Issue 1/2023
Content (208 Articles)
Differential vulnerability of the dentate gyrus to tauopathies in dementias
Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E. Flanagan, Rudolph Castellani, Eileen H. Bigio, M. Marsel Mesulam, Changiz Geula, Tamar Gefen
Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities
Gemma Solé-Guardia, Emma Custers, Arthur de Lange, Elyne Clijncke, Bram Geenen, Jose Gutierrez, Benno Küsters, Jurgen A. H. R. Claassen, Frank-Erik de Leeuw, Maximilian Wiesmann, Amanda J. Kiliaan
Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome
Léa Guerrini-Rousseau, Arnault Tauziède-Espariat, David Castel, Etienne Rouleau, Philipp Sievers, Raphaël Saffroy, Kévin Beccaria, Thomas Blauwblomme, Lauren Hasty, Franck Bourdeaut, Jacques Grill, Pascale Varlet, Marie-Anne Debily
Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking
Alexander H. Swan, Roland F. R. Schindler, Marco Savarese, Isabelle Mayer, Susanne Rinné, Felix Bleser, Anne Schänzer, Andreas Hahn, Mario Sabatelli, Francesco Perna, Kathryn Chapman, Mark Pfuhl, Alan C. Spivey, Niels Decher, Bjarne Udd, Giorgio Tasca, Thomas Brand
Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy
L. Arouche-Delaperche, S. Cadoni, C. Joffrois, G. Labernede, M. Valet, Q. César, J. Dégardin, S. Girardon, C. Gabriel, S. Krantic, S. Picaud
Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging
Franziska Linke, James E. C. Johnson, Stefanie Kern, Christopher D. Bennett, Anbarasu Lourdusamy, Daniel Lea, Steven C. Clifford, Catherine L. R. Merry, Snow Stolnik, Morgan R. Alexander, Andrew C. Peet, David J. Scurr, Rian L. Griffiths, Anna M. Grabowska, Ian D. Kerr, Beth Coyle
Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses
Konstantin Okonechnikov, Aniello Federico, Daniel Schrimpf, Philipp Sievers, Felix Sahm, Jan Koster, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Andrey Korshunov
PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth
Abigail H. Cleveland, Daniel Malawsky, Mehal Churiwal, Claudia Rodriguez, Frances Reed, Matthew Schniederjan, Jose E. Velazquez Vega, Ian Davis, Timothy R. Gershon
NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression
Arnault Tauziède-Espariat, Yassine Ajlil, Marie-Anne Debily, David Castel, Jacques Grill, Stéphanie Puget, Lauren Hasty, Fabrice Chrétien, Alice Métais, Volodia Dangouloff-Ros, Nathalie Boddaert, Pascale Varlet
Reduced T-cell densities in cranial nerves of patients who died with SARS-CoV-2 infection
Juliane Bremer, Johannes Friemann, Saskia von Stillfried, Peter Boor, Joachim Weis
AI-based MRI auto-segmentation of brain tumor in rodents, a multicenter study
Shuncong Wang, Xin Pang, Frederik de Keyzer, Yuanbo Feng, Johan V. Swinnen, Jie Yu, Yicheng Ni
Mutational signature of extracranial meningioma metastases and their respective primary tumors
A. Biczok, J. Thorsteinsdottir, P. Karschnia, V. C. Ruf, J. C. Tonn, J. Herms, C. Schichor, M. M. Dorostkar
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim, Şevin Turcan
Clinico-pathological and epigenetic heterogeneity of diffuse gliomas with FGFR3::TACC3 fusion
Alice Métais, Arnault Tauziède-Espariat, Jeremy Garcia, Romain Appay, Emmanuelle Uro-Coste, David Meyronet, Claude-Alain Maurage, Fanny Vandenbos, Valérie Rigau, Dan Christian Chiforeanu, Johan Pallud, Suhan Senova, Raphaël Saffroy, Carole Colin, Myriam Edjlali, Pascale Varlet, Dominique Figarella-Branger, A. Rousseau, C. Godfraind, G. Gauchotte, K. Mokhtari, F. Bielle, F. Escande, F. Fina
Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice
Joe Yasa, Claudia E. Reed, Adam M. Bournazos, Frances J. Evesson, Ignatius Pang, Mark E. Graham, Jesse R. Wark, Brunda Nijagal, Kim H. Kwan, Thomas Kwiatkowski, Rachel Jung, Noah Weisleder, Sandra T. Cooper, Frances A. Lemckert
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
Valeria Vasciaveo, Antonella Iadarola, Antonino Casile, Davide Dante, Giulia Morello, Lorenzo Minotta, Elena Tamagno, Alessandro Cicolin, Michela Guglielmotto
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice
Susanne Bauer, Chwen-Yu Chen, Maria Jonson, Lech Kaczmarczyk, Srivathsa Subramanya Magadi, Walker S. Jackson
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve
James R. Tribble, Anna Hagström, Kenza Jusseaume, Emma Lardner, Raymond Ching-Bong Wong, Gustav Stålhammar, Pete A. Williams
Parkin coregulates glutathione metabolism in adult mammalian brain
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Stefan Nicolau, Aneesha Dasgupta, Surendra Dasari, M. Cristine Charlesworth, Kenneth L. Johnson, Akhilesh Pandey, Jason D. Doles, Margherita Milone
Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration
Anne-Sophie Cabron, Uwe Borgmeyer, Julia Richter, Helga Peisker, Katharina Gutbrod, Peter Dörmann, Anja Capell, Markus Damme
Mesenchymal non-meningothelial tumors of the central nervous system: a literature review and diagnostic update of novelties and emerging entities
Arnault Tauziède-Espariat, Lauren Hasty, Alice Métais, Pascale Varlet
Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas
Sandra Ferreyra Vega, Thomas Olsson Bontell, Teresia Kling, Asgeir Store Jakola, Helena Carén
Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells
Linhao Yuan, Peiliang Li, Jiang Li, Jiayi Peng, Jianlong Zhouwen, Shunchang Ma, Guijun Jia, Wang Jia, Peng Kang
