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Ependymoma 

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  1. Open Access 01-12-2024 | Ependymoma | OriginalPaper

    CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas

    A novel methylation class, “neuroepithelial tumor, with PLAGL1 fusion” (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor with recurrent histopathological features suggesting an …

  2. Open Access 01-12-2024 | Schwannoma | OriginalPaper

    Convolutional neural network-based magnetic resonance image differentiation of filum terminale ependymomas from schwannomas

    Filum terminale ependymomas (FTEs) are common primary spinal cord tumours of the lumbosacral segment, and their incidence is secondary only to that of schwannomas [ 1 , 2 ]. Spinal magnetic resonance (MR) is the state-of-the-art method for …

  3. 02-01-2024 | Ependymoma | OriginalPaper

    Supratentorial extra-ventricular ependymoma as a mass lesion in a child: report and literature review

    Supratentorial extra-ventricular ependymoma (SEE) are extremely rare in pediatric population and have varied presentation based on size, location, epicentre and compression on neurovascular structure. The authors report a 7-year-old girl …

  4. Open Access 04-03-2024 | Ependymoma | Online First

    Clinical presentation and extent of resection impacts progression-free survival in spinal ependymomas

    Spinal ependymomas are the most common glial spinal tumor in adults comprising up to 60% of intramedullary neoplasms [ 1 , 2 ]. Ependymomas derive from the ependymal cell lining within the central spinal canal and filum terminale and are generally …

  5. Open Access 01-12-2024 | Ependymoma | OriginalPaper

    Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma

    Brain tumors are the leading cause of cancer-related deaths in children [ 1 ]. Although advances in surgery and adjuvant therapy have improved survival of children with medulloblastoma and low-grade glioma (LGG), whose 5-year survival rate is now …

  6. Open Access 01-12-2024 | Ependymoma | OriginalPaper

    Pediatric spinal ependymoma with chromothripsis of chromosome 6: a case report and review of the literature 

    Ependymomas (EPNS) can develop anywhere along the neuroaxis, and recent data suggest they may arise from radial glial cells [ 1 ]. They are the third most common central nervous system (CNS) tumor in the pediatric population [ 2 ], representing …

  7. Open Access 01-06-2024 | Ependymoma | OriginalPaper

    Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas

    The diagnosis of ependymoma has moved from a purely histopathological review with limited prognostic value to an integrated diagnosis, relying heavily on molecular information. However, as the integrated approach is still novel and some molecular …

  8. Open Access 01-06-2024 | Ependymoma | OriginalPaper

    Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology

    Posterior fossa type A (PF-EPN-A, PFA) ependymoma are aggressive tumors that mainly affect children and have a poor prognosis. Histopathology shows significant intratumoral heterogeneity, ranging from loose tissue to often sharply demarcated …

  9. 24-02-2024 | Ependymoma | OriginalPaper

    Whole-tumor histogram analysis of postcontrast T1-weighted and apparent diffusion coefficient in predicting the grade and proliferative activity of adult intracranial ependymomas

    Ependymomas originate from the ependymal lining of the ventricles, cerebral hemispheres, and central canal of the spinal cord, representing approximately 7% of all primary central nervous system (CNS) tumors with an increasing incidence [ 1 ].

  10. Open Access 01-06-2024 | Ependymoma | OriginalPaper

    Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation

    Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class “spinal ependymoma” (SP-EPN) represent the most common intramedullary neoplasms in children and adults.

  11. 02-09-2023 | Ependymoma | OriginalPaper

    Imaging features to distinguish posterior fossa ependymoma subgroups

    Ependymal tumors are neuroepithelial malignancies of the central nervous system (CNS) that occur in both children and adults [ 1 ]. These tumors can arise along the entire neuroaxis, comprising the hemispheres, hindbrain, and spinal cord. In …

  12. 27-10-2023 | Ependymoma | OriginalPaper

    Lateral-type posterior fossa ependymomas in pediatric patients: a national collaborative study

    Central nervous system tumors constitute the most common tumors in pediatric patients, with an incidence of 5.74 cases per 100,000 pediatric population. Ependymomas are uncommon tumors which barely represent 5% of primary central nervous system …

  13. 17-10-2023 | Ependymoma | Letter

    Superficial siderosis of the central nervous system caused by myxopapillary ependymoma of cauda equine: a case report

  14. 06-12-2023 | Ependymoma | OriginalPaper

    RFX2 promotes tumor cell stemness through epigenetic regulation of PAF1 in spinal ependymoma

    Ependymal tumors are neuroepithelial neoplasms that frequently grow attached to ventricles or to the central canal of the spinal cord which principally occur in children, but may also disturb adults [ 1 ]. Patients with spinal ependymoma (SE) …

  15. Open Access 01-12-2023 | Ependymoma | Letter

    Molecular reclassification reveals low prevalence of germline predisposition in children with ependymoma

    Ependymoma is the second most common malignant childhood brain tumor, accounting for approximately 6% of all central nervous system (CNS) tumors in children [ 6 ]. Nonetheless, our knowledge of its underlying etiology is sparse. Since the …

  16. Open Access 01-12-2023 | Ependymoma | OriginalPaper

    Multifocal thoracic intradural extramedullary anaplastic ependymoma: case report and review of the literature

    Ependymomas are neuroectodermal tumors arising from the ependymal cell of the ventricles and the central canal of the spinal cord and account about 4–6% of all tumors of the central nervous system. They are the most common tumors of the spinal …

  17. Open Access 01-12-2023 | Ependymoma | OriginalPaper

    Extensive anaplastic multi-centric ependymoma in a young adult: case report and literature review

    Ependymoma is a glial neoplasm that originates from the ependymal cells lining the brain ventricles and the central canal of the spinal cord. There is a clear predominance in infants compared to the adult population. It also remains clinically …

  18. Open Access 01-12-2023 | Ependymoma | OriginalPaper

    Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and Ependymoma

    The awareness of genetic predisposition in children and adolescents affected by cancer is steadily increasing. Cancer predisposition syndromes (CPS) have been reported in up to 8.5% of cases [ 1 , 2 ]. CPS are associated with a range of pediatric …

  19. Open Access 01-12-2023 | Ependymoma | OriginalPaper

    Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

    Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs). H3K27-altered DMGs are largely characterized by lysine-to-methionine …

  20. 14-10-2023 | Ependymoma | OriginalPaper

    “Soap bubble” sign as an imaging marker for posterior fossa ependymoma Group B

    Ependymomas are primary central nervous system (CNS) tumors in children and adults that can occur throughout the neuraxis, including three major anatomic compartments (supratentorial [ST], posterior fossa [PF], and spinal cord) [ 1 – 3 ]. The …

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