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Solid Tumor Thoracic Cancer

Thoracic Cancer

Bacterial contributions to oncogenesis

From the mechanistic contributions of pathogenic bacteria to tumor initiation, to the role dysbiosis plays in influencing systemic cancer behavior, understand the impact bacteria has as a driver of cancer development.

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Editor's Choice

Baseline fatigue linked to worse toxicity from cancer treatments

Among people with cancer, the presence of fatigue before starting treatment is associated with an increased risk for severe, life-threatening, or fatal adverse events.

Who benefits from treatment intensification in NSCLC?

  • Open Access
  • NSCLC
  • Review

Recent trials have shown survival benefits of intensified regimens in EGFR-mutant NSCLC, but they come at the cost of increased toxicity and treatment burden. So which patients should receive upfront intensification?

Lung cancer in nonsmoking women

Familiarize yourself with the current evidence on risk factors, molecular pathology, and treatment strategies for lung cancer in nonsmoking women, and understand the critical role of gender susceptibility.

Lung cancer presenting with arginine vasopressin deficiency

A complicated case in which a patient admitted with polyuria and polydipsia was diagnosed with arginine vasopressin deficiency, which was ultimately found to be a manifestation of lung cancer.

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At a glance: The KEYNOTE lung cancer trials

A quick guide to the KEYNOTE trials investigating the anti-PD-1 agent pembrolizumab in non-small-cell and small-cell lung cancer.

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Incorporating comprehensive genomic profiling into the standard-of-care for NSCLC and thyroid cancer

In this interactive webinar, experts Dr. Subbiah, Dr. Drilon, and Dr. Williams discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations.

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Dr. Vivek Subbiah
Dr. Alexander Drilon
Dr. Michelle Williams
Developed by: Springer Health+
Watch now
Video

Case Studies

Lung cancer presenting with arginine vasopressin deficiency

A complicated case in which a patient admitted with polyuria and polydipsia was diagnosed with arginine vasopressin deficiency, which was ultimately found to be a manifestation of lung cancer.

Combined SCLC: a difficult-to-treat variant

  • Open Access
  • SCLC
  • Case Study

An extremely rare case of combined small-cell lung cancer with adenocarcinoma. Such variants can be difficult to diagnose and treat. How would you manage this patient?

Coronary angiogenesis in SCLC

  • Open Access
  • SCLC
  • Case Study

Small-cell lung cancer (SCLC) can show extensive angiogenesis, but direct arterial feeders arising from coronary vessels are exceedingly rare. We report a case where the left circumflex artery perfusing the tumor was successfully treated with coil embolization.

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
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Video

Current Reviews

Efficacy and safety of trilaciclib to prevent chemotherapy-induced myelosuppression in advanced solid tumors: a systematic review and meta-analysis

Chemotherapy remains a mainstay in managing advanced and metastatic solid tumors, but its hematologic toxicity may restrict its application [ 1 ]. Chemotherapy-induced myelosuppression (CIM) is one of the common side effects of systemic …

Effect of patient education in improving quality of life, fatigue and anxiety in people diagnosed with lung cancer: systematic review

Lung cancer is currently the most common cancer worldwide, with almost 2.5 million diagnoses and 1.8 million deaths in 2022. The disease is responsible for nearly one in five cancer deaths (18.7%) [ 1 ], with a low global five-year survival rate …

Emerging Anti-Cancer and Repurposed Therapies for Overcoming Multidrug Resistance in Lung Cancer

Multidrug resistance (MDR) still constitutes a significant barrier to the effective treatment of lung cancer and makes a significant contribution to the poor clinical results. MDR is explained by a set of mechanisms; increase of drug efflux …

Episode 7: A deep dive into ADAURA

The ADAURA trial has, as of this year, demonstrated an overall survival benefit with the adjuvant use of osimertinib in people with resectable NSCLC. 

We take an in-depth look at the study with Dr. Luis Paz-Ares, who outlines the study findings, discusses the clinical implications, and addresses the pertinent questions raised by the trial.

Dr. Luis Paz-Ares
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Podcast

CME & eLearning

Emerging biomarkers and comprehensive genomic profiling for NSCLC and thyroid cancer

  • NSCLC
  • On-demand Webinar

In this interactive webinar, experts discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations. 

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Developed by: Springer Health+

Biomarker-driven management of NSCLC (Link opens in a new window)

0.75 AMA PRA Category 1 Credit(s)

Expert-led, multiformat program which addresses the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Use the guidance on integrating shared decision making into clinical practice, drawing on insights from a patient on how best to communicate.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.
Developed by: Springer Health+ IME

Case-based insights: Oncology and hematology

Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.

Developed by: Springer Medizin

Further Reading

Value of [18F]AlF-NOTA-FAPI PET/CT in guiding radiotherapy planning for stage I-IIIC lung cancer: A comparison with contrast-enhanced CT and [18F]FDG PET/CT

Radiotherapy is a critical modality in the treatment of lung cancer. Evidence-based indications for radiotherapy apply to 77% of all lung cancer patients [ 1 ]. However, an evidence-based population modelling study of the overall lung cancer …

Pseudotime-Based derivation of a PET-Based metabolic progression index for prognostic stratification in Extensive-Stage SCLC

  • Open Access
  • SCLC
  • Original Article

Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy accounting for approximately 15% of all lung cancers and is characterized by rapid proliferation, early systemic dissemination, and poor long-term outcomes [ 1 ]. Despite high …

Optimized patient-derived lung cancer organoids recapitulating the immune landscape for precision therapy evaluation

Lung cancer remains a worldwide leading cause of cancer-related morbidity and mortality. The International Agency for Research on Cancer has estimated about 2.48 million new cases of lung cancer and 1.8 million deaths in 2022 [ 1 ]. Most patients …

Related topics

Bacterial contributions to oncogenesis

From the mechanistic contributions of pathogenic bacteria to tumor initiation, to the role dysbiosis plays in influencing systemic cancer behavior, understand the impact bacteria has as a driver of cancer development.

Read more
Image Credits
Malignant cancer cells/© koto_feja / Getty Images / iStock, Older man sitting on the edge of a bed/© andreswd / E+ / Getty Images (symbolic image with model), Yellow question mark in front of a row of wooden figures/© Abu Hanifah / Getty Images / iStock, Woman consulting with doctor/© Wesley / peopleimages.com / Stock.adobe.com (symbolic image with models), CT scan of lung cancer patient presenting with arginine vasopressin deficiency/© 2025, Maryam Alsadat Tabatabaei et al, J Med Case Reports, Music score/© photology1971 / Stock.adobe.com, Fast food and drinks/© hin255 / stock.adobe.com, Syringe and vial/© Ake Ngiamsanguan / Getty Images / iStock, Genetic code/© Springer Healthcare, Immunohistochemistry of patient with combined SCLC/© 2025, Xiao Wu et al, J Cancer Res Clin Oncol, Coronary angiography demonstrating an ectatic vessel arising from the left circumflex artery supplying a lung mass/© 2025, Muath A. Baniowda et al, BMC Cardiovascular Disorders, Antibody drug conjugated with cytotoxic payload/© Love Employee / Getty images / iStock, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Biomarker-driven management of NSCLC logo/© Springer Health+ IME, Case-Based Insights teaser image/© Eva Künzel, Close-up of the mouth of a person with stomatitis/© showcake / Getty Images / iStock (symbolic image with model)