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Astrocytoma 

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  1. 10-04-2024 | Astrocytoma | Letter

    Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma

  2. 01-06-2024 | Astrocytoma | BriefCommunication

    Methylation class oligosarcoma, IDH-mutant could exhibit astrocytoma-like molecular features

  3. 01-04-2024 | Astrocytoma | Online First

    Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma

    Diffuse gliomas are the most frequent and aggressive primary brain tumors in adults. The 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) implemented the integrated diagnosis, incorporating …

  4. 24-01-2024 | Astrocytoma | OriginalPaper

    CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization

    Cyclin Dependent Kinase inhibitor ( CDKN2A / B) genes, play a pivotal role in the surveillance of cell cycle progression via p16/INK4a, p14/ARF and p15 proteins [ 1 ]. Inactivating alterations like homo/hemizygous deletion, point mutation …

  5. 15-02-2024 | Astrocytoma | Erratum

    Correction to: CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization

  6. Open Access 07-02-2024 | Astrocytoma | OriginalPaper

    Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas

    IDH wildtype (wt) astrocytomas, despite being considered as WHO grade II or III based on histologic criteria alone (e.g., no microvascular proliferation or necrosis), have poorer overall survival (OS) when compared with IDH mutated astrocytomas …

  7. Open Access 01-12-2024 | Tuberous Sclerosis | OriginalPaper

    Subependymal giant cell astrocytoma as presentation of tuberous sclerosis: a case report

    Subependymal giant cell astrocytoma (SEGA) is a low-grade, slow-growing tumour usually arising in the wall of lateral ventricle. Majority are sporadic due to somatic mutation. The incidence rate of SEGA among patients with confirmed tuberous …

  8. Open Access 01-06-2024 | Astrocytoma | OriginalPaper

    Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma

    Prognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease characteristics, prognostic markers, and outcome in patients with this newly …

  9. Open Access 22-12-2023 | Astrocytoma | Letter

    Response to: Trigeminal nerve chronic motor denervation caused by cerebellar peduncle pilocytic astrocytoma

  10. Open Access 01-02-2024 | Glioblastoma | OriginalPaper

    A subregion-based RadioFusionOmics model discriminates between grade 4 astrocytoma and glioblastoma on multisequence MRI

    Glioblastoma (GBM) is the most aggressive and malignant adult brain tumor that has a poor prognosis (Singh et al. 2021 ). According to the 2016 edition of the World Health Organization (WHO) classification criterion, gliomas can be grouped as per …

  11. 25-10-2023 | Magnetic Resonance Imaging | OriginalPaper

    The use of sodium MRI in the diagnosis of an anaplastic astrocytoma during immunotherapy: a case report

    Gliomas in the pediatric population are targeted with immune-modulating therapies. The gold standard imaging modality for diagnosis and monitoring treatment response is magnetic resonance imaging (MRI); however, the complex post-therapy-induced …

  12. 23-09-2023 | Astrocytoma | OriginalPaper

    Proton MR spectroscopy shows improved performance to segregate high-grade astrocytoma subgroups when defined with the new 2021 World Health Organization classification of central nervous system tumors

    The World Health Organization (WHO) launched the fifth edition of the classification of tumors of the central nervous system (CNS) at the end of 2021 [ 1 , 2 ]. This new classification introduces major changes that advance the role of molecular …

  13. Open Access 23-01-2024 | Glioblastoma | OriginalPaper

    Phase I study targeting newly diagnosed grade 4 astrocytoma with bispecific antibody armed T cells (EGFR BATs) in combination with radiation and temozolomide

    Glioblastoma (GBM) is the most frequent type of primary malignant brain tumor, with an estimated 13,000 new cases in the US in 2023 [ 1 ]. Despite standard surgical resection followed by radiation therapy (RT) and temozolomide (TMZ), the median …

  14. Open Access 29-01-2024 | Oligodendroglioma | Online First

    Differentiating IDH-mutant astrocytomas and 1p19q-codeleted oligodendrogliomas using DSC-PWI: high performance through cerebral blood volume and percentage of signal recovery percentiles

    The imaging-based presurgical differentiation between astrocytomas and oligodendrogliomas represents an unsolved challenge in neuro-oncology. This differentiation has potential implications for diagnosis and initial patient management in several …

  15. 06-11-2023 | OriginalPaper

    NMDA Glutamate Receptor Expression Activity in Anaplastic Astrocytomas

    Objectives. To study the relationship between the expression activity of NMDA glutamate receptors and the proliferative activity and genetic properties of anaplastic astrocytomas, as well as the survival of patients with this disease. Materials …

  16. Open Access 24-11-2023 | Astrocytoma | OriginalPaper

    Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow

    Low-grade gliomas (pLGG) are the most common pediatric brain tumors and account for about 30% of all pediatric brain tumors [ 1 ]. pLGG, commonly displaying a hallmark MAPK activation, comprise a set of different WHO grade I and II entities [ 2 ].

  17. Open Access 01-12-2023 | Astrocytoma | OriginalPaper

    Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting

    As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this process is of paramount importance for improved patient care. In this project, we analyzed matched …

  18. Open Access 15-01-2024 | Astrocytoma | OriginalPaper

    Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted

    Isocitrate dehydrogenase (IDH) enzymes play a key role in glioma tumorigenesis [ 1 ]. A previous study revealed that IDH mutations were more frequently observed in diffuse low-grade gliomas, including astrocytomas and oligodendrogliomas [ 2 ]. The …

  19. Open Access 01-12-2023 | Astrocytoma | OriginalPaper

    Primary pilocytic astrocytoma of cerebello-pontine angle in the pediatric age group: literature review and case report

    Pilocytic astrocytoma constitutes 5–10% of primary pediatric tumors and is the most common intrinsic brain tumor in this age group. It is seen mostly in the cerebellum, brainstem, optic pathway, hypothalamus, and rarely in the cerebellopontine …

  20. Open Access 01-12-2023 | Astrocytoma | OriginalPaper

    Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma

    In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive. Here, we report a unique case of IDH2 mutant astrocytoma, CNS WHO grade 3 that developed tumor …

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