A report of primary endobronchial melanoma that sheds light on the clinical presentation, histopathology, diagnostic challenges, and treatment options for this rare entity.
Adding a novel mRNA-based individualized neoantigen therapy to adjuvant pembrolizumab could improve the outcomes of patients with completely resected melanoma.
The past decade has seen significant advancements in the treatment of melanoma brain and leptomeningeal metastases. The sequence of therapies depends on factors such as the number and size of metastases, status of systemic disease control, and neurological symptoms.
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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.
A report of primary endobronchial melanoma that sheds light on the clinical presentation, histopathology, diagnostic challenges, and treatment options for this rare entity.
When primary CNS melanoma has a spinal location, it typically manifests in the thoracic sections. This case report describes a patient with an uncommon presentation in the cervical spine.
Melanoma, a malignant neoplasm of melanocytes, is characterised by its rapid proclivity for both regional and distant metastasis, rendering it a leading cause of global morbidity and mortality [ 1 ]. While melanoma accounts for only a fraction of …
Primary squamous cell carcinoma of the parotid gland (pSCCP) has long been recognized as a separate entity and is included in the WHO classifications of salivary gland tumors. However, it is widely accepted among head and neck pathologists that …
Cancer is widely considered a disease of aging. The care of older adults with cancer is complicated by factors such as frailty, multiple comorbidities, and age-related organ dysfunction [ 1 ]. These issues pose specific challenges to optimal …
Isolated limb perfusion (ILP) is a regional chemotherapy technique used in the treatment of locally advanced or unresectable extremity soft tissue sarcoma (ESTS) or malignant melanoma (MM) of the limbs. It allows for high concentrations of …
Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.
An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.
Primary squamous cell carcinoma of the parotid gland (pSCCP) has long been recognized as a separate entity and is included in the WHO classifications of salivary gland tumors. However, it is widely accepted among head and neck pathologists that …
Liver metastasis remains a clinical challenge for immune checkpoint inhibitor therapy in melanoma, with an estimated response rate ranging from 3 to 10% [ 1 ]. Recent translational studies have dissected the mechanism of an immune suppression …
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by targeting the brakes of the immune system and restoring antitumor activity. The clinical indications for ICIs, one of the novel standard treatments for various cancer …