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Cerebral Small Vessel Disease 

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  1. Open Access 01-12-2024 | Cerebral Small Vessel Disease | OriginalPaper

    SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study

    Cerebral small vessel disease (CSVD) accounts for nearly 20% of all ischemic strokes and is associated with a high risk of vascular dementia [ 1 , 2 ]. Type-2 diabetes mellitus (T2DM) is a well-established risk factor for cerebrovascular diseases …

  2. Open Access 06-04-2024 | Cerebral Small Vessel Disease | Online First

    NFL and GFAP in (pre)symptomatic RVCL-S carriers: a monogenic cerebral small vessel disease

    Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is an autosomal dominant vasculopathy caused by C-terminal truncating mutations in the TREX1 gene [ 1 – 3 ]. The main features of RVCL-S are progressive …

  3. 02-04-2024 | Cerebral Small Vessel Disease | Online First

    Activation of NLRP3 inflammasome in a rat model of cerebral small vessel disease

    Cerebral small vessel disease (CSVD) is increasingly being recognized as a leading contributor to cognitive impairment in the elderly. However, there is a lack of effective preventative or therapeutic options for CSVD. In this exploratory study …

  4. Open Access 21-02-2024 | Mild Cognitive Impairment | OriginalPaper

    Effect of cerebral small vessel disease on the integrity of cholinergic system in mild cognitive impairment patients: a longitudinal study

    We aimed to investigate the effect of cerebral small vessel disease (SVD) on cholinergic system integrity in mild cognitive impairment (MCI) patients. Nucleus basalis of Meynert (NBM) volume and cholinergic pathways integrity was evaluated at …

  5. Open Access 01-12-2024 | Cerebral Small Vessel Disease | OriginalPaper

    Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population

    Cerebral small vessel disease (CSVD) includes pathologies of the small vessels in the brain, including small arteries, arterioles, venules, and capillaries. These pathologies are diagnosed and identified on magnetic resonance imaging (MRI) as …

  6. 27-03-2024 | OriginalPaper

    The Role of Changes in the Expression of Inflammation-Associated Genes in Cerebral Small Vessel Disease with Cognitive Impairments

    Objectives. To clarify the role of changes in the expression of inflammation-associated genes in cerebral small vessel disease (cSVD). Materials and methods. A total of 44 patients with cSVD (mean age 61.4 ± 9.2 years) and 11 volunteers (mean age …

  7. 28-11-2023 | Epilepsy | OriginalPaper

    Cerebral small vessel disease increases risk for epilepsy: a Mendelian randomization study

    Cerebral small vessel disease (CSVD) encompasses a range of clinical syndromes resulting from abnormalities in the cerebral vasculature such as small arteries, arterioles, capillaries, and venules [ 1 ]. The primary manifestations of CSVD include …

  8. Open Access 01-12-2024 | Cerebral Small Vessel Disease | OriginalPaper

    Whole exome sequencing in a sample of Egyptian patients with covert cerebral small vessel disease

    Cerebral small vessel disease (CSVD) refers to various pathological processes affecting the brain’s small arteries, arterioles, capillaries, and venules [ 1 ].

  9. 05-03-2024 | Cerebral Small Vessel Disease | Online First

    Cerebral Perfusion Characteristics and Dynamic Brain Structural Changes in Stroke-Prone Renovascular Hypertensive Rats: A Preclinical Model for Cerebral Small Vessel Disease

    Hypertension is a leading cause of cerebral small vessel disease (CSVD) and vascular dementia in elderly individuals. We aimed to assess cerebral perfusion and dynamic changes in brain structure in stroke-prone renovascular hypertensive rats …

  10. Open Access 01-12-2024 | Cerebral Small Vessel Disease | OriginalPaper

    The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants

    The glymphatic system connects perivascular spaces (PVS) over which cerebrospinal fluid (CSF) surrounding the brain exchanges with the interstitial fluid (ISF) within the parenchyma [ 1 ]. Its essential function is to take away wastes from the …

