Issue 1/2022
Content (190 Articles)
Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study
Carine Jiguet-Jiglaire, Sebastien Boissonneau, Emilie Denicolai, Victoria Hein, Romain Lasseur, Josep Garcia, Sylvie Romain, Romain Appay, Thomas Graillon, Warren Mason, Antoine F. Carpentier, Alba A. Brandes, L.’Houcine Ouafik, Wolfgang Wick, Ania Baaziz, Julien P. Gigan, Rafael J. Argüello, Dominique Figarella-Branger, Olivier Chinot, Emeline Tabouret
Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome
Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P. Silverman, Thomas Wisniewski
Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels
Malin Wennström, Shorena Janelidze, K. Peter R. Nilsson, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage, Oskar Hansson
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa, Pierre Dourlen
Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival
Azadeh Ebrahimi, Andrey Korshunov, Guido Reifenberger, David Capper, Joerg Felsberg, Elena Trisolini, Bianca Pollo, Chiara Calatozzolo, Marco Prinz, Ori Staszewski, Leonille Schweizer, Jens Schittenhelm, Patrick N. Harter, Werner Paulus, Christian Thomas, Patricia Kohlhof-Meinecke, Marcel Seiz-Rosenhagen, Till Milde, Belén M. Casalini, Abigail Suwala, Annika K. Wefers, Annekathrin Reinhardt, Philipp Sievers, Christof M. Kramm, Nima Etminam, Andreas Unterberg, Wolfgang Wick, Christel Herold-Mende, Dominik Sturm, Stefan M. Pfister, Martin Sill, David T. W. Jones, Daniel Schrimpf, David E. Reuss, Ken Aldape, Zied Abdullaev, Felix Sahm, Andreas von Deimling, Damian Stichel
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates
Andreas Zellner, Stephan A. Müller, Barbara Lindner, Nathalie Beaufort, Annemieke J. M. Rozemuller, Thomas Arzberger, Nils C. Gassen, Stefan F. Lichtenthaler, Bernhard Kuster, Christof Haffner, Martin Dichgans
Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation
Chao Sun, Lin Qi, Yang Cheng, Yi Zhao, Chen Gu
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans-Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra
Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation
Denis Silachev, Alexey Koval, Mikhail Savitsky, Guru Padmasola, Charles Quairiaux, Fabrizio Thorel, Vladimir L. Katanaev
Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury
Marta Celorrio, Kirill Shumilov, Camryn Payne, Sangeetha Vadivelu, Stuart H. Friess
Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen
Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination
Susan L. Lindsay, Aleksandra M. Molęda, Lindsay M. MacLellan, Siew Min Keh, Daniel E. McElroy, Christopher Linington, Carl S. Goodyear, Susan C. Barnett
Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature
Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients
Angela Genchi, Aurora Semerano, Ghil Schwarz, Beatrice Dell’Acqua, Giorgia Serena Gullotta, Michela Sampaolo, Enzo Boeri, Angelo Quattrini, Francesca Sanvito, Susanna Diamanti, Andrea Bergamaschi, Stefano Grassi, Paola Podini, Pietro Panni, Caterina Michelozzi, Franco Simionato, Francesco Scomazzoni, Paolo Remida, Luca Valvassori, Andrea Falini, Carlo Ferrarese, Patrik Michel, Guillaume Saliou, Steven Hajdu, Simone Beretta, Luisa Roveri, Massimo Filippi, Davide Strambo, Gianvito Martino, Marco Bacigaluppi
A novel LARGE1-AFF2 fusion expanding the molecular alterations associated with the methylation class of neuroepithelial tumors with PATZ1 fusions
Arnault Tauziède-Espariat, Guillaume Chotard, François le Loarer, Jessica Baud, Rihab Azmani, Volodia Dangouloff-Ros, Nathalie Boddaert, Céline Icher-de-Bouyn, Edouard Gimbert, Lauren Hasty, Alice Métais, Fabrice Chrétien, Pascale Varlet
White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition
Sheelakumari Raghavan, Scott A. Przybelski, Robert I. Reid, Timothy G. Lesnick, Vijay K. Ramanan, Hugo Botha, Billie J. Matchett, Melissa E. Murray, R. Ross Reichard, David S. Knopman, Jonathan Graff-Radford, David T. Jones, Val J. Lowe, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Kejal Kantarci, Jennifer L. Whitwell, Keith A. Josephs, Clifford R. Jack Jr, Prashanthi Vemuri
The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies
Nicole Becker, Steven A. Moore, Karra A. Jones
Intratumoural spatial distribution of S100B + folliculostellate cells is associated with proliferation and expression of FSH and ERα in gonadotroph tumours
Mirela Diana Ilie, Alexandre Vasiljevic, Marie Chanal, Nicolas Gadot, Laura Chinezu, Emmanuel Jouanneau, Ana Hennino, Gérald Raverot, Philippe Bertolino
Immune cell gene expression signatures in diffuse glioma are associated with IDH mutation status, patient outcome and malignant cell state, and highlight the importance of specific cell subsets in glioma biology
Bharati Mehani, Saleembhasha Asanigari, Hye-Jung Chung, Karen Dazelle, Arashdeep Singh, Sridhar Hannenhalli, Kenneth Aldape
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics
Gaël Nicolas, Myriam Sévigny, François Lecoquierre, Florent Marguet, Andréanne Deschênes, Maria Carment del Pelaez, Sébastien Feuillette, Anaïs Audebrand, Magalie Lecourtois, Stéphane Rousseau, Anne-Claire Richard, Kévin Cassinari, Vincent Deramecourt, Charles Duyckaerts, Anne Boland, Jean-François Deleuze, Vincent Meyer, Jordi Clarimon Echavarria, Ellen Gelpi, Haruhiko Akiyama, Masato Hasegawa, Ito Kawakami, Tsz H. Wong, Jeroen G. J. Van Rooij, John C. Van Swieten, Dominique Campion, Paul A. Dutchak, David Wallon, Flavie Lavoie-Cardinal, Annie Laquerrière, Anne Rovelet-Lecrux, Chantelle F. Sephton
Antemortem detection of Parkinson’s disease pathology in peripheral biopsies using artificial intelligence
Maxim Signaevsky, Bahram Marami, Marcel Prastawa, Nabil Tabish, Megan A. Iida, Xiang Fu Zhang, Mary Sawyer, Israel Duran, Daniel G. Koenigsberg, Clare H. Bryce, Lana M. Chahine, Brit Mollenhauer, Sherri Mosovsky, Lindsey Riley, Kuldip D. Dave, Jamie Eberling, Chris S. Coffey, Charles H. Adler, Geidy E. Serrano, Charles L. White III, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, Thomas G. Beach, John F. Crary
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation
Feilin Liu, Dmytro Morderer, Melissa C. Wren, Sara A. Vettleson-Trutza, Yanzhe Wang, Benjamin E. Rabichow, Michelle R. Salemi, Brett S. Phinney, Björn Oskarsson, Dennis W. Dickson, Wilfried Rossoll
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling
Jamie M. Walker, Shiva Kazempour Dehkordi, Anna Fracassi, Alison Vanschoiack, Anna Pavenko, Giulio Taglialatela, Randall Woltjer, Timothy E. Richardson, Habil Zare, Miranda E. Orr
High-grade childhood intra-parenchymal brain tumor clustering with ATRT and expanding the cancer spectrum related to inherited SMARCE1 truncating variations
Fabien Forest, Julien Masliah-Planchon, Claire Berger, Fabienne Prieur, Elodie Girard, Fanny Burel-Vandenbos, Claire Boutet, François Vassal, Franck Bourdeaut, Catherine Godfraind
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
Bongyong Lee, Iqbal Mahmud, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett, Ranjan J. Perera
Ischemic stroke causes Parkinson’s disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein
Stephanie Lohmann, Jessica Grigoletto, Maria Eugenia Bernis, Verena Pesch, Liang Ma, Sara Reithofer, Gültekin Tamgüney
Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation
Andy J. Liu, Jay B. Lusk, John Ervin, James Burke, Richard O’Brien, Shih-Hsiu J. Wang
Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions
Hongsun Park, Tomoyuki Yamanaka, Yumiko Toyama, Atsushi Fujita, Hiroshi Doi, Takashi Nirasawa, Shigeo Murayama, Naomichi Matsumoto, Tomomi Shimogori, Masaya Ikegawa, Matti J. Haltia, Nobuyuki Nukina
Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease
Hsiang-Han Chen, Abdallah Eteleeb, Ciyang Wang, Maria Victoria Fernandez, John P. Budde, Kristy Bergmann, Joanne Norton, Fengxian Wang, Curtis Ebl, John C. Morris, Richard J. Perrin, Randall J. Bateman, Eric McDade, Chengjie Xiong, Alison Goate, Martin Farlow, Jasmeer Chhatwal, Peter R. Schofield, Helena Chui, Oscar Harari, Carlos Cruchaga, Laura Ibanez
Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
Courtney A. Marshall, Jennifer D. McBride, Lakshmi Changolkar, Dawn M. Riddle, John Q. Trojanowski, Virginia M.-Y. Lee
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
Natalia Salvadores, Ines Moreno-Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas-Gomez, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto, Felipe A. Court
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas
Yan Liu, Adwait Amod Sathe, Kalil G. Abdullah, Samuel K. McBrayer, Steven H. Adams, Andrew J. Brenner, Kimmo J. Hatanpaa, Mariano S. Viapiano, Chao Xing, Jamie M. Walker, Timothy E. Richardson
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M. Van Deerlin, John Q. Trojanowski, Edward B. Lee, Fenghua Hu
Progressive multifocal fibrosing neuropathy: description of a novel disease
Fabian A. Mendoza, Jennifer Bagley, Michael Gochfeld, Marinos C. Dalakas, John L. Farber, Sergio A. Jimenez
The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis
Xiaojing Bai, Meiting Mai, Kai Yao, Mengqi Zhang, Yue Huang, Wenbin Zhang, Xiaorou Guo, Yixuan Xu, Ying Zhang, Atikam Qurban, Lijie Duan, Jimei Bu, Jianfeng Zhang, Junfeng Wu, Yongfei Zhao, Xiangshan Yuan, Hengbing Zu
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S. Bouvier
Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease
Catarina Oliveira Miranda, Rui Jorge Nobre, Vitor Hugo Paiva, João Valente Duarte, João Castelhano, Lorena Itatí Petrella, José Sereno, Magda Santana, Sónia Afonso, Cristina Januário, Miguel Castelo-Branco, Luís Pereira de Almeida
Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients
Pierre Bady, Christine Marosi, Michael Weller, Bjørn H. Grønberg, Henrik Schultz, Martin J. B. Taphoorn, Johanna M. M. Gijtenbeek, Martin J. van den Bent, Andreas von Deimling, Roger Stupp, Annika Malmström, Monika E. Hegi
Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia
Dwayne J. Byrne, M. Elena Garcia-Pardo, Nelson B. Cole, Belguun Batnasan, Sophia Heneghan, Anood Sohail, Craig Blackstone, Niamh C. O’Sullivan
AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in obstructive hydrocephalus
Leandro Castañeyra-Ruiz, Ibrahim González-Marrero, Luis G. Hernández-Abad, Emilia M. Carmona-Calero, Marta R. Pardo, Rebeca Baz-Davila, Seunghyun Lee, Michael Muhonen, Ricardo Borges, Agustín Castañeyra-Perdomo
Droplet digital PCR-based analyses for robust, rapid, and sensitive molecular diagnostics of gliomas
Marietta Wolter, Jörg Felsberg, Bastian Malzkorn, Kerstin Kaulich, Guido Reifenberger
Rare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion
Liene Bossaerts, Elisabeth Hendrickx Van de Craen, Rita Cacace, Bob Asselbergh, Christine Van Broeckhoven
Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease
Clayton W. Winkler, Chad S. Clancy, Rebecca Rosenke, Karin E. Peterson
Mical modulates Tau toxicity via cysteine oxidation in vivo
Engie Prifti, Eleni N. Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M. C. Skoulakis, Katerina Papanikolopoulou
Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Olivia A. Shipton, Clara S. Tang, Ole Paulsen, Mariana Vargas-Caballero
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis
Swati Dhar, Samantha Gadd, Priyam Patel, Jake Vaynshteyn, G. Praveen Raju, Rintaro Hashizume, Daniel J. Brat, Oren J. Becher
Muscle histological changes in a large cohort of patients affected with Becker muscular dystrophy
Michela Ripolone, Daniele Velardo, Stefania Mondello, Simona Zanotti, Francesca Magri, Elisa Minuti, Sara Cazzaniga, Francesco Fortunato, Patrizia Ciscato, Francesca Tiberio, Monica Sciacco, Maurizio Moggio, Paolo Bettica, Giacomo P. Comi
Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat
Lindsey N. Campion, Alan Mejia Maza, Rachita Yadav, Ellen B. Penney, Micaela G. Murcar, Kevin Correia, Tammy Gillis, Cara Fernandez-Cerado, M. Salvie Velasco-Andrada, G. Paul Legarda, Niecy G. Ganza-Bautista, J. Benedict B. Lagarde, Patrick J. Acuña, Trisha Multhaupt-Buell, Gabrielle Aldykiewicz, Melanie L. Supnet, Jan K. De Guzman, Criscely Go, Nutan Sharma, Edwin L. Munoz, Mark C. Ang, Cid Czarina E. Diesta, D. Cristopher Bragg, Laurie J. Ozelius, Vanessa C. Wheeler
Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change
