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Vascular Dementia 

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  1. Open Access 01-12-2024 | Dementia | OriginalPaper

    Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study

    The number of dementia cases worldwide is continuously rising and is projected to double nearly every 20 years [ 1 ]. With the approval of Aduhelm , Leqembi, and Donanemab as the first effective treatments against Alzheimer’s disease (AD) by the …

  2. Open Access 01-12-2024 | Stroke | OriginalPaper

    Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study

    We continue to live longer, and the impact of age-related diseases such as stroke and dementia is growing [ 1 ]. In addition to the functional disability a stroke may cause, cognitive impairment after stroke is common. Post-stroke cognitive …

  3. Open Access 01-12-2024 | Vascular Dementia | OriginalPaper

    Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion

    Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood flow. Pathological changes in the hippocampus predispose to cognitive impairment and dementia. The role of hippocampal pericytes in …

  4. Open Access 01-12-2024 | OriginalPaper

    The effect of acupuncture on oxidative stress in animal models of vascular dementia: a systematic review and meta-analysis

    Vascular dementia (VaD) is the second most common type of dementia ranked behind Alzheimer’s disease. The typical symptoms of VaD are progressive cognitive impairment, behavioural abnormalities, affective disorder, and neurological dysfunction …

  5. 29-01-2024 | Dementia | Online First

    Study of electronic biofeedback combined with nursing intervention in the treatment of vascular cognitive impairment-no dementia

    With increasing life expectancy, the incidence of age-related dementia has been increasing yearly. With an estimated 50 million people affected globally in 2018 and a projected threefold increase by 2050, the socio-economic costs of the disease …

  6. Open Access 01-12-2023 | Vascular Dementia | OriginalPaper

    Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia

    Dementia is a progressively debilitating disease, afflicting an estimated 47.5 million people worldwide and up to 10% of community dwelling older adults in Singapore [ 1 , 2 ]. The high prevalence of dementia has many social and economic …

  7. Open Access 01-12-2023 | Alzheimer's Disease | OriginalPaper

    Associations of screen-based sedentary activities with all cause dementia, Alzheimer’s disease, vascular dementia: a longitudinal study based on 462,524 participants from the UK Biobank

    With the aging of population, dementia has become a major public concern worldwide and is expected to affect 1.5 million people by 2050, placing an enormous burden on society [ 1 , 2 ]. Current drug treatments for dementia, especially Alzheimer's …

  8. Open Access 01-12-2023 | Alzheimer's Disease | ReviewPaper

    Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

    This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). Humans have a peripheral lipoprotein profile where …

  9. 23-01-2023 | Dementia | OriginalPaper

    Exercise Improves Cerebral Blood Flow and Functional Outcomes in an Experimental Mouse Model of Vascular Cognitive Impairment and Dementia (VCID)

    Vascular cognitive impairment and dementia (VCID) are a growing threat to public health without any known treatment. The bilateral common carotid artery stenosis (BCAS) mouse model is valid for VCID. Previously, we have reported that remote …

  10. Open Access 01-12-2023 | Acute Pancreatitis | OriginalPaper

    Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report

    Valproic acid (VPA) is a widely used drug for the treatment of epileptic seizures and mania in bipolar disorder, as well as for the prevention of migraine headaches [ 1 ]. VPA is a relatively safe drug [ 2 ]; however, a rare side effect is acute …

  11. 01-01-2023 | Vascular Dementia | ReviewPaper

    The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia

    White matter injury is a progressive vascular disease that leads to neurological deficits and vascular dementia. It comprises up to 30% of all diagnosed strokes, though up to ten times as many events go undiagnosed in early stages. There are …

  12. 28-02-2023 | Dementia | OriginalPaper

    Impact of interventions scenarios targeting three main vascular risk factors on the future burden of dementia in France

    The epidemiological and societal burden of dementia is expected to increase in the coming decades due to the world population aging. In this context, the evaluation of the potential impact of intervention scenarios aiming at reducing the …

  13. 01-04-2023 | Alzheimer's Disease | OriginalPaper

    A Large Retrospective Cohort Study on the Risk of Alzheimer’s Disease and Related Dementias in Association with Vascular Diseases and Cancer Therapy in Men with Prostate Cancer

    A lzheimer’s disease (AD) and related dementias (ADRDs) have had an increasing prevalence in the United States and worldwide over the past few decades ( 1 – 5 ). The causes of ADRD remained unknown, but a number of risk factors have been documented …

  14. Open Access 01-12-2023 | Cerebral Small Vessel Disease | ReviewPaper

    Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

    Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-stroke dementia, subcortical ischemic …

  15. Open Access 01-12-2021 | Alzheimer's Disease | OriginalPaper

    Loss with ageing but preservation of frontal cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer’s disease

    Cerebral pericytes are an integral component of the neurovascular unit, which governs the blood–brain barrier. There is paucity of knowledge on cortical pericytes across different dementias. We quantified cortical pericytes in capillaries in 124 …

  16. 01-10-2021 | Stroke | ReviewPaper

    Atrial Fibrillation Is Associated with Cognitive Impairment, All-Cause Dementia, Vascular Dementia, and Alzheimer’s Disease: a Systematic Review and Meta-Analysis

    Atrial fibrillation (AF) and dementia frequently coexist, affecting predominantly the elderly. 1 As global population aging is accelerated, the burden of both disorders is projected to increase dramatically. Specifically, the number of patients …

  17. 01-12-2021 | Dementia | Original Research

    Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia

    Increases in brain and systemic inflammation, and decreased brain blood flow, as seen during heart failure (HF) [ 1 ], are strongly correlated with the development of vascular contributions to cognitive impairment and dementia (VCID) and …

  18. Open Access 01-12-2022 | Coronary Heart Disease | OriginalPaper

    Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies

    For decades, the non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA) has been widely used at a low dose of 100 to 300 mg per day for secondary prevention of atherosclerotic cardiovascular disease (ASCVD) [ 1 ]. Although the …

  19. Open Access 01-12-2021 | Vascular Dementia | OriginalPaper

    Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism

    Idiopathic normal pressure hydrocephalus (iNPH) is characterized by cognitive decline, gait disturbance, and urinary incontinence [ 1 , 2 ]. The condition is increasingly recognized and prevalence is higher than previously believed [ 3 , 4 ].

  20. 24-01-2023 | Vascular Dementia | OriginalPaper

    Uric acid levels and their association with vascular dementia and Parkinson’s disease dementia: a meta-analysis

    Dementia is characterized as a syndrome rather than a particular disease that can seriously affect an individual’s work and life [ 1 ]. Because of its high prevalence, dementia has become a serious public health issue around the world [ 2 ].

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