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Nasopharyngeal Cancer 

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  1. 16-04-2024 | Online First

    Anti-angiogenesis agents plus chemoradiotherapy for locally advanced nasopharyngeal cancer: a systematic review and meta-analysis

    Nasopharyngeal carcinoma (NPC), a malignant tumor originating from nasopharyngeal mucosal epithelial cells, is one of the most prevalent malignant tumors in the head and neck region. The distribution of NPC exhibits significant regional …

  2. 05-04-2024 | Metastasis | Online First

    Patterns of failure in patients with nasopharyngeal cancer of Northeastern region of India: a retrospective observational study

    Nasopharyngeal carcinoma (NPC) is a rare malignancy worldwide, but is disproportionately prevalent in southern China and Southeast Asia [ 1 ]. NPC’s etiology and prevalence are unique and distinct among all head and neck malignancies [ 2 ]. A …

  3. 28-12-2023 | Radiotherapy | OriginalPaper

    Is a total dose of 54 Gy with radiochemotherapy sufficient for treatment of intermediate-risk volumes in nasopharyngeal cancer?

  4. Open Access 01-12-2024 | Cytostatic Therapy | OriginalPaper

    Cost-effectiveness of pembrolizumab versus chemotherapy in patients with platinum-pretreated, recurrent or metastatic nasopharyngeal cancer

    Nasopharyngeal carcinoma (NPC) is a malignancy arising from the malignant epithelial cells in the nasopharyngeal cavity, specifically on the top and side walls. This type of cancer is characterized by its highly invasive nature and exhibits …

  5. Open Access 01-12-2023 | Human Papillomavirus | OriginalPaper

    HPV18 L1 and long control region sequences variation and E6/E7 differential expression in nasopharyngeal and cervical cancers: a comparative study

    Cervical and nasopharyngeal cancers are two well-known pathogen-associated cancers [ 1 ]. Cervical cancer (CC) is the fourth leading cause of death globally in women, accounting for an estimated 604 000 new cases in 2020 with about 90% of these …

  6. Open Access 26-07-2023 | ReviewPaper

    The risk of second primary cancer after nasopharyngeal cancer: a systematic review

    Nasopharyngeal carcinoma (NPC) is a relatively rare malignancy in most parts of the world, but the incidence is as much as 50–100 fold higher in ethnic Cantonese Chinese populations in Southern China and Southeast Asia, where it is endemic.

  7. Open Access 01-12-2023 | Radiotherapy | ReviewPaper

    Weekly versus triweekly cisplatin treatment in patients with locally advanced nasopharyngeal cancer during concurrent chemoradiotherapy

    Nasopharyngeal cancer (NPC) is the most common primary neoplasm of the nasopharynx and is mainly found in Asia, especially in southern China. There are approximately 13,000 new cases of the disease diagnosed worldwide each year [ 1 ]. In addition …

  8. 02-06-2023 | OriginalPaper

    Conditional survival nomogram for monitoring real-time survival of young non-metastatic nasopharyngeal cancer survivors

    Nasopharyngeal carcinoma (NPC) is a highly heterogeneous head and neck cancer with unique geographic, ethnic, and histologic distribution differences (Chen et al. 2019 ; Ou et al. 2007 ; Wong et al. 2021 ). Benefiting from individualized management …

  9. 02-06-2023 | OriginalPaper

    A Systematic Review on Clinico-Aetiopathological Trends of Nasopharyngeal Cancer in Asia

    Background: Nasopharyngeal cancer (NPC) is a type of malignancy that is highly prevalent in Asian countries. Therefore, an understanding between NPC epidemiological trend, the clinico-pathological and aetiological profiles are needed. This …

  10. Open Access 01-12-2022 | OriginalPaper

    Occupational risk variation of nasopharyngeal cancer in the Nordic countries

    Close to 850,000 new head and neck squamous cell carcinoma (HNSCC) cases are diagnosed annually worldwide, and approximately 130,000 of these are nasopharyngeal carcinomas (NPC) [ 1 ]. The NPC incidence is much higher in South-Asia than in Europe …

  11. Open Access 01-12-2023 | Tooth Extraction | OriginalPaper

    The predictive value of pretreatment hemoglobin-to-platelet ratio on osteoradionecrosis incidence rates of locally advanced nasopharyngeal cancer patients managed with concurrent chemoradiotherapy

    Concurrent chemoradiotherapy (C-CRT) is currently considered the gold standard treatment for locally advanced nasopharyngeal cancers (LA-NPC) [ 1 ]. Sadly, this treatment was accompanied by an increase in early complications like mucositis and …

  12. 11-08-2023 | Tooth Extraction | OriginalPaper

    Utility of pre-chemoradiotherapy Pan-Immune-Inflammation-Value for predicting the osteoradionecrosis rates in locally advanced nasopharyngeal cancers

    Concurrent chemoradiotherapy (CCRT) is the current treatment standard for locally advanced nasopharyngeal cancers (LA-NPCs), based on the positive results of randomized clinical studies and meta-analyses [ 1 ]. Regrettably, the locoregional control …

  13. Open Access 01-12-2022 | Epstein-Barr Virus | OriginalPaper

    Immune cells markers within local tumor microenvironment are associated with EBV oncoprotein in nasopharyngeal cancer

    The immune markers CD8 and FOXP3 correlated with EBNA1 or LMP1 in clinical nasopharyngeal specimens. Furthermore, all those markers were associated with nasopharyngeal cancer progression at least locally.

  14. Open Access 01-12-2022 | Radiotherapy | OriginalPaper

    Integrated radiomics, dose-volume histogram criteria and clinical features for early prediction of saliva amount reduction after radiotherapy in nasopharyngeal cancer patients

    Xerostomia is a common side effect of nasopharyngeal carcinoma (NPC) radiotherapy (RT) [ 1 , 2 ]. It seriously affects the quality of life (QOL) of patients, including oral infection, eating problem, undernutrition, and insomnia [ 3 – 5 ].

  15. 01-12-2022 | Osteonecrosis

    Progression and postoperative complications of osteoradionecrosis of the jaw: a 20-year retrospective study of 124 non-nasopharyngeal cancer cases and meta-analysis

    Head and neck cancers (HNC) are the seventh most common malignancies worldwide and have been treated effectively by comprehensive sequence therapy, chiefly including surgery, chemotherapy and radiotherapy[ 1 , 2 ]. Over the past decades …

  16. 07-02-2023 | Tooth Extraction | OriginalPaper

    Pre-chemoradiotherapy low hemoglobin levels indicate increased osteoradionecrosis risk in locally advanced nasopharyngeal cancer patients

    The current gold standard for treating patients with locally advanced nasopharyngeal cancer (LA-NPC) is concurrent chemoradiotherapy (CCRT), which has been shown to improve loco-regional control and survival [ 1 ]. Regrettably, elevated rates of …

  17. 01-12-2021 | Epstein-Barr Virus

    ASCO 2021 highlights head and neck cancer: nasopharyngeal carcinoma

    During the ASCO 2021 virtual meeting, multiple clinically relevant studies were presented addressing open questions regarding the therapy of nasopharyngeal carcinomas (NPC): Is immunotherapy plus chemotherapy the new first line standard of care …

  18. Open Access 01-12-2023 | OriginalPaper

    Intra- and peritumoral MRI radiomics assisted in predicting radiochemotherapy response in metastatic cervical lymph nodes of nasopharyngeal cancer

    Nasopharyngeal cancer (NPC) is the most frequent type of head and neck cancer in Southeast Asia and South China [ 1 – 3 ]. NPC has a higher incidence (86.4%) of cervical lymph node metastasis [ 4 ]. Intensity-modulated radiotherapy (IMRT) is the …

  19. Open Access 01-12-2023 | Magnetic Resonance Imaging | OriginalPaper

    Automatic detection and recognition of nasopharynx gross tumour volume (GTVnx) by deep learning for nasopharyngeal cancer radiotherapy through magnetic resonance imaging

    As reported by the International Agency for Research on Cancer, there were around 129,000 new cases of nasopharyngeal cancer diagnosed in 2018, which accounts for 0.7% of all types of cancers [ 1 ]. More than 70% of new cases are in east and …

  20. 01-03-2023 | OriginalPaper

    Nasopharyngeal cancer: the impact of guidelines and teaching on radiation target volume delineation

    Target volume delineation in the radiation treatment of nasopharyngeal cancer is challenging due to several reasons such as the complex anatomy of the site, the need for the elective coverage of definite anatomical regions, the curative intent of …

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