Irene Mattavelli, Elisabetta Salvioni, Daniela Pellegrino, Marco Bezzio, Federica Olmati, Arianna Sanna, Arianna Schifano, Dario Angelone, Antonio Fabozzi, Simona Santoro, Anna Fumagalli, Aurora Merolla, Valentina Canti, Maria Pia Ruggiero, Marco Messina, Marina Biganzoli, Danilo Buonsenso, Alice Ianniello, Vincenzo Galluzzo, Laura Macculi, Valeria Maria Bottaro, Luca Bonaffini, Anna Spolti, Nicola Squillace, Terence Campanino, Teresita Aloè, Elena Tagliabue, Federica Testerini, Marzia Miglionico, Antonia Barbitta, Chiara Cenciarelli, Gianluca Pagnanelli, Giuseppe Piccinni, Paola Gnerre, Lionello Parodi, Eugenia Monaco, Sandra Buscaglia, Antonella Visconti, Kwelusukila Loso, Giuseppe Pio Martino, Giuseppina Bitti, Laura Postacchini, Antonella Cognigni, Maria Antonietta di Rosolini, Sergio Mavilla, Domenico Maurizio Toraldo, Guido Vagheggini, Giulio Bardi, Giuseppa Levantino, Cristina Stefan, Gianfranco Parati, Elisa Perger, Enrico Gianfranceschi, Francesca Pozzoli, Pasqualina De Leo, Sara Grignolo, Caterina Monari, Leila Bianchi, Luisa Galli, Lorenzo Surace, Elisabetta Falbo, Silvia Boni, Claudia Battello, Caterina Baghiris, Gaetano Serviddio

Analysing premature cardiovascular disease mortality in the United States by obesity status and educational attainment

Han Li, Tim Adair

Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study

Fei Chen, Jinping Wang, Siyao He, Yifan He, Yali An, Qiuhong Gong, Xiaoping Chen, Ying Shuai, Xuan Wang, Yanyan Chen, Bo Zhang, Guangwei Li

Triglyceride-lowering therapies in hypertriglyceridemia-associated acute pancreatitis in China: a multicentre prospective cohort study

Jing Zhou, Zuozheng Wang, Qinghong Liu, Longxiang Cao, Enrique de-Madaria, Gabriele Capurso, Christian Stoppe, Dong Wu, Wei Huang, Yingjie Chen, Siyao Liu, Donghuang Hong, Yun Sun, Zhenguo Zeng, Kaixiu Qin, Haibin Ni, Yi Sun, Yue Long, Feng Guo, Xiaofeng Liu, Xisheng Zheng, Guoxiu Zhang, Xiangcheng Zhang, Kai Zhou, Yizhe Chen, Qinghai Jiao, Xinsen Zou, Xiang Luo, Gang Li, Bo Ye, Chao Li, Lanting Wang, Shuai Li, John Windsor, Yuxiu Liu, Zhihui Tong, Weiqin Li, Lu Ke, Wenjian Mao, Jiajia Lin, Mingfeng Huang, Mengjie Lu, Yan Chen, Baiqiang Li, Tao Chen, Fang Shao, Nonghua Lv, Yin Zhu, Liang Xia, Wenhua He, Zhenping Chen, Xinting Pan, Qingyun Zhu, Youdong Wan, Hong Mei, Kang Li, Miao Chen, Chengjian He, Hongyi Yao, Zigui Zhu, Weili Gu, Weihua Lu, Jingyi Wu, Feng Zhou, Shumin Tu, Long Fu, Bing Xue, Xiaofei Huang, Dandan Zhou, Lening Ren, Dahuan Li, Xiangyang Zhao, Wei Zhao, Xiaomei Chen, Junli Sun, Keke Xin, Weiwei Chen, Qingcheng Xu, Jingchun Song, Qingbo Zeng, Min Shao, Dongsheng Zhao, Jianfeng Tu, Hongguo Yang, Bin Wu, Huaguang Ye, Mingzhi Chen, Mei Yang, Hong Gao, Qiang Li, Lijuan Zhao, Guobing Chen, Yafei Li, Honghai Xia, Dongliang Yang, Shusheng Zhou, Jiyan Lin, Songjing Shi, Weijie Yao, Shan Xu, Lei Yu, Yongjun Lin, Yun Zhou, Quanxing Feng, Zhiyong Liu