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Matthew Pun, Drew Pratt, Patricia R. Nano, Piyush K. Joshi, Li Jiang, Bernhard Englinger, Arvind Rao, Marcin Cieslik, Arul M. Chinnaiyan, Kenneth Aldape, Stefan Pfister, Mariella G. Filbin, Aparna Bhaduri, Sriram Venneti
CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population
Arnault Tauziède-Espariat, Emmanuelle Uro-Coste, Philipp Sievers, Yvan Nicaise, Cassandra Mariet, Aurore Siegfried, Gaëlle Pierron, Delphine Guillemot, Joseph Benzakoun, Johan Pallud, Margaux Roques, Fabrice Bonneville, Delphine Larrieu-Ciron, Patrick Chaynes, Raphaël Saffroy, Jocelyne Hamelin, Lauren Hasty, Alice Métais, Fabrice Chrétien, Marcel Kool, Johannes Gojo, Pascale Varlet
Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer’s disease
Kyle J. Brymer, Emily P. Hurley, Jessica C. Barron, Bandhan Mukherjee, Jocelyn R. Barnes, Firoozeh Nafar, Matthew P. Parsons
Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice
Bradley R. Groveman, Brent Race, Simote T. Foliaki, Katie Williams, Andrew G. Hughson, Chase Baune, Gianluigi Zanusso, Cathryn L. Haigh
Bi-allelic variations in CRB2, encoding the crumbs cell polarity complex component 2, lead to non-communicating hydrocephalus due to atresia of the aqueduct of sylvius and central canal of the medulla
Aude Tessier, Nathalie Roux, Lucile Boutaud, Elodie Lunel, Leila Hakkakian, Mélanie Parisot, Meriem Garfa-Traoré, Amale Ichkou, Nadia Elkhartoufi, Christine Bole, Patrick Nitschke, Jeanne Amiel, Jelena Martinovic, Férechté Encha-Razavi, Tania Attié-Bitach, Sophie Thomas
Spontaneous intracerebral haemorrhage associated with early-onset cerebral amyloid angiopathy and Alzheimer’s disease neuropathological changes five decades after cadaveric dura mater graft
Riccardo Milani, Lucio Aniello Mazzeo, Daniela Vismara, Ilaria Salemi, Emanuele Dainese, Emanuela Maderna, Elisa Pellencin, Marcella Catania, Nicole Campanella, Giuseppe Di Fede, Giorgio Giaccone, Andrea Salmaggi
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
Clara Muñoz-Castro, Marina Mejias-Ortega, Elisabeth Sanchez-Mejias, Victoria Navarro, Laura Trujillo-Estrada, Sebastian Jimenez, Juan Antonio Garcia-Leon, Juan Jose Fernandez-Valenzuela, Maria Virtudes Sanchez-Mico, Carmen Romero-Molina, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica
A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age
Andre Obenaus, Beatriz Rodriguez-Grande, Jeong Bin Lee, Christophe J. Dubois, Marie-Line Fournier, Martine Cador, Stéphanie Caille, Jerome Badaut
An integrated genetic analysis of epileptogenic brain malformed lesions
Atsushi Fujita, Mitsuhiro Kato, Hidenori Sugano, Yasushi Iimura, Hiroharu Suzuki, Jun Tohyama, Masafumi Fukuda, Yosuke Ito, Shimpei Baba, Tohru Okanishi, Hideo Enoki, Ayataka Fujimoto, Akiyo Yamamoto, Kentaro Kawamura, Shinsuke Kato, Ryoko Honda, Tomonori Ono, Hideaki Shiraishi, Kiyoshi Egawa, Kentaro Shirai, Shinji Yamamoto, Itaru Hayakawa, Hisashi Kawawaki, Ken Saida, Naomi Tsuchida, Yuri Uchiyama, Kohei Hamanaka, Satoko Miyatake, Takeshi Mizuguchi, Mitsuko Nakashima, Hirotomo Saitsu, Noriko Miyake, Akiyoshi Kakita, Naomichi Matsumoto
Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency
Elsa Ghirardini, Giulia Sagona, Angel Marquez-Galera, Francesco Calugi, Carmen M. Navarron, Francesco Cacciante, Siwei Chen, Federica Di Vetta, Lorenzo Dadà, Raffaele Mazziotti, Leonardo Lupori, Elena Putignano, Pierre Baldi, Jose P. Lopez-Atalaya, Tommaso Pizzorusso, Laura Baroncelli
Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Daniela C. Ivan, Kristina Carolin Berve, Sabrina Walthert, Gianni Monaco, Katharina Borst, Elisa Bouillet, Filipa Ferreira, Henry Lee, Jasmin Steudler, Thorsten Buch, Marco Prinz, Britta Engelhardt, Giuseppe Locatelli
Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic
Francesca Logiacco, Laura Cathleen Grzegorzek, Elizabeth C. Cordell, Oliver Popp, Philipp Mertins, David H. Gutmann, Helmut Kettenmann, Marcus Semtner
Ballooned neurons in semi-recent severe traumatic brain injury
Jean Michaud, Isabelle Plu, Jacqueline Parai, André Bourgault, Caroline Tanguay, Danielle Seilhean, John Woulfe
The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas
Keisuke Katsushima, Rudramani Pokhrel, Iqbal Mahmud, Menglang Yuan, Rabi Murad, Prabin Baral, Rui Zhou, Prem Chapagain, Timothy Garrett, Stacie Stapleton, George Jallo, Chetan Bettegowda, Eric Raabe, Robert J. Wechsler-Reya, Charles G. Eberhart, Ranjan J. Perera
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
Zemin Wang, Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino, Yuan Hu, Tim Weeden, Matthew P. Frosch, Tracy L. Young-Pearse, Laurent Pradier, Dennis Selkoe, Dominic M. Walsh
Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue
Christina V. Tauber, Sigrid C. Schwarz, Thomas W. Rösler, Thomas Arzberger, Steve Gentleman, Otto Windl, Mandy Krumbiegel, André Reis, Viktoria C. Ruf, Jochen Herms, Günter U. Höglinger
Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition
Manuela Silginer, Eleanna Papa, Emese Szabó, Flavio Vasella, Martin Pruschy, Christopher Stroh, Patrick Roth, Tobias Weiss, Michael Weller
Roles of neuropathology-associated reactive astrocytes: a systematic review
Jill M. Lawrence, Kayla Schardien, Brian Wigdahl, Michael R. Nonnemacher
CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm
Arnault Tauziède-Espariat, Dominique Figarella-Branger, Alice Métais, Emmanuelle Uro-Coste, Claude-Alain Maurage, Benoît Lhermitte, Aude Aline-Fardin, Lauren Hasty, Alexandre Vasiljevic, Dan Chiforeanu, Guillaume Chotard, Homa Adle-Biassette, Alexandra Meurgey, Raphaël Saffroy, Delphine Guillemot, Gaëlle Pierron, Philipp Sievers, Pascale Varlet
Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
Pei-Ying Wang, Ting-Yu Kuo, Lee-Hsin Wang, Wen-Hsing Liang, Guey-Shin Wang
The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER
Ryan K. Shahidehpour, Abraham S. Nelson, Lydia G. Sanders, Chloe R. Embry, Peter T. Nelson, Adam D. Bachstetter
Clinicopathological and molecular characterization of a case classified by DNA‑methylation profiling as “CNS embryonal tumor with BRD4–LEUTX fusion”
Laetitia Lebrun, Sacha Allard-Demoustiez, Nathalie Gilis, Claude Van Campenhout, Marine Rodesch, Celine Roman, Pierluigi Calò, Valentina Lolli, Philippe David, Christophe Fricx, Olivier De Witte, Fabienne Escande, Claude-Alain Maurage, Isabelle Salmon
Exceptionally rare IDH1-mutant adult medulloblastoma with concurrent GNAS mutation revealed by in vivo magnetic resonance spectroscopy and deep sequencing
Roberto Liserre, Francesca Branzoli, Francesca Pagani, Magdalena Gryzik, Manuela Cominelli, Evelina Miele, Małgorzata Marjańska, Francesco Doglietto, Pietro Luigi Poliani
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant
Nastasia Cardone, Melissa Moula, Rianne J. Baelde, Ariane Biquand, Marcello Villanova, Corinne Metay, Chiara Fiorillo, Serena Baratto, Luciano Merlini, Patrizia Sabatelli, Norma B. Romero, Frederic Relaix, François Jérôme Authier, Valentina Taglietti, Marco Savarese, Josine de Winter, Coen Ottenheijm, Isabelle Richard, Edoardo Malfatti
Localized microglia dysregulation impairs central nervous system myelination in development
Rebecca K. Holloway, Liang Zhang, Irene Molina-Gonzalez, Kathy Ton, James A. R. Nicoll, James P. Boardman, Yan Liang, Anna Williams, Veronique E. Miron
Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Joshua A. Regal, María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, Zachary J. Reitman
Cerebellar presence of immune cells in patients with neuro-coeliac disease
Maxine D. Rouvroye, Hetty J. Bontkes, John G. J. M. Bol, Birgit Lissenberg-Witte, Valerie Byrnes, Fadel Bennani, Ekaterina S. Jordanova, Micha M. M. Wilhelmus, Chris J. Mulder, Paul van der Valk, Annemieke J. M. Rozemuller, Gerd Bouma, Anne-Marie Van Dam
Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
Oana C. Marian, Jonathan D. Teo, Jun Yup Lee, Huitong Song, John B. Kwok, Ramon Landin-Romero, Glenda Halliday, Anthony S. Don
Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation
Lingling Kong, Cera W. Hassinan, Florian Gerstner, Jannik M. Buettner, Jeffrey B. Petigrow, David O. Valdivia, Michelle H. Chan-Cortés, Amy Mistri, Annie Cao, Scott Alan McGaugh, Madeline Denton, Stephen Brown, Joshua Ross, Markus H. Schwab, Christian M. Simon, Charlotte J. Sumner
Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain
Wenzhang Wang, Fanpeng Zhao, Yubing Lu, Sandra L. Siedlak, Hisashi Fujioka, Hao Feng, George Perry, Xiongwei Zhu
Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease
Laura Carrero, Desireé Antequera, Ignacio Alcalde, Diego Megías, Joana Figueiro-Silva, Jesús Merayo-Lloves, Cristina Municio, Eva Carro
Myelin in Alzheimer’s disease: culprit or bystander?
Michel Maitre, Hélène Jeltsch-David, Nwife Getrude Okechukwu, Christian Klein, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease
Kanza M. Khan, Nagalakshmi Balasubramanian, Gabriel Gaudencio, Ruixiang Wang, Govindhasamy Pushpavathi Selvakumar, Louis Kolling, Samantha Pierson, Satya M. Tadinada, Ted Abel, Marco Hefti, Catherine A. Marcinkiewcz
A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma
Arnault Tauziède-Espariat, Marie Simbozel, Anthony P. Y. Liu, Giles W. Robinson, Julien Masliah-Planchon, Philipp Sievers, Alexandre Vasiljevic, Mathilde Duchesne, Stéphanie Puget, Volodia Dangouloff-Ros, Nathalie Boddaert, Alice Métais, Lauren Hasty, Christelle Dufour, Pascale Varlet
Upregulation of carbonic anhydrase 1 beneficial for depressive disorder
Ke Cheng, Yue Wang, Yong He, Yu Tian, Junjie Li, Chong Chen, Xingzhe Xu, Zhonghao Wu, Heming Yu, Xiangyu Chen, Yili Wu, Weihong Song, Zhifang Dong, Huatai Xu, Peng Xie
Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection
Alanna G. Spiteri, Claire L. Wishart, Duan Ni, Barney Viengkhou, Laurence Macia, Markus J. Hofer, Nicholas J. C. King
Exogenous interleukin 33 enhances the brain’s lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice
Mingqi Liu, Jinhao Huang, Tao Liu, Jiangyuan Yuan, Chuanxiang Lv, Zhuang Sha, Chenrui Wu, Weiwei Jiang, Xuanhui Liu, Meng Nie, Yupeng Chen, Shiying Dong, Yu Qian, Chuang Gao, Yibing Fan, Di Wu, Rongcai Jiang
IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma
Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors
Luigi Fiondella, Priya Gami-Patel, Christian A. Blok, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Marta Scarioni, Anke A. Dijkstra
Tumor lineage-specific immune response in brain metastatic disease: opportunities for targeted immunotherapy regimen?
