Changes in seizure semiology and MRI findings indicated the unusual coexistence of low-grade glioma and hippocampal sclerosis in a 29-year-old patient with Sturge–Weber syndrome.
PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.
Diagnosis of PCNSL can be challenging, but genomic cfDNA testing on CSF has emerged as a new tool. The disease is now often curable in patients younger than 65 years, with several promising clinical trials ongoing for older patients.
Evidence-based guidelines from the Congress of Neurological Surgeons on the role of chemotherapy in patients with newly diagnosed WHO grade II diffuse glioma. Explore the latest recommendations.
Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.
In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.
Please note, this webinar is not intended for healthcare professionals based in the US and UK.
Malignant melanotic nerve sheath tumors are rare and highly aggressive. In this case MMNST was misdiagnosed as a benign vascular malformation, then recurred 7 months after resection.
A 68-year-old woman was admitted to the emergency department with headache, mental confusion, and a mild hemiparesis. Explore the imaging findings, differential diagnosis, and histopathological findings that revealed the patient’s diagnosis.
Intracranial GCTs developed occult extracranial malignancy with negative tumor markers, indicating that tumor marker monitoring may need to be combined with regular follow-up abdominal imaging for early detection.
Radiotherapy remains a cornerstone of brain tumor treatment; however, its effectiveness is frequently undermined by the development of radioresistance. This review highlights the pivotal role of molecular chaperones in promoting radioresistance …
Malignancies of the central nervous system (CNS) encompass a group of aggressive tumors arising within the intracranial and spinal regions, primarily including gliomas, ependymomas, lymphomas, germ cell tumors, and metastatic lesions. Patients …
Pediatric gliomas are a diverse and complex group of tumors that develop from transformed glial cells, glial precursor cells, or neural stem cells in the brain from infancy through adolescence. Gliomas are the most common central nervous system …
Autoimmune encephalitis (AIE) represents a group of inflammatory neurological disorders of the central nervous system (CNS). In 2016 Graus et al. proposed diagnostic AIE criteria that do not rely solely on autoantibody status, but primarily on …
An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.
High-grade gliomas (HGGs) are the most common primary malignant brain tumors in adults [ 1 – 4 ]. In this study, HGG refers to IDH-mutant WHO grade 3 or 4 astrocytomas and IDH wild-type glioblastomas, consistent with the 2021 WHO CNS5 …
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a perfusion imaging sequence valuable in predicting the WHO grades of astrocytomas [ 1 ], and in distinguishing pseudoprogression [ 2 ] and radiation-induced effects [ 3 ] from true …
Ependymomas account for about 5% of primary intracranial tumors in children and are the third most common malignant intracranial neoplasm [ 1 ]. These tumors can develop in all compartments of the central nervous system (CNS), most frequently in …
Medulloblastoma is the most common malignant paediatric central nervous system (CNS) tumor [ 1 – 5 ]. With modern post-surgical therapy including craniospinal irradiation (CSI) with boost and chemotherapy, the survival rate is 70–85% [ 2 ]. Though …
