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Solid Tumor Genitourinary Cancer

Genitourinary Cancer

Open Access Prostate Cancer Review

Advances in the management of mCRPC

What are the latest advances in the ever-expanding list of treatment options for metastatic castration-resistant prostate cancer? And how can you best integrate these agents into your clinical practice?

Editor's Choice

Arrhythmia secondary to abiraterone treatment

A man receiving abiraterone for prostate cancer developed severe hypokalemia, which led to polymorphic ventricular tachycardia and cardiac arrest. It is important to consider iatrogenic causes in cases of arrhythmia.

Postoperative pembrolizumab improves OS in high-risk RCC

18-04-2024 Kidney Cancer News

Adjuvant treatment with pembrolizumab is associated with a significant overall survival benefit in individuals with high-risk renal cell carcinoma.

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Delve into the efficacy and safety data for the antibody–drug conjugates currently approved by the US FDA across tumor types such as hematologic, genitourinary, and gynecologic cancers.

Three-phase screening approach promising for prostate cancer

11-04-2024 Prostate Cancer News

The ProScreen trial points to the potential of a single round of prostate cancer screening involving a PSA test, a kallikrein panel, and an MRI scan.

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Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Live Webinar | 01-10-2024 | 12:30 (CEST)

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

Live: Tuesday 1st October 2024, 12:30-14:00 (CEST)

In this live webinar, Professor Martin Dreyling and an esteemed, international panel of CAR-T experts will discuss the very latest data on the safety, efficacy and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL, as presented at ASH 2023, EU CAR-T 2024, and EHA 2024. 

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by: Novartis Pharma AG

Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare

Case Studies

Arrhythmia secondary to abiraterone treatment

A man receiving abiraterone for prostate cancer developed severe hypokalemia, which led to polymorphic ventricular tachycardia and cardiac arrest. It is important to consider iatrogenic causes in cases of arrhythmia.

Lung erosion following adjuvant immunotherapy

Open Access Pneumothorax Case Study

Adjuvant pembrolizumab treatment after resection of lung metastases in a patient with renal cell carcinoma may have led to lung erosion that resulted in a pneumothorax.

Progressive encephalomyelitis with rigidity and myoclonus (PERM) associated with urothelial carcinoma

The first reported case of PERM associated with anti-glycine receptor antibodies in a patient with bladder cancer. PERM, a stiff-person syndrome, has paraneoplastic etiology in about 20% of cases.

Case-Based Insights: Oncology and Hematology (Link opens in a new window)

Refresh your knowledge in Oncology and Hematology: 

  • 45 clinical cases across different topics with relevant clinical images
  • Written by renowned experts 
  • Knowledge-check questions with answers
Try the first set of cases now

Current Reviews

Targeted biopsy of the prostate

Diagnostic multiparametric MRI of the prostate has steadily evolved over the last three decades and can now reliably depict the dominant tumor in most men with prostate cancer. In response, several methods of targeted biopsy to direct tissue …

Is MRI ready to replace biopsy during active surveillance?

Active surveillance (AS) is a management option recommended for patients diagnosed with low-risk prostate cancer (PCa) and selected cases with intermediate-risk PCa. The primary goal of AS is to mitigate the risk of overtreatment and …

Feasibility of Indirect Treatment Comparisons Between Niraparib Plus Abiraterone Acetate and Other First-Line Poly ADP-Ribose Polymerase Inhibitor Treatment Regimens for Patients with BRCA1/2 Mutation-Positive Metastatic Castration-Resistant Prostate Cancer

Open Access Prostate Cancer Review

Prostate cancer (PC) is the second-most common cancer among men worldwide, accounting for approximately 375,304 deaths in 2020 [ 1 ]. This clinically heterogeneous disease exhibits distinct genetic, molecular, and clinical characteristics wherein …

Focal Therapy in Grade Group 3 Prostate Cancer

Open Access Prostate Cancer Review

Prostate cancer is the leading cause of cancer in men over 50 years old. With the wide use of screening since the late 1980’s there has been a large increase in the number of men diagnosed with early prostate cancer. The shifting of time of …

Webinar | 16-05-2023 | 17:30 (CEST)

Keynote webinar | Spotlight on cardio-oncology

An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.

Prof. Rudolf de Boer
Prof. Lorenz Lehmann
Dr. Teresa Lopéz Fernández

CME & eLearning

eLearning (Link opens in a new window)

The evolving landscape of metastatic urothelial carcinoma brings with it many challenges, such as optimally sequencing therapies and managing adverse events. Navigate your way through these with the Ultimate mUC challenge game and expert-to-expert interviews.

Supported by:
  • Merck Healthcare KGaA, Darmstadt, Germany and Astellas
Developed by: Springer Healthcare IME

eLearning | Interviews | Cases (Link opens in a new window)

Multiformat program highlighting evidence-based best practice for the management of metastatic urothelial carcinoma.

Supported by:
  • Pfizer and Merck Healthcare KGaA, Darmstadt, Germany
Developed by: Springer Healthcare IME

Further Reading

Psychosocial distress after radical prostatectomy, radical cystectomy, or (partial) nephrectomy – a comprehensive analysis of 4,290 German cancer patients during the COVID-19 pandemic

Open Access Nephrectomy

Psychosocial distress (PD) is highly prevalent among cancer patients and may not only significantly impact mental health but also quality of life and is therefore considered the “sixth vital sign” in cancer patients in addition to the established …

Physiological biodistribution on Ga68-PSMA PET/CT and the factors effecting biodistribution

Open Access Prostate Cancer Original article

Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death among men in 2020 [ 1 ]. Recently Ga 68 -PSMA PET/CT has been introduced, targeting prostate-specific membrane antigen (PSMA) which is a cell surface …

Diagnostic accuracy of the Clear Cell Likelihood Score and selected MRI parameters in the characterization of indeterminate renal masses – a single-institution study

Open Access Magnetic Resonance Imaging Kidneys, Ureters, Bladder, Retroperitoneum

The clear cell likelihood score (ccLS) is a five-category Likert scale (from 1 point = very unlikely to 5 points = very likely) designed to enhance the prediction of histopathological characteristics of small renal masses (SRMs) in multiparametric …

Deep learning-based image quality assessment: impact on detection accuracy of prostate cancer extraprostatic extension on MRI

Open Access Artificial Intelligence Pelvis

Beyond its role in detecting clinically significant prostate cancer, multiparametric MRI (mpMRI) plays an important role in preoperative local staging, particularly in depicting extraprostatic extension (EPE). EPE is a significant indicator of …