Shiva Najjary, Johan M. Kros, Willem de Koning, Disha Vadgama, Karishma Lila, Janina Wolf, Dana A. M. Mustafa
The locus coeruleus input to the rostral ventromedial medulla mediates stress-induced colorectal visceral pain
Dexu Kong, Yunchun Zhang, Po Gao, Chao Pan, Haoyue Deng, Saihong Xu, Dan Tang, Jie Xiao, Yingfu Jiao, Weifeng Yu, Daxiang Wen
Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation
Marina Célestine, Muriel Jacquier-Sarlin, Eve Borel, Fanny Petit, Jean-Baptiste Perot, Anne-Sophie Hérard, Luc Bousset, Alain Buisson, Marc Dhenain
Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations
Jessica Brown, Elena Camporesi, Juan Lantero-Rodriguez, Maria Olsson, Alice Wang, Blanca Medem, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari, Mark Wall, Emily Hill
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease
Muhammad Ali, Derek B. Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, Maria V. Fernández, Ting-Chen Wang, Claudia L. Satizabal, Qiong Yang, Alexa S. Beiser, Ruiqi Wang, Gengsheng Chen, Brian Gordon, Tammie L. S. Benzinger, Chengjie Xiong, John C. Morris, Randall J. Bateman, Celeste M. Karch, Eric McDade, Alison Goate, Sudha Seshadri, Richard P. Mayeux, Reisa A. Sperling, Rachel F. Buckley, Keith A. Johnson, Hong-Hee Won, Sang-Hyuk Jung, Hang-Rai Kim, Sang Won Seo, Hee Jin Kim, Elizabeth Mormino, Simon M. Laws, Kang-Hsien Fan, M. Ilyas Kamboh, Prashanthi Vemuri, Vijay K. Ramanan, Hyun-Sik Yang, Allen Wenzel, Hema Sekhar Reddy Rajula, Aniket Mishra, Carole Dufouil, Stephanie Debette, Oscar L. Lopez, Steven T. DeKosky, Feifei Tao, Michael W. Nagle, Timothy J. Hohman, Yun Ju Sung, Logan Dumitrescu, Carlos Cruchaga
Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain
Molly E. V. Swanson, Miran Mrkela, Helen C. Murray, Maize C. Cao, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter
Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
NOTCH2NLC GGC repeat expansion causes retinal pathology with intranuclear inclusions throughout the retina and causes visual impairment
Jun Sone, Shinji Ueno, Akio Akagi, Hiroaki Miyahara, Chisato Tamai, Yuichi Riku, Hiroyuki Yabata, Ryuichi Koizumi, Tomohiro Hattori, Hiroshi Hirose, Yoshito Koyanagi, Rei Kobayashi, Hisashi Okada, Yoshiyuki Kishimoto, Yoshio Hashizume, Gen Sobue, Mari Yoshida, Yasushi Iwasaki
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
P16 immunohistochemistry is a sensitive and specific surrogate marker for CDKN2A homozygous deletion in gliomas
Meenakshi Vij, Benjamin B. Cho, Raquel T. Yokoda, Omid Rashidipour, Melissa Umphlett, Timothy E. Richardson, Nadejda M. Tsankova
Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
Chao Qi, Masato Hasegawa, Masaki Takao, Motoko Sakai, Mayasuki Sasaki, Masashi Mizutani, Akio Akagi, Yasushi Iwasaki, Hiroaki Miyahara, Mari Yoshida, Sjors H. W. Scheres, Michel Goedert
TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
Ayse N. Menevse, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Marcell Kupczyk, Julia Lorenz, Lorraine Weidner, Abir Hussein, Julian Sax, Jasmin Mühlbauer, Nicole Heuschneider, Celine Rohrmus, Laura S. Mai, Birgit Jachnik, Slava Stamova, Valentina Volpin, Franziska C. Durst, Antonio Sorrentino, Maria Xydia, Vladimir M. Milenkovic, Stefanie Bader, Frank K. Braun, Christian Wetzel, Nathalie L. Albert, Joerg-Christian Tonn, Peter Bartenstein, Martin Proescholdt, Nils O. Schmidt, Ralf A. Linker, Markus J. Riemenschneider, Philipp Beckhove, Peter Hau
ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics
Mahmod Panahi, Yoshiki Hase, Xavier Gallart-Palau, Sumonto Mitra, Atsushi Watanabe, Roger C Low, Yumi Yamamoto, Diego Sepulveda-Falla, Atticus H Hainsworth, Masafumi Ihara, Siu Kwan Sze, Matti Viitanen, Homira Behbahani, Raj N Kalaria
Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature
Suzan van Amerongen, Suzie Kamps, Kyra K. M. Kaijser, Yolande A. L. Pijnenburg, Philip Scheltens, Charlotte E. Teunissen, Frederik Barkhof, Rik Ossenkoppele, Annemieke J. M. Rozemuller, Robert A. Stern, Jeroen J. M. Hoozemans, Everard G. B. Vijverberg
SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature
Laetitia Lebrun, Lara Absil, Myriam Remmelink, Ricardo De Mendonça, Nicky D’Haene, Nicolas Gaspard, Stefan Rusu, Marie-Lucie Racu, Amandine Collin, Justine Allard, Egor Zindy, Andrea Alex Schiavo, Sarah De Clercq, Olivier De Witte, Christine Decaestecker, Maria-Beatriz Lopes, Isabelle Salmon
Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators
Berta Segura-Collar, Sara Hiller-Vallina, Olaya de Dios, Marta Caamaño-Moreno, Lucia Mondejar-Ruescas, Juan M. Sepulveda-Sanchez, Ricardo Gargini
Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains
Eugen Semikasev, Barbara Ahlemeyer, Till Acker, Anne Schänzer, Eveline Baumgart-Vogt
Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures
Miguel A. Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S. Perez Garcia, Gissel M. Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, Allison Sowa, Timothy Tetreault, Merina Varghese, David G. Cook, Carolyn W. Zhu, Susan J. Tappan, William G. M. Janssen, Patrick R. Hof, Stephen T. Ahlers, Gregory A. Elder
Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
Nuria Suelves, Shirine Saleki, Tasha Ibrahim, Debora Palomares, Sebastiaan Moonen, Marta J. Koper, Céline Vrancx, Devkee M. Vadukul, Nicolas Papadopoulos, Nikenza Viceconte, Eloïse Claude, Rik Vandenberghe, Christine A. F. von Arnim, Stefan N. Constantinescu, Dietmar Rudolf Thal, Anabelle Decottignies, Pascal Kienlen-Campard
Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
Dayana Pérez-Acuña, Ka Hyun Rhee, Soo Jean Shin, Jeeyun Ahn, Jee-Young Lee, Seung-Jae Lee
Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Luise A. Seeker, Nadine Bestard-Cuche, Sarah Jäkel, Nina-Lydia Kazakou, Sunniva M. K. Bøstrand, Laura J. Wagstaff, Justyna Cholewa-Waclaw, Alastair M. Kilpatrick, David Van Bruggen, Mukund Kabbe, Fabio Baldivia Pohl, Zahra Moslehi, Neil C. Henderson, Catalina A. Vallejos, Gioele La Manno, Goncalo Castelo-Branco, Anna Williams
Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons
Lien Andries, Daliya Kancheva, Luca Masin, Isabelle Scheyltjens, Hannah Van Hove, Karen De Vlaminck, Steven Bergmans, Marie Claes, Lies De Groef, Lieve Moons, Kiavash Movahedi
Astrocytic pathology in Alpers’ syndrome
Laura A Smith, Chun Chen, Nichola Z Lax, Robert W Taylor, Daniel Erskine, Robert McFarland
Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, Simone Eggert
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration
Shunsuke Koga, Michael A. Metrick II, Lawrence I. Golbe, Alessia Santambrogio, Minji Kim, Alexandra I. Soto-Beasley, Ronald L. Walton, Matthew C. Baker, Cristhoper Fernandez De Castro, Michael DeTure, David Russell, Bradford A. Navia, Christine Sandiego, Owen A. Ross, Michele Vendruscolo, Byron Caughey, Dennis W. Dickson
Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort
Ruth S. Nelson, Erin L. Abner, Gregory A. Jicha, Frederick A. Schmitt, Jing Di, Donna M. Wilcock, Justin M. Barber, Linda J. Van Eldik, Yuriko Katsumata, David W. Fardo, Peter T. Nelson
X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease
Anastasia Gromova, Byeonggu Cha, Erica M. Robinson, Laura M. Strickland, Nhat Nguyen, Mai K. ElMallah, Constanza J. Cortes, Albert R. La Spada
Quantitative multiplex immunohistochemistry with colorimetric staining (QUIVER) may still benefit from MILAN
Maddalena M. Bolognesi, Asier Antoranz, Francesca Maria Bosisio, Giorgio Cattoretti
Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes
Amer Toutonji, Carsten Krieg, Davis M. Borucki, Mamatha Mandava, Silvia Guglietta, Stephen Tomlinson
Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment
Vismitha Rajeev, Yuek Ling Chai, Luting Poh, Sharmelee Selvaraji, David Y. Fann, Dong-Gyu Jo, T. Michael De Silva, Grant R. Drummond, Christopher G. Sobey, Thiruma V. Arumugam, Christopher P. Chen, Mitchell K. P. Lai
Molecular reclassification reveals low prevalence of germline predisposition in children with ependymoma
Jon Foss-Skiftesvik, René Mathiasen, Thomas van Overeem Hansen, Karin Wadt, Kjeld Schmiegelow, Ulrik Kristoffer Stoltze
Intracranial mesenchymal tumor with (novel) COX14::PTEN rearrangement
Antonio d’Amati, Francesca Gianno, Luciana Scuccimarri, Michele Lastilla, Raffaella Messina, Francesco Signorelli, Domenico Sergio Zimatore, Sabina Barresi, Evelina Miele, Rita Alaggio, Sabrina Rossi, Eugenio Maiorano, Giuseppe Ingravallo, Felice Giangaspero, Manila Antonelli
Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone
Marc-Antoine Da-Veiga, Natacha Coppieters, Arnaud Lombard, Bernard Rogister, Virginie Neirinckx, Caroline Piette
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Martin Ingelsson, Jinar Rostami, Maria Lindskog, Anna Erlandsson
Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy
Ksenija Martinović, Jan Bauer, Markus Kunze, Johannes Berger, Sonja Forss-Petter
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick Sullivan, David R. Borchelt, Stefan Prokop, Paramita Chakrabarty
Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis
Wendy Oost, Allard J. Huitema, Kim Kats, Ben N. G. Giepmans, Susanne M. Kooistra, Bart J. L. Eggen, Wia Baron
Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence
Laura Pérez-Cervera, Silvia De Santis, Encarni Marcos, Zahra Ghorbanzad-Ghaziany, Alejandro Trouvé-Carpena, Mohamed Kotb Selim, Úrsula Pérez-Ramírez, Simone Pfarr, Patrick Bach, Patrick Halli, Falk Kiefer, David Moratal, Peter Kirsch, Wolfgang H. Sommer, Santiago Canals
DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice
Wen-bin Zhang, Yue Huang, Xiao-rou Guo, Meng-qi Zhang, Xiang-shan Yuan, Heng-bing Zu
Regional vulnerability of brain white matter in vanishing white matter
Jodie H.K. Man, Charlotte A.G.H. van Gelder, Marjolein Breur, Douwe Molenaar, Truus Abbink, Maarten Altelaar, Marianna Bugiani, Marjo S. van der Knaap
On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells
F. Ah-Pine, M. Khettab, Y. Bedoui, Y. Slama, M. Daniel, B. Doray, P. Gasque
The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease
Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Huie, Hsin-Pei Wang, Delaney A. Flaherty, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger
The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration
Katherine Fodder, Rohan de Silva, Thomas T. Warner, Conceição Bettencourt
Reduction of oxytocin-containing neurons and enhanced glymphatic activity in the hypothalamic paraventricular nucleus of patients with type 2 diabetes mellitus
Felipe Correa-da-Silva, Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang, Samantha E. C. Wolff, Nikita L. Korpel, Dick F. Swaab, Eric Fliers, Andries Kalsbeek, Chun-Xia Yi
Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis
Milton Guilherme Forestieri Fernandes, Abdulshakour Mohammadnia, Florian Pernin, Laura Eleonora Schmitz-Gielsdorf, Caroline Hodgins, Qiao-Ling Cui, Moein Yaqubi, Manon Blain, Jeffery Hall, Roy Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Jo Anne Stratton, Moses Rodriguez, Tanja Kuhlmann, Wayne Moore, Timothy E. Kennedy, Jack P. Antel
Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
Shunsuke Koga, Aya Murakami, Alexandra I. Soto-Beasley, Ronald L. Walton, Matthew C. Baker, Monica Castanedes-Casey, Keith A. Josephs, Owen A. Ross, Dennis W. Dickson
Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations
Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh, Tanveer Sharif
Dynamic profiling of medulloblastoma surfaceome
David Bakhshinyan, Yujin Suk, Laura Kuhlmann, Ashley A. Adile, Vladimir Ignatchenko, Stefan Custers, William D. Gwynne, Andrew Macklin, Chitra Venugopal, Thomas Kislinger, Sheila K. Singh
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo
Henrick Riemenschneider, Francesca Simonetti, Udit Sheth, Eszter Katona, Stefan Roth, Saskia Hutten, Daniel Farny, Meike Michaelsen, Brigitte Nuscher, Michael K. Schmidt, Andrew Flatley, Aloys Schepers, Lara A. Gruijs da Silva, Qihui Zhou, Thomas Klopstock, Arthur Liesz, Thomas Arzberger, Jochen Herms, Regina Feederle, Tania F. Gendron, Dorothee Dormann, Dieter Edbauer
DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironment
Szymon Baluszek, Paulina Kober, Natalia Rusetska, Michał Wągrodzki, Tomasz Mandat, Jacek Kunicki, Mateusz Bujko
Correction: Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking
Alexander H. Swan, Roland F. R. Schindler, Marco Savarese, Isabelle Mayer, Susanne Rinné, Felix Bleser, Anne Schänzer, Andreas Hahn, Mario Sabatelli, Francesco Perna, Kathryn Chapman, Mark Pfuhl, Alan C. Spivey, Niels Decher, Bjarne Udd, Giorgio Tasca, Thomas Brand
Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination
Kirsten Scarlett Evonuk, Sen Wang, Josh Mattie, C. J. Cracchiolo, Reine Mager, Željko Ferenčić, Ethan Sprague, Brandon Carrier, Kai Schofield, Evelyn Martinez, Zachary Stewart, Tara Petrosino, Gregory Andrew Johnson, Isharat Yusuf, Warren Plaisted, Zachary Naiman, Timothy Delp, Laura Carter, Suzana Marušić
Correction to: Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators
Berta Segura-Collar, Sara Hiller-Vallina, Olaya de Dios, Marta Caamaño-Moreno, Lucia Mondejar-Ruescas, Juan M. Sepulveda-Sanchez, Ricardo Gargini
Publisher Correction to: Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
Shunsuke Koga, Aya Murakami, Alexandra I. Soto-Beasley, Ronald L. Walton, Matthew C. Baker, Monica Castanedes-Casey, Keith A. Josephs, Owen A. Ross, Dennis W. Dickson
Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury
Sydney M. A. Juan, Maria Daglas, Phan H. Truong, Celeste Mawal, Paul A. Adlard
Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
Grace M. Lloyd, Brooke Long, Stephan Quintin, Zachary A. Sorrentino, Kimberly-Marie M. Gorion, Brach M. Bell, Denise Carrillo, Patrick Sullivan, David Borchelt, Benoit I. Giasson
Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study
Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schön, Tobias M. Boeckers, Jakob Matschke, Christian Mawrin, Albert C. Ludolph, Kelly Del Tredici, Francesco Roselli, Heiko Braak
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS
Priya Jhelum, Stephanie Zandee, Fari Ryan, Juan G. Zarruk, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Wendy Klement, Alexandre Prat, Samuel David
Impact of H3K27 trimethylation loss in meningiomas: a meta-analysis
Gregory Cello, Ruchit V. Patel, James Tanner McMahon, Sandro Santagata, Wenya Linda Bi
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Grace Rosen, Daniel Kirsch, Sarah Horowitz, Jonathan D. Cherry, Raymond Nicks, Hunter Kelley, Madeline Uretsky, Kevin Dell’Aquila, Rebecca Mathias, Kerry A. Cormier, Caroline A. Kubilus, Jesse Mez, Yorghos Tripodis, Thor D. Stein, Victor E. Alvarez, Michael L. Alosco, Ann C. McKee, Bertrand R. Huber
Mitochondrial DNA mutations in Medulloblastoma
Viktoria L. E. Funke, Sarah Sandmann, Viktoria Melcher, Jochen Seggewiss, Judit Horvath, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Stefan Rutkowski, Martin Mynarek, Julian Varghese, Ronald Sträter, Stephan Rust, Anja Seelhöfer, Janine Reunert, Barbara Fiedler, Ulrich Schüller, Thorsten Marquardt, Kornelius Kerl
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis
Xin Wang, Qian Sun, Weiwen Wang, Baohui Liu, Ying Gu, Liang Chen
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Lucia AA Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke JM Rozemuller, John C van Swieten, Harro Seelaar
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
David L. Dai, Mingyao Li, Edward B. Lee
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. Backes, Robert J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn, Sébastien Foulquier
The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
Dan-Dan Wang, Mitali Katoch, Samir Jabari, Ingmar Blumcke, David B. Blumenthal, De-Hong Lu, Roland Coras, Yu-Jiao Wang, Jie Shi, Wen-Jing Zhou, Katja Kobow, Yue-Shan Piao
A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy
Kohji Mori, Kazue Shigenobu, Goichi Beck, Ryota Uozumi, Yuto Satake, Maki Suzuki, Shizuko Kondo, Shiho Gotoh, Yuki Yonenobu, Makiko Kawai, Yuki Suzuki, Yuko Saito, Eiichi Morii, Masato Hasegawa, Hideki Mochizuki, Shigeo Murayama, Manabu Ikeda
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