Serum urea concentration and risk of 16 site-specific cancers, overall cancer, and cancer mortality in individuals with metabolic syndrome: a cohort study

E Wu, Guo-Fang Wei, Yang Li, Meng-Kai Du, Jun-Tao Ni

Canada needs a national COVID-19 inquiry now

David Fisman, Jillian Horton, Matthew Oliver, Mark Ungrin, Joseph Vipond, Julia M. Wright, Dick Zoutman

Effect of combined treatment with transcranial direct current stimulation and repetitive transcranial magnetic stimulation compared to monotherapy for the treatment of chronic insomnia: a randomised, double-blind, parallel-group, controlled trial

Qi Zhou, Zhiwang Liu, Chang Yu, Qiao Wang, Wenhao Zhuang, Yafang Tang, Tianming Zheng, Haihang Yu, Dongsheng Zhou

Impact of implantable cardioverter defibrillators on mortality in heart failure receiving quadruple guideline-directed medical therapy: a propensity score-matched study

Anil Sahin, Ahmet Celik, Dilek Ural, Inci Tugce Colluoglu, Naim Ata, Emine Arzu Kanik, Mustafa Mahir Ulgu, Suayip Birinci, Mehmet Birhan Yilmaz

Impact of medication nonadherence and drug-drug interaction testing on the management of primary care patients with polypharmacy: a randomized controlled trial

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Randy E. David, Kelsy Gibson Ferrara, Joshua Schrecker, David Paculdo, Steven Johnson, Rhonda Bentley-Lewis, Rebecca Heltsley, John W. Peabody

Impacts of sugar and sweetener warning labels on substitution between sugar- and non-sugar-sweetened beverages in a non-hypothetical selection task

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Caroline Miller, Enola Kay, Joanne Dono, Kerry Ettridge

Offline to online: a systematic mapping review of evidence to inform nutrition-related policies applicable to online food delivery platforms

Si Si Jia, Allyson R. Todd, Lana Vanderlee, Penny Farrell, Margaret Allman-Farinelli, Gary Sacks, Alice A. Gibson, Stephanie R. Partridge

Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission

Shufen Li, Hongyu Ni, Yaping Wang, Xiaohui Wu, Jianqiang Bi, Haiyan Ou, Zhongwei Li, Junjiao Ping, Zhongju Wang, Renhao Chen, Qiong Yang, Meijun Jiang, Liping Cao, Tingyun Jiang, Siqiang Ren, Cunyou Zhao

Diastolic dysfunction and risks of heart failure and death in long-term adult cancer survivors

Rongjian Yu, Juze Lin, Tingting Fu, Xuhui Huang, Fei Xu, Caizhi Yang, Yuanfeng Fu, Hongwen Fei, Lizhu Lin

Health impacts of takeaway management zones around schools in six different local authorities across England: a public health modelling study using PRIMEtime

Nina Trivedy Rogers, Ben Amies-Cull, Jean Adams, Michael Chang, Steven Cummins, Daniel Derbyshire, Suzan Hassan, Matthew Keeble, Bochu Liu, Antonieta Medina-Lara, Bea Savory, John Rahilly, Richard Smith, Claire Thompson, Martin White, Oliver Mytton, Thomas Burgoine

Retrospective epidemiologic and genomic surveillance of arboviruses in 2023 in Brazil reveals high co-circulation of chikungunya and dengue viruses