  11. Open Access 01-12-2024 | Cerebral Small Vessel Disease | OriginalPaper

    Monocyte to high-density lipoprotein cholesterol ratio is associated with cerebral small vessel diseases

    Cerebral small vessel disease (cSVD) is a subclinical pathology commonly observed in current health examinations due to aging and the development of brain imaging technology [ 1 ]. cSVD increases the risk of dementia and stroke, and has received …

  12. Open Access 17-10-2023 | Cerebral Small Vessel Disease | ReviewPaper

    Clinical and neuroimaging review of monogenic cerebral small vessel disease from the prenatal to adolescent developmental stage

    Cerebral small vessel disease (cSVD) refers to a group of pathological processes with various etiologies affecting the small vessels of the brain. Most cases are sporadic, with age-related and hypertension-related sSVD and cerebral amyloid …

  13. Open Access 01-12-2023 | Cerebral Small Vessel Disease | OriginalPaper

    Chronic gastritis may predict risk of cerebral small vessel disease

    The neuroimaging markers of cerebral small vessel disease (CSVD) include white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces (EPVS) and cerebral microbleeds (CMBs) [ 1 ]. As a subtype of ischemic stroke, CSVD is responsible …

  14. 21-11-2023 | Cerebral Small Vessel Disease | Online First

    Influence of cerebral small vessel disease on functional outcome and recurrence of cerebral infarction in patients with type 2 diabetes

    With the rising number of adult patients with diabetes worldwide, type 2 diabetes has become a worldwide public health problem [ 1 – 3 ]. It is especially important to prevent the occurrence and recurrence of diabetic vascular complications …

  15. Open Access 01-12-2023 | Cerebral Small Vessel Disease | OriginalPaper

    Micro-RNA in a sample of Egyptian patients with incidental cerebral small vessel disease

    Over the past few years, the prevalence, mortality, and morbidity of different neurological disorders have increased, despite the implementation of intervention programs aiming to reduce their health care burden [ 1 ]. This has incited the …

  16. Open Access 29-11-2023 | Cerebral Small Vessel Disease | OriginalPaper

    An Integrative Nomogram for Identifying Cognitive Impairment Using Seizure Type and Cerebral Small Vessel Disease Neuroimaging Markers in Patients with Late-Onset Epilepsy of Unknown Origin

    New-onset epilepsy, referred to as late-onset epilepsy (LOE), markedly develops after 50 years of age [ 1 , 2 ]. There are no established definitions of LOE. The current age thresholds range from 50 to 70 years among different studies [ 3 ].

  17. 21-10-2023 | Cerebral Small Vessel Disease | Online First

    Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms

    Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes involving the brain small vessels and leading to vascular cognitive impairment, intracerebral hemorrhage, and acute lacunar ischemic stroke. Despite the …

  18. Open Access 01-12-2023 | Cerebral Small Vessel Disease | OriginalPaper

    Absence of fluctuation and inverted circadian rhythm of blood pressure increase the risk of cognitive dysfunction in cerebral small vessel disease patients

    Circadian rhythms originated from the evolutionary needs to maximize the fitness of daily organisms on a 24-h timescale by enabling organisms to produce anticipatory and adaptive responses to recurrent light-dark cycles and associated …

  19. Open Access 27-06-2023 | Stroke | OriginalPaper

    A typology of cerebral small vessel disease based on imaging markers

    Cerebral small vessel disease (SVD) has been identified to cause numerous neurological and neuropsychiatric pathologies, including stroke [ 1 ], dementia [ 2 , 3 ], depression [ 4 ], and motor disability [ 5 ]. SVD is a disease of the cerebral

  20. Open Access 21-06-2023 | Epilepsy | OriginalPaper

    Epileptogenicity of white matter lesions in cerebral small vessel disease: a systematic review and meta-analysis

    Stroke and seizures have a strong reciprocal relationship: Cortical stroke is the most common etiology of late-onset epilepsy [ 1 ]. Vice versa, late-onset epilepsy of unknown etiology is associated with an up to threefold increased risk of …

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