Issue 1/2020
Content (223 Articles)
Correction to: Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma
Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann, David H. Gutmann
Innate signaling within the central nervous system recruits protective neutrophils
Reza Khorooshi, Joanna Marczynska, Ruthe Storgaard Dieu, Vian Wais, Christian Rønn Hansen, Stephanie Kavan, Mads Thomassen, Mark Burton, Torben Kruse, Gill A. Webster, Trevor Owens
A robust TDP-43 knock-in mouse model of ALS
Shih-Ling Huang, Lien-Szu Wu, Min Lee, Chin-Wen Chang, Wei-Cheng Cheng, Yu-Sheng Fang, Yun-Ru Chen, Pei-Lin Cheng, Che-Kun James Shen
N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing brain
Amin Mottahedin, Sandrine Blondel, Joakim Ek, Anna-Lena Leverin, Pernilla Svedin, Henrik Hagberg, Carina Mallard, Jean-Francois Ghersi-Egea, Nathalie Strazielle
Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies
Tatiana Orme, Dena Hernandez, Owen A. Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E. Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St. George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q. Trojanowski, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J. Cairns, John C. Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J. Stone, Dennis W. Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bras
Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice
Ya-Yun Cheng, Ying-Tsen Chou, Feng-Jie Lai, Ming-Shiou Jan, Tsung-Hao Chang, I-Ming Jou, Pei-Shiuan Chen, Jui-Yen Lo, Shiang-Suo Huang, Nan-Shan Chang, Yung-Tsai Liou, Po-Chih Hsu, Hui-Ching Cheng, Yee-Shin Lin, Li-Jin Hsu
DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations
Byung Woo Kim, Ye Eun Jeong, Margaret Wong, Lee J. Martin
H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant
Sachi Maeda, Fumiharu Ohka, Yusuke Okuno, Kosuke Aoki, Kazuya Motomura, Kazuhito Takeuchi, Hironao Kusakari, Nobuyuki Yanagisawa, Shinya Sato, Junya Yamaguchi, Kuniaki Tanahashi, Masaki Hirano, Akira Kato, Hiroyuki Shimizu, Yotaro Kitano, Shintaro Yamazaki, Shinji Yamashita, Hideo Takeshima, Keiko Shinjo, Yutaka Kondo, Toshihiko Wakabayashi, Atsushi Natsume
Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells
Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, Alwin Kamermans, Sandra Amor, Jack van Horssen, Maarten E. Witte, Gijs Kooij, Helga E. de Vries
Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma
Maria-Magdalena Georgescu, Adriana Olar
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity
Sanne Simone Kaalund, Luca Passamonti, Kieren S. J. Allinson, Alexander G. Murley, Trevor W. Robbins, Maria Grazia Spillantini, James B. Rowe
Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models
Seiko Ikezu, Kaitlin L. Ingraham Dixie, Lacin Koro, Takashi Watanabe, Kozo Kaibuchi, Tsuneya Ikezu
Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease
Malcolm Roberts, Ioanna Sevastou, Yoichi Imaizumi, Kavita Mistry, Sonia Talma, Madhurima Dey, Jane Gartlon, Hiroshi Ochiai, Zhi Zhou, Shigeru Akasofu, Naoki Tokuhara, Makoto Ogo, Muneo Aoyama, Hirofumi Aoyagi, Kate Strand, Ezat Sajedi, Kishan Lal Agarwala, Jared Spidel, Earl Albone, Kanta Horie, James M. Staddon, Rohan de Silva
Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease
Gabriel Crevier-Sorbo, Vladimir V. Rymar, Raphael Crevier-Sorbo, Abbas F. Sadikot
The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas
Matthew McCord, Alicia Steffens, Rodrigo Javier, Kwok-Ling Kam, Kathleen McCortney, Craig Horbinski
Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels
Xuanhui Liu, Chuang Gao, Jiangyuan Yuan, Tangtang Xiang, Zhitao Gong, Hongliang Luo, Weiwei Jiang, Yiming Song, Jinhao Huang, Wei Quan, Dong Wang, Ye Tian, Xintong Ge, Ping Lei, Jianning Zhang, Rongcai Jiang
Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein
Chris McKinnon, Mitchell L. De Snoo, Elise Gondard, Clemens Neudorfer, Hien Chau, Sophie G. Ngana, Darren M. O’Hara, Jonathan M. Brotchie, James B. Koprich, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia
Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb
Jenni M. Laitila, Elyshia L. McNamara, Catherine D. Wingate, Hayley Goullee, Jacob A. Ross, Rhonda L. Taylor, Robbert van der Pijl, Lisa M. Griffiths, Rachel Harries, Gianina Ravenscroft, Joshua S. Clayton, Caroline Sewry, Michael W. Lawlor, Coen A. C. Ottenheijm, Anthony J. Bakker, Julien Ochala, Nigel G. Laing, Carina Wallgren-Pettersson, Katarina Pelin, Kristen J. Nowak
Single-nucleus RNA-seq identifies Huntington disease astrocyte states
Osama Al-Dalahmah, Alexander A. Sosunov, A. Shaik, Kenneth Ofori, Yang Liu, Jean Paul Vonsattel, Istvan Adorjan, Vilas Menon, James E. Goldman
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases
Michael A. Metrick II, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey
Chronic traumatic encephalopathy in a former Australian rules football player diagnosed with Alzheimer’s disease
Alan J. Pearce, Joanne Sy, Maggie Lee, Antony Harding, Rowena Mobbs, Jennifer Batchelor, Catherine M. Suter, Michael E. Buckland
Correction to: Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells
Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, Alwin Kamermans, Sandra Amor, Jack van Horssen, Maarten E. Witte, Gijs Kooij, Helga E. de Vries
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L. Croteau, Marie-Christine Galas, Vilhelm A. Bohr
Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain
Wasco Wruck, James Adjaye
Low-grade developmental and epilepsy associated brain tumors: a critical update 2020
Rutger Juriaan Slegers, Ingmar Blumcke
Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape
Malte Mohme, Cecile L. Maire, Simon Schliffke, Simon A. Joosse, Malik Alawi, Jakob Matschke, Ulrich Schüller, Judith Dierlamm, Tobias Martens, Klaus Pantel, Sabine Riethdorf, Katrin Lamszus, Manfred Westphal
Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients
Rasmus Rydbirk, Jonas Folke, Florence Busato, Elodie Roché, Alisha Shahzad Chauhan, Annemette Løkkegaard, Anne-Mette Hejl, Matthias Bode, Morten Blaabjerg, Mette Møller, Erik Hvid Danielsen, Tomasz Brudek, Bente Pakkenberg, Jorg Tost, Susana Aznar
Pediatric low-grade glioma in the era of molecular diagnostics
Scott Ryall, Uri Tabori, Cynthia Hawkins
Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease
Grace M. Lloyd, Jorge A. Trejo-Lopez, Yuxing Xia, Karen N. McFarland, Sarah J. Lincoln, Nilüfer Ertekin-Taner, Benoit I. Giasson, Anthony T. Yachnis, Stefan Prokop
CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model
Chun-jie Luan, Wenting Guo, Lei Chen, Xi-wei Wei, Yimin He, Yan Chen, Su-ying Dang, Robert Prior, Xihua Li, Ying Kuang, Zhu-gang Wang, Ludo Van Den Bosch, Ming-min Gu
Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts
Deniz Yilmazer-Hanke, Theresa Mayer, Hans-Peter Müller, Hermann Neugebauer, Alireza Abaei, Angelika Scheuerle, Joachim Weis, Karin M. E. Forsberg, Katharina Althaus, Julia Meier, Albert C. Ludolph, Kelly Del Tredici, Heiko Braak, Jan Kassubek, Volker Rasche
Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy
Alexander M. Rossor, James N. Sleigh, Michael Groves, Francesco Muntoni, Mary M. Reilly, Casper C. Hoogenraad, Giampietro Schiavo
Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis
Sabela Rodríguez-Lorenzo, David Miguel Ferreira Francisco, Ricardo Vos, Bert van het Hof, Merel Rijnsburger, Horst Schroten, Hiroshi Ishikawa, Wissam Beaino, Rémy Bruggmann, Gijs Kooij, Helga E. de Vries
Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen
Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma
Drew Pratt, Martha Quezado, Zied Abdullaev, Debra Hawes, Fusheng Yang, Hugh J. L. Garton, Alexander R. Judkins, Rajen Mody, Arul Chinnaiyan, Kenneth Aldape, Carl Koschmann, Sriram Venneti
Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria
Stefanie Berger, Miranda Stattmann, Ana Cicvaric, Francisco J. Monje, Pierluca Coiro, Matej Hotka, Gerda Ricken, Johannes Hainfellner, Susanne Greber-Platzer, Makiko Yasuda, Robert J. Desnick, Daniela D. Pollak
Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series
H. Geut, D. H. Hepp, E. Foncke, H. W. Berendse, J. M. Rozemuller, I. Huitinga, W. D. J. van de Berg
The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation
Rui-Chao Chai, Yao-Wu Zhang, Yu-Qing Liu, Yu-Zhou Chang, Bo Pang, Tao Jiang, Wen-Qing Jia, Yong-Zhi Wang
KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment
Niklas von Spreckelsen, Natalie Waldt, Rebecca Poetschke, Christoph Kesseler, Hildegard Dohmen, Hui-Ke Jiao, Attila Nemeth, Stefan Schob, Cordula Scherlach, Ibrahim Erol Sandalcioglu, Martina Deckert, Frank Angenstein, Boris Krischek, Pantelis Stavrinou, Marco Timmer, Marc Remke, Elmar Kirches, Roland Goldbrunner, E. Antonio Chiocca, Stefan Huettelmaier, Till Acker, Christian Mawrin
Annexin A2–STAT3–Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma
Yuji Matsumoto, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Yoshihiro Otani, Atsushi Fujimura, Kentaro Fujii, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Nobushige Tsuboi, Keisuke Kaneda, Keigo Makino, Isao Date
Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis
Guilian Xu, Susan E. Fromholt, Paramita Chakrabarty, Fanchao Zhu, Xuefei Liu, Michael C. Pace, Jin Koh, Todd E. Golde, Yona Levites, Jada Lewis, David R. Borchelt
Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia
Wen-Qiang Cui, Wen-Wen Zhang, Teng Chen, Qian Li, Fei Xu, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang, Yu-Xia Chu
Biological links between traumatic brain injury and Parkinson’s disease
Vedad Delic, Kevin D. Beck, Kevin C. H. Pang, Bruce A. Citron
Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury
Erica L. Littlejohn, Danielle Scott, Kathryn E. Saatman
Abnormal mitosis in reactive astrocytes
Alexander Sosunov, Xiaoping Wu, Robert McGovern, Charles Mikell, Guy M. McKhann II, James E. Goldman
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination
Aurélien Trimouille, Florent Marguet, Fanny Sauvestre, Eulalie Lasseaux, Fanny Pelluard, Marie-Laure Martin-Négrier, Claudio Plaisant, Caroline Rooryck, Didier Lacombe, Benoît Arveiler, Odile Boespflug-Tanguy, Sophie Naudion, Annie Laquerrière
Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes
Irina Tsymala, Magdalini Nigritinou, Bleranda Zeka, Rouven Schulz, Felix Niederschick, Mia Matković, Isabel J. Bauer, Michael Szalay, Kathrin Schanda, Magdalena Lerch, Tatsuro Misu, Kazuo Fujihara, Jeffrey L. Bennett, Charlotte Dahle, Florence Pache, Paulus Rommer, Fritz Leutmezer, Zsolt Illes, Maria Isabel Leite, Jacqueline Palace, Petra Scholze, Markus Reindl, Hans Lassmann, Monika Bradl
Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease
Irene H. Flønes, Gerda Ricken, Sigrid Klotz, Alexandra Lang, Thomas Ströbel, Christian Dölle, Gabor G. Kovacs, Charalampos Tzoulis
Characterising cellular and molecular features of human peripheral nerve degeneration
Matthew B. Wilcox, Simão G Laranjeira, Tuula M. Eriksson, Kristjan R. Jessen, Rhona Mirsky, Tom J. Quick, James B. Phillips
Simultaneous detection of EGFR amplification and EGFRvIII variant using digital PCR-based method in glioblastoma
Maxime Fontanilles, Florent Marguet, Philippe Ruminy, Carole Basset, Adrien Noel, Ludivine Beaussire, Mathieu Viennot, Pierre-Julien Viailly, Kevin Cassinari, Pascal Chambon, Doriane Richard, Cristina Alexandru, Isabelle Tennevet, Olivier Langlois, Frédéric Di Fiore, Annie Laquerrière, Florian Clatot, Nasrin Sarafan-Vasseur
A high–throughput digital script for multiplexed immunofluorescent analysis and quantification of sarcolemmal and sarcomeric proteins in muscular dystrophies
Dominic Scaglioni, Matthew Ellis, Francesco Catapano, Silvia Torelli, Darren Chambers, Lucy Feng, Caroline Sewry, Jennifer Morgan, Francesco Muntoni, Rahul Phadke
Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures
Achira Roy, Kathleen J. Millen, Raj P. Kapur
Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition
Gonzalo S. Nido, Fiona Dick, Lilah Toker, Kjell Petersen, Guido Alves, Ole-Bjørn Tysnes, Inge Jonassen, Kristoffer Haugarvoll, Charalampos Tzoulis
Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat
Luis O. Soto-Rojas, Irma A. Martínez-Dávila, Claudia Luna-Herrera, María E. Gutierrez-Castillo, Francisco E. Lopez-Salas, Bismark Gatica-Garcia, Guadalupe Soto-Rodriguez, María Elena Bringas Tobon, Gonzalo Flores, America Padilla-Viveros, Cecilia Bañuelos, Víctor Manuel Blanco-Alvarez, José Dávila-Ayala, David Reyes-Corona, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-lópez, Daniel Martinez-Fong
Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG
Jason Chiang, Alexander K. Diaz, Lydia Makepeace, Xiaoyu Li, Yuanyuan Han, Yimei Li, Paul Klimo Jr, Frederick A. Boop, Suzanne J. Baker, Amar Gajjar, Thomas E. Merchant, David W. Ellison, Alberto Broniscer, Zoltan Patay, Christopher L. Tinkle
Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism
Janusz Frackowiak, Bozena Mazur-Kolecka, Pankaj Mehta, Jerzy Wegiel
Validation of machine learning models to detect amyloid pathologies across institutions
Juan C. Vizcarra, Marla Gearing, Michael J. Keiser, Jonathan D. Glass, Brittany N. Dugger, David A. Gutman
Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity
Ahmed Elsherbini, Alexander S. Kirov, Michael B. Dinkins, Guanghu Wang, Haiyan Qin, Zhihui Zhu, Priyanka Tripathi, Simone M. Crivelli, Erhard Bieberich
Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes
Sandra O. Tomé, Rik Vandenberghe, Simona Ospitalieri, Evelien Van Schoor, Thomas Tousseyn, Markus Otto, Christine A. F. von Arnim, Dietmar Rudolf Thal
Differential gene methylation and expression of HOX transcription factor family in orbitofacial neurofibroma
Antje Arnold, Eddie Luidy Imada, M. Lisa Zhang, Deepak P. Edward, Luigi Marchionni, Fausto J. Rodriguez
Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson’s disease pathogenesis
Stefanie Smolders, Christine Van Broeckhoven
RNA modifications in brain tumorigenesis
Albert Z. Huang, Alberto Delaidelli, Poul H. Sorensen
Transmission of ALS pathogenesis by the cerebrospinal fluid
Pooja Shree Mishra, Hejer Boutej, Geneviève Soucy, Christine Bareil, Sunny Kumar, Vincent Picher-Martel, Nicolas Dupré, Jasna Kriz, Jean-Pierre Julien
Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration
Rachel E. James, Renee Schalks, Eleanor Browne, Ioanna Eleftheriadou, Carmen Picon Munoz, Nicholas D. Mazarakis, Richard Reynolds
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model
Yoichiro Abe, Natsumi Ikegawa, Keitaro Yoshida, Kyosuke Muramatsu, Satoko Hattori, Kenji Kawai, Minetaka Murakami, Takumi Tanaka, Wakami Goda, Motohito Goto, Taichi Yamamoto, Tadafumi Hashimoto, Kaoru Yamada, Terumasa Shibata, Hidemi Misawa, Masaru Mimura, Kenji F. Tanaka, Tsuyoshi Miyakawa, Takeshi Iwatsubo, Jun-ichi Hata, Takako Niikura, Masato Yasui
Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets
Eric Prince, Ros Whelan, Andrew Donson, Susan Staulcup, Astrid Hengartner, Trinka Vijmasi, Chibueze Agwu, Kevin O. Lillehei, Nicholas K. Foreman, James M. Johnston, Luca Massimi, Richard C. E. Anderson, Mark M. Souweidane, Robert P. Naftel, David D. Limbrick, Gerald Grant, Toba N. Niazi, Roy Dudley, Lindsay Kilburn, Eric M. Jackson, George I. Jallo, Kevin Ginn, Amy Smith, Joshua J. Chern, Amy Lee, Annie Drapeau, Mark D. Krieger, Michael H. Handler, Todd C. Hankinson
Correction to: Differential gene methylation and expression of HOX transcription factor family in orbitofacial neurofibroma
Antje Arnold, Eddie Luidy Imada, M. Lisa Zhang, Deepak P. Edward, Luigi Marchionni, Fausto J. Rodriguez
Restoration of miR-193a expression is tumor-suppressive in MYC amplified Group 3 medulloblastoma
Harish Shrikrishna Bharambe, Annada Joshi, Kedar Yogi, Sadaf Kazi, Neelam Vishwanath Shirsat
Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis
Conceição Bettencourt, Ignazio S. Piras, Sandrine C. Foti, Joshua Talboom, Yasuo Miki, Tammaryn Lashley, Robert Balazs, Emmanuelle Viré, Thomas T. Warner, Matt J. Huentelman, Janice L. Holton
Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K. Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W. Dickson
Meningomyeloencephalitis secondary to Mycobacterium haemophilum infection in AIDS
Sandra Leskinen, Xena Flowers, Katharina Thoene, Anne-Catrin Uhlemann, James E. Goldman, Richard A. Hickman
Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation
Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J. M. Hoozemans
Oculopharyngodistal myopathy with coexisting histology of systemic neuronal intranuclear inclusion disease: Clinicopathologic features of an autopsied patient harboring CGG repeat expansions in LRP12
Rie Saito, Hiroshi Shimizu, Takeshi Miura, Norikazu Hara, Naomi Mezaki, Yo Higuchi, Akinori Miyashita, Izumi Kawachi, Kazuhiro Sanpei, Yoshiaki Honma, Osamu Onodera, Takeshi Ikeuchi, Akiyoshi Kakita
Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease
Ignazio S. Piras, Christiane Bleul, Isabelle Schrauwen, Joshua Talboom, Lorida Llaci, Matthew D. De Both, Marcus A. Naymik, Glenda Halliday, Conceicao Bettencourt, Janice L. Holton, Geidy E. Serrano, Lucia I. Sue, Thomas G. Beach, Nadia Stefanova, Matthew J. Huentelman
No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington’s disease
Ting-Ting Huang, Ruben Smith, Karl Bacos, Dong-Yan Song, Richard M. Faull, Henry J. Waldvogel, Jia-Yi Li
Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients
Armin Sebastian Guntner, Andreas Peyrl, Lisa Mayr, Bernhard Englinger, Walter Berger, Irene Slavc, Wolfgang Buchberger, Johannes Gojo
The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer’s disease
Kunie Ando, Marième Ndjim, Sabrina Turbant, Gaëlle Fontaine, Gustavo Pregoni, Luce Dauphinot, Zehra Yilmaz, Valérie Suain, Salwa Mansour, Michèle Authelet, Robert De Dekker, Karelle Leroy, Benoît Delatour, Franck Letournel, Marie-Laure Martin-Négrier, Françoise Chapon, Catherine Godfraind, Claude-Alain Maurage, Vincent Deramecourt, David Meyronnet, Nathalie Streichenberger, André Maues de Paula, Valérie Rigau, Fanny Vandenbos-Burel, Charles Duyckaerts, Danielle Seilhean, Susana Boluda, Isabelle Plu, Serge Milin, Dan Christian Chiforeanu, Annie Laquerrière, Béatrice Lannes, Charles Duyckaerts, Marie-Claude Potier, Jean-Pierre Brion
Fusions involving BCOR and CREBBP are rare events in infiltrating glioma
David J. Pisapia, Kentaro Ohara, Rohan Bareja, David C. Wilkes, Erika Hissong, Jaclyn A. Croyle, Joon-Hyung Kim, Jad Saab, Theresa Y. MacDonald, Shaham Beg, Catherine O’Reilly, Sarah Kudman, Mark A. Rubin, Olivier Elemento, Andrea Sboner, Jeffrey Greenfield, Juan Miguel Mosquera
Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke
Bettina H. Clausen, Martin Wirenfeldt, Sofie S. Høgedal, Lars H. Frich, Helle H. Nielsen, Henrik D. Schrøder, Kamilla Østergaard, Bente Finsen, Bjarne W. Kristensen, Kate L. Lambertsen
DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma
Harish N. Vasudevan, Maria R. H. Castro, Julieann C. Lee, Javier E. Villanueva-Meyer, Nancy Ann Oberheim Bush, Michael W. McDermott, David A. Solomon, Arie Perry, Stephen T. Magill, David R. Raleigh
Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes
Anne Ward, Jason R. Hollister, Kristin McNally, Diane L. Ritchie, Gianluigi Zanusso, Suzette A. Priola
Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits
Genevieve M. Sullivan, Andrew K. Knutsen, Luca Peruzzotti-Jametti, Alexandru Korotcov, Asamoah Bosomtwi, Bernard J. Dardzinski, Joshua D. Bernstock, Sandra Rizzi, Frank Edenhofer, Stefano Pluchino, Regina C. Armstrong
A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease
Satish K. Nemani, Xiangzhu Xiao, Ignazio Cali, Laura Cracco, Gianfranco Puoti, Massimiliano Nigro, Jody Lavrich, Anuradha Bharara Singh, Brian S. Appleby, Valerie L. Sim, Silvio Notari, Witold K. Surewicz, Pierluigi Gambetti
Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
Yuta Takaichi, James K. Chambers, Hiroyuki Inoue, Yasuhisa Ano, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida
A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma
Thidathip Wongsurawat, Piroon Jenjaroenpun, Annick De Loose, Duah Alkam, David W. Ussery, Intawat Nookaew, Yuet-Kin Leung, Shuk-Mei Ho, John D. Day, Analiz Rodriguez
Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
Yuxing Xia, Stefan Prokop, Kimberly-Marie M. Gorion, Justin D. Kim, Zachary A. Sorrentino, Brach M. Bell, Alyssa N. Manaois, Paramita Chakrabarty, Peter Davies, Benoit I. Giasson
Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome
Alexandra Botté, Jeanne Lainé, Laura Xicota, Xavier Heiligenstein, Gaëlle Fontaine, Amal Kasri, Isabelle Rivals, Pollyanna Goh, Orestis Faklaris, Jack-Christophe Cossec, Etienne Morel, Anne-Sophie Rebillat, Dean Nizetic, Graça Raposo, Marie-Claude Potier
Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K. Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W. Dickson
RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases
Mahlon Collins, Yang Li, Robert Bowser
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
J. Saul, E. Hutchins, R. Reiman, M. Saul, L. W. Ostrow, B. T. Harris, K. Van Keuren-Jensen, R. Bowser, N. Bakkar
A novel AFG3L2 mutation close to AAA domain leads to aberrant OMA1 and OPA1 processing in a family with optic atrophy
Valentina Baderna, Joshua Schultz, Lisa S. Kearns, Michael Fahey, Bryony A. Thompson, Jonathan B. Ruddle, Aamira Huq, Francesca Maltecca
de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia
Kunie Ando, Lorenzo Ferlini, Valérie Suain, Zehra Yilmaz, Salwa Mansour, Isabelle Le Ber, Cécile Bouchard, Karelle Leroy, Alexandra Durr, Fabienne Clot, Marie Sarazin, Jean-Christophe Bier, Jean-Pierre Brion
Diffuse leptomeningeal glioneuronal tumor: a double misnomer? A report of two cases
Romain Appay, Mélanie Pages, Carole Colin, David T. W. Jones, Pascale Varlet, Dominique Figarella-Branger
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy
Si Jie Tang, Arman Fesharaki-Zadeh, Hideyuki Takahashi, Sarah Helena Nies, Levi M. Smith, Anin Luo, Annabel Chyung, Marius Chiasseu, Stephen M. Strittmatter
Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease
Joseph A. White II, Thomas J. Krzystek, Hayley Hoffmar-Glennon, Claire Thant, Katherine Zimmerman, Gary Iacobucci, Julia Vail, Layne Thurston, Saad Rahman, Shermali Gunawardena
Quantitative patterns of motor cortex proteinopathy across ALS genotypes
Matthew Nolan, Connor Scott, Menuka Pallebage Gamarallage, Daniel Lunn, Kilda Carpenter, Elizabeth McDonough, Dan Meyer, Sireesha Kaanumalle, Alberto Santamaria-Pang, Martin R. Turner, Kevin Talbot, Olaf Ansorge
Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage
Lieke Jäkel, H. Bea Kuiperij, Lara P. Gerding, Emma E. M. Custers, Emma van den Berg, Wilmar M. T. Jolink, Floris H. B. M. Schreuder, Benno Küsters, Catharina J. M. Klijn, Marcel M. Verbeek
In vivo evidence of exosome-mediated Aβ neurotoxicity
Ahmed Elsherbini, Haiyan Qin, Zhihui Zhu, Priyanka Tripathi, Simone M. Crivelli, Erhard Bieberich
High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma
Mark Raffeld, Zied Abdullaev, Svetlana D. Pack, Liqiang Xi, Sushma Nagaraj, Nicole Briceno, Elizabeth Vera, Stefania Pittaluga, Osorio Lopes Abath Neto, Martha Quezado, Kenneth Aldape, Terri S. Armstrong, Mark R. Gilbert
Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis
Lifu Sheng, Tessandra Stewart, Dishun Yang, Eric Thorland, David Soltys, Patrick Aro, Tarek Khrisat, Zhiying Xie, Na Li, Zongran Liu, Chen Tian, Matthew Bercow, Junichi Matsumoto, Cyrus P. Zabetian, Elaine Peskind, Joseph F. Quinn, Min Shi, Jing Zhang
Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies
Christopher Hatton, Amy Reeve, Nichola Zoe Lax, Alasdair Blain, Yi Shiau Ng, Omar El-Agnaf, Johannes Attems, John-Paul Taylor, Doug Turnbull, Daniel Erskine
The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts
A. Tauziède-Espariat, M-A Debily, D. Castel, J. Grill, S. Puget, A. Roux, R. Saffroy, M. Pagès, A. Gareton, F. Chrétien, E. Lechapt, V. Dangouloff-Ros, N. Boddaert, P. Varlet
Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes
Maria Łastowska, Joanna Trubicka, Anna Sobocińska, Bartosz Wojtas, Magdalena Niemira, Anna Szałkowska, Adam Krętowski, Agnieszka Karkucińska-Więckowska, Magdalena Kaleta, Maria Ejmont, Marta Perek-Polnik, Bożenna Dembowska-Bagińska, Wiesława Grajkowska, Ewa Matyja
Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation
Meng-Han Tsai, Haw-Yuan Cheng, Fang-Shin Nian, Chen Liu, Nian-Hsin Chao, Kuo-Liang Chiang, Shu-Fang Chen, Jin-Wu Tsai
Molecular and clinicopathologic features of gliomas harboring NTRK fusions
Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Anne-Florence Blandin, Melanie Pages, Azra H. Ligon, Fei Dong, David M. Meredith, MacLean P. Nasrallah, Craig Horbinski, Sonika Dahiya, Keith L. Ligon, Mariarita Santi, Shakti H. Ramkissoon, Mariella G. Filbin, Matija Snuderl, Sanda Alexandrescu
Fyn depletion ameliorates tauP301L-induced neuropathology
Guanghao Liu, Kimberly L. Fiock, Yona Levites, Todd E. Golde, Marco M. Hefti, Gloria Lee
The unfolded protein response is activated in the olfactory system in Alzheimer’s disease
Helen C. Murray, Birger Victor Dieriks, Molly E. V. Swanson, Praju Vikas Anekal, Clinton Turner, Richard L. M. Faull, Leonardo Belluscio, Alan Koretsky, Maurice A. Curtis
C9orf72-associated SMCR8 protein binds in the ubiquitin pathway and with proteins linked with neurological disease
John L. Goodier, Alisha O. Soares, Gavin C. Pereira, Lauren R. DeVine, Laura Sanchez, Robert N. Cole, Jose Luis García-Pérez
Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma
M.-M. Georgescu, M. Z. Islam, Y. Li, M. L. Circu, J. Traylor, C. M. Notarianni, C. N. Kline, D. K. Burns
A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult
Kyungmin Ko, Takashi Kitani, Brent T. Harris, Amjad N. Anaizi, David Solomon, Arie Perry, Jeffrey Toretsky, Metin Ozdemirli
Orbital Rosai-Dorfman disease initially diagnosed as IgG4-related disease: a case report
Nishanth S. Iyengar, Danielle Golub, Michelle W. McQuinn, Travis Hill, Karen Tang, Sharon L. Gardner, David H. Harter, Chandranath Sen, David A. Staffenberg, Kristen Thomas, Zachary Elkin, Irina Belinsky, Christopher William
Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Sarah Findakly, Abrar Choudhury, Vikas Daggubati, Melike Pekmezci, Ursula E. Lang, David R. Raleigh
A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features
Mac Lean P. Nasrallah, Arati Desai, Donald M. O’Rourke, Lea F. Surrey, Joel M. Stein
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Michael Briese, Lena Saal-Bauernschubert, Patrick Lüningschrör, Mehri Moradi, Benjamin Dombert, Verena Surrey, Silke Appenzeller, Chunchu Deng, Sibylle Jablonka, Michael Sendtner
Towards an improved early diagnosis of neurodegenerative diseases: the emerging role of in vitro conversion assays for protein amyloids
