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Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
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Oncology Solid Tumor

Solid Tumor
Open Access Glioblastoma Review

Improving drug delivery in glioblastoma

Read more

Glioblastoma remains resistant to most conventional treatments. Emerging therapies aim to overcome the challenges posed by the blood–brain barrier and tumor microenvironment.

Editor's Choice

Insulinoma misidentified as schizophrenia

Free for a limited time Insulinoma Case Study

Intermittently scanning CGM detected hypoglycemia in a woman previously diagnosed with schizophrenia and treated with antipsychotic medication. Insulinoma was diagnosed and resected, resolving her neuropsychiatric symptoms.

Development of bronchopleural fistula after neoadjuvant immunochemotherapy

Open Access Adverse Effects of Cancer Therapy Case Study

Bronchopleural fistula is a rare but potentially fatal complication that can occur after surgery in patients receiving neoadjuvant immunochemotherapy for stage III NSCLC.

Some reassurance on ICI use in pregnancy from VigiBase analysis

23-04-2024 Checkpoint Inhibitors News

A study has found little over-reporting of adverse maternofetal outcomes among pregnant women with cancer using ICIs versus other anticancer agents.

Advances in radionuclide therapies for neuroendocrine tumors

Open Access Neuroendocrine Tumor Review

What is the current role of peptide receptor radionuclide therapy in patients with advanced neuroendocrine tumors, and what combinations could enhance its efficacy?

Our tailored content service will keep you up to date…

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Latest News

Some reassurance on ICI use in pregnancy from VigiBase analysis

23-04-2024 Checkpoint Inhibitors News

Postoperative pembrolizumab improves OS in high-risk RCC

18-04-2024 Kidney Cancer News

Potential of T-cell therapy shown for rare types of soft-tissue sarcomas

15-04-2024 Sarcoma News

Three-phase screening approach promising for prostate cancer

11-04-2024 Prostate Cancer News

Alectinib may cause androgen deficiency in men with NSCLC

09-04-2024 Adverse Effects of Cancer Therapy News

Forgoing axillary surgery does not increase breast cancer recurrence

04-04-2024 Breast Cancer News
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine

Case Studies

Insulinoma misidentified as schizophrenia

Free for a limited time Insulinoma Case Study

Intermittently scanning CGM detected hypoglycemia in a woman previously diagnosed with schizophrenia and treated with antipsychotic medication. Insulinoma was diagnosed and resected, resolving her neuropsychiatric symptoms.

Development of bronchopleural fistula after neoadjuvant immunochemotherapy

Open Access Adverse Effects of Cancer Therapy Case Study

Bronchopleural fistula is a rare but potentially fatal complication that can occur after surgery in patients receiving neoadjuvant immunochemotherapy for stage III NSCLC.

Vocal cord paralysis caused by metastasized endometrial cancer

Open Access Endometrial Cancer Case Study

The first case of vocal cord paralysis due to a mediastinal metastasis developing 16 years after the patient's endometrial cancer was treated by hysterectomy, external beam radiotherapy, and chemotherapy.
Cancer Biomarker Video

Next-generation sequencing

Watch now

Next-generation sequencing is a powerful tool that can identify mutations or fusions in a wide range of cancers, enabling physicians to provide targeted therapy to patients and improve outcomes. 

In this vodcast, Professor Andrew Beggs discusses practical aspects of this technique from the clinical viewpoint. 

Supported by: Illumina, Inc., and Eli Lilly and Company

Prof. Andrew Beggs
Developed by: Springer Healthcare

Current Reviews

Complications and visual outcomes following surgical resection of pediatric optic pathway/hypothalamic gliomas: a systematic review and meta-analysis

Glioma Review

Pediatric optic pathway/hypothalamic gliomas (OPHG) pose challenges in treatment due to their location and proximity to vital structures. Surgical resection plays a key role in the management of OPHG especially when the tumor exhibits mass effect …

Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies

Thyroid Cancer Review article

While thyroid cancer stands as the most common form of endocrine cancer, it is a comparatively uncommon malignancy, representing a mere 4% of global cancer cases according to GLOBOCAN 2018 statistics [ 1 ]. Furthermore, Asia is the region where 60% …

Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?

Glioblastoma

Immunotherapy for glioblastoma (GBM) remains an intensive area of investigation. Given the seismic impact of cancer immunotherapy across a range of malignancies, there is optimism that harnessing the power of immunity will influence GBM as well.

Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape

Cytostatic Therapy REVIEW

With the age of monoclonal antibodies (mabs) ushered in by Köhler and Milstein’s 1975 breakthrough in hybridoma technology, there came potential for developing specific, targeted cancer therapeutics. One of the most significant has been …
NSCLC Podcast

Episode 7: A deep dive into ADAURA

Listen now

The ADAURA trial has, as of this year, demonstrated an overall survival benefit with the adjuvant use of osimertinib in people with resectable NSCLC. 

We take an in-depth look at the study with Dr. Luis Paz-Ares, who outlines the study findings, discusses the clinical implications, and addresses the pertinent questions raised by the trial.

Dr. Luis Paz-Ares

CME & eLearning

Webinar (Link opens in a new window)

Lung Cancer

1.25 AMA PRA Category 1 Credit(s)™

A collaborative program highlighting the importance of molecular assessments and targeted treatment selection in people with biomarker-positive disease. Submit your questions for the experts now.

Supported by:
  • Roche and Illumina
Developed by: Springer Healthcare IME

Webcast | Videos | Cases (Link opens in a new window)

Thyroid Cancer

Identifying molecular biomarkers is crucial in determining the best targeted treatment options for your patients with advanced thyroid cancer.

Join our expert-led multi-format educational program that explores the continuing discovery of new genomic targets and delivers the latest research in molecular testing and the application of targeted therapies for thyroid cancer.

Start by watching our webcast and short vodcasts.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME

eLearning | Interviews | Digital Treatment Map (Link opens in a new window)

NSCLC

1.0 AMA PRA Category 1 Credit(s)™

Expert-led, multiformat program which will address the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Will also include guidance on integrating shared decision making into your clinical practice, drawing on insights from a patient on how best to communicate.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.
Developed by: Springer Healthcare IME
Biomarkers Podcast

Episode 5: Next-generation sequencing

Listen now

Emerging biomarkers in thyroid and non-small cell lung cancers

Next-generation sequencing is a powerful tool that can identify mutations or fusions in a wide range of cancers, enabling physicians to provide targeted therapy to patients and improve outcomes. In this podcast, Professor Andrew Beggs discusses practical aspects of this technique from the clinical viewpoint.

This content is intended only for healthcare providers and was made possible by educational funding provided by Illumina, Inc., and Eli Lilly and Company.

Prof. Andrew Beggs
Developed by: Springer Healthcare

Further Reading

Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country

Open Access Colorectal Cancer Original Contribution

Folate-mediated one-carbon metabolism (FOCM) plays an important role in colorectal carcinogenesis. Previous studies have assessed the role of folate-mediated one-carbon metabolism (FOCM)-related gene-diet interaction in the aetiology of colorectal …

Predictors of significant distress in cervical cancer patients: a cross sectional study

Open Access Cervical Cancer Gynecologic Oncology

Cervical cancer is the fourth most common malignancy in women worldwide [ 1 ]. With the introduction of cervical cancer screening programs, a decrease in the incidence of cervical cancer since 1970 was achieved. Nonetheless 4575 women were newly …

To trust or not to trust: evaluating the reliability and safety of AI responses to laryngeal cancer queries

Open Access Laryngeal Cancer Laryngology

The Internet serves as a widely accessible platform for information, yet the reliability of the information it offers remains uncertain. It has become an indispensable resource for health-related information, with a significant proportion of …

Oncologic outcomes of the most prevalent major salivary gland cancers: retrospective cohort study from single center

Open Access Salivary Gland Cancer Head and Neck

Salivary gland tumors (SGT) constitute less than 3–4% of all head and neck tumors. They form a histologically heterogeneous group, with unpredictable and often highly aggressive clinical behavior. The wide variety of tumor etiology, microscopic …

Related topics

Open Access Glioblastoma Review

Improving drug delivery in glioblastoma

Glioblastoma remains resistant to most conventional treatments. Emerging therapies aim to overcome the challenges posed by the blood–brain barrier and tumor microenvironment.

Read more

Novel therapies for glioblastoma

Free for a limited time Glioblastoma Review

Antiepileptic strategies for patients with brain tumors

Open Access Central Nervous System Cancer Review

Childhood cancer survivors benefit from getting active

08-02-2024 Pediatric Cancer News

CNS tumors: what should the neonatologist know?

Open Access CNS Tumors in Pediatrics Review

Primary central nervous system lymphoma

Lymphoma of the Central Nervous System Review
Free for a limited time Insulinoma Case Study

Insulinoma misidentified as schizophrenia

Intermittently scanning CGM detected hypoglycemia in a woman previously diagnosed with schizophrenia and treated with antipsychotic medication. Insulinoma was diagnosed and resected, resolving her neuropsychiatric symptoms.

