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Osteosarcoma 

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  1. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    High expression of SRSF1 facilitates osteosarcoma progression and unveils its potential mechanisms

    Osteosarcoma (OS) is a highly malignant tumor that primarily affects the pediatric and adolescent populations. Efforts have largely centered on understanding the mechanisms associated with its metastases [ 1 , 2 ], elucidating the molecular …

  2. 06-05-2024 | Osteosarcoma | Online First

    Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review

    Parosteal and low-grade central osteosarcomas comprise 4% and 1–2%, respectively, of all osteosarcomas, which are primary malignant bone tumors with several histological subtypes [ 1 , 2 ]. Parosteal osteosarcomas arise at the cortical bone …

  3. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1

    Circular RNAs (circRNAs) are a newly appreciated type of endogenous noncoding RNAs that play vital roles in the development of various human cancers, including osteosarcoma (OS). In this study, we investigated three circRNAs (circ_0076684 …

  4. Open Access 23-04-2024 | Osteosarcoma | Online First

    Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis

    Osteosarcoma is recognized as the predominant primary malignant bone tumor in the adolescent population, with an incidence rate of approximately 8.7 per million individuals [ 1 ]. This malignancy exhibits a high level of severity, characterized by …

  5. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    Functional and oncological outcomes of patients with proximal humerus osteosarcoma managed by limb salvage

    Osteosarcoma is the most common primary bone malignancy in skeletally immature patients. Osteosarcoma commonly occurs in the metaphysis of a long bone. The most common sites are the femur (42%), the tibia (19%) and the humerus (10%). The overall …

  6. 03-04-2024 | Osteosarcoma | Online First

    Osteosarcoma of Mandible — A Case Report

    After plasma cell neoplasia, osteosarcoma is the most common primary bone tumor which accounts for 20% of all sarcomas. A malignant tumor is characterized by the formation of bone or osteoid by tumor cells. Long bones are the most common site of …

  7. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    Identification of allograft inflammatory factor-1 suppressing the progression and indicating good prognosis of osteosarcoma

    Osteosarcoma, derived from mesenchymal tissue, is the most common primary malignant bone tumor and usually occurs in adolescents with high malignancy and poor prognosis [ 1 ]. In the past few decades, the treatment of osteosarcoma has progressed …

  8. 11-03-2024 | Osteosarcoma | Online First

    Low-grade central osteosarcoma with extraosseous dedifferentiation: a rare case

    Low-grade central osteosarcoma (LGCOS), which arises from the intramedullary cavity of the metaphysis of long bones, occasionally exhibits extraosseous spread. Approximately 10–30% of patients with LGCOS exhibit dedifferentiation, but it is rare …

  9. Open Access 01-05-2024 | Osteosarcoma | OriginalPaper

    Targeting osteosarcoma with canine B7-H3 CAR T cells and impact of CXCR2 Co-expression on functional activity

    The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. The goal of the present study was to …

  10. Open Access 09-02-2024 | Sarcoma | OriginalPaper

    Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications

    Small cell osteosarcoma (SCOS), a variant of conventional high-grade osteosarcoma (COS), may mimic fusion-driven round cell sarcomas (FDRCS) by overlapping clinico-radiological and histomorphological/immunohistochemical characteristics, hampering …

  11. 01-05-2024 | Osteosarcoma | OriginalPaper

    Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing

    Osteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in unsatisfactory outcomes, particularly for metastatic cases. The tumor microenvironment (TME) has been …

  12. 21-11-2023 | Osteosarcoma | OriginalPaper

    A Rare Case Report of Osteosarcoma of Maxilla with Double Free-Flap Reconstruction

    Osteosarcomas are rare and highly malignant bone tumours which are composed of malignant mesenchymal cells producing osteoid or immature bone. Maxillary osteosarcomas are rare tumours accounting for less than 1% of head and neck malignancies.

  13. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells

    Osteosarcoma (OS), a common bone malignancy in adolescents, has a high mortality and disability rates [ 1 ]. Surgical resection was a primary method for treatment of OS in the past, and the use of neoadjuvant chemotherapy has raised the survival …

  14. Open Access 01-12-2024 | OriginalPaper

    LncRNA RPARP-AS1 promotes the progression of osteosarcoma cells through regulating lipid metabolism

    Osteosarcoma (OS) is a highly malignant tumor, and its dysregulated lipid metabolism is associated with tumorigenesis and unfavorable prognosis. Interestingly, long noncoding RNAs (lncRNAs) have emerged as pivotal regulators of lipid metabolism …

  15. Open Access 01-12-2024 | Osteosarcoma | Erratum

    Retraction Note: Down-regulation of LINC00472 promotes osteosarcoma tumorigenesis by reducing FOXO1 expressions via miR-300

  16. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma

    Extraskeletal osteosarcoma (EOS) or soft tissue osteosarcoma refers to osteosarcoma that occurs within the soft tissue and does not originate from bone. EOS is extremely rare, accounting for approximately 1% of all soft tissue sarcomas and …

  17. 18-12-2023 | Osteosarcoma | OriginalPaper

    Therapeutic efficacy of an alpha-particle emitter labeled anti-GD2 humanized antibody against osteosarcoma—a proof of concept study

    Humanized 3F8 (hu3F8 or naxitamab-gqgk) is an FDA-approved IgG1 anti-GD2 monoclonal antibody that is being used in combination with granulocyte–macrophage colony-stimulating factor to treat children and adults with high-risk neuroblastoma [ 1 , 2 …

  18. Open Access 01-12-2024 | giant cell tumor | OriginalPaper

    Deep learning for differentiation of osteolytic osteosarcoma and giant cell tumor around the knee joint on radiographs: a multicenter study

    Bone tumors are a group of primary or secondary neoplastic lesions of bone with various pathological types and biological behaviors [ 1 ]. According to the 5th edition of the World Health Organization (WHO) classification of bone tumors published …

  19. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity

    Osteosarcoma (OS) is the most common primary bone tumor of adolescents, and both frequently metastasizes to the lungs and is resistant to chemoradiotherapy, resulting in poor prognosis [ 1 ]. Aberrant molecular signaling pathways and non-coding …

  20. Open Access 01-12-2024 | Osteosarcoma | OriginalPaper

    Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection in regulating apoptosis in osteosarcoma

    Osteosarcoma, the prevalent primary malignant tumor of the bone, tends to manifest in adolescents and children. High genetic and pathological heterogeneity are distinguishing features of this condition [ 1 , 2 ]. According to research, the 5-year …

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