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28508 search results for:

Immunomodulator 

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  1. Open Access 01-06-2024 | Probiotics | OriginalPaper

    Synergistic immunomodulatory effect of synbiotics pre- and postoperative resection of pancreatic ductal adenocarcinoma: a randomized controlled study

    Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a highly immunosuppressive microenvironment. This single-blind, randomized study aimed to evaluate the synergistic immunomodulatory effects of synbiotics (probiotics and inulin …

  2. 01-05-2024 | OriginalPaper

    Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma

    The persistent creeper Bacopa monnieri , commonly known as Brahmi, has long been recognized for its multifaceted properties across various cultures and geographical regions. Revered as “water hyssop,” “thyme-leafed gratiola,” “herb of grace,” or …

  3. Open Access 28-02-2024 | Hepatitis B | ReviewPaper

    A Review of Hepatitis B Reactivation Risk on Immunosuppressants with a Focus on Newer Immunomodulators

    Hepatitis B virus (HBV) infection is a public health threat worldwide that can result in chronic hepatitis with progression to liver cirrhosis and/or cancer [ 1 ]. It is estimated that 3.2% of the global population lives with chronic HBV, amounting …

  4. 08-05-2024 | Arthritis | Online First

    Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network

    Micromeria biflora (M.B) Benth has proven anti-inflammatory efficacy, thereby, the goal of the current investigation was to assess the anti-arthritic potential of M.B ethanolic extract and fractions as well as to investigate the likely mechanism …

  5. Open Access 01-05-2024 | OriginalPaper

    The prognostic and potentially immunomodulatory role of cartilage oligomeric matrix protein in patients with gastric and esophageal adenocarcinoma

    Understanding the mechanisms of resistance to immunotherapy in different types of cancers will allow for the usage of novel effective treatments by providing new targets that can enhance the effect of immunotherapy.

  6. 01-12-2024 | Immunomodulator | OriginalPaper

    Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis

    Allergic eye disease refers to various hypersensitivity disorders that affect the entire ocular surface, including the conjunctiva, lids, cornea, lacrimal glands, and tear film, with an estimated prevalence of 20% worldwide, and within the United …

  7. 09-04-2024 | Probiotics | Online First

    Lacticaseibacillus casei K11 exerts immunomodulatory effects by enhancing natural killer cell cytotoxicity via the extracellular regulated-protein kinase pathway

    Natural killer (NK) cells, a subset of cytotoxic lymphocytes, are integral components of the immune system [ 1 ]. NK cells account for approximately 10% of all peripheral blood lymphocytes [ 2 ]. Unlike T and B cells, NK cells can directly …

  8. Open Access 01-12-2024 | Neurotomy | OriginalPaper

    The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks

    Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of the IR, offering a safe and cost-effective …

  9. Open Access 01-12-2024 | Uveitis | OriginalPaper

    Intravenous cyclophosphamide therapy for patients with severe ocular inflammatory diseases who failed other immunomodulatory therapies

    Cyclophosphamide (CP) is an alkylating agent and displays a cytotoxic effect on rapidly proliferating cells [ 1 ]. Its mechanism of action mainly inhibits the functioning of both T and B cells, resulting in suppression of the immune system [ 2 ].

  10. 06-02-2024 | Edema | OriginalPaper

    Phytochemical analysis and immunomodulatory activities in vitro and in vivo of Aframomum melegueta K Schum seed extracts

    Aframomum melegueta K Schum (A. melegueta), an herbaceous plant renowned for its medicinal seeds, was investigated for its potential immunomodulatory effects in vitro and in vivo using ethanolic and methanolic extracts. The immunomodulatory effect …

  11. Open Access 01-12-2024 | Kawasaki Disease | ReviewPaper

    Immunomodulatory effects of iTr35 cell subpopulation and its research progress

    The spotlight in recent years has increasingly focused on inducible regulatory T cells 35 (iTr35), a novel subpopulation of regulatory T cells characterized by phenotypic stability, heightened reactivity, and potent immunosuppressive function …

  12. 01-05-2024 | NSCLC | OriginalPaper

    Immunomodulatory effects of Diospyros peregrina fruit preparation (DFP) in non-small cell lung cancer (NSCLC) by utilizing dendritic cell-mediated antigen presentation and T helper (TH) cell differentiation

    Diospyros peregrina is a dioecious plant which is native to India. It belongs to the family of Ebenaceae and is extensively used to treat various ailments, such as leucorrhoea and other uterine-related problems. Though few studies have been on D.

  13. 16-03-2024 | Celiac Disease | Online First

    Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients

    Celiac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in gliadin-induced inflammation. Vitamin A (retinol; Ret) and its metabolite, retinoic acid (RA), along with …

  14. Open Access 01-12-2024 | Breast Cancer | OriginalPaper

    Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

    Globally, breast cancer (BC) is considered the most prevalent type of malignancy as well as the second leading cause of cancer-related deaths [ 1 ]. BCs are classified according to their expression patterns of certain molecules including estrogen …

  15. Open Access 01-03-2024 | OriginalPaper

    Comparative bioactivity and immunomodulatory potential of the new Bioroot Flow and AH Plus Bioceramic sealer: An in vitro study on hPDLSCs

    Root canal treatment (RCT) comprises the chemical–mechanical disinfection of the root canal system and its subsequent filling. Root canal filling should aim to provide a three-dimensional seal of the root canal system with dimensionally stable …

  16. 24-11-2023 | Pulmonary Hypertension | ReviewPaper

    Immunomodulatory macrophages and Treg in pulmonary hypertension

    Pulmonary hypertension (PH) is a disease that affects the right ventricle and venous circulation. The need for improvement in the discovery of novel therapeutic targets and drugs focusing on the immunomodulatory for the treatment of pulmonary …

  17. 12-01-2024 | OriginalPaper

    Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16–F10, MC38 and Hep1-6 Tumor Models

  18. Open Access 01-12-2024 | Cytokines | OriginalPaper

    Melatonin as an immunomodulator in CD19-targeting CAR-T cell therapy: managing cytokine release syndrome

    With its extraordinary potency and sustained clinical response, chimeric antigen receptor (CAR-T) cell therapy represents a breakthrough in the treatment of hematologic cancer. CARs, which are engineered synthetic receptors, enable the redirection …

  19. 01-12-2024 | Cytokines | Erratum

    Retraction Note: 6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats

  20. Open Access 01-12-2024 | COVID-19 | OriginalPaper

    Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study

    Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with influenza-like initial symptoms such as cough, fever, fatigue, headache, myalgias, and diarrhoea [ 1 ]. Patients with COVID-19 may …

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