Kamar E. Ameen-Ali, Abigail Bretzin, Edward B. Lee, Rebecca Folkerth, Lili-Naz Hazrati, Diego Iacono, C. Dirk Keene, Julia Kofler, Gabor G. Kovacs, Amber Nolan, Daniel P. Perl, David S. Priemer, Douglas H. Smith, Douglas J. Wiebe, William Stewart, Safa Al-Sarraj, Etty Cortes, John Crary, Kristin Dams-O’Connor, Ramon Diaz-Arrastia, Jean-Pierre Dollé, Brian Edlow, Bruce Fischl, Col. Sidney Hinds, Victoria E. Johnson, Geoffrey Manley, David Meaney, David Okonkwo, Andrea L. C. Schneider, Julie Schneider, Claire Troakes, John Q. Trojanowski, Andre van der Kouwe, Kristine Yaffe
Mapping of neuroinflammation-induced hypoxia in the spinal cord using optoacoustic imaging
Marta Ramos-Vega, Pontus Kjellman, Mihail Ivilinov Todorov, Tekla Maria Kylkilahti, B. Thomas Bäckström, Ali Ertürk, Chris Denis Madsen, Iben Lundgaard
Interface astrogliosis in contact sport head impacts and military blast exposure
Katharine J. Babcock, Bobak Abdolmohammadi, Patrick T. Kiernan, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Lee E. Goldstein, Thor D. Stein, Ann C. McKee, Bertrand R. Huber
The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome
Eleanor Drummond, Tomas Kavanagh, Geoffrey Pires, Mitchell Marta-Ariza, Evgeny Kanshin, Shruti Nayak, Arline Faustin, Valentin Berdah, Beatrix Ueberheide, Thomas Wisniewski
Expanding the clinical-pathological and genetic spectrum of RYR1-related congenital myopathies with cores and minicores: an Italian population study
Aurora Fusto, Denise Cassandrini, Chiara Fiorillo, Valentina Codemo, Guja Astrea, Adele D’Amico, Lorenzo Maggi, Francesca Magri, Marika Pane, Giorgio Tasca, Daniele Sabbatini, Luca Bello, Roberta Battini, Pia Bernasconi, Fabiana Fattori, Enrico Silvio Bertini, Giacomo Comi, Sonia Messina, Tiziana Mongini, Isabella Moroni, Chiara Panicucci, Angela Berardinelli, Alice Donati, Vincenzo Nigro, Antonella Pini, Melania Giannotta, Claudia Dosi, Enzo Ricci, Eugenio Mercuri, Giovanni Minervini, Silvio Tosatto, Filippo Santorelli, Claudio Bruno, Elena Pegoraro
The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade
Richard A. Hickman, Phyllis L. Faust, Karen Marder, Ai Yamamoto, Jean-Paul Vonsattel
Epigenetic and genomic profiling of chordoid meningioma: implications for clinical management
Elena V. Daoud, Kelsey Zhu, Bruce Mickey, Hussein Mohamed, Mandisa Wen, Michael Delorenzo, Ivy Tran, Jonathan Serrano, Kimmo J. Hatanpaa, Jack M. Raisanen, Matija Snuderl, Chunyu Cai
Impact of APOE genotype on prion-type propagation of tauopathy
Tristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, Guilian Xu, Karen McFarland, Benoit I. Giasson, Patrick Sullivan, David R. Borchelt, Paramita Chakrabarty
Correction to: Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
Bongyong Lee, Iqbal Mahmud, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett, Ranjan J. Perera
Longitudinal dynamics of microvascular recovery after acquired cortical injury
Xiaoxiao Lin, Lujia Chen, Amandine Jullienne, Hai Zhang, Arjang Salehi, Mary Hamer, Todd C. Holmes, Andre Obenaus, Xiangmin Xu
Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis
Valentina Taglietti, Kaouthar Kefi, Iwona Bronisz-Budzyńska, Busra Mirciloglu, Mathilde Rodrigues, Nastasia Cardone, Fanny Coulpier, Baptiste Periou, Christel Gentil, Melissa Goddard, François-Jérôme Authier, France Pietri-Rouxel, Edoardo Malfatti, Peggy Lafuste, Laurent Tiret, Frederic Relaix
Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Qiao Ding, Kaamini Kesavan, Kah Meng Lee, Elyse Wimberger, Thomas Robertson, Melinder Gill, Dominique Power, Jeryn Chang, Atefeh T. Fard, Jessica C. Mar, Robert D. Henderson, Susan Heggie, Pamela A. McCombe, Rosalind L. Jeffree, Michael J. Colditz, Massimo A. Hilliard, Dominic C. H. Ng, Frederik J. Steyn, William D. Phillips, Ernst J. Wolvetang, Shyuan T. Ngo, Peter G. Noakes
Correction to: Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat
Lindsey N. Campion, Alan Mejia Maza, Rachita Yadav, Ellen B. Penney, Micaela G. Murcar, Kevin Correia, Tammy Gillis, Cara Fernandez-Cerado, M. Salvie Velasco-Andrada, G. Paul Legarda, Niecy G. Ganza-Bautista, J. Benedict B. Lagarde, Patrick J. Acuña, Trisha Multhaupt-Buell, Gabrielle Aldykiewicz, Melanie L. Supnet, Jan K. De Guzman, Criscely Go, Nutan Sharma, Edwin L. Munoz, Mark C. Ang, Cid Czarina E. Diesta, D. Cristopher Bragg, Laurie J. Ozelius, Vanessa C. Wheeler
Correction to: Mical modulates Tau toxicity via cysteine oxidation in vivo
Engie Prifti, Eleni N. Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M. C. Skoulakis, Katerina Papanikolopoulou
Thoracic low grade glial neoplasm with concurrent H3 K27M and PTPN11 mutations
Michael G. Argenziano, Julia L. Furnari, Michael L. Miller, Yu Sun, Matei A. Banu, Justin A. Neira, Matija Snuderl, Jeffrey N. Bruce, Mary Welch, Paul McCormick, Peter Canoll
Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness
Lisa Gabler, Carola Nadine Jaunecker, Sonja Katz, Sushilla van Schoonhoven, Bernhard Englinger, Christine Pirker, Thomas Mohr, Petra Vician, Mirjana Stojanovic, Valentin Woitzuck, Anna Laemmerer, Dominik Kirchhofer, Lisa Mayr, Mery LaFranca, Friedrich Erhart, Sarah Grissenberger, Andrea Wenninger-Weinzierl, Caterina Sturtzel, Barbara Kiesel, Alexandra Lang, Brigitte Marian, Bettina Grasl-Kraupp, Martin Distel, Julia Schüler, Johannes Gojo, Michael Grusch, Sabine Spiegl-Kreinecker, Daniel J. Donoghue, Daniela Lötsch, Walter Berger
Deep learning from multiple experts improves identification of amyloid neuropathologies
Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White III, Atul J. Butte, Brittany N. Dugger, Michael J. Keiser
Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury
Kryslaine L. Radomski, Xiaomei Zi, Fritz W. Lischka, Mark D. Noble, Zygmunt Galdzicki, Regina C. Armstrong
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
Stefanie Rauskolb, Thomas Andreska, Sophie Fries, Cora Ruedt von Collenberg, Robert Blum, Camelia-Maria Monoranu, Carmen Villmann, Michael Sendtner
Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV
Jacinta Murray, Gregory Meloni, Etty P. Cortes, Ariadna KimSilva, Michelle Jacobs, Alyssa Ramkissoon, John F. Crary, Susan Morgello
Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma
Derek Wong, Tae Hoon Lee, Amy Lum, Valerie Lan Tao, Stephen Yip
DNA methylation as a diagnostic tool
Kristyn Galbraith, Matija Snuderl
Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages
Raquel N. Taddei, Maria V. Sanchez-Mico, Orla Bonnar, Theresa Connors, Angelica Gaona, Dominique Denbow, Matthew P. Frosch, Teresa Gómez-Isla
The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis
Anna Westerhaus, Thea Joseph, Alison J. Meyers, Yura Jang, Chan Hyun Na, Clinton Cave, Shanthini Sockanathan
Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses
Florent Marguet, Mélanie Brosolo, Gaëlle Friocourt, Fanny Sauvestre, Pascale Marcorelles, Céline Lesueur, Stéphane Marret, Bruno J. Gonzalez, Annie Laquerrière
Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis
Seong Kwon Hur, Mandana Hunter, Myrna A. Dominique, Madona Farag, Dejania Cotton-Samuel, Tahiyana Khan, John Q. Trojanowski, Krista J. Spiller, Virginia M.-Y. Lee
Clinical significance of NF2 alteration in grade I meningiomas revisited; prognostic impact integrated with extent of resection, tumour location, and Ki-67 index
Yu Teranishi, Atsushi Okano, Satoru Miyawaki, Kenta Ohara, Daiichiro Ishigami, Hiroki Hongo, Shogo Dofuku, Hirokazu Takami, Jun Mitsui, Masako Ikemura, Daisuke Komura, Hiroto Katoh, Tetsuo Ushiku, Shumpei Ishikawa, Masahiro Shin, Hirofumi Nakatomi, Nobuhito Saito
Retraction Note: Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function
Teresita L. Briones, Julie Woods, Magdalena Rogozinska
Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function
Rose B. Creed, Adeel A. Memon, Sindhu P. Komaragiri, Sandeep K. Barodia, Matthew S. Goldberg
The polyG diseases: a new disease entity
Tongling Liufu, Yilei Zheng, Jiaxi Yu, Yun Yuan, Zhaoxia Wang, Jianwen Deng, Daojun Hong
Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor
Sasi Arunachalam, Karol Szlachta, Samuel W. Brady, Xiaotu Ma, Bensheng Ju, Bridget Shaner, Heather L. Mulder, John Easton, Benjamin J. Raphael, Matthew Myers, Christopher Tinkle, Sariah J. Allen, Brent A. Orr, Cynthia J. Wetmore, Suzanne J. Baker, Jinghui Zhang
The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile
Arnault Tauziède-Espariat, Thibaut Pierre, Michel Wassef, David Castel, Florence Riant, Jacques Grill, Alexandre Roux, Johan Pallud, Edouard Dezamis, Damien Bresson, Sandro Benichi, Thomas Blauwblomme, Djallel Benzohra, Guillaume Gauchotte, Celso Pouget, Sophie Colnat-Coulbois, Karima Mokhtari, Corinne Balleyguier, Frédérique Larousserie, Volodia Dangouloff-Ros, Nathalie Boddaert, Marie-Anne Debily, Lauren Hasty, Marc Polivka, Homa Adle-Biassette, Alice Métais, Emmanuèle Lechapt, Fabrice Chrétien, Felix Sahm, Philipp Sievers, Pascale Varlet
CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols-Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang, Cristina Tomas-Zapico, Jose J. Lucas, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez-Pastor
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies
Tim E. Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N. Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Gregor Dernick, Wilma D. J. van de Berg, Markus Britschgi
Inclusion body myositis and associated diseases: an argument for shared immune pathologies
Christopher Nelke, Felix Kleefeld, Corinna Preusse, Tobias Ruck, Werner Stenzel
Pleomorphic xanthoastrocytoma in the multiverse of epigenomics: is it time to recognize the variants?
João Víctor Alves de Castro, Felipe D’Almeida Costa
Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome
Emma C. Utagawa, David G. Moreno, Kristian T. Schafernak, Nicoleta C. Arva, Michael H. Malek-Ahmadi, Elliott J. Mufson, Sylvia E. Perez
Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis
Gabrielle M. Mey, Kirsten S. Evonuk, McKenzie K. Chappell, Laura M. Wolfe, Rupesh Singh, Julia C. Batoki, Minzhong Yu, Neal S. Peachey, Bela Anand-Apte, Robert Bermel, Daniel Ontaneda, Kunio Nakamura, Kedar R. Mahajan, Tara M. DeSilva
Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation
Javier Megías, Teresa San-Miguel, Mirian Sánchez, Lara Navarro, Daniel Monleón, Silvia Calabuig-Fariñas, José Manuel Morales, Lisandra Muñoz-Hidalgo, Pedro Roldán, Miguel Cerdá-Nicolás, Concha López-Ginés
Correction to: CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols‑Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang, Cristina Tomas‑Zapico, Jose J. Lucas, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez‑Pastor
Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease
Sara Hall, Christina D. Orrù, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey, Oskar Hansson
Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway
Yann Dromard, Margarita Arango-Lievano, Amelie Borie, Maheva Dedin, Pierre Fontanaud, Joan Torrent, Michael J. Garabedian, Stephen D. Ginsberg, Freddy Jeanneteau
Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease
S. Tok, H. Maurin, C. Delay, D. Crauwels, N. V. Manyakov, W. Van Der Elst, D. Moechars, W. H. I. M. Drinkenburg
Resilience of females to acute blood–brain barrier damage and anxiety behavior following mild blast traumatic brain injury
W. Brad Hubbard, Gopal V. Velmurugan, Emily P. Brown, Patrick G. Sullivan
Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology
Giavanna Paterno, Brach M. Bell, Kimberly-Marie M. Gorion, Stefan Prokop, Benoit I. Giasson
Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10
Tian Liu, Jung-A. A. Woo, Mohammed Zaheen Bukhari, Xinming Wang, Yan Yan, Sara Cazzaro Buosi, Aizara Ermekbaeva, Apoorva Sista, Peter Kotsiviras, Patrick LePochat, Ann Chacko, Xingyu Zhao, David E. Kang
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvänen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson
Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy
Elana Molotsky, Yuhong Liu, Andrew P. Lieberman, Diane E. Merry
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
David J. Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon, Olivia G. J. Todd, Marta Leite, Johannes Attems, Tiago F. Outeiro
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan
Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia
Suzanne S. M. Miedema, Merel O. Mol, Frank T. W. Koopmans, David C. Hondius, Pim van Nierop, Kevin Menden, Christina F. de Veij Mestdagh, Jeroen van Rooij, Andrea B. Ganz, Iryna Paliukhovich, Shamiram Melhem, Ka Wan Li, Henne Holstege, Patrizia Rizzu, Ronald E. van Kesteren, John C. van Swieten, Peter Heutink, August B. Smit
Severe ACTA1-related nemaline myopathy: intranuclear rods, cytoplasmic bodies, and enlarged perinuclear space as characteristic pathological features on muscle biopsies
Clémence Labasse, Guy Brochier, Ana-Lia Taratuto, Bruno Cadot, John Rendu, Soledad Monges, Valérie Biancalana, Susana Quijano-Roy, Mai Thao Bui, Anaïs Chanut, Angéline Madelaine, Emmanuelle Lacène, Maud Beuvin, Helge Amthor, Laurent Servais, Yvan de Feraudy, Marcela Erro, Maria Saccoliti, Osorio Abath Neto, Julien Fauré, Béatrice Lannes, Vincent Laugel, Sandra Coppens, Fabiana Lubieniecki, Ana Buj Bello, Nigel Laing, Teresinha Evangelista, Jocelyn Laporte, Johann Böhm, Norma B. Romero
Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma
Feng Xu, Angela N. Viaene, Jenny Ruiz, Jeffrey Schubert, Jinhua Wu, Jiani Chen, Kajia Cao, Weixuan Fu, Rochelle Bagatell, Zhiqian Fan, Ariel Long, Luca Pagliaroli, Yiming Zhong, Minjie Luo, Portia A. Kreiger, Lea F. Surrey, Gerald B. Wertheim, Kristina A. Cole, Marilyn M. Li, Mariarita Santi, Phillip B. Storm
Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures
Rebecca R. Valentino, Chloe Ramnarine, Michael G. Heckman, Patrick W. Johnson, Alexandra I. Soto-Beasley, Ronald L. Walton, Shunsuke Koga, Koji Kasanuki, Melissa E. Murray, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard, Neill R. Graff-Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross
Correction to: Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis
Gabrielle M. Mey, Kirsten S. Evonuk, McKenzie K. Chappell, Laura M. Wolfe, Rupesh Singh, Julia C. Batoki, Minzhong Yu, Neal S. Peachey, Bela Anand‑Apte, Robert Bermel, Daniel Ontaneda, Kunio Nakamura, Kedar R. Mahajan, Tara M. DeSilva
DNA methylation alterations across time and space in paediatric brain tumours
Anna Wenger, Sandra Ferreyra Vega, Elizabeth Schepke, Maja Löfgren, Thomas Olsson Bontell, Magnus Tisell, Daniel Nilsson, Teresia Kling, Helena Carén
Widespread alterations in microRNA biogenesis in human Huntington’s disease putamen
Serena Petry, Rémi Keraudren, Behnaz Nateghi, Andréanne Loiselle, Karolina Pircs, Johan Jakobsson, Chantelle Sephton, Mélanie Langlois, Isabelle St-Amour, Sébastien S. Hébert
Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
Sarah Pickles, Tania F. Gendron, Yuka Koike, Mei Yue, Yuping Song, Jennifer M. Kachergus, J. Shi, Michael DeTure, E. Aubrey Thompson, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Zbigniew K. Wszolek, Keith A. Josephs, Dennis W. Dickson, Leonard Petrucelli, Casey N. Cook, Mercedes Prudencio
Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature
Helen C. Murray, Chelsie Osterman, Paige Bell, Luca Vinnell, Maurice A. Curtis
Novel rapid intraoperative qualitative tumor detection by a residual convolutional neural network using label-free stimulated Raman scattering microscopy
David Reinecke, Niklas von Spreckelsen, Christian Mawrin, Adrian Ion-Margineanu, Gina Fürtjes, Stephanie T. Jünger, Florian Khalid, Christian W. Freudiger, Marco Timmer, Maximilian I. Ruge, Roland Goldbrunner, Volker Neuschmelting
Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease
Connor M. Wander, Tamy Harumy Moraes Tsujimoto, John F. Ervin, Chanung Wang, Spencer M. Maranto, Vanya Bhat, Julian D. Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K. Scott, David M. Holtzman, Todd J. Cohen
Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology
Adam Martersteck, Ivan Ayala, Daniel T. Ohm, Callen Spencer, Christina Coventry, Sandra Weintraub, Eileen H. Bigio, M. -Marsel Mesulam, Changiz Geula, Emily Rogalski
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Suzanne Lam, Anne-Sophie Hérard, Susana Boluda, Fanny Petit, Sabiha Eddarkaoui, Karine Cambon, Franck Letournel, Marie-Laure Martin-Négrier, Maxime Faisant, Catherine Godfraind, Jean Boutonnat, Claude-Alain Maurage, Vincent Deramecourt, Mathilde Duchesne, David Meyronet, Tanguy Fenouil, André Mauès de Paula, Valérie Rigau, Fanny Vandenbos-Burel, Danielle Seilhean, Charles Duyckaerts, Susana Boluda, Isabelle Plu, Dan Christian Chiforeanu, Annie Laquerrière, Florent Marguet, Béatrice Lannes, Benoît Lhermitte, Jean-Luc Picq, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Marc Dhenain
Modeling the early stages of Alzheimer’s disease by administering intracerebroventricular injections of human native Aβ oligomers to rats
Eva Baerends, Katia Soud, Jonas Folke, Anna-Kathrine Pedersen, Simon Henmar, Lisa Konrad, Matthew D. Lycas, Yuki Mori, Bente Pakkenberg, David P. D. Woldbye, Oksana Dmytriyeva, Stanislava Pankratova
Sporadic Creutzfeldt-Jakob disease VM1: phenotypic and molecular characterization of a novel subtype of human prion disease
Ellen Gelpi, Simone Baiardi, Carlos Nos, Sofia Dellavalle, Iban Aldecoa, Raquel Ruiz-Garcia, Lourdes Ispierto, Domingo Escudero, Virgina Casado, Elena Barranco, Anuncia Boltes, Laura Molina-Porcel, Nuria Bargalló, Marcello Rossi, Angela Mammana, Dorina Tiple, Luana Vaianella, Elisabeth Stoegmann, Ingrid Simonitsch-Klupp, Gregor Kasprian, Sigrid Klotz, Romana Höftberger, Herbert Budka, Gabor G. Kovacs, Isidre Ferrer, Sabina Capellari, Raquel Sanchez-Valle, Piero Parchi
Chromosomal instability in adult-type diffuse gliomas
Timothy E. Richardson, Jamie M. Walker, Kalil G. Abdullah, Samuel K. McBrayer, Mariano S. Viapiano, Zarmeen M. Mussa, Nadejda M. Tsankova, Matija Snuderl, Kimmo J. Hatanpaa
C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner
YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma
Matthias A. Karajannis, Bryan K. Li, Mark M. Souweidane, Benjamin Liechty, JinJuan Yao, Jamal K. Benhamida, Tejus A. Bale, Marc K. Rosenblum
Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients
Carola Rutigliani, James R. Tribble, Anna Hagström, Emma Lardner, Gauti Jóhannesson, Gustav Stålhammar, Pete A. Williams
Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge!
Arnault Tauziède-Espariat, Aurore Siegfried, Emmanuelle Uro-Coste, Yvan Nicaise, David Castel, Annick Sevely, Marion Gambart, Sergio Boetto, Lauren Hasty, Alice Métais, Fabrice Chrétien, Joseph Benzakoun, Stéphanie Puget, Jacques Grill, Volodia Dangouloff-Ros, Nathalie Boddaert, Azadeh Ebrahimi, Pascale Varlet
Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling
Corina Anastasaki, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne M. Scheaffer, Amanda De Andrade Costa, Anna F. Wilson, Chloe M. Kernan, Ameera H. Zafar, Xia Ge, Joel R. Garbow, Fausto J. Rodriguez, David H. Gutmann
BDNF-dependent modulation of axonal transport is selectively impaired in ALS
Andrew P. Tosolini, James N. Sleigh, Sunaina Surana, Elena R. Rhymes, Stephen D. Cahalan, Giampietro Schiavo
Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration
Benjamin G. Trist, Jennifer A. Fifita, Alison Hogan, Natalie Grima, Bradley Smith, Claire Troakes, Caroline Vance, Christopher Shaw, Safa Al-Sarraj, Ian P. Blair, Kay L. Double
Redefining germline predisposition in children with molecularly characterized ependymoma: a population-based 20-year cohort
Jon Foss-Skiftesvik, Ulrik Kristoffer Stoltze, Thomas van Overeem Hansen, Lise Barlebo Ahlborn, Erik Sørensen, Sisse Rye Ostrowski, Solvej Margrete Aldringer Kullegaard, Adrian Otamendi Laspiur, Linea Cecilie Melchior, David Scheie, Bjarne Winther Kristensen, Jane Skjøth-Rasmussen, Kjeld Schmiegelow, Karin Wadt, René Mathiasen
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants
Lisa Bauer, Melanie Rissmann, Feline F. W. Benavides, Lonneke Leijten, Peter van Run, Lineke Begeman, Edwin J. B. Veldhuis Kroeze, Bas Lendemeijer, Hilde Smeenk, Femke M. S. de Vrij, Steven A. Kushner, Marion P. G. Koopmans, Barry Rockx, Debby van Riel
Progression of Alzheimer's disease parallels unusual structural plasticity of human dentate granule cells
B. Márquez-Valadez, A. Rábano, M. Llorens-Martín
Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche
Jiaxin Li, Fredrik Ek, Roger Olsson, Mattias Belting, Johan Bengzon
α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression
Cheryl A. Hawkes, Christopher J. Heath, Matthew M. Sharp, Dariusz C. Górecki, Roxana O. Carare
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
Marta J. Koper, Sandra O. Tomé, Klara Gawor, Annelies Belet, Evelien Van Schoor, Jolien Schaeverbeke, Rik Vandenberghe, Mathieu Vandenbulcke, Estifanos Ghebremedhin, Markus Otto, Christine A. F. von Arnim, Sriram Balusu, Matthew B. Blaschko, Bart De Strooper, Dietmar Rudolf Thal
Lymphatic vessels are present in human saccular intracranial aneurysms
Nora Huuska, Eliisa Netti, Satu Lehti, Petri T. Kovanen, Mika Niemelä, Riikka Tulamo
Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits
Ilknur Özen, Hongcheng Mai, Alessandro De Maio, Karsten Ruscher, Georgios Michalettos, Fredrik Clausen, Michael Gottschalk, Saema Ansar, Sertan Arkan, Ali Erturk, Niklas Marklund
Interpretable deep learning of myelin histopathology in age-related cognitive impairment
Andrew T. McKenzie, Gabriel A. Marx, Daniel Koenigsberg, Mary Sawyer, Megan A. Iida, Jamie M. Walker, Timothy E. Richardson, Gabriele Campanella, Johannes Attems, Ann C. McKee, Thor D. Stein, Thomas J. Fuchs, Charles L. White III, Jean-Paul Vonsattel, Andy F. Teich, Marla Gearing, Jonathan Glass, Juan C. Troncoso, Matthew P. Frosch, Bradley T. Hyman, Dennis W. Dickson, Melissa E. Murray, Johannes Attems, Margaret E. Flanagan, Qinwen Mao, M.-Marsel Mesulam, Sandra Weintraub, Randy L. Woltjer, Thao Pham, Julia Kofler, Julie A. Schneider, Lei Yu, Dushyant P. Purohit, Vahram Haroutunian, Patrick R. Hof, Sam Gandy, Mary Sano, Thomas G. Beach, Wayne Poon, Claudia Kawas, María Corrada, Robert A. Rissman, Jeff Metcalf, Sara Shuldberg, Bahar Salehi, Peter T. Nelson, John Q. Trojanowski, Edward B. Lee, David A. Wolk, Corey T. McMillan, C. Dirk Keene, Caitlin S. Latimer, Thomas J. Montine, Gabor G. Kovacs, Mirjam I. Lutz, Peter Fischer, Richard J. Perrin, Nigel J. Cairns, Erin E. Franklin, Ping Shang, Jeff Harris, Chan Foong, Kurt Farrell, John F. Crary
Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
Nana Jin, Jianlan Gu, Ruozhen Wu, Dandan Chu, Yunn Chyn Tung, Jerzy Wegiel, Thomas Wisniewski, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
Hiroaki Sekiya, Asato Tsuji, Yuki Hashimoto, Mariko Takata, Shunsuke Koga, Katsuya Nishida, Naonobu Futamura, Michi Kawamoto, Nobuo Kohara, Dennis W. Dickson, Hisatomo Kowa, Tatsushi Toda
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
Christina E. Toomey, Wendy E. Heywood, James R. Evans, Joanne Lachica, Sarah N. Pressey, Sandrine C. Foti, Mesfer Al Shahrani, Karishma D’Sa, Iain P. Hargreaves, Simon Heales, Michael Orford, Claire Troakes, Johannes Attems, Ellen Gelpi, Miklos Palkovits, Tammaryn Lashley, Steve M. Gentleman, Tamas Revesz, Kevin Mills, Sonia Gandhi
Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Issa O. Yusuf, Tao Qiao, Sepideh Parsi, Ronak Tilvawala, Paul R. Thompson, Zuoshang Xu
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia
Haoshen Shi, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R. Davis, Jered W. Wilson, Milica A. Margeta, Kristen M. Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L. Graham, Vivek K. Gupta, Keith L. Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaoui
Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis
Cassandra Mariet, David Castel, Jacques Grill, Raphaël Saffroy, Volodia Dangouloff-Ros, Nathalie Boddaert, Francisco Llamas-Guttierrez, Céline Chappé, Stéphanie Puget, Lauren Hasty, Fabrice Chrétien, Alice Métais, Pascale Varlet, Arnault Tauziède-Espariat
Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours
Ashutosh Rai, Soujanya D. Yelamanchi, Bishan D. Radotra, Sunil K. Gupta, Kanchan K. Mukherjee, Manjul Tripathi, Rajesh Chhabra, Chirag K. Ahuja, Narendra Kumar, Akhilesh Pandey, Márta Korbonits, Pinaki Dutta, Carles Gaston-Massuet
TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome
Luis Gustavo Perez-Rivas, Julia Simon, Adriana Albani, Sicheng Tang, Sigrun Roeber, Guillaume Assié, Timo Deutschbein, Martin Fassnacht, Monica R. Gadelha, Ad R. Hermus, Günter K. Stalla, Maria A. Tichomirowa, Roman Rotermund, Jörg Flitsch, Michael Buchfelder, Isabella Nasi-Kordhishti, Jürgen Honegger, Jun Thorsteinsdottir, Wolfgang Saeger, Jochen Herms, Martin Reincke, Marily Theodoropoulou
Unraveling axonal mechanisms of traumatic brain injury
