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European Archives of Oto-Rhino-Laryngology

Open Access 23-04-2024 | Salivary Gland Cancer | Head and Neck

Oncologic outcomes of the most prevalent major salivary gland cancers: retrospective cohort study from single center

Authors: Ewa Kucharska, Anna Rzepakowska, Michał Żurek, Julia Pikul, Piotr Daniel, Angelika Oleszczak, Kazimierz Niemczyk

Published in: European Archives of Oto-Rhino-Laryngology

Abstract

Background

The preoperative diagnosis of salivary gland cancer (SGC) is crucial for the application of appropriate treatment, particularly involving the extension of the resection.

Methods

Retrospective search of medical database identified 116 patients treated surgically with malignant tumors of salivary gland between 2010 and 2020. Analysis included the demographical data, clinical course, type of surgical and adjuvant treatment, histology type and margin status, perivascular invasion (LVI), perineural invasion (PNI), metastatic lymph nodes (LN). