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Solid Tumor Gastrointestinal Cancer

Gastrointestinal Cancer

Managing the side effects of BRAF and MEK inhibitors

BRAF and MEK inhibitors represent a significant advance in the treatment of BRAF-mutated malignancies, but they come with unique toxicity profiles that require vigilant monitoring and management.

Editor's Choice

Advances in the management of colorectal liver metastases

Open Access Colorectal Cancer Review

Explore the latest evidence for the key surgical, systemic, and local therapies for the management of synchronous liver metastases of colorectal cancer.

Tislelizumab plus chemo could be new option for gastric cancer

30-05-2024 Gastric Cancer News

Adding tislelizumab to first-line chemotherapy significantly prolongs the overall survival of patients with advanced gastric or gastroesophageal junction cancer.

Genetic predisposition to sarcoma: what should clinicians know?

Sarcoma Review

Learn about when to test for cancer predisposition syndromes in patients with sarcoma, and the additional considerations for treatment and imaging in case of a positive result.

Consensus on the management of metastatic gastric cancer

Open Access Gastric Cancer Review

Guidance on the diagnosis, treatment, and care of patients with metastatic gastric cancer, based on the findings of the international multidisciplinary Bertinoro workshop held in November 2022.

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Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Live Webinar | 01-10-2024 | 12:30 (CEST)

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

Live: Tuesday 1st October 2024, 12:30-14:00 (CEST)

In this live webinar, Professor Martin Dreyling and an esteemed, international panel of CAR-T experts will discuss the very latest data on the safety, efficacy and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL, as presented at ASH 2023, EU CAR-T 2024, and EHA 2024. 

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by: Novartis Pharma AG

Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare

Case Studies

Insulinoma misidentified as schizophrenia

Insulinoma Case Study

Intermittently scanning CGM detected hypoglycemia in a woman previously diagnosed with schizophrenia and treated with antipsychotic medication. Insulinoma was diagnosed and resected, resolving her neuropsychiatric symptoms.

Profound hypotension induced by ICI treatment

A case of extreme hypotension that could have been prevented or mitigated with awareness of the underlying hypothyroidism related to nivolumab treatment.

An uncommon presentation of CRC

Open Access Colorectal Cancer Case Study

Sciatica due to Streptococcus gallolyticus infection of the spinal epidural space led to a diagnosis of colorectal cancer in a person with none of the usual signs and symptoms.

Case-Based Insights: Oncology and Hematology (Link opens in a new window)


Refresh your knowledge in Oncology and Hematology: 

  • 45 clinical cases across different topics with relevant clinical images
  • Written by renowned experts 
  • Knowledge-check questions with answers
Try the first set of cases now

Current Reviews

Immunosuppression in adult liver transplant recipients: a 2024 update from the Italian Liver Transplant Working Group

Open Access Sarcopenia Review Article

Advances in surgical procedures and immunosuppressive therapy have substantially contributed to improving the outcomes of liver transplantation. Over the past few decades, calcineurin inhibitors (CNIs) have been essential components of …

A contemporary view on vascular resections and reconstruction during hepatectomies

Liver Resection Review Article

Oncological hepatic surgery carries the possibility to perform vascular reconstructions for advanced tumours with vessel invasion since surgery often represents the only potentially curative approach for these tumours. An extended review was …

A systematic review on the effectiveness of robot-assisted minimally invasive gastrectomy

Open Access Gastrectomy Review Article

Globally, gastric cancer is the third leading cause of cancer-related mortality [ 1 ]. Open gastrectomy has been the traditional surgical approach for decades, either combined with peri-operative chemotherapy or not [ 2 – 4 ]. Laparoscopic …

“Textbook outcome(s)” in colorectal surgery: a systematic review and meta-analysis

Open Access Enterostomy Review Article

Conventional quality measurement has relied on assessing individual outcome indicators such as post operative complications, mortality and length of hospital stay (LOS). Composite outcome measures, may be more meaningful and clinically relevant …

Webinar | 16-05-2023 | 17:30 (CEST)

Keynote webinar | Spotlight on cardio-oncology

An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.

Prof. Rudolf de Boer
Prof. Lorenz Lehmann
Dr. Teresa Lopéz Fernández

CME & eLearning

Cases

Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.

Developed by: Springer Medizin

Further Reading

Dose–response relationship between serum N-glycan markers and liver fibrosis in chronic hepatitis B

Open Access Hepatitis B Original Article

As of 2022, there were 257.5 million (216.6–316.4) individuals positive for HBsAg globally [ 1 ]. Decompensate cirrhosis and hepatocellular carcinoma (HCC) were the main causes of death in chronic HBV-infected individuals [ 2 – 4 ]. Over 85% of HCC …

Regulation of the PD-1/PD-L1 Axis and NK Cell Dysfunction by Exosomal miR-552-5p in Gastric Cancer

Open Access Gastric Cancer Original Article

Natural killer (NK) cells are innate lymphocytes that can act against viruses and malignancies without antigen-specific identification and amplification [ 1 ]. However, there were accumulating evidence suggests that the tumor microenvironment can …

Immunosuppression in adult liver transplant recipients: a 2024 update from the Italian Liver Transplant Working Group

Open Access Sarcopenia Review Article

Advances in surgical procedures and immunosuppressive therapy have substantially contributed to improving the outcomes of liver transplantation. Over the past few decades, calcineurin inhibitors (CNIs) have been essential components of …

Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses

Open Access Esophageal Cancer Research

The annual incidence of newly diagnosed esophageal cancer (EC) was estimated to be 26,382 in Japan in 2019, ranking 11th among all cancers [ 1 ], and to be 20,640 in the US in 2022, accounting for 1.1% of all cancers [ 2 ]. EC is classified …