Victorio M. Pozo Devoto, Valentina Lacovich, Monica Feole, Pratiksha Bhat, Jaroslav Chovan, Maria Čarna, Isaac G. Onyango, Neda Dragišić, Martina Sűsserová, Martin E. Barrios-Llerena, Gorazd B. Stokin
Letter to the editor on a paper by Kaivola et al. (2020): carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is not associated with amyotrophic lateral sclerosis or frontotemporal dementia
Sterre C. M. de Boer, Lauren Woolley, Merel O. Mol, Maria Serpente, Lianne M. Reus, Rick van Minkelen, Joke F. A. van Vugt, Federica Sorrentino, Jan H. Veldink, Harro Seelaar, Daniela Galimberti, Fred van Ruissen, Simon Mead, Ekaterina Rogaeva, Yolande A. L. Pijnenburg, Sven J. van der Lee
The neuropathologic findings in a case of progressive cavitating leukoencephalopathy due to NDUFV1 pathogenic variants
Nicole Becker, Aditi Sharma, Matthew Gosse, Brooke Kubat, Kyle S. Conway
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova, Miroslav Koblizek, Josef Zamecnik, Martin Kyncl, Zuzana Holubova, Petr Liby, Jakub Taborsky, Vladimir Benes III, Ivana Pernikova, David T. W. Jones, Martin Sill, Terezia Stancokova, Lenka Krskova, Michal Zapotocky
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Alireza Faridar, Matthew Vasquez, Aaron D. Thome, Zheng Yin, Hui Xuan, Jing Hong Wang, Shixiang Wen, Xuping Li, Jason R. Thonhoff, Weihua Zhao, Hong Zhao, David R. Beers, Stephen T. C. Wong, Joseph C. Masdeu, Stanley H. Appel
Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina
Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek Robin Hsiung, Geoffrey Charm, Elliott F. To, Alice Q. Liu, Katerina Schwab, Kailun Jiang, Marinko Sarunic, Mirza Faisal Beg, Wellington Pham, Jing Cui, Eleanor To, Sieun Lee, Joanne A. Matsubara
Tau seeding in cases of multiple sclerosis
Michael S. LaCroix, Hilda Mirbaha, Ping Shang, Stephanie Zandee, Chan Foong, Alexandre Prat, Charles L. White III, Olaf Stuve, Marc I. Diamond
Impact of gulf war toxic exposures after mild traumatic brain injury
Scott Ferguson, Robyn McCartan, Mackenzie Browning, Coral Hahn-Townsend, Arissa Gratkowski, Alexander Morin, Laila Abdullah, Ghania Ait-Ghezala, Joseph Ojo, Kimberly Sullivan, Michael Mullan, Fiona Crawford, Benoit Mouzon
Plasma proteome profiling identifies changes associated to AD but not to FTD
R. Babapour Mofrad, M. del Campo, C. F. W. Peeters, L. H. H. Meeter, H. Seelaar, M. Koel-Simmelink, I. H. G. B. Ramakers, H. A. M. Middelkoop, P. P. De Deyn, J. A. H. R. Claassen, J. C. van Swieten, C. Bridel, J. J. M. Hoozemans, P. Scheltens, W. M. van der Flier, Y. A. L. Pijnenburg, Charlotte E. Teunissen
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Balagopal Pai, Jessica Tome-Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma
Guisheng Zhao, Patrick Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin S. Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri, Javad Nazarian, Michael E. Pacold, Daniel J. Brat, Theodore Nicolaides, Bin Chen, Rintaro Hashizume
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma
Ahmad Joshkon, Emeline Tabouret, Wael Traboulsi, Richard Bachelier, Stéphanie Simoncini, Sandrine Roffino, Carine Jiguet-Jiglaire, Bassam Badran, Benjamin Guillet, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Françoise Dignat-George, Olivier Chinot, Hussein Fayyad-Kazan, Nathalie Bardin, Marcel Blot-Chabaud
Inclusion body myositis and Sjögren’s syndrome: the association works both ways
Margherita Giannini, Renaud Felten, Jacques-Eric Gottenberg, Bernard Geny, Alain Meyer
Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer’s amyloid pathology
Anastasiia A. Stepanchuk, Megan L. Morgan, Jeffrey T. Joseph, Peter K. Stys
Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy
Miriam L. Fichtner, Kenneth B. Hoehn, Easton E. Ford, Marina Mane-Damas, Sangwook Oh, Patrick Waters, Aimee S. Payne, Melissa L. Smith, Corey T. Watson, Mario Losen, Pilar Martinez-Martinez, Richard J. Nowak, Steven H. Kleinstein, Kevin C. O’Connor
The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
Nina C. Teske, Joo-Yeon Engelen-Lee, Susanne Dyckhoff-Shen, Hans-Walter Pfister, Matthias Klein, Diederik van de Beek, Carsten K. Kirschning, Uwe Koedel, Matthijs C. Brouwer
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex
Zsofia I. Laszlo, Nicole Hindley, Anna Sanchez Avila, Rachel A. Kline, Samantha L. Eaton, Douglas J. Lamont, Colin Smith, Tara L. Spires-Jones, Thomas M. Wishart, Christopher M. Henstridge
Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
Gabriel A. Marx, Daniel G. Koenigsberg, Andrew T. McKenzie, Justin Kauffman, Russell W. Hanson, Kristen Whitney, Maxim Signaevsky, Marcel Prastawa, Megan A. Iida, Charles L. White III, Jamie M. Walker, Timothy E. Richardson, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, John F. Crary, Kurt Farrell
Single-cell spatial proteomic imaging for human neuropathology
Kausalia Vijayaragavan, Bryan J. Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J. P. Oliveria, Syed A. Bukhari, Dunja Mrdjen, M. Ryan Corces, Erin F. McCaffrey, Noah F. Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S. Montine, R. Michael Angelo, Thomas J. Montine, Sean C. Bendall
Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation
Nelli S. Lakis, Alexander S. Brodsky, Galina Karashchuk, Amanda J. Audesse, Dongfang Yang, Ashlee Sturtevant, Kara Lombardo, Ian Y. Wong, Ashley E. Webb, Douglas C. Anthony
A case of primary optic pathway demyelination caused by oncocytic oligodendrogliopathy of unknown origin
Simon Hametner, Sara Silvaieh, Majda Thurnher, Assunta Dal-Bianco, Hakan Cetin, Markus Ponleitner, Karin Zebenholzer, Berthold Pemp, Siegfried Trattnig, Karl Rössler, Thomas Berger, Hans Lassmann, Johannes A. Hainfellner, Gabriel Bsteh
Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease
Jessy A. Slota, Babu V. Sajesh, Kathy F. Frost, Sarah J. Medina, Stephanie A. Booth
Correction to: Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova, Miroslav Koblizek, Josef Zamecnik, Martin Kyncl, Zuzana Holubova, Petr Liby, Jakub Taborsky, Vladimir Benes III, Ivana Pernikova, David T. W. Jones, Martin Sill, Terezia Stancokova, Lenka Krskova, Michal Zapotocky
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders
Melek Firat Altay, Alan King Lun Liu, Janice L. Holton, Laura Parkkinen, Hilal A. Lashuel
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease
Meaghan Morris, Abhay Moghekar, Haidan Guo, Olga Pletnikova, Javier Redding-Ochoa, Marilyn Albert, Susan M. Resnick, Liam Chen
