Pediatric low-grade gliomas often cause long-term morbidities despite high overall survival rates. But advances in molecular characterization, targeted therapies, and surgical techniques are improving outcomes.
Malignant melanotic nerve sheath tumors are rare and highly aggressive. In this case MMNST was misdiagnosed as a benign vascular malformation, then recurred 7 months after resection.
Recent clinical trials in glioblastoma have investigated a wide variety of therapeutic options, such as targeted agents, immunotherapies, and vaccine-based therapies. Find out more in this review.
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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.
Live: Tuesday 1st October 2024, 12:30-14:00 (CEST)
In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.
Please note, this webinar is not intended for healthcare professionals based in the US and UK.
Malignant melanotic nerve sheath tumors are rare and highly aggressive. In this case MMNST was misdiagnosed as a benign vascular malformation, then recurred 7 months after resection.
A 68-year-old woman was admitted to the emergency department with headache, mental confusion, and a mild hemiparesis. Explore the imaging findings, differential diagnosis, and histopathological findings that revealed the patient’s diagnosis.
Intracranial GCTs developed occult extracranial malignancy with negative tumor markers, indicating that tumor marker monitoring may need to be combined with regular follow-up abdominal imaging for early detection.
Brain cancer remains a significant epidemiological challenge, with incidence rates of 5 to 7 per 100,000, according to SEER’s recent trends in age-adjusted incidence rates [ 1 ]. Glioblastoma Multiforme (GBM) is the most prevalent primary brain …
Psychiatric disorders, notably depression and anxiety, pose common yet historically under-recognized challenges in cancer patients [ 1 ]. Consistent with the biopsychosocial model highlighting interconnections between physical, mental, and social …
Endovascular surgical neuro-oncology is a relatively new subspecialty which uses endovascular neuro-interventional techniques for the management of nervous system tumors and tumor-related vascular conditions. Although there are several …
Brain tumors continue to exhibit a poor prognosis, with less than 20% of patients surviving beyond 5 years post-diagnosis [ 1 ]. Glioblastoma multiforme (GBM) represents the most prevalent primary malignant brain tumor. Despite various therapeutic …
An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.
Isocitrate dehydrogenase-wildtype (IDH-wt) gliomas are aggressively malignant brain tumors, which pose significant challenges in clinical management with a dismal prognosis [ 1 ], necessitating advancements in diagnostic and therapeutic strategies …
Gliomas are the most common brain tumors, with an incidence varying from 4.67 to 5.73 per 100,000 persons [ 1 , 2 ]. They are classified and graded according to the WHO classification of tumors of the central nervous system based on their …
Central nervous system (CNS) tumors and metastases, encompassing those of the brain, are among the most lethal cancers, contributing significantly to morbidity and mortality [ 1 – 3 ]. A subgroup of significant clinical relevance, termed …
Intracranial tumors present a significant therapeutic challenge due to their physiological location. Immunotherapy presents an attractive method for targeting these intracranial tumors due to relatively low toxicity and tumor specificity. Here we …