Read more

Advances in radionuclide therapies for neuroendocrine tumors

Open Access Neuroendocrine Tumor Review

An unusual pancreatic neuroendocrine microtumor

Open Access Neuroendocrine Tumor Case Study

Follicular adenoma with a papillary architecture originating from an ectopic thyroid gland

Open Access Thyroid Disease Case Study

Clinical use of thyroglobulin: Thyroid cancer and beyond

Open Access Thyroid Disease Review

Metastatic papillary thyroid cancer in the pleural space

Open Access Thyroid Cancer Case Study
Open Access Gastric Cancer Review

International consensus on the management of metastatic gastric cancer

Guidance on the diagnosis, treatment, and care of patients with metastatic gastric cancer, based on the findings of the international multidisciplinary Bertinoro workshop held in November 2022.

Read more

Insulinoma misidentified as schizophrenia

Free for a limited time Insulinoma Case Study

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Profound hypotension induced by ICI treatment

Open Access Adverse Effects of Cancer Therapy Case Study

Clinical practice guidelines for esophagogastric junction cancer

Open Access Gastroesophageal Junction Cancer Review

An uncommon presentation of CRC

Open Access Colorectal Cancer Case Study
18-04-2024 Kidney Cancer News

Postoperative pembrolizumab improves OS in high-risk RCC

Adjuvant treatment with pembrolizumab is associated with a significant survival benefit in individuals with high-risk renal cell carcinoma.

Read more

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Three-phase screening approach promising for prostate cancer

11-04-2024 Prostate Cancer News

Lymph node dissection in testicular cancer

Open Access Testicular Cancer Review

Exercise may serve as a painkiller for cancer survivors

22-02-2024 Lifestyle Modifications News

Treating rare malignancies of the urinary tract — one size fits some

Bladder Carcinoma Review
Open Access Endometrial Cancer Case Study

Vocal cord paralysis caused by metastasized endometrial cancer

The first case of vocal cord paralysis due to a mediastinal metastasis developing 16 years after the patient's endometrial cancer was treated by hysterectomy, external beam radiotherapy, and chemotherapy.

Read more

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Forgoing axillary surgery does not increase breast cancer recurrence

04-04-2024 Breast Cancer News

Ovarian suppression in breast cancer

Open Access Breast Cancer Review

Adding pembrolizumab to CRT boosts cervical cancer PFS

27-03-2024 Cervical Cancer News

Profound hypotension induced by ICI treatment

Open Access Adverse Effects of Cancer Therapy Case Study
15-02-2024 Head and Neck Cancer News

Stroke prevention measures warranted for head and neck cancer survivors

People with a history of head and neck cancer have an increased risk for stroke, highlighting the need for early screening and intervention.

Read more

An aggressive presentation of secretory carcinoma

Open Access Salivary Gland Cancer Case Study

Breast metastases in a male patient with nasopharyngeal carcinoma

Open Access Nasopharyngeal Cancer Case Study

Carcinosarcoma of the parotid gland

Open Access Salivary Gland Cancer Case Study

HER2-positive mucoepidermoid carcinoma of the breast

Open Access Breast Cancer Case Study

Add-on toripalimab prolongs advanced nasopharyngeal carcinoma survival

05-12-2023 Nasopharyngeal Cancer News
23-04-2024 Checkpoint Inhibitors News

Some reassurance on ICI use in pregnancy from VigiBase analysis

A study has found little over-reporting of adverse maternofetal outcomes among pregnant women with cancer using ICIs versus other anticancer agents.

Read more

Primary melanoma of the lung

Open Access Melanoma Case Study

Individualized neoantigen therapy may benefit people with resected melanoma

25-01-2024 Melanoma News

Treatment of melanoma brain and leptomeningeal metastases

Melanoma Review

Genetic counseling ‘should be considered’ for patients with early-onset MCC

05-01-2024 Merkel Cell Carcinoma News

Primary melanoma presenting in the cervical spine

Open Access Melanoma Case Study
Open Access Adverse Effects of Cancer Therapy Case Study

Development of bronchopleural fistula after neoadjuvant immunochemotherapy

Bronchopleural fistula is a rare but potentially fatal complication that can occur after surgery in patients receiving neoadjuvant immunochemotherapy for stage III NSCLC.

Read more

Severe megaloblastic anemia related to erlotinib

Open Access NSCLC Case Study

Trial reassures on SABR use in NSCLC patients with ILD

14-03-2024 NSCLC News

Managing malignant pleural effusion

Open Access Pleural Effusion Review

Lung cancer in a transplanted lung

Open Access Lung Cancer Case Study

Late onset of immune checkpoint inhibitor-induced type 1 diabetes

Open Access Type 1 Diabetes Case Study
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