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
YuHong Fu, Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, Ping Wu, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim
The hippocampal sparing subtype of Alzheimer’s disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review
Daniel Ferreira, Rosaleena Mohanty, Melissa E. Murray, Agneta Nordberg, Kejal Kantarci, Eric Westman
Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology
Cheyanne C. Slocum, Hyeon Jin Park, Inji Baek, Jeff Catalano, Martin T. Wells, Benjamin Liechty, Susan Mathew, Wei Song, James P. Solomon, David J. Pisapia
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
Jesse J. Westfall, Wesley N. Schwind, Sahibjot Sran, Jason B. Navarro, Jeffrey Leonard, Jonathan A. Pindrik, Christopher R. Pierson, Daniel R. Boué, Daniel C. Koboldt, Adam P. Ostendorf, Richard K. Wilson, Elaine R. Mardis, Katherine E. Miller, Tracy A. Bedrosian
The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias
Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao
Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson’s-like pathology burden
Vedad Delic, Joshua H. Karp, Maynard Guzman, Gabriel R. Arismendi, Katherine J. Stalnaker, Julia A. Burton, Kathleen E. Murray, Joshua P. Stamos, Kevin D. Beck, Arpine Sokratian, Andrew B. West, Bruce A. Citron
Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Balagopal Pai, Jessica Tome‑Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
CTCF loss induces giant lamellar bodies in Purkinje cell dendrites
Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi
Response to the letter by de Boer et al. (2022)
Karri Kaivola, Pentti J. Tienari
Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain
Anna-Lena Lang, Tiffany Eulalio, Eddie Fox, Koya Yakabi, Syed A. Bukhari, Claudia H. Kawas, Maria M. Corrada, Stephen B. Montgomery, Frank L. Heppner, David Capper, Daniel Nachun, Thomas J. Montine
Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients
Zeliha Gözde Turan, Vincent Richter, Jana Bochmann, Poorya Parvizi, Etka Yapar, Ulas Işıldak, Sarah-Kristin Waterholter, Sabrina Leclere-Turbant, Çağdaş Devrim Son, Charles Duyckaerts, İdil Yet, Thomas Arendt, Mehmet Somel, Uwe Ueberham
Intranuclear inclusions in muscle biopsy can differentiate oculopharyngodistal myopathy and oculopharyngeal muscular dystrophy
Masashi Ogasawara, Nobuyuki Eura, Aritoshi Iida, Theerawat Kumutpongpanich, Narihiro Minami, Ikuya Nonaka, Shinichiro Hayashi, Satoru Noguchi, Ichizo Nishino
Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient
Rie Saito, Yui Tada, Daisuke Oikawa, Yusuke Sato, Makiko Seto, Akira Satoh, Kodai Kume, Nozomi Ueki, Masahiro Nakashima, Shintaro Hayashi, Yasuko Toyoshima, Fuminori Tokunaga, Hideshi Kawakami, Akiyoshi Kakita
Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study
Anna Raunio, Ville Kivistö, Mia Kero, Jarno Tuimala, Sara Savola, Minna Oinas, Eloise Kok, Kia Colangelo, Anders Paetau, Tuomo Polvikoski, Pentti J. Tienari, Henri Puttonen, Liisa Myllykangas
Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model
Enric Vidal, Manuel A. Sánchez-Martín, Hasier Eraña, Sonia Pérez Lázaro, Miguel A. Pérez-Castro, Alicia Otero, Jorge M. Charco, Belén Marín, Rafael López-Moreno, Carlos M. Díaz-Domínguez, Mariví Geijo, Montserrat Ordóñez, Guillermo Cantero, Michele di Bari, Nuria L. Lorenzo, Laura Pirisinu, Claudia d’Agostino, Juan María Torres, Vincent Béringue, Glenn Telling, Juan J. Badiola, Martí Pumarola, Rosa Bolea, Romolo Nonno, Jesús R. Requena, Joaquín Castilla
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
Jennifer L. Brown, Damyan W. Hart, Gabriel E. Boyle, Taylor G. Brown, Michael LaCroix, Andrés M. Baraibar, Ross Pelzel, Minwoo Kim, Mathew A. Sherman, Samuel Boes, Michelle Sung, Tracy Cole, Michael K. Lee, Alfonso Araque, Sylvain E. Lesné
Genomic, transcriptomic and RNA editing analysis of human MM1 and VV2 sporadic Creutzfeldt-Jakob disease
Martina Tarozzi, Simone Baiardi, Claudia Sala, Anna Bartoletti-Stella, Piero Parchi, Sabina Capellari, Gastone Castellani
Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease
Zhiqun Tan, B. Maximiliano Garduño, Pedro Fernández Aburto, Lujia Chen, Nicole Ha, Patricia Cogram, Todd C. Holmes, Xiangmin Xu
Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells
Ugne Dubonyte, Andrea Asenjo-Martinez, Thomas Werge, Kasper Lage, Agnete Kirkeby
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway
Zongyi Wang, Xinliang Wang, Lingyu Shi, Yuan Cai, Bing Hu
NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
Natasha Ranu, Jenni Laitila, Hannah F. Dugdale, Jennifer Mariano, Justin S. Kolb, Carina Wallgren-Pettersson, Nanna Witting, John Vissing, Juan Jesus Vilchez, Chiara Fiorillo, Edmar Zanoteli, Mari Auranen, Manu Jokela, Giorgio Tasca, Kristl G. Claeys, Nicol C. Voermans, Johanna Palmio, Sanna Huovinen, Maurizio Moggio, Thomas Nyegaard Beck, Aikaterini Kontrogianni-Konstantopoulos, Henk Granzier, Julien Ochala
Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases
Sonal Agrawal, Jose M. Farfel, Konstantinos Arfanakis, Lena Al-Harthi, Tanner Shull, Tara L. Teppen, Arnold M. Evia, Mayur B. Patel, E. Wesley Ely, Sue. E. Leurgans, David A. Bennett, Rupal Mehta, Julie A. Schneider
The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage
Yanrong Sun, E. Liu, Yanhong Pei, Qinhan Yao, Haowen Ma, Yakun Mu, Yingjie Wang, Yan Zhang, Xiaomei Yang, Xing Wang, Jiajia Xue, Jiliang Zhai, Roxana O. Carare, Lihua Qin, Junhao Yan
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Shuo Chen, Yuzhou Chang, Liangping Li, Diana Acosta, Yang Li, Qi Guo, Cankun Wang, Emir Turkes, Cody Morrison, Dominic Julian, Mark E. Hester, Douglas W. Scharre, Chintda Santiskulvong, Sarah XueYing Song, Jasmine T. Plummer, Geidy E. Serrano, Thomas G. Beach, Karen E. Duff, Qin Ma, Hongjun Fu
Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor
Samuele Negro, Fabio Lauria, Marco Stazi, Toma Tebaldi, Giorgia D’Este, Marco Pirazzini, Aram Megighian, Francesca Lessi, Chiara M. Mazzanti, Gabriele Sales, Chiara Romualdi, Silvia Fillo, Florigio Lista, James N. Sleigh, Andrew P. Tosolini, Giampietro Schiavo, Gabriella Viero, Michela Rigoni
Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Merel O. Mol, Suzanne S. M. Miedema, Shamiram Melhem, Ka Wan Li, Frank Koopmans, Harro Seelaar, Kurt Gottmann, Volkmar Lessmann, Netherlands Brain Bank, August B. Smit, John C. van Swieten, Jeroen G. J. van Rooij