Augusto César Parreiras de Jesus, Paula Luize Camargos Fonseca, Hugo José Alves, Diego Menezes Bonfim, João Victor Rodrigues Dutra, Filipe Romero Rebello Moreira, Cristiane Pinheiro Toscano de Brito Mendonça, Jéssica Silqueira Hickson Rios, Joice do Prado Silva, Frederico Scott Varella Malta, Isabela Braga-Paz, João Locke Ferreira de Araújo, Jaqueline Silva de Oliveira, Carolina Senra Alves de Souza, Sandra Elisa Barbosa da Silva, Danielle Costa Capistrano Chaves, Renée da Silva Carvalho, Eneida Santos de Oliveira, Marisa de Oliveira Ribeiro, Monica Barcellos Arruda, Patricia Alvarez, Rennan Garcias Moreira, Renan Pedra de Souza, Danielle Alves Gomes Zauli, Renato Santana Aguiar

Systematic review of Mendelian randomization studies on antihypertensive drugs

Bohan Fan, Junmeng Zhang, Jie V. Zhao

Strategic interventions in clinical randomized trials for metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity in the pediatric population: a systematic review with meta-analysis and bibliometric analysis

Isabel Omaña-Guzmán, Marisol Rosas-Diaz, Yoscelina Estrella Martínez-López, L. Monserrat Perez-Navarro, Alvaro Diaz-Badillo, Anthony Alanis, Alejandra Bustamante, Octelina Castillo-Ruiz, Noemi del Toro-Cisneros, Diego Armando Esquivel-Hernandez, Gloria Garcia-Villalobos, Nayely Garibay-Nieto, Esperanza Milagros Garcia-Oropesa, Juan Carlos Hernandez-Martinez, Elena Beatriz Lopez-Sosa, Carlos Maldonado, David Martinez, Joshua Membreno, Oscar Omar Moctezuma-Chavez, Claudia X. Munguia-Cisneros, Edna J. Nava-González, Adriana L. Perales-Torres, Adolfo Pérez-García, Hector Rivera-Marrero, Alisha Valdez, Alfonso Alejandro Vázquez-Chávez, Carlos Ramirez-Pfeiffer, Kathleen V. Carter, Beatriz Tapia, Leonel Vela, Juan Carlos Lopez-Alvarenga

Economic costs attributable to modifiable risk factors: an analysis of 24 million urban residents in China

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Xuechen Xiong, Zhaohua Huo, Yinan Zhou, David M. Bishai, Karen A. Grépin, Philip M. Clarke, Cynthia Chen, Li Luo, Jianchao Quan

Longitudinal decline in DAT binding in Parkinson’s disease: connections with sleep disturbances

Junli Ren, Haobo Xie, Yiyun Weng, Yaoying Ge, Ruotong Yao, Zihan Jiang, Jinxiu Zhang, Yusheng Zhu, Xiaotong Fu, Junchao Wang, Zijia Liu, Shishu Zhang, Tingxuan Zhang, Guangyong Chen, Dehao Yang

Effectiveness of geriatric rehabilitation in inpatient and day hospital settings: a systematic review and meta-analysis

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Eric K. C. Wong, Peter M. Hoang, Andrew Kouri, Sandeep Gill, Yu Qing Huang, Janice C. Lee, Sophie M. Weiss, Raymond Daniel, Jessie McGowan, Krystle Amog, Joanna E. M. Sale, Wanrudee Isaranuwatchai, David M. J. Naimark, Andrea C. Tricco, Sharon E. Straus

Estimation of physiological aging based on routine clinical biomarkers: a prospective cohort study in elderly Chinese and the UK Biobank

Ziwei Zhu, Jingjing Lyu, Xingjie Hao, Huan Guo, Xiaomin Zhang, Meian He, Xiang Cheng, Shanshan Cheng, Chaolong Wang

Rapid and non-invasive analysis of paracetamol overdose using paper arrow-mass spectrometry: a prospective observational study

Yufeng Zhou, Silothabo Dliso, Jennie Craske, Andrea Gill, Louise Bracken, Kiran Landa, Philip Arnold, Laura Walker, Ionela Grasim, Gabrielle Seddon, Tao Chen, Andrew S. Davison, Tung-Ting Sham, Barry Smith, Daniel B. Hawcutt, Simon Maher

Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells versus placebo added to second-line therapy in patients with steroid-refractory acute graft-versus-host disease: a multicentre, randomized, double-blind, phase 2 trial

