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Salivary Gland Cancer 

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  1. 19-04-2024 | Salivary Gland Cancer | Online First

    Imaging of salivary gland cancers derived from a sublingual gland herniated into the submandibular space: a report of three cases

    Sublingual gland herniation into the submandibular space through a mylohyoid muscle defect is a common anatomical variation; however, salivary gland cancers that arise from a herniated sublingual gland have not been described yet. Here, we report …

  2. Open Access 23-04-2024 | Salivary Gland Cancer | Online First

    Oncologic outcomes of the most prevalent major salivary gland cancers: retrospective cohort study from single center

    Salivary gland tumors (SGT) constitute less than 3–4% of all head and neck tumors. They form a histologically heterogeneous group, with unpredictable and often highly aggressive clinical behavior. The wide variety of tumor etiology, microscopic …

  3. Open Access 16-03-2024 | Online First

    Salivary gland-type cancers: cross-organ demographics of a rare cancer

    Salivary gland tumors are rare, occurring at an incidence of 2.5 to 3.0 cases per 100,000 people per year in the Western world [ 1 ]. As of 2021, malignant salivary gland tumors accounted for only 0.2% of all cancers registered by the “Designated …

  4. 07-05-2023 | Scintigraphy | OriginalPaper

    Effects of apitherapy against salivary gland disorder after radioactive iodine therapy for differentiated thyroid cancer

    Radioactive iodine (RAI) 131 is widely used as an effective treatment for differentiated thyroid cancer (DTC) [ 1 – 3 ]. The effect of RAI therapy (RAIT), in addition to remnant ablation of thyroid tissues after total thyroidectomy, can be …

  5. 13-12-2022 | Salivary Gland Cancer | OriginalPaper

    Pre-treatment quality of life in patients with salivary gland cancer in comparison with those of head and neck cancer patients

    Quality of life (QoL) of a cancer patient is a sense of well-being, and it is important for patient, family and caregivers. Salivary gland cancer (SGC) is a rare malignant tumor arising from the salivary glands; however, there are limited QoL data …

  6. Open Access 01-12-2022 | Salivary Gland Cancer | OriginalPaper

    The expression profiles of CD47 in the tumor microenvironment of salivary gland cancers: a next step in histology-driven immunotherapy

    CD47 is a transmembrane protein expressed in various cell types that belongs to the immunoglobulin superfamily [ 1 ]. CD47 binds to its ligands signal regulatory protein α (SIRPα), thrombospondin-1 (TSP-1), and integrins αvβ3 and α2β1 [ 2 ].

  7. Open Access 22-07-2023 | Salivary Gland Cancer | OriginalPaper

    Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker

    Many locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin, an antibody–drug conjugate binding to Nectin-4, recently gained FDA approval for third-line urothelial carcinoma. Therefore, the aim …

  8. Open Access 22-08-2022 | Salivary Gland Cancer | OriginalPaper

    Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany

    Primary salivary gland carcinomas (SGC) are rare and account for approximately 3–6% of all head and neck malignancies (Guzzo et al. 2010 ; Mendenhall et al. 2005 ). Due to their heterogeneity regarding morphology, aggressiveness, and risk of …

  9. Open Access 01-12-2023 | Radioiodine Therapy | OriginalPaper

    The effect of selenium supplementation on sonographic findings of salivary glands in papillary thyroid cancer (PTC) patients treated with radioactive iodine: study protocol for a double-blind, randomized, placebo-controlled clinical trial

    Note: the numbers in curly brackets in this protocol refer to the SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  10. 01-01-2022 | Radiotherapy | News

    Cabozantinib associated with excessive toxicity for salivary gland cancer in phase II trial

  11. Open Access 01-12-2021 | Salivary Gland Cancer | OriginalPaper

    Lymph node ratio as a predictor for minor salivary gland cancer in head and neck

    Lymph node on pathological examination is investigated as useful predictors of survival results in several types of cancer [ 1 , 2 ]. Representative continuous variables of lymph nodes was the number of positive lymph nodes after neck dissection …

  12. 01-07-2021 | Breast Cancer | BriefCommunication

    Malignant salivary gland tumours in families with breast cancer susceptibility

    Salivary gland cancers (SGCs) are rare malignancies with highly heterogeneous histological features. Patients affected with SGCs are at increased risk of secondary malignancies, including breast cancer (BC). Previous studies enlightened a possible …

  13. Open Access 23-06-2022 | Human Papillomavirus | OriginalPaper

    Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology

    The treatment of head and neck and salivary gland tumours is complicated and evolves constantly. Prognostic and predictive indicators of response to treatment are enormously valuable for designing individualized therapies, which justifies their …

  14. Open Access 01-02-2022 | Systemic Therapy | OriginalPaper

    Patterns of care analysis for salivary gland cancer: a survey within the German Society of Radiation Oncology (DEGRO) and recommendations for daily practice

    Salivary gland cancer (SGC) is a rare tumor entity including a variety of different histologic subtypes. Due to the lack of prospective, randomized trials, therapeutic strategies remain controversial and no general guideline focusing on detailed …

  15. Open Access 01-05-2022 | Metastasis | OriginalPaper

    High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases

    Salivary gland cancer (SGC) is a rare disease (0.6–1.4 per 100,000 [ 1 ]) including various histological tumor subtypes (more than 20 according to the WHO classification of head and neck cancers of 2017) [ 2 ]. The established standard therapy is …

  16. 01-02-2023 | Salivary Gland Cancer | ReviewPaper

    Prognostic Impact of Tumor Immune Microenvironment and Its Predictive Role in Salivary Gland Cancer

    Tumor immune microenvironment (TIME) plays a role in carcinogenesis and both tumor regression and progression, comprising innate immune cells as macrophages, neutrophils, mast cells, dendritic cells and natural killer cells, and adaptive immune …

  17. 01-07-2021 | Radiotherapy

    Radiation-induced toxicities and outcomes after radiotherapy are independent of patient age in elderly salivary gland cancer patients: results from a matched-pair analysis of a rare disease

    Primary malignant salivary gland tumors are rare with an annual incidence of about 1 in 100,000 people, accounting for about 5% of all head-and-neck cancer cases [ 1 , 2 ]. Primary salivary gland cancers form a heterogeneous group with different …

  18. 01-06-2020 | Ameloblastoma | OriginalPaper

    Salivary Gland Cancer in the Era of Routine Next-Generation Sequencing

    Next-Generation Sequencing (NGS) is being utilized with increasing frequency in the characterization of salivary gland tumours. The potential scenarios which may be encountered by using this technique in routine practice will be outlined in …

  19. 01-06-2020 | Radioiodine Therapy | EditorialNotes

    Reduction of Salivary Gland Damage During Radioiodine Therapy for Differentiated Thyroid Cancers

  20. Open Access 20-12-2022 | Salivary Gland Cancer | OriginalPaper

    Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting

    Salivary gland carcinomas (SGCs) are uncommon malignancies, representing approximately 0.3% of all cancers, with an estimated annual incidence of 0.05 to 2 per 100,000 [ 1 ]. These malignancies exhibit considerable pathologic, biological, and …

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