Yeboah Kofi Gyening, Keren Boris, Mignot Cyril, Richard S. Brush, Marie-Cécile Nassogne, Martin-Paul Agbaga
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M. C. Fisher, Frances K. Wiseman
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Chang Zeng, Xiao Song, Zhou Zhang, Qinyun Cai, Jiajun Cai, Craig Horbinski, Bo Hu, Shi-Yuan Cheng, Wei Zhang
Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury
Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru Peterson, Madison R. Mix, John T. Harty, Thomas Nickl-Jockschat, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
Simone M. Crivelli, Zainuddin Quadri, Hemendra J. Vekaria, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Liping Zhang, Patrick G. Sullivan, Erhard Bieberich
Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling
Arnault Tauziède-Espariat, Julien Masliah-Planchon, Mamy Andrianteranagna, Philipp Sievers, Felix Sahm, Andreas von Deimling, Lauren Hasty, Olivier Delattre, Kévin Beccaria, Alice Métais, Fabrice Chrétien, Pascale Varlet, Franck Bourdeaut
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse
George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser, Sarah E. Stabenfeldt
A neuropathologic feature of brain aging: multi-lumen vascular profiles
Eseosa T. Ighodaro, Ryan K. Shahidehpour, Adam D. Bachstetter, Erin L. Abner, Ruth S. Nelson, David W. Fardo, Andy Y. Shih, Roger I. Grant, Janna H. Neltner, Frederick A. Schmitt, Gregory A. Jicha, Richard J. Kryscio, Donna M. Wilcock, Linda J. Van Eldik, Peter T. Nelson
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value
Henning Leske, Ulrike Camenisch Gross, Silvia Hofer, Marian Christoph Neidert, Sabine Leske, Michael Weller, Dirk Lehnick, Elisabeth Jane Rushing
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
Javier Morón-Oset, Lilly Katharina Sophie Fischer, Nathalie Jauré, Pingze Zhang, Annika Julia Jahn, Tessa Supèr, André Pahl, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Laura Cracco, Gianfranco Puoti, Antonio Cornacchia, Katie Glisic, Seong‑Ki Lee, Zerui Wang, Mark L. Cohen, Brian S. Appleby, Ignazio Cali
Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease
Jaemyung Jang, Seungeun Yeo, Soonbong Baek, Hyun Jin Jung, Mi Suk Lee, Seung Hee Choi, Youngshik Choe
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
Matthew D. Wood, Carol Beadling, Tanaya Neff, Steve Moore, Christina A. Harrington, Lissa Baird, Christopher Corless
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Chao Li, Shanyan Chen, Heather R. Siedhoff, DeAna Grant, Pei Liu, Ashley Balderrama, Marcus Jackson, Amitai Zuckerman, C. Michael Greenlief, Firas Kobeissy, Kevin W. Wang, Ralph G. DePalma, Ibolja Cernak, Jiankun Cui, Zezong Gu
Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation
Hasier Eraña, Carlos M. Díaz-Domínguez, Jorge M. Charco, Enric Vidal, Ezequiel González-Miranda, Miguel A. Pérez-Castro, Patricia Piñeiro, Rafael López-Moreno, Cristina Sampedro-Torres-Quevedo, Leire Fernández-Veiga, Juan Tasis-Galarza, Nuria L. Lorenzo, Aileen Santini-Santiago, Melisa Lázaro, Sandra García-Martínez, Nuno Gonçalves-Anjo, Maitena San-Juan-Ansoleaga, Josu Galarza-Ahumada, Eva Fernández-Muñoz, Samanta Giler, Mikel Valle, Glenn C. Telling, Mariví Geijó, Jesús R. Requena, Joaquín Castilla
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
Lorraine Weidner, Julia Lorenz, Stefanie Quach, Frank K. Braun, Tanja Rothhammer-Hampl, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Laura M. Bartos, Franziska J. Dekorsy, Adrien Holzgreve, Sabrina V. Kirchleitner, Niklas Thon, Tobias Greve, Viktoria Ruf, Jochen Herms, Stefanie Bader, Vladimir M. Milenkovic, Louisa von Baumgarten, Ayse N. Menevse, Abir Hussein, Julian Sax, Christian H. Wetzel, Rainer Rupprecht, Martin Proescholdt, Nils O. Schmidt, Philipp Beckhove, Peter Hau, Joerg-Christian Tonn, Peter Bartenstein, Matthias Brendel, Nathalie L. Albert, Markus J. Riemenschneider
Amygdala granular fuzzy astrocytes are independently associated with both LATE neuropathologic change and argyrophilic grains: a study of Japanese series with a low to moderate Braak stage
Osamu Yokota, Tomoko Miki, Hanae Nakashima-Yasuda, Hideki Ishizu, Takashi Haraguchi, Chikako Ikeda, Akinori Miyashita, Takeshi Ikeuchi, Shintaro Takenoshita, Seishi Terada, Manabu Takaki
APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology
Seth Talyansky, Yann Le Guen, Nandita Kasireddy, Michael E. Belloy, Michael D. Greicius
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren-Thorsson, Gunnar K. Gouras, Melinda Rezeli, Laurent Roybon
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, Matilde Contardo, Evelien Van Schoor, Raheem Fazal, Dietmar Rudolf Thal, Siddharthan Chandran, Renzo Mancuso, Ludo Van Den Bosch, Philip Van Damme
TDP43 pathology in chronic traumatic encephalopathy retinas
Ragini Phansalkar, Vanessa S. Goodwill, Jeffrey J. Nirschl, Chiara De Lillo, Jihee Choi, Elizabeth Spurlock, David G. Coughlin, Donald Pizzo, Christina J. Sigurdson, Annie Hiniker, Victor E. Alvarez, Ann C. Mckee, Jonathan H. Lin
Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro-Oncology Group study
Kohei Fukuoka, Jun Kurihara, Tomoko Shofuda, Naoki Kagawa, Kai Yamasaki, Ryo Ando, Joji Ishida, Masayuki Kanamori, Atsufumi Kawamura, Young-Soo Park, Chikako Kiyotani, Takuya Akai, Dai Keino, Yosuke Miyairi, Atsushi Sasaki, Junko Hirato, Takeshi Inoue, Atsuko Nakazawa, Katsuyoshi Koh, Ryo Nishikawa, Isao Date, Motoo Nagane, Koichi Ichimura, Yonehiro Kanemura