Erlie Jiang, Kun Qian, Lu Wang, Donglin Yang, Yangliu Shao, Liangding Hu, Yuhang Li, Chen Yao, Mingzhe Han, Xiaoqiang Hou, Daihong Liu

Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children

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Shaoling Zhao, Haowen Su, Jing Cong, Xue Wen, Hang Yang, Peiyu Chen, Guowei Wu, Qingchen Fan, Yiyao Ma, Xiaoyu Xu, Chuanpeng Hu, Hongming Li, Arielle Keller, Adam Pines, Runsen Chen, Zaixu Cui

Exacerbated ischemic brain damage in type 2 diabetes via methylglyoxal-mediated miR-148a-3p decline

Zhenguo Yang, Cheng Huang, Wenhui Huang, Chao Yan, Xueyi Wen, Di Hu, Hesong Xie, Kejing He, Chi Kwan Tsang, Keshen Li

Carrageenan and insulin resistance in humans: a randomised double-blind cross-over trial

Robert Wagner, Janine Buettner, Martin Heni, Louise Fritsche, Stephanie Kullmann, Moritz Wagmüller, Andreas Peter, Hubert Preissl, Jürgen Machann, Reiner Jumpertz von Schwartzenberg, Andreas L. Birkenfeld, Ulrich-Frank Pape, Gerrit van Hall, Peter Plomgaard, Hans-Ulrich Häring, Andreas Fritsche, Kelsey N. Thompson, Reinhild Klein, Norbert Stefan

The association between ozone exposure and blood pressure in a general Chinese middle-aged and older population: a large-scale repeated-measurement study

Chen Tang, Yiqin Zhang, Jingping Yi, Zhonghua Lu, Xianfa Xuan, Hanxiang Jiang, Dongbei Guo, Hanyu Xiang, Ting Wu, Jianhua Yan, Siyu Zhang, Yuxin Wang, Jie Zhang

Colorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population

Baohua Wang, Yunzhi Zhang, Jun Liu, Bin Deng, Qing Li, Hongmei Liu, Yi Sui, Ning Wang, Qin Xiao, Wei Liu, Yan Chen, Yongsheng Li, Haipeng Jia, Qilong Yuan, Cuiping Wang, Wenjun Pan, Fan Li, Huimin Yang, Yongfeng Wang, Yanbing Ding, Daoliang Xu, Rui Liu, Jing-Yuan Fang, Jing Wu

Even moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age

Priti Mishra, Suresh Anand Sadananthan, Jadegoud Yaligar, Kok Hian Tan, Yap Seng Chong, Peter D. Gluckman, Keith M. Godfrey, Marielle V. Fortier, Johan G. Eriksson, Jerry Kok Yen Chan, Shiao-Yng Chan, Dennis Wang, S. Sendhil Velan, Navin Michael

Exploring the link between dietary patterns and gastric adenocarcinoma in Brazil: a mediation analysis

Alex Richard Costa Silva, Gianfranco Alicandro, Valdete Regina Guandalini, Patrícia Paula da Fonseca Grili, Paulo Pimentel Assumpção, Mônica Santiago Barbosa, Rosane Oliveira de Sant’Ana, Felipe José Fernández Coimbra, Maria Paula Curado

Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria

Azrin N. Abd-Rahman, Daniel Kaschek, Anne Kümmel, Rebecca Webster, Adam J. Potter, Anand Odedra, Stephen D. Woolley, Stacey Llewellyn, Lachlan Webb, Louise Marquart, Stephan Chalon, Myriam El Gaaloul, James S. McCarthy, Jörg J. Möhrle, Bridget E. Barber

The use and impact of surveillance-based technology initiatives in inpatient and acute mental health settings: a systematic review

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Jessica L. Griffiths, Katherine R. K. Saunders, Una Foye, Anna Greenburgh, Ciara Regan, Ruth E. Cooper, Rose Powell, Ellen Thomas, Geoff Brennan, Antonio Rojas-García, Brynmor Lloyd-Evans, Sonia Johnson, Alan Simpson

Investigating pain-related medication use and contribution to polypharmacy in adults with intellectual disabilities: a systematic review

