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Plasmodium Falciparum 

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  1. Open Access 01-12-2024 | Malaria | OriginalPaper

    The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum

    Malaria remains one of the most important infectious diseases globally with 249 million cases and 608,000 deaths in 2022 [ 1 ]. Approximately 77% of deaths occurred in children under 5 years of age, with the greatest burden in those under 3 years …

  2. Open Access 01-12-2024 | Plasmodium Falciparum | OriginalPaper

    Plasmodium falciparum alters the trophoblastic barrier and stroma villi organization of human placental villi explants

    The most vulnerable population to P. falciparum infection includes pregnant women and children under 5 years old. Specifically, during pregnancy, P. falciparum causes approximately 150,000 fetal deaths and 10,000 maternal deaths annually in …

  3. Open Access 01-12-2024 | Plasmodium Falciparum | OriginalPaper

    Genotyping Plasmodium falciparum gametocytes using amplicon deep sequencing

    During the erythrocytic stage of the malaria parasite in humans, a fraction of asexual parasites differentiates into gametocytes [ 1 ]. Gametocytes are the sexual form of the parasite transmitted from humans to mosquitoes and are an important …

  4. Open Access 01-12-2024 | Plasmodium Falciparum | OriginalPaper

    A simple, field-applicable method to increase the infectivity of wild isolates of Plasmodium falciparum to mosquito vectors

    Conducting experimental infections of Anopheles mosquito vectors with Plasmodium parasites is pivotal in advancing both fundamental and applied malariology. Controlled laboratory infections are essential for unraveling the intricacies of the …

  5. Open Access 01-12-2024 | Plasmodium Falciparum | OriginalPaper

    A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial

    With almost 250 million infections and approximately 600 thousand deaths per year, malaria remains a global health priority. The renewed focus on malaria elimination has increased the priority of research into interventions to block malaria …

  6. Open Access 01-12-2024 | Malaria | OriginalPaper

    Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity

    Malaria remains a major public health problem worldwide, with nearly half of the world’s population at risk and lives in areas where malaria transmission occurs, but with the majority of cases and deaths from sub-Saharan (SSA) [ 1 ]. In 2022, over …

  7. Open Access 01-12-2024 | Malaria | OriginalPaper

    Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro

    Novel vaccines and drugs are urgently needed to alleviate the burden of disease by malaria and reverse the recent resurgence of cases [ 1 – 3 ]. Plasmodium falciparum sporozoites (SPZ), the infective form of malaria, are considered a key target for …

  8. Open Access 01-12-2024 | Malaria | OriginalPaper

    Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania

    Artemisinin-based combination therapy (ACT) remains a treatment of choice for uncomplicated Plasmodium falciparum malaria globally [ 1 , 2 ]. Six artemisinin-based combinations have been pre-qualified by the World Health Organization (WHO) for …

  9. Open Access 01-12-2024 | Plasmodium Falciparum | ReviewPaper

    Plasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis

    Plasmodium falciparum presents a significant public health challenge in sub-Saharan Africa (SSA), constituting the majority of reported malaria cases. In 2022, out of the 249 million malaria cases recorded globally, 233 million occurred in SSA …

  10. Open Access 01-12-2024 | Malaria | OriginalPaper

    Evaluating the performance of Plasmodium falciparum genetic metrics for inferring National Malaria Control Programme reported incidence in Senegal

    Pathogen genomics is revolutionizing public health by providing a rich data source for informing real-time, actionable recommendations for public health programmes [ 1 ]. Each pathogen genome is a unique record of its previous transmission history …

  11. Open Access 01-12-2024 | Epigenetics | ReviewPaper

    Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum

    Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be …

  12. Open Access 01-12-2024 | Malaria | OriginalPaper

    Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021

    Anti-malarial drugs, particularly artemisinin-based combinations, are recommended and widely used for effective case management, but drug resistance is a major threat that has impacted their effectiveness for malaria control and elimination. The …

  13. Open Access 01-12-2024 | Plasmodium Falciparum | OriginalPaper

    Artificial nighttime lighting impacts Plasmodium falciparum mature stage V gametocytes infectivity in Anopheles stephensi

    Malaria is one of the most important vector-borne diseases of humans with an estimated 241 million cases worldwide in 2020, being Africa the region that recorded the 95% of the malaria cases and the 96% of deaths worldwide [ 1 ]. A huge effort was …

  14. Open Access 01-12-2024 | Malaria | OriginalPaper

    Molecular surveillance of Kelch 13 polymorphisms in Plasmodium falciparum isolates from Kenya and Ethiopia

    Efficacious antimalarial drugs are mainstays of malaria control and elimination programs. Widespread resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) led to the adoption of artemisinin-based combination therapy (ACT) as the first- …

  15. Open Access 01-12-2024 | Malaria | OriginalPaper

    Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning

    Malaria continues to be one of the most serious infectious diseases worldwide. There were an estimated 247 million cases of malaria and 619,000 malaria deaths worldwide in 2021, with sub-Saharan Africa bearing the highest proportions of cases [ 1 …

  16. Open Access 01-12-2024 | Malaria | OriginalPaper

    Geospatial analysis of Plasmodium falciparum serological indicators: school versus community sampling in a low-transmission malaria setting

    Malaria is a disease caused by infection with Plasmodium parasites, and global cases and deaths have declined substantially since 2000 [ 1 ], with 25 countries achieving zero locally acquired cases and many more approaching this significant …

  17. Open Access 01-12-2024 | Malaria | OriginalPaper

    msp1, msp2, and glurp genotyping to differentiate Plasmodium falciparum recrudescence from reinfections during prevention of reestablishment phase, Sri Lanka, 2014–2019

    Sri Lanka eliminated indigenous malaria in 2012, and was certified as a malaria free country in 2016. The conducive tropical environment still facilitates the perennial breeding of the major vector of malaria, Anopheles culicifacies , in many parts …

  18. Open Access 01-12-2024 | Falciparum Malaria | ReviewPaper

    Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?

    The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy (ACT) generally remains efficacious for the treatment of falciparum malaria. The emergence of partial …

  19. Open Access 01-12-2024 | Malaria | OriginalPaper

    Dynamics of malaria vector composition and Plasmodium falciparum infection in mainland Tanzania: 2017–2021 data from the national malaria vector entomological surveillance

    Malaria is still a major cause of illness in about 85 countries worldwide, with an estimated 249 million cases in 2022 [ 1 ]. Globally, malaria cases have increased by 7.39% from the baseline year of the Global Technical Strategy for malaria …

  20. Open Access 01-12-2024 | Malaria | OriginalPaper

    Anopheles arabiensis continues to be the primary vector of Plasmodium falciparum after decades of malaria control in southwestern Ethiopia

    Female Anopheles mosquitoes can carry Plasmodium protozoan parasites, some of which transmit to humans. The majority of malaria caused by Plasmodium falciparum and Plasmodium vivax occurs in Africa. Between 2010 and 2017, there was a noticeable …

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