Niccolò Candelise, Simone Baiardi, Alessia Franceschini, Marcello Rossi, Piero Parchi
Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
Sathish Kumar, Cynthia A. Lemere, Jochen Walter
Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease
Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Andrew J. Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Erny
BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy
Seiji Kaji, Takakuni Maki, Jun Ueda, Tomoyuki Ishimoto, Yutaka Inoue, Ken Yasuda, Masanori Sawamura, Rie Hikawa, Takashi Ayaki, Hodaka Yamakado, Ryosuke Takahashi
Correction to: Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Markus Otto, Thomas G. Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P. L. Smith, Sathish Kumar, Gill Farrar, Jochen Walter
The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD
Fang He, Brittany N. Flores, Amy Krans, Michelle Frazer, Sam Natla, Sarjina Niraula, Olamide Adefioye, Sami J. Barmada, Peter K. Todd
Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
Jennifer Ngolab, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Margarita Trejo, Deborah Masliah, Anthony Adame, Eliezer Masliah, Robert A. Rissman
A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology
Julia Lorenz, Tanja Rothhammer-Hampl, Saida Zoubaa, Elisabeth Bumes, Tobias Pukrop, Oliver Kölbl, Selim Corbacioglu, Nils O. Schmidt, Martin Proescholdt, Peter Hau, Markus J. Riemenschneider
Distinct tissue injury patterns in juvenile dermatomyositis auto-antibody subgroups
Mailan Nguyen, Vy Do, Paul C. Yell, Chanhee Jo, Jie Liu, Dennis K. Burns, Tracey Wright, Chunyu Cai
Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models
Francesca Vitale, Jasmin Ortolan, Bruce T. Volpe, Philippe Marambaud, Luca Giliberto, Cristina d’Abramo
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett
Clinical, radiological and molecular characterization of intramedullary astrocytomas
Laetitia Lebrun, Barbara Meléndez, Oriane Blanchard, Nancy De Nève, Claude Van Campenhout, Julie Lelotte, Danielle Balériaux, Matteo Riva, Jacques Brotchi, Michaël Bruneau, Olivier De Witte, Christine Decaestecker, Nicky D’Haene, Isabelle Salmon
Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
J. Michael, M. S. Unger, R. Poupardin, P. Schernthaner, H. Mrowetz, J. Attems, L. Aigner
Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients
Xin-Yue Jiang, Song Lei, Le Zhang, Xu Liu, Min-Tao Lin, Ingmar Blumcke, Yue-Shan Piao, Dong Zhou, Jin-Mei Li
Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia
Matthew MacGregor Sharp, Satoshi Saito, Abby Keable, Maureen Gatherer, Roxana Aldea, Nivedita Agarwal, Julie E. Simpson, Stephen B. Wharton, Roy O. Weller, Roxana O. Carare
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
Kathleen M. Farmer, Gaurav Ghag, Nicha Puangmalai, Mauro Montalbano, Nemil Bhatt, Rakez Kayed
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Novel CHP1 mutation in autosomal-recessive cerebellar ataxia: autopsy features of two siblings
Rie Saito, Norikazu Hara, Mari Tada, Yoshiaki Honma, Akinori Miyashita, Osamu Onodera, Takeshi Ikeuchi, Akiyoshi Kakita
Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis
Lorna Hayden, Tiia Semenoff, Verena Schultz, Simon F. Merz, Katie J. Chapple, Moses Rodriguez, Arthur E. Warrington, Xiaohong Shi, Clive S. McKimmie, Julia M. Edgar, Katja Thümmler, Chris Linington, Marieke Pingen
Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis
Chotima Böttcher, Marlijn van der Poel, Camila Fernández-Zapata, Stephan Schlickeiser, Julia K. H. Leman, Cheng-Chih Hsiao, Mark R. Mizee, Adelia, Maria C. J. Vincenten, Desiree Kunkel, Inge Huitinga, Jörg Hamann, Josef Priller
Tau reduction in aged mice does not impact Microangiopathy
Rachel E. Bennett, Miwei Hu, Analiese Fernandes, Marta Perez-Rando, Ashley Robbins, Tarun Kamath, Simon Dujardin, Bradley T. Hyman
RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM
Nandini Ramesh, Sukhleen Kour, Eric N. Anderson, Dhivyaa Rajasundaram, Udai Bhan Pandey
BRAF V600E mutation mediates FDG-methionine uptake mismatch in polymorphous low-grade neuroepithelial tumor of the young
Kensuke Tateishi, Naoki Ikegaya, Naoko Udaka, Jo Sasame, Takahiro Hayashi, Yohei Miyake, Tetsuhiko Okabe, Ryogo Minamimoto, Hidetoshi Murata, Daisuke Utsunomiya, Shoji Yamanaka, Tetsuya Yamamoto
Defining novel functions for cerebrospinal fluid in ALS pathophysiology
Koy Chong Ng Kee Kwong, Arpan R. Mehta, Maiken Nedergaard, Siddharthan Chandran
Assessment of radial glia in the frontal lobe of fetuses with Down syndrome
Ana A. Baburamani, Regina T. Vontell, Alena Uus, Maximilian Pietsch, Prachi A. Patkee, Jo Wyatt-Ashmead, Evonne C. Chin-Smith, Veena G. Supramaniam, J. Donald Tournier, Maria Deprez, Mary A. Rutherford
Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy
Joshua S. Clayton, Elyshia L. McNamara, Hayley Goullee, Stefan Conijn, Keren Muthsam, Gabrielle C. Musk, David Coote, James Kijas, Alison C. Testa, Rhonda L. Taylor, Amanda J. O’Hara, David Groth, Coen Ottenheijm, Gianina Ravenscroft, Nigel G. Laing, Kristen J. Nowak
Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease
Rachel E. Lackie, Jose Marques-Lopes, Valeriy G. Ostapchenko, Sarah Good, Wing-Yiu Choy, Patricija van Oosten-Hawle, Stephen H. Pasternak, Vania F. Prado, Marco A. M. Prado
Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis
Sharon Melamed, Roy Avraham, Deborah E. Rothbard, Noam Erez, Tomer Israely, Ziv Klausner, Anthony H. Futerman, Nir Paran, Einat B. Vitner
New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma
Tiziana Pierini, Carlotta Nardelli, Anair Graciela Lema Fernandez, Valentina Pierini, Fabrizia Pellanera, Valeria Nofrini, Paolo Gorello, Martina Moretti, Silvia Arniani, Giovanni Roti, Paolo Giovenali, Marco Lupattelli, Giulio Metro, Carmen Molica, Corrado Castrioto, Rodolfo Corinaldesi, Maria Elena Laurenti, Stefano Ascani, Cristina Mecucci, Roberta La Starza
Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2
Wenhui Huang, Xianshu Bai, Erika Meyer, Anja Scheller
Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage
Osama Al-Dalahmah, Kiran T. Thakur, Anna S. Nordvig, Morgan L. Prust, William Roth, Angela Lignelli, Anne-Catrin Uhlemann, Emily Happy Miller, Shajo Kunnath-Velayudhan, Armando Del Portillo, Yang Liu, Gunnar Hargus, Andrew F. Teich, Richard A. Hickman, Kurenai Tanji, James E. Goldman, Phyllis L. Faust, Peter Canoll
Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure
Masayoshi Nakano, Yuichi Riku, Kenya Nishioka, Masato Hasegawa, Yukihiko Washimi, Yutaka Arahata, Akinori Takeda, Kentaro Horibe, Akiko Yamaoka, Keisuke Suzuki, Masashi Tsujimoto, Yuanzhe Li, Hiroyo Yoshino, Nobutaka Hattori, Akio Akagi, Hiroaki Miyahara, Yasushi Iwasaki, Mari Yoshida
Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Kanta Horie, Nicolas R. Barthélemy, Nipun Mallipeddi, Yan Li, Erin E. Franklin, Richard J. Perrin, Randall J. Bateman, Chihiro Sato
Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Allison J. Schaser, Teresa L. Stackhouse, Leah J. Weston, Patrick C. Kerstein, Valerie R. Osterberg, Claudia S. López, Dennis W. Dickson, Kelvin C. Luk, Charles K. Meshul, Randall L. Woltjer, Vivek K. Unni
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor
Calixto-Hope G. Lucas, Rohit Gupta, Pamela Doo, Julieann C. Lee, Cathryn R. Cadwell, Biswarathan Ramani, Jeffrey W. Hofmann, Emily A. Sloan, Bette K. Kleinschmidt-DeMasters, Han S. Lee, Matthew D. Wood, Marjorie Grafe, Donald Born, Hannes Vogel, Shahriar Salamat, Diane Puccetti, David Scharnhorst, David Samuel, Tabitha Cooney, Elaine Cham, Lee-way Jin, Ziad Khatib, Ossama Maher, Gabriel Chamyan, Carole Brathwaite, Serguei Bannykh, Sabine Mueller, Cassie N. Kline, Anu Banerjee, Alyssa Reddy, Jennie W. Taylor, Jennifer L. Clarke, Nancy Ann Oberheim Bush, Nicholas Butowski, Nalin Gupta, Kurtis I. Auguste, Peter P. Sun, Jarod L. Roland, Corey Raffel, Manish K. Aghi, Philip Theodosopoulos, Edward Chang, Shawn Hervey-Jumper, Joanna J. Phillips, Melike Pekmezci, Andrew W. Bollen, Tarik Tihan, Susan Chang, Mitchel S. Berger, Arie Perry, David A. Solomon
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples
Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano, José Sereno, Arnulf Koeppen, Miguel Castelo-Branco, Luís Pereira de Almeida
Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies
Vera I. Wiersma, Jeroen J. M. Hoozemans, Wiep Scheper
Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation
Julia Schuld, Zacharias Orfanos, Frédéric Chevessier, Britta Eggers, Lorena Heil, Julian Uszkoreit, Andreas Unger, Gregor Kirfel, Peter F. M. van der Ven, Katrin Marcus, Wolfgang A. Linke, Christoph S. Clemen, Rolf Schröder, Dieter O. Fürst
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis
Wan Yun Ho, Sheeja Navakkode, Fujia Liu, Tuck Wah Soong, Shuo-Chien Ling
Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice
Tao Yang, Harry Liu, Kevin C. Tran, Albert Leng, Stephen M. Massa, Frank M. Longo
Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression
Erin M. Taylor, Stephanie D. Byrum, Jacob L. Edmondson, Christopher P. Wardell, Brittany G. Griffin, Sara C. Shalin, Murat Gokden, Issam Makhoul, Alan J. Tackett, Analiz Rodriguez
Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila
Ryan J. H. West, Joanne L. Sharpe, André Voelzmann, Anna L. Munro, Ines Hahn, Richard A. Baines, Stuart Pickering-Brown
Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury
Masataka Ifuku, Lukas Hinkelmann, Leonard D. Kuhrt, Ibrahim E. Efe, Victor Kumbol, Alice Buonfiglioli, Christina Krüger, Philipp Jordan, Marcus Fulde, Mami Noda, Helmut Kettenmann, Seija Lehnardt
Assessment of genetic risk for improved clinical-neuropathological correlations
Barbara E. Spencer, Robin G. Jennings, Chun C. Fan, James B. Brewer
Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice
Manuela Lehmann, Matthew Marklund, Anna-Lena Bolender, Elaheh E. Bidhendi, Per Zetterström, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund, Jonathan D. Gilthorpe, Ulrika Nordström
Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures
Rebecca R. Valentino, Nikoleta Tamvaka, Michael G. Heckman, Patrick W. Johnson, Alexandra I. Soto-Beasley, Ronald L. Walton, Shunsuke Koga, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations
Meixiang Huang, Erica Modeste, Eric Dammer, Paola Merino, Georgia Taylor, Duc M. Duong, Qiudong Deng, Christopher J. Holler, Marla Gearing, Dennis Dickson, Nicholas T. Seyfried, Thomas Kukar
Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD
Shaoteng Wang, Micaela Tatman, Mervyn J. Monteiro
A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease
James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts
Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI
Alexander Morin, Benoit Mouzon, Scott Ferguson, Daniel Paris, Mackenzie Browning, William Stewart, Mike Mullan, Fiona Crawford
rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy
Jacob A. Ross, Hichem Tasfaout, Yotam Levy, Jennifer Morgan, Belinda S. Cowling, Jocelyn Laporte, Edmar Zanoteli, Norma B. Romero, Dawn A. Lowe, Heinz Jungbluth, Michael W. Lawlor, David L. Mack, Julien Ochala
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
Marta Perez-Rando, Simon Dujardin, Rachel E. Bennett, Caitlin Commins, Tara Nibhanupudy, Bradley T. Hyman
Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas
Daniel F. Marker, Thomas M. Pearce
Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis
Molly E. V. Swanson, Emma L. Scotter, Leon C. D. Smyth, Helen C. Murray, Brigid Ryan, Clinton Turner, Richard L. M. Faull, Mike Dragunow, Maurice A. Curtis
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic
Erik A. Williams, Sandro Santagata, Hiroaki Wakimoto, Ganesh M. Shankar, Fred G. Barker II, Radwa Sharaf, Abhinav Reddy, Phoebe Spear, Brian M. Alexander, Jeffrey S. Ross, Priscilla K. Brastianos, Daniel P. Cahill, Shakti H. Ramkissoon, Tareq A. Juratli
Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy
Samantha L. Strickland, Hélène Morel, Christian Prusinski, Mariet Allen, Tulsi A. Patel, Minerva M. Carrasquillo, Olivia J. Conway, Sarah J. Lincoln, Joseph S. Reddy, Thuy Nguyen, Kimberly G. Malphrus, Alexandra I. Soto, Ronald L. Walton, Julia E. Crook, Melissa E. Murray, Bradley F. Boeve, Ronald C. Petersen, John A. Lucas, Tanis J. Ferman, Ryan J. Uitti, Zbigniew K. Wszolek, Owen A. Ross, Neill R. Graff-Radford, Dennis W. Dickson, Nilüfer Ertekin-Taner
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma
Chenan Zhang, Quinn T. Ostrom, Eleanor C. Semmes, Vijay Ramaswamy, Helen M. Hansen, Libby Morimoto, Adam J. de Smith, Melike Pekmezci, Zalman Vaksman, Hakon Hakonarson, Sharon J. Diskin, Catherine Metayer, Elizabeth B. Claus, Dora Il’yasova, Kyle M. Walsh, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein, Christoffer Johansen, Robert B. Jenkins, Beatrice S. Melin, Margaret R. Wrensch, Richard S. Houlston, Melissa L. Bondy, Michael D. Taylor, Joseph L. Wiemels, Melissa L. Bondy, Kyle M. Walsh
Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role
D. Mercurio, M. Oggioni, S. Fumagalli, N. J. Lynch, S. Roscher, D. Minuta, C. Perego, S. Ippati, R. Wallis, W. J. Schwaeble, M.-G. De Simoni
Mild hypoxia triggers transient blood–brain barrier disruption: a fundamental protective role for microglia
Sebok K. Halder, Richard Milner
Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions
Ryohei Watanabe, Shinji Higashi, Takashi Nonaka, Ito Kawakami, Kenichi Oshima, Kazuhiro Niizato, Haruhiko Akiyama, Mari Yoshida, Masato Hasegawa, Tetsuaki Arai
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
Nandini Ramesh, Elizabeth L. Daley, Amanda M. Gleixner, Jacob R. Mann, Sukhleen Kour, Darilang Mawrie, Eric N. Anderson, Julia Kofler, Christopher J. Donnelly, Evangelos Kiskinis, Udai Bhan Pandey
The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”
Arnault Tauziède-Espariat, Gaëlle Pierron, Aurore Siegfried, Delphine Guillemot, Emmanuelle Uro-Coste, Yvan Nicaise, David Castel, Isabelle Catalaa, Delphine Larrieu-Ciron, Patrick Chaynes, Amaury de Barros, Julien Nicolau, Albane Gareton, Emmanuèle Lechapt, Fabrice Chrétien, Franck Bourdeaut, François Doz, Yassine Bouchoucha, Jacques Grill, Kévin Beccaria, Nathalie Boddaert, Raphaël Saffroy, Mélanie Pagès, Pascale Varlet
Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma
Maxime Fontanilles, Florent Marguet, Ludivine Beaussire, Nicolas Magne, Louis-Ferdinand Pépin, Cristina Alexandru, Isabelle Tennevet, Chantal Hanzen, Olivier Langlois, Fabrice Jardin, Annie Laquerrière, Nasrin Sarafan-Vasseur, Fréderic Di Fiore, Florian Clatot
Correction to: Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
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Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model
Shin Heun Kim, Ji Hoon Ahn, Hyunwoo Yang, Peter Lee, Gou Young Koh, Yong Jeong
Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas
Margot A. Lazow, Lindsey Hoffman, Austin Schafer, Diana S. Osorio, Daniel R. Boué, Sarah Rush, Erin Wright, Adam Lane, Mariko D. DeWire-Schottmiller, Teresa Smolarek, Jared Sipple, Heather Taggert, Jaime Reuss, Ralph Salloum, Trent R. Hummel, Peter de Blank, Natasha Pillay-Smiley, Mary E. Sutton, Anthony Asher, Charles B. Stevenson, Rachid Drissi, Jonathan L. Finlay, Maryam Fouladi, Christine Fuller
EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression
C. Antin, A. Tauziède-Espariat, M.-A. Debily, D. Castel, J. Grill, M. Pagès, O. Ayrault, F. Chrétien, A. Gareton, F. Andreiuolo, E. Lechapt, P. Varlet
Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity
Annelies Quaegebeur, Idoia Glaria, Tammaryn Lashley, Adrian M. Isaacs
Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms
Pu-Yun Shih, Bing-Yuan Hsieh, Ching-Yen Tsai, Chiu-An Lo, Brian E. Chen, Yi-Ping Hsueh
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions
Douglas A. Mata, Jamal K. Benhamida, Andrew L. Lin, Chad M. Vanderbilt, Soo-Ryum Yang, Liliana B. Villafania, Donna C. Ferguson, Philip Jonsson, Alexandra M. Miller, Viviane Tabar, Cameron W. Brennan, Nelson S. Moss, Martin Sill, Ryma Benayed, Ingo K. Mellinghoff, Marc K. Rosenblum, Maria E. Arcila, Marc Ladanyi, Tejus A. Bale
Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population
Karri Kaivola, Samuli J. Salmi, Lilja Jansson, Jyrki Launes, Laura Hokkanen, Anna-Kaisa Niemi, Kari Majamaa, Jari Lahti, Johan G. Eriksson, Timo Strandberg, Hannu Laaksovirta, Pentti J. Tienari
Spinal muscular atrophy type III complicated by spinal superficial siderosis: a case report with molecular and neuropathological findings
Catherine Elizabeth Pringle, Robert Nelson, Willie Miller, Rashmi Kothary, Jean Michaud
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
Peter M. J. Quinn, Paula I. Moreira, António Francisco Ambrósio, C. Henrique Alves
Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis
Hélène Lasolle, Mad-Hélénie Elsensohn, Anne Wierinckx, Eudeline Alix, Clément Bonnefille, Alexandre Vasiljevic, Christine Cortet, Bénédicte Decoudier, Nathalie Sturm, Stephan Gaillard, Amandine Ferrière, Pascal Roy, Emmanuel Jouanneau, Philippe Bertolino, Claire Bardel, Damien Sanlaville, Gérald Raverot
Clinical and mutational profiles of adult medulloblastoma groups
Gabriel Chun-Hei Wong, Kay Ka-Wai Li, Wei-Wei Wang, Anthony Pak-Yin Liu, Queenie Junqi Huang, Aden Ka-Yin Chan, Manix Fung-Man Poon, Nellie Yuk-Fei Chung, Queenie Hoi-Wing Wong, Hong Chen, Danny Tat Ming Chan, Xian-Zhi Liu, Ying Mao, Zhen-Yu Zhang, Zhi-Feng Shi, Ho-Keung Ng
In vivo RyR1 reduction in muscle triggers a core-like myopathy
Laurent Pelletier, Anne Petiot, Julie Brocard, Benoit Giannesini, Diane Giovannini, Colline Sanchez, Lauriane Travard, Mathilde Chivet, Mathilde Beaufils, Candice Kutchukian, David Bendahan, Daniel Metzger, Clara Franzini Armstrong, Norma B. Romero, John Rendu, Vincent Jacquemond, Julien Fauré, Isabelle Marty
Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice
Angie C. A. Chiang, Alexandre V. Seua, Pooja Singhmar, Luis D. Arroyo, Rajasekaran Mahalingam, Jian Hu, Annemieke Kavelaars, Cobi J. Heijnen
Is the eye a window to the brain in Sanfilippo syndrome?
Helen Beard, Glyn Chidlow, Daniel Neumann, Nazzmer Nazri, Meghan Douglass, Paul J. Trim, Marten F. Snel, Robert J. Casson, Kim M. Hemsley
Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain
Anne-Eva van der Wijk, Theodosia Georgakopoulou, Jisca Majolée, Jan S. M. van Bezu, Miesje M. van der Stoel, Bert J. van het Hof, Helga E. de Vries, Stephan Huveneers, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease
Laura Ibanez, Jorge A. Bahena, Chengran Yang, Umber Dube, Fabiana H. G. Farias, John P. Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin, Nigel J. Cairns, John O’Donnell, Ignacio Álvarez, Monica Diez-Fairen, Miquel Aguilar, Rebecca Miller, Albert A. Davis, Pau Pastor, Paul Kotzbauer, Meghan C. Campbell, Joel S. Perlmutter, Herve Rhinn, Oscar Harari, Carlos Cruchaga, Bruno A. Benitez
A novel structure associated with aging is augmented in the DPP6-KO mouse brain
Lin Lin, Ronald S. Petralia, Ross Lake, Ya-Xian Wang, Dax A. Hoffman
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
Vanessa Laversenne, Sameer Nazeeruddin, Emma C. Källstig, Philippe Colin, Christel Voize, Bernard L. Schneider
Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons
Madlin Potratz, Luca M. Zaeck, Carlotta Weigel, Antonia Klein, Conrad M. Freuling, Thomas Müller, Stefan Finke
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice
Pamela McMillan, Jeanna Wheeler, Rachel E. Gatlin, Laura Taylor, Tim Strovas, Misa Baum, Thomas D. Bird, Caitlin Latimer, C. Dirk Keene, Brian C. Kraemer, Nicole F. Liachko
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease
Haoshen Shi, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Kolja Wawrowsky, Shouri Lahiri, Keith L. Black, Maya Koronyo-Hamaoui
TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations
Hideyuki Arita, Yuko Matsushita, Ryunosuke Machida, Kai Yamasaki, Nobuhiro Hata, Makoto Ohno, Shigeru Yamaguchi, Takashi Sasayama, Shota Tanaka, Fumi Higuchi, Toshihiko Iuchi, Kuniaki Saito, Masayuki Kanamori, Ken-ichiro Matsuda, Yohei Miyake, Kaoru Tamura, Sho Tamai, Taishi Nakamura, Takehiro Uda, Yoshiko Okita, Junya Fukai, Daisuke Sakamoto, Yasuhiko Hattori, Eriel Sandika Pareira, Ryusuke Hatae, Yukitomo Ishi, Yasuji Miyakita, Kazuhiro Tanaka, Shunsaku Takayanagi, Ryohei Otani, Tsukasa Sakaida, Keiichi Kobayashi, Ryuta Saito, Kazuhiko Kurozumi, Tomoko Shofuda, Masahiro Nonaka, Hiroyoshi Suzuki, Makoto Shibuya, Takashi Komori, Hikaru Sasaki, Masahiro Mizoguchi, Haruhiko Kishima, Mitsutoshi Nakada, Yukihiko Sonoda, Teiji Tominaga, Motoo Nagane, Ryo Nishikawa, Yonehiro Kanemura, Aya Kuchiba, Yoshitaka Narita, Koichi Ichimura
Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes
Mutsumi Takadera, Kaishi Satomi, Frank Szulzewsky, Patrick J. Cimino, Eric C. Holland, Tetsuya Yamamoto, Koichi Ichimura, Tatsuya Ozawa
CGG expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy with neurological manifestations
Masashi Ogasawara, Aritoshi Iida, Theerawat Kumutpongpanich, Ayami Ozaki, Yasushi Oya, Hirofumi Konishi, Akinori Nakamura, Ryuta Abe, Hiroshi Takai, Ritsuko Hanajima, Hiroshi Doi, Fumiaki Tanaka, Hisayoshi Nakamura, Ikuya Nonaka, Zhaoxia Wang, Shinichiro Hayashi, Satoru Noguchi, Ichizo Nishino
Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains
Anne-Sophie Hérard, Fanny Petit, Charlotte Gary, Martine Guillermier, Susana Boluda, Clément M. Garin, Franck Letournel, Marie-Laure Martin-Négrier, Maxime Faisant, Catherine Godfraind, Claude-Alain Maurage, Vincent Deramecourt, Mathilde Duchesne, David Meyronnet, André Maues de Paula, Valérie Rigau, Fanny Vandenbos-Burel, Charles Duyckaerts, Danielle Seilhean, Susana Boluda, Isabelle Plu, Serge Milin, Dan Christian Chiforeanu, Annie Laquerrière, Béatrice Lannes, Suzanne Lam, Marc Dhenain
Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility
Yoneko Hayase, Shigeru Amano, Koichi Hashizume, Takashi Tominaga, Hiroyuki Miyamoto, Yukie Kanno, Yukiko Ueno-Inoue, Takayoshi Inoue, Mayumi Yamada, Shigehiro Ogata, Shabeesh Balan, Ken Hayashi, Yoshiki Miura, Kentaro Tokudome, Yukihiro Ohno, Takuma Nishijo, Toshihiko Momiyama, Yuchio Yanagawa, Akiko Takizawa, Tomoji Mashimo, Tadao Serikawa, Akihiro Sekine, Eiji Nakagawa, Eri Takeshita, Takeo Yoshikawa, Chikako Waga, Ken Inoue, Yu-ichi Goto, Yoichi Nabeshima, Nobuo Ihara, Kazuhiro Yamakawa, Shinichiro Taya, Mikio Hoshino
Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS
Ramona Gerhards, Lena Kristina Pfeffer, Jessica Lorenz, Laura Starost, Luise Nowack, Franziska S. Thaler, Miriam Schlüter, Heike Rübsamen, Caterina Macrini, Stephan Winklmeier, Simone Mader, Mattias Bronge, Hans Grönlund, Regina Feederle, Hung-En Hsia, Stefan F. Lichtenthaler, Juliane Merl-Pham, Stefanie M. Hauck, Tanja Kuhlmann, Isabel J. Bauer, Eduardo Beltran, Lisa Ann Gerdes, Aleksandra Mezydlo, Amit Bar-Or, Brenda Banwell, Mohsen Khademi, Tomas Olsson, Reinhard Hohlfeld, Hans Lassmann, Tania Kümpfel, Naoto Kawakami, Edgar Meinl
Prenatal alcohol exposure is a leading cause of interneuronopathy in humans
Florent Marguet, Gaëlle Friocourt, Mélanie Brosolo, Fanny Sauvestre, Pascale Marcorelles, Céline Lesueur, Stéphane Marret, Bruno J. Gonzalez, Annie Laquerrière
Cerebral organoids: emerging ex vivo humanoid models of glioblastoma
Michail-Dimitrios Papaioannou, Kevin Sangster, Rifat Shahriar Sajid, Ugljesa Djuric, Phedias Diamandis
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Aleksandra M. Wojtas, Yari Carlomagno, Jonathon P. Sens, Silvia S. Kang, Tanner D. Jensen, Aishe Kurti, Kelsey E. Baker, Taylor J. Berry, Virginia R. Phillips, Monica Casey Castanedes, Ayesha Awan, Michael DeTure, Cristhoper H. Fernandez De Castro, Ariston L. Librero, Mei Yue, Lillian Daughrity, Karen R. Jansen-West, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, John D. Fryer
Neuroinflammation and protein pathology in Parkinson’s disease dementia
Antonina Kouli, Marta Camacho, Kieren Allinson, Caroline H. Williams-Gray
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
Tadafumi Hashimoto, Daisuke Fujii, Yasushi Naka, Mayu Kashiwagi-Hakozaki, Yuko Matsuo, Yusuke Matsuura, Tomoko Wakabayashi, Takeshi Iwatsubo
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease
Rodrigo Morales, Claudia Duran-Aniotz, Javiera Bravo-Alegria, Lisbell D. Estrada, Mohammad Shahnawaz, Ping-Ping Hu, Carlos Kramm, Diego Morales-Scheihing, Akihiko Urayama, Claudio Soto
Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia
Yongchao Mou, Yi Dong, Zhenyu Chen, Kyle R. Denton, Michael O. Duff, Craig Blackstone, Su-Chun Zhang, Xue-Jun Li
Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease
Ryan J. Bevan, Tim R. Hughes, Pete A. Williams, Mark A. Good, B. Paul Morgan, James E. Morgan
Influence of APOE genotype in primary age-related tauopathy
Andrew C. Robinson, Yvonne S. Davidson, Federico Roncaroli, James Minshull, Phillip Tinkler, Michael A. Horan, Antony Payton, Neil Pendleton, David M. A. Mann
Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy
Jinming Han, Heela Sarlus, Zbigniew K. Wszolek, Virginija Danylaité Karrenbauer, Robert A. Harris
MAPT subhaplotypes in corticobasal degeneration: assessing associations with disease risk, severity of tau pathology, and clinical features
Rebecca R. Valentino, Shunsuke Koga, Ronald L. Walton, Alexandra I. Soto-Beasley, Naomi Kouri, Michael A. DeTure, Melissa E. Murray, Patrick W. Johnson, Ronald C. Petersen, Bradley F. Boeve, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Michael G. Heckman
Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells
Tina Yi-Ting Huang, Andrea Piunti, Jin Qi, Marc Morgan, Elizabeth Bartom, Ali Shilatifard, Amanda M. Saratsis
Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein
M. Flint Beal, Jayandra Chiluwal, Noel Y. Calingasan, Ginger L. Milne, Mikhail S. Shchepinov, Victor Tapias
Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma
Ming Li, Guoping Li, Juri Kiyokawa, Zain Tirmizi, Leland G. Richardson, Jianfang Ning, Saumya Das, Robert L. Martuza, Anat Stemmer-Rachamimov, Samuel D. Rabkin, Hiroaki Wakimoto
Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development
Dominik Röhr, Baayla D. C. Boon, Martin Schuler, Kristin Kremer, Jeroen J. M. Hoozemans, Femke H. Bouwman, Samir F. El-Mashtoly, Andreas Nabers, Frederik Großerueschkamp, Annemieke J. M. Rozemuller, Klaus Gerwert
Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons
Maximilian Paul Thelen, Brunhilde Wirth, Min Jeong Kye
Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination
Melanie Lohrberg, Anne Winkler, Jonas Franz, Franziska van der Meer, Torben Ruhwedel, Nikoloz Sirmpilatze, Rakshit Dadarwal, Ronja Handwerker, Daniel Esser, Kerstin Wiegand, Christian Hagel, Andreas Gocht, Fatima Barbara König, Susann Boretius, Wiebke Möbius, Christine Stadelmann, Alonso Barrantes-Freer