Christine Pacitti, Deborah Cairns, Laura Ward, Barbara I. Nicholl

Effect of fecal microbiota transplantation on patients with sporadic amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled trial

Renyi Feng, Qingyong Zhu, Ao Wang, Hanzhen Wang, Jiuqi Wang, Pei Chen, Rui Zhang, Dongxiao Liang, Junfang Teng, Mingming Ma, Xuebing Ding, Xuejing Wang

Peripheral artery disease, antithrombotic treatment and outcomes in European and Asian patients with atrial fibrillation: analysis from two prospective observational registries

Davide Antonio Mei, Giulio Francesco Romiti, Tommaso Bucci, Bernadette Corica, Jacopo Francesco Imberti, Niccolò Bonini, Marco Vitolo, Alena Shantsila, Hung-Fat Tse, Tze-Fan Chao, Giuseppe Boriani, Marco Proietti, Gregory Y. H. Lip

Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses

Emily DiBlasi, Erin A. Kaufman, Sam Webster, Emily E. Hagn, Andrey A. Shabalin, Danli Chen, Seonggyun Han, Rana Jawish, Eric T. Monson, Michael J. Staley, Brooks R. Keeshin, Anna R. Docherty, Amanda V. Bakian, Akiko Okifuji, Hilary Coon

Differences in intention to receive clinician-collected and self-collected samples for HPV DNA testing and its determinants between heterosexual males and females in Hong Kong, China: findings of a territory-wide household survey

Zixin Wang, Siyu Chen, Ngai Sze Wong, Annie Wai-Ling Cheung, Zoe Pui-Yee Tam, Sze Long Chung, Denise Pui-Chung Chan, Phoenix K. H. Mo, Eliza Lai-Yi Wong

Inequalities in the prevalence recording of 205 chronic conditions recorded in primary and secondary care for 12 million patients in the English National Health Service

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Shaolin Wang, Yiu-Shing Lau, Matt Sutton, Michael Anderson, Christodoulos Kypridemos, Anna Head, Ben Barr, Richard Cookson, Chris Bentley, Laura Anselmi

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions

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Fan Mei, Minghong Yao, Yuning Wang, Jiayidaer Huan, Yu Ma, Guowei Li, Kang Zou, Ling Li, Xin Sun

Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism

Charlotte Ling, Magdalena Vavakova, Bilal Ahmad Mir, Johanna Säll, Alexander Perfilyev, Melina Martin, Per-Anders Jansson, Cajsa Davegårdh, Olof Asplund, Ola Hansson, Allan Vaag, Emma Nilsson

Impact of HIV exposure without infection on hospital course and mortality among young children in sub-Saharan Africa: a multi-site cohort study

Christopher Lwanga, Peace Aber, Kirkby D. Tickell, Moses M. Ngari, John Mukisa, Michael Atuhairwe, Lindsay Brown, Ezekiel Mupere, Isabel Potani, Lubaba Shahrin, Brooks Morgan, Benson O. Singa, Victoria Nankabirwa, Richard K. Mugambe, Zakaria Mukasa, Judd L. Walson, James A. Berkley, Christina L. Lancioni

The chemoprotective effect of anti-platelet agents on cancer incidence in people with non-alcoholic fatty liver disease (NAFLD): a retrospective cohort study

Matthew Anson, Jun Shang Poon, Alex E. Henney, David Riley, Gema H. Ibarbaru, Cyril Sieberhagen, Daniel J. Cuthbertson, Uazman Alam, Theresa Hydes

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum

Ian C. Scott, Noor Daud, James Bailey, Helen Twohig, Samantha L. Hider, Christian D. Mallen, Kelvin P. Jordan, Sara Muller

Efficacy of melatonin for prolonged disorders of consciousness: a double-blind, randomized clinical trial

Xinrui Wen, Jie Yu, Genying Zhu, Jinhua Wang, Yangyang Sun, Jiajia Zhou, Jiaye Cai, Fanxia Meng, Yi Ling, Yi Sun, Jiajia Zhao, Fangping He, Qisheng Cheng, Chuan Xu, Jian Gao, Jingqi Li, Benyan Luo

