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Progressive Supranuclear Palsy 

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  1. Open Access 09-05-2024 | Online First

    Low-intensity vestibular noise stimulation improves postural symptoms in progressive supranuclear palsy

    Progressive supranuclear palsy (PSP) is a rare and rapidly progressing neurodegenerative disease that clinically belongs to the group of atypical parkinsonian syndromes and is characterized by cerebral aggregation of tau protein [ 7 , 53 ]. Early …

  2. 03-05-2024 | Progressive Supranuclear Palsy | Online First

    Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study

    Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease that is characterized by supranuclear gaze palsy, akinetic rigidity, gait disturbance, and dementia [ 1 ]. PSP presents with various clinical phenotypes that mimic …

  3. 17-04-2024 | Progressive Supranuclear Palsy | Online First

    Frontal hypometabolism in the diagnosis of progressive supranuclear palsy clinical variants

    Progressive supranuclear palsy (PSP) is a 4-repeat (4R) tauopathy that may present with a variety of cognitive, motor, and behavioral symptoms [ 39 ]. PSP can present clinically with several variants, including but not limited to the classic …

  4. Open Access 19-04-2024 | Progressive Supranuclear Palsy | Online First

    Longitudinal change of energy expenditure, body composition and dietary habits in Progressive Supranuclear Palsy patients

    Changes in the metabolic state, body composition and dietary intake are present in all neurodegenerative diseases [ 1 – 3 ]. Resting energy expenditure (REE) represents the number of calories required by the body to maintain vital physiological …

  5. 18-01-2024 | Progressive Supranuclear Palsy | Review

    Progressive Supranuclear Palsy Diagnosis and Treatment

    Progressive supranuclear palsy (PSP) is a neurodegenerative condition in the category of atypical parkinsonian disorders.

  6. Open Access 24-03-2024 | Dysphagia | Online First

    Dysphagia Prevalence in Progressive Supranuclear Palsy: A Systematic Review and Meta-Analysis

    Atypical parkinsonian disorders (APD) are characterised by their rapid progression [ 1 ] and short survival time in contrast to idiopathic Parkinson’s disease (IPD) [ 2 – 5 ]. Progressive supranuclear palsy (PSP) is the most common type of disorder …

  7. Open Access 12-04-2024 | Progressive Supranuclear Palsy | Online First

    Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study

    Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are two related rare neurodegenerative diseases which can cause parkinsonism. Due to their rarity, single centre or regional studies are frequently limited by sample size.

  8. 22-08-2023 | Paraneoplastic Syndromes | Letter

    Progressive supranuclear palsy phenotypic presentation associated with anti MA2 antibody

    PSP is a slowly progressive neuro-degenerative disorder mainly causing oculomotor dysfunction, postural instability, akinesia and cognitive dysfunction.

  9. Open Access 06-10-2023 | Progressive Supranuclear Palsy | OriginalPaper

    The comorbidity and co-medication profile of patients with progressive supranuclear palsy

    Progressive supranuclear palsy (PSP) is a rare neurodegenerative movement disorder with a mean onset between 60 and 66 years of age [ 1 , 2 ]. Hence, PSP is a disease of elderly people, who often suffer from various additional chronic diseases. A …

  10. 14-08-2023 | Parkinson's Disease | OriginalPaper

    Quantitative susceptibility mapping from basal ganglia and related structures: correlation with disease severity in progressive supranuclear palsy

    Progressive supranuclear palsy (PSP) is the second-most common neurodegenerative Parkinsonian disorder [ 1 ]. It is a disabling and fatal disease with a median survival of around 7 years [ 2 ]. PSP is a 4R tauopathy. The current treatment of PSP is …

  11. 11-10-2023 | Parkinson's Disease | ReviewPaper

    Differentiating progressive supranuclear palsy from other movement disorders using transcranial sonography: a systematic review and meta-analysis

    Progressive supranuclear palsy (PSP) is an atypical parkinsonism that presents with different phenotypes. There are still no validated diagnostic biomarkers for early diagnosis of PSP. Transcranial sonography (TCS) is a promising tool in the …

  12. Open Access 01-12-2023 | Progressive Supranuclear Palsy | OriginalPaper

    Accurate digital quantification of tau pathology in progressive supranuclear palsy

    The development of novel treatments for Progressive Supranuclear Palsy (PSP) is hindered by a knowledge gap of the impact of neurodegenerative neuropathology on brain structure and function. The current standard practice for measuring postmortem …

  13. Open Access 01-12-2023 | Progressive Supranuclear Palsy | OriginalPaper

    Remote at-home wearable-based gait assessments in Progressive Supranuclear Palsy compared to Parkinson’s Disease

    Digital health technologies have the potential to provide objective, quantitative digital biomarkers of disease remotely in participants’ homes (reviewed in [ 1 ]). While remote in-home wearable sensors have been successfully used to measure PD …

  14. 22-09-2023 | Blepharospasm | Letter

    Alternating unilateral blepharospasm with apraxia of eyelid opening in a patient with progressive supranuclear palsy

    Apraxia of lid opening (ALO) is a nonparalytic motor abnormality “characterized by difficulty initiating the act of lid elevation after lid closure” [ 2 ]. It often occurs together with blepharospasm but may also occur alone [ 2 ]. Most of the …

  15. Open Access 01-12-2023 | Magnetic Resonance Imaging | OriginalPaper

    Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson’s disease on MRI

    Neurodegenerative diseases especially dementias show a strongly increasing prevalence in an ageing population, that reduce the quality of life of affected persons and their caregivers and create a significant economic burden [ 1 ]. Although …

  16. 05-09-2023 | Movement Disorder | OriginalPaper

    Investigating differences in young- and late-onset progressive supranuclear palsy

    Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease associated with both motor and cognitive symptoms, belongs to frontotemporal degeneration disorders, and is often categorized as an atypical parkinsonism. Richardson, Steele, and …

  17. Open Access 03-08-2023 | Magnetic Resonance Imaging | OriginalPaper

    Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy

    Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural …

  18. Open Access 01-12-2023 | Progressive Supranuclear Palsy | OriginalPaper

    Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration

    Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are distinct clinicopathological subtypes of frontotemporal lobar degeneration. They both have atypical parkinsonism, and they usually have distinct clinical features. The …

  19. 05-04-2023 | Dysarthria | Letter

    Saw-tooth vertical saccades in progressive supranuclear palsy

  20. 18-03-2023 | Affective Disorder | ReviewPaper

    Pathomechanisms of depression in progressive supranuclear palsy

    Depression is one of the most frequent neuropsychiatric symptoms in progressive supranuclear palsy (PSP), a four-repeat tauopathy and most common atypical parkinsonian disorder, but its pathophysiology and pathogenesis are poorly understood.

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