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Clinical Collections
Women’s Health Knowledge Hub Advances in Alzheimer’s

Navigating neuroimaging in Alzheimer disease care

PET imaging is playing an increasingly critical role in managing AD, but how can you effectively integrate it into clinical practice? Our expert-led program will empower you with practical strategies and real-world case studies.

This content is intended for healthcare professionals outside of the UK.
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Solid Tumor Skin Cancer

Skin Cancer

Melanoma risk doubled in childhood cancer survivors

Compared with the general population, childhood cancer survivors have a twofold increased risk for melanoma, with substantially worse survival for those who develop invasive melanoma.

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Editor's Choice

Emerging therapies for brain metastases

Therapies designed to penetrate the blood-brain barrier and target key drivers like EGFR, ALK, HER2, and BRAF have revolutionized treatment of brain metastases from non-small-cell lung cancer, breast cancer, and melanoma.

Uncommon type of malignant melanoma

The amelanotic variant of conjunctival malignant melanoma is extremely rare and can be difficult to diagnose. Clinicians must be vigilant when changes in the conjunctiva and eyelids are noticed.

Advances in therapy for non-melanoma skin cancers

The incidence of non-melanoma skin cancer continues to rise. Learn about the latest approved and emerging systemic therapies for locally advanced and metastatic disease.

Managing the side effects of BRAF and MEK inhibitors

BRAF and MEK inhibitors represent a significant advance in the treatment of BRAF-mutated malignancies, but they come with unique toxicity profiles that require vigilant monitoring and management.

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

  • On-demand Webinar

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
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Video

Latest News

Dual ICIs alongside radiosurgery may increase necrosis risk

Limited intracranial response to ICIs after anti-PD-1 therapy

Melanoma risk doubled in childhood cancer survivors

High corticosteroid peak doses adversely affect ICI efficacy

Neoadjuvant dual immunotherapy improves melanoma outcomes

Some reassurance on ICI use in pregnancy from VigiBase analysis

SPONSORED

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by:
  • Novartis Pharma AG
Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare
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Video

Case Studies

Uncommon type of malignant melanoma

The amelanotic variant of conjunctival malignant melanoma is extremely rare and can be difficult to diagnose. Clinicians must be vigilant when changes in the conjunctiva and eyelids are noticed.

Oncolytic virus therapy promising in mucosal melanoma

Intralesional treatment with the oncolytic virus talimogene laherparepvec led to a complete local response in a patient with oral mucosal melanoma who was ineligible for other anticancer therapies.

A challenging diagnosis: melanoma or clear cell sarcoma?

A case of clear cell sarcoma of soft tissue misdiagnosed as malignant melanoma underscores the need for an integrated diagnostic approach involving clinical, histopathological, and radiological evaluations.

Case-based insights: Oncology and hematology (Link opens in a new window)


Refresh your knowledge in oncology and hematology: 

  • 45 clinical cases across different topics with relevant clinical images
  • Written by renowned experts 
  • Knowledge-check questions with answers
Try the first set of cases now

Current Reviews

Combination Immunotherapy for Mucosal Melanoma: Molecular Mechanism, Research Status, and Future Directions

Mucosal melanoma is a rare and aggressive subtype of melanoma, accounting for 1%-2% of new cases in the United States in 2023, and 20%-30% in China and other Asian countries. Its origin is often occult, with the lack of early clinical features …

Mohs Micrographic Surgery and Improved Survival in Skin Cancer: A Narrative Review

Mohs micrographic surgery (MMS) has been shown to achieve very low recurrence rates in skin cancer, and some studies suggest it may improve survival. We conducted a narrative review to assess the impact of MMS on the survival of patients with …

The therapeutic efficacy and application prospects of tumor-treating fields (TTFields) in resolving malignant tumors of central nervous system

Malignancies of the central nervous system (CNS) encompass a group of aggressive tumors arising within the intracranial and spinal regions, primarily including gliomas, ependymomas, lymphomas, germ cell tumors, and metastatic lesions. Patients …

Melanoma skin cancer statistics derived from 7442 Japanese patients: Japanese melanoma study

Malignant melanoma (MM) arises from the pigment cells of the skin and is a rare form of cutaneous cancer. Although the annual incidence of melanoma in Japan has been reported to be 1–2 patients/100,000 [ 1 , 2 ], MM-related mortalities are close to …

Keynote webinar | Spotlight on cardio-oncology

An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.

Prof. Rudolf de Boer
Prof. Lorenz Lehmann
Dr. Teresa Lopéz Fernández
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Video

CME & eLearning

Patient Cases

Take on interactive case studies with a focus on hematology. Each case has been prepared by renowned experts in the field and features knowledge-check questions with answers to help keep you and your practice up to date.

Developed by: Springer Medizin

Further Reading

Tattoos and cutaneous squamous cell carcinoma: a population-based case-control study

The prevalence of tattoos in western countries is about 20%. Tattoo ink may contain carcinogenic compounds. The aim of this study was to investigate if tattoo exposure is associated with an increased risk of cutaneous squamous cell carcinoma in …

Mohs Micrographic Surgery and Improved Survival in Skin Cancer: A Narrative Review

Mohs micrographic surgery (MMS) has been shown to achieve very low recurrence rates in skin cancer, and some studies suggest it may improve survival. We conducted a narrative review to assess the impact of MMS on the survival of patients with …

Epidemiology and palliative care of in-patient cerebral metastases cases in Germany

Palliative care aims to alleviate distressing symptoms and improve the quality-of-life for patients with potentially life-threatening diseases. The diagnosis of cerebral metastasis (CM) presents significant physical, psychological, social, and …

Tumor-specific CXCR6 positive precursor CD8+ T cells mediate tumor control in metastatic melanoma

Metastasis is the leading cause of cancer-related mortality and a significant barrier to curative therapies [ 1 ]. Traditional clinical approaches such as surgery and radiotherapy often fail to treat tumor metastasis. To overcome this limitation …

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