Ethics practices associated with reusing health data: an assessment of patient registries

  • Open Access
  • Research

Olmo R. van den Akker, Susanne Stark, Daniel Strech

Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Tomás Duraj, Miriam Kalamian, Giulio Zuccoli, Joseph C. Maroon, Dominic P. D’Agostino, Adrienne C. Scheck, Angela Poff, Sebastian F. Winter, Jethro Hu, Rainer J. Klement, Alicia Hickson, Derek C. Lee, Isabella Cooper, Barbara Kofler, Kenneth A. Schwartz, Matthew C. L. Phillips, Colin E. Champ, Beth Zupec-Kania, Jocelyn Tan-Shalaby, Fabiano M. Serfaty, Egiroh Omene, Gabriel Arismendi-Morillo, Michael Kiebish, Richard Cheng, Ahmed M. El-Sakka, Axel Pflueger, Edward H. Mathews, Donese Worden, Hanping Shi, Raffaele Ivan Cincione, Jean Pierre Spinosa, Abdul Kadir Slocum, Mehmet Salih Iyikesici, Atsuo Yanagisawa, Geoffrey J. Pilkington, Anthony Chaffee, Wafaa Abdel-Hadi, Amr K. Elsamman, Pavel Klein, Keisuke Hagihara, Zsófia Clemens, George W. Yu, Athanasios E. Evangeliou, Janak K. Nathan, Kris Smith, David Fortin, Jorg Dietrich, Purna Mukherjee, Thomas N. Seyfried

Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator

L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty, C. P. Walsh

Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian Mother, Father, and Child Cohort Study

Karoline H. Skåra, Yunsung Lee, Astanand Jugessur, Håkon K. Gjessing, Abraham Aviv, Ben Brumpton, Øyvind Næss, Álvaro Hernáez, Hans Ivar Hanevik, Per Magnus, Maria C. Magnus

Neurobehavioral disorders among children born to mothers exposed to illicit substances during pregnancy

Vincent Chin-Hung Chen, Charles Tzu-Chi Lee, Shu-I. Wu, Michael Gossop

The double life of glucose metabolism: brain health, glycemic homeostasis, and your patients with type 2 diabetes

Stanley S. Schwartz, Mary E. Herman, May Thet Hmu Tun, Eugenio Barone, D. Allan Butterfield

Immune changes in pregnancy: associations with pre-existing conditions and obstetrical complications at the 20th gestational week—a prospective cohort study

David Westergaard, Agnete Troen Lundgaard, Kilian Vomstein, Line Fich, Kathrine Vauvert Römmelmayer Hviid, Pia Egerup, Ann-Marie Hellerung Christiansen, Josefine Reinhardt Nielsen, Johanna Lindman, Peter Christoffer Holm, Tanja Schlaikjær Hartwig, Finn Stener Jørgensen, Anne Zedeler, Astrid Marie Kolte, Henrik Westh, Henrik Løvendahl Jørgensen, Nina la Cour Freiesleben, Karina Banasik, Søren Brunak, Henriette Svarre Nielsen

Implementing and sustaining dementia care coordinators across integrated care systems: a realist evaluation

Ruth Abrams, Johanna Spiers, Jill Maben, Wendy Grosvenor, Morro Touray, Heather Gage

Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective cohort study

Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang, Jiahui Chu, Shuang Wang, Qian Xu, Jianyuan Zhou, Shulun Nie, Miao Huang, Ruitao Xu, Qiushi Wang, Xinyu Song, Di Zhang, Zhaodi Nan, Song Li, Lian Liu

The association of HDL-cholesterol levels with incident major adverse cardiovascular events and mortality in 0.6 million individuals with type 2 diabetes: a population-based retrospective cohort study

David Tak Wai Lui, Lanlan Li, Xiaodong Liu, Xi Xiong, Eric Ho Man Tang, Chi Ho Lee, Yu Cho Woo, Brian Hung Hin Lang, Carlos King Ho Wong, Kathryn Choon Beng Tan

