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Solid Tumor Gynecologic Cancer

Gynecologic Cancer

Baseline fatigue linked to worse toxicity from cancer treatments

Among people with cancer, the presence of fatigue before starting treatment is associated with an increased risk for severe, life-threatening, or fatal adverse events.

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Editor's Choice

WISDOM trial makes case for risk-based breast cancer screening

Risk-based screening for breast cancer is noninferior to standard annual mammography for the identification of stage IIB and more advanced disease but does not reduce the need for biopsy.

Resistance to ADCs in cancer: mechanisms and possible solutions

While antibody–drug conjugates have revolutionized cancer treatment, their effectiveness is often compromised by the development of resistance, which limits their clinical potential. How can these challenges be overcome?

Metachronous multiple primary cancers

A rare occurrence of four primary malignancies – bilateral breast cancer, ovarian cancer, and undifferentiated high-grade pleomorphic sarcoma. Could the patient have a hereditary cancer syndrome?

Concomitant PPI use linked to worse breast cancer outcomes

Taking proton pump inhibitors alongside anticancer therapy could worsen the overall survival and progression-free survival of people with breast cancer.

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Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

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SPONSORED

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by:
  • Novartis Pharma AG
Chaired by: Prof. Martin Dreyling
Developed by: Springer Health+
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Video

Case Studies

Metachronous multiple primary cancers

A rare occurrence of four primary malignancies – bilateral breast cancer, ovarian cancer, and undifferentiated high-grade pleomorphic sarcoma. Could the patient have a hereditary cancer syndrome?

Managing dual primary liver metastases

The treatment strategy for liver metastases is predominantly determined by the primary cancer site, which made this patient with metastases from breast and colorectal cancer quite challenging to manage.

Glycemic fluctuations during capivasertib treatment for metastatic breast cancer

A woman with metastatic breast cancer developed marked hyperglycemia on day 11 of capivasertib therapy. Intermittently scanned CGM showed it only occurred on days when capivasertib was administered.

At a glance: The DESTINY-Breast trials

The antibody–drug conjugate trastuzumab deruxtecan is being investigated in the DESTINY-Breast trials for the treatment of breast cancer.

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Current Reviews

Non-metastatic breast cancer patients discontinuing aromatase inhibitor on denosumab: what next?

Aromatase inhibitors (AIs) are one of the adjuvant endocrine therapies of choice, for estrogen receptor-positive breast cancer in postmenopausal women and premenopausal women with ovarian suppression. However, treatment with AIs leads to …

ASCO 2025: key highlights in endometrial cancer

The 2025 ASCO Annual Meeting did not present immediately practice-changing results in endometrial cancer but showcased substantial progress across multiple therapeutic strategies. A phase II trial combining letrozole, abemaciclib, and metformin in …

Non-Invasive Breast Cancer Receptor Typing from Mammograms Using Artificial Intelligence: A Systematic Review and Meta-Analysis

Artificial intelligence (AI) applied to screening mammography may non-invasively predict breast cancer molecular subtype and receptor status. We conducted a PRISMA-DTA systematic review and bivariate random-effects meta-analysis (PROSPERO …

3D bioprinting innovations: a new frontier in breast cancer research

Breast cancer (BC) is a widely recognized second most frequent female cancer globally that is histologically and molecularly heterogeneous. Nevertheless, despite intensive studies, currently available preclinical models, particularly animal …

Episode 15: Breastfeeding after breast cancer

POSITIVEly reassuring results from a clinical trial

The POSITIVE trial previously showed that women with breast cancer can safely interrupt endocrine therapy in order to become pregnant. But what about breastfeeding - is that possible and safe for the mother and baby?

Women can take heart from the latest findings, says Dr. Cristina Saura, as she takes us through these important clinical updates.

Dr. Cristina Saura
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Podcast

CME & eLearning

Case-based insights: Oncology and hematology

Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.

Developed by: Springer Medizin

Further Reading

Resveratrol potentiates chemotherapeutic efficacy of olaparib in MCF7 human breast cancer cells by inducing apoptosis

Natural products are compounds found in abundant natural sources like plants, possessing biological effects. Many therapeutic drugs, such as alkaloids, taxanes, and flavonoids, are derived from these sources. Recently, there has been a growing …

A novel quantification method for automatic computation of breast density from mammography images using deep learning

Dense breast tissue is an independent risk factor for breast cancer and can obscure malignancies on mammography [ 1 ]. The American College of Radiology’s Breast Imaging Reporting and Data System (BI-RADS) classifies breast composition into four …

ASCO 2025: key highlights in endometrial cancer

The 2025 ASCO Annual Meeting did not present immediately practice-changing results in endometrial cancer but showcased substantial progress across multiple therapeutic strategies. A phase II trial combining letrozole, abemaciclib, and metformin in …

Image Credits
Older man sitting on the edge of a bed/© andreswd / E+ / Getty Images (symbolic image with model), Mammogram image on a screen/© Valerii Apetroaiei / stock.adobe.com, Antibody drug conjugates/© huenstructurebio.com / stock.adobe.com, Histology of patient with multiple primary cancers/© 2025, Rongze Sun et al, J Cancer Res Clin Oncol, Heap of blue, white, and beige pills and capsules/© AlexRaths / Getty Images / iStock, Stylized collage of women/© (M) VictoriaBar / Getty Images / iStock, Lymph nodes concept/© Artur / stock.adobe.com, CAR T-cell attacking cancer cells/© Springer Medicine, June 2024, under a creative commons [CCBY] license., 3D reconstruction of liver metastases from breast and colorectal cancer/© 2025, Ryota Ito et al, under exclusive licence to Japanese Society of Gastroenterology, Clin J Gastroenterol, Beige oblong pills/© elvis901 / iStock / Getty Images Plus, Crystal ball on pink background/© EyeEm Mobile GmbH / Getty Images / iStock, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Case-Based Insights teaser image/© Eva Künzel