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Published in: Acta Neuropathologica Communications 1/2023

Open Access 01-12-2023 | Vascular Dementia | Review

Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment

Authors: Vismitha Rajeev, Yuek Ling Chai, Luting Poh, Sharmelee Selvaraji, David Y. Fann, Dong-Gyu Jo, T. Michael De Silva, Grant R. Drummond, Christopher G. Sobey, Thiruma V. Arumugam, Christopher P. Chen, Mitchell K. P. Lai

Published in: Acta Neuropathologica Communications | Issue 1/2023

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Abstract

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically involved in cognitive processes must feature as the main driver of VCI, the underlying mechanisms and interactions with related disease processes remain to be fully elucidated. Recent clinical studies of cerebral blood flow measurements have supported the role of chronic cerebral hypoperfusion (CCH) as a major driver of the vascular pathology and clinical manifestations of VCI. Here we review the pathophysiological mechanisms as well as neuropathological changes of CCH. Potential interventional strategies for VCI are also reviewed. A deeper understanding of how CCH can lead to accumulation of VCI-associated pathology could potentially pave the way for early detection and development of disease-modifying therapies, thus allowing preventive interventions instead of symptomatic treatments.
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Metadata
Title
Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment
Authors
Vismitha Rajeev
Yuek Ling Chai
Luting Poh
Sharmelee Selvaraji
David Y. Fann
Dong-Gyu Jo
T. Michael De Silva
Grant R. Drummond
Christopher G. Sobey
Thiruma V. Arumugam
Christopher P. Chen
Mitchell K. P. Lai
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Acta Neuropathologica Communications / Issue 1/2023
Electronic ISSN: 2051-5960
DOI
https://doi.org/10.1186/s40478-023-01590-1

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