Strength of clinical evidence supporting the United States Food and Drug Administration Accelerated Approvals from 2015 to 2022

  • Open Access
  • Research article

Xiaofang Zhang, Carl C. Peck, Yaning Wang, Thomas D. Szucs, Wan Sun, Xue Bai, Siyu Chen, Fengzhi Wang, Yangfeng Wu

The burden and clinical trajectory of immune checkpoint inhibitor-induced endocrinopathies: an 8-year experience

Fateen Ata, Adeel Ahmad Khan, Emad Algorani, Amr Faisal Musaed Alsharafi, Reham Abo Shdid, Mohammad Nofal, Ayman R. Ibrahim, Loai Abdullah, Khalil Youssef El Annan, Tareq Emad Hawash Al-Bkoor, Kakil Ibrahim Rasul, Tarik Elhadd, Haval Surchi

Healthy eating patterns associated with reduced risk of inflammatory bowel disease by lowering low-grade inflammation: evidence from a large prospective cohort study

Bin Xia, Yan Li, Linmin Hu, Peng Xie, Ningning Mi, Liyuan Lv, Zixin Liang, Yuxuan Sun, Ying Li, Xiaodong Jiang, Guinan Liu, Yuanyuan Feng, Yingxin Zhu, Bo Zhan, Qiangsheng He, Pingguang Lei, Jian Qi, Pengpeng Wang, Jinqiu Yuan

The benefit of inhibitory control training for insomnia with short sleep duration phenotype: a pilot randomized trial

Haobo Zhang, Zhangwei Lv, Hanfei Chen, Zijie Tang, Xu Lei

Physiological measures variability and risks of heart disease and stroke: evidence from three cohort studies

  • Open Access
  • Research

Wei Liu, Lieyang Fan, Da Shi, Linling Yu, Jiahao Song, Ruyi Liang, Xuefeng Lai, Hao Wang, Yongfang Zhang, Shuhui Wan, Yueru Yang, Bin Wang

Relationships between neurodivergence status and adverse childhood experiences, and impacts on health, wellbeing, and criminal justice outcomes: findings from a regional household survey study in England

  • Open Access
  • Research

Charley Wilson, Nadia Butler, Zara Quigg, David Moore, Mark Bellis

Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation

Vasco Iten, Elena Herber, Michael Coslovsky, Elisa Hennings, Rebecca E. Paladini, Tobias Reichlin, Nicolas Rodondi, Andreas S. Müller, Annina Stauber, Juerg H. Beer, Roman Brenner, Giulio Conte, Richard Kobza, Marcello Di Valentino, Patricia Chocano Bedoya, Freschteh Moradi, Tim Sinnecker, Leo H. Bonati, Michael Kühne, Stefan Osswald, David Conen, Stefanie Aeschbacher, Christine S. Zuern

Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design

  • Open Access
  • Research

Daniel S. Barron, Karin Saltoun, Hannah Kiesow, Melanie Fu, Jessica Cohen-Tanugi, Paul Geha, Dustin Scheinost, Zacharia Isaac, David Silbersweig, Danilo Bzdok

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation

  • Open Access
  • Research

Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang, Jiangping Song

A proposal to simplify the definition of pediatric hypertension: bridging the gap between perception and action

Lili Yang, Yanan Qiao, Min Zhao, Bo Xi

Risk of mortality between warfarin and direct oral anticoagulants: population-based cohort studies

Zixuan Wang, Julian Matthewman, John Tazare, Qiuyan Yu, Ka Shing Cheung, Celine S. L. Chui, Esther W. Y. Chan, Krishnan Bhaskaran, Liam Smeeth, Ian C. K. Wong, Ian J. Douglas, Angel Y. S. Wong

Global prevalence of Helicobacter pylori antibiotic resistance among children in the world health organization regions between 2000 and 2023: a systematic review and meta-analysis

Aryan Salahi-Niri, Ali Nabavi-Rad, Tanya Marie Monaghan, Theodore Rokkas, Michael Doulberis, Amir Sadeghi, Mohammad Reza Zali, Yoshio Yamaoka, Evelina Tacconelli, Abbas Yadegar