Rapid isolation of intact retinal astrocytes: a novel approach
Paul F. Cullen, Arpan G. Mazumder, Daniel Sun, John G. Flanagan
Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development
Ádám Mészáros, Kinga Molnár, Csilla Fazakas, Bernát Nógrádi, Adél Lüvi, Tamás Dudás, László Tiszlavicz, Attila Elek Farkas, István Adorján Krizbai, Imola Wilhelm
Meningiomas in patients with neurofibromatosis type 2 predominantly comprise ‘immunogenic subtype’ tumours characterised by macrophage infiltration
Yu Teranishi, Satoru Miyawaki, Masahiro Nakatochi, Atsushi Okano, Kenta Ohara, Hiroki Hongo, Daiichiro Ishigami, Yu Sakai, Daisuke Shimada, Shunsaku Takayanagi, Masako Ikemura, Daisuke Komura, Hiroto Katoh, Jun Mitsui, Shinichi Morishita, Tetsuo Ushiku, Shumpei Ishikawa, Hirofumi Nakatomi, Nobuhito Saito
Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo
Sofia Spataro, Bohumil Maco, Stéphane Escrig, Louise Jensen, Lubos Polerecky, Graham Knott, Anders Meibom, Bernard L. Schneider
Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas
Vladimir Amani, Kent A. Riemondy, Rui Fu, Andrea M. Griesinger, Enrique Grimaldo, Graziella Ribeiro De Sousa, Ahmed Gilani, Molly Hemenway, Nicholas K. Foreman, Andrew M. Donson, Nicholas Willard
Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease
Louise Reveret, Manon Leclerc, Vincent Emond, Cyntia Tremblay, Andréanne Loiselle, Philippe Bourassa, David A. Bennett, Sébastien S. Hébert, Frédéric Calon
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert
Determinants of astrocytic pathology in stem cell models of primary tauopathies
Kimberly L. Fiock, Jordan N. Hook, Marco M. Hefti
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders
Stefan Bräuer, Marcello Rossi, Johann Sajapin, Thomas Henle, Thomas Gasser, Piero Parchi, Kathrin Brockmann, Björn H. Falkenburger
CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity
Jared T. Ahrendsen, Yi Nong, Yuda Huo, Jasmine Steele, Matthew P. Anderson
Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
Craig L. Bennett, Somasish Dastidar, Frederick J. Arnold, Spencer U. McKinstry, Cameron Stockford, Brian D. Freibaum, Bryce L. Sopher, Meilin Wu, Glen Seidner, William Joiner, J. Paul Taylor, Ryan J. H. West, Albert R. La Spada
Muscle fibrosis as a prognostic biomarker in facioscapulohumeral muscular dystrophy: a retrospective cohort study
Elvira Ragozzino, Sara Bortolani, Lorena Di Pietro, Andrea Papait, Ornella Parolini, Mauro Monforte, Giorgio Tasca, Enzo Ricci
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikezu
Myopathologic trajectory in Duchenne muscular dystrophy (DMD) reveals lack of regeneration due to senescence in satellite cells
Nastasia Cardone, Valentina Taglietti, Serena Baratto, Kaouthar Kefi, Baptiste Periou, Ciryl Gitiaux, Christine Barnerias, Peggy Lafuste, France Leturcq Pharm, Juliette Nectoux Pharm, Chiara Panicucci, Isabelle Desguerre, Claudio Bruno, François-Jerome Authier, Chiara Fiorillo, Frederic Relaix, Edoardo Malfatti
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
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Correction to: Higher angiotensin‑converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease
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MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Carolin Göbel, Shweta Godbole, Melanie Schoof, Dörthe Holdhof, Catena Kresbach, Carolin Loose, Julia Neumann, Ulrich Schüller
Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results
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Antoni Andreu Martija, Alexandra Krauß, Natalie Bächle, Laura Doth, Arne Christians, Damir Krunic, Martin Schneider, Dominic Helm, Rainer Will, Christian Hartmann, Christel Herold-Mende, Andreas von Deimling, Stefan Pusch
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Deep histopathology genotype–phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb
Jonas Honke, Lucas Hoffmann, Roland Coras, Katja Kobow, Costin Leu, Tom Pieper, Till Hartlieb, Christian G. Bien, Friedrich Woermann, Thomas Cloppenborg, Thilo Kalbhenn, Ahmed Gaballa, Hajo Hamer, Sebastian Brandner, Karl Rössler, Arnd Dörfler, Stefan Rampp, Johannes R. Lemke, Sara Baldassari, Stéphanie Baulac, Dennis Lal, Peter Nürnberg, Ingmar Blümcke
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Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families
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Neuronal SNCA transcription during Lewy body formation
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma
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Nuclear face of Tau: an inside player in neurodegeneration
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ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease
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miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4
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Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample
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Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
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Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation
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Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data
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