The potential impact of inflammation on the lipid paradox in patients with acute myocardial infarction: a multicenter study

Guyu Zeng, Ce Zhang, Ying Song, Zheng Zhang, Jingjing Xu, Zhenyu Liu, Xiaofang Tang, Xiaozeng Wang, Yan Chen, Yongzhen Zhang, Pei Zhu, Xiaogang Guo, Lin Jiang, Zhifang Wang, Ru Liu, Qingsheng Wang, Yi Yao, Yingqing Feng, Yaling Han, Jinqing Yuan

Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial

A. Jennings, O. M. Shannon, R. Gillings, V. Lee, R. Elsworthy, R. Bundy, G. Rao, S. Hanson, W. Hardeman, S-M. Paddick, M. Siervo, S. Aldred, J. C. Mathers, M. Hornberger, A. M. Minihane

Comparison of models to predict incident chronic liver disease: a systematic review and external validation in Chinese adults

Xue Cong, Shuyao Song, Yingtao Li, Kaiyang Song, Cameron MacLeod, Yujie Cheng, Jun Lv, Canqing Yu, Dianjianyi Sun, Pei Pei, Ling Yang, Yiping Chen, Iona Millwood, Shukuan Wu, Xiaoming Yang, Rebecca Stevens, Junshi Chen, Zhengming Chen, Liming Li, Christiana Kartsonaki, Yuanjie Pang

Temptation at every corner: exploring public perceptions of food cues and policy support for governmental food cue regulation in outdoor public spaces

  • Open Access
  • Research

Tamika M. Wopereis, Sanne K. Djojosoeparto, Frédérique C. Rongen, Sanne C. Peeters, Emely de Vet, Maartje P. Poelman

A meta-analysis and systematic review of myocardial infarction-induced cardiomyocyte proliferation in adult mouse heart

Ya Liu, Lingyan Liu, Pengcheng Zhuang, Jiamin Zou, Xiaokang Chen, Hao Wu, Bingjun Lu, Wei Eric Wang

Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021

Cong Li, Lijun Zhang, Jie Zhang, Jinghua Jiao, Guangyao Hua, Yan Wang, Xue He, Chingyu Cheng, Honghua Yu, Xiaohong Yang, Lei Liu

Intensified conditioning containing decitabine versus standard myeloablative conditioning for adult patients with KMT2A-rearranged leukemia: a multicenter retrospective study

Zhongli Hu, Zinan Feng, Shiqi Liu, Hai He, Ying Dong, Zhiping Fan, Yiqing Li, Fen Huang, Na Xu, Can Liu, Yunxin Zeng, Ping Zhu, Ren Lin, Hua Jin, Xiong Zhang, Ruijuan Sun, Qifa Liu, Li Xuan

Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank

  • Open Access
  • Gout
  • Research

Zijian Kang, Jianzheng Zhang, Chen Zhu, Ying Zhu, Hanlei Jiang, Qiang Tong, Sheng-Ming Dai

Changes in sarcopenia and incident cardiovascular disease in prospective cohorts

Qingyue Zeng, Lijun Zhao, Qian Zhong, Zhenmei An, Shuangqing Li

Assessment of the efficacy of palliative sedation in advanced cancer patients by evaluating discomfort levels: a prospective, international, multicenter observational study

Maaike Rijpstra, Kris Vissers, Alazne Belar, Michael Van der Elst, Séverine Marie Surges, Claudio Adile, Rocío Rojí, Yasmine Grassi, Ewald Bronkhorst, Sebastiano Mercadante, Lukas Radbruch, Johan Menten, Carlos Centeno, Evelien Kuip, Jeroen Hasselaar

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Keynote webinar | Spotlight on adolescent vaping

Growing numbers of young people are using e-cigarettes, despite warnings of respiratory effects and addiction. How can doctors tackle the epidemic, and what health effects should you prepare to manage in your clinics?

Prof. Ann McNeill
Dr. Debbie Robson
Benji Horwell
Developed by: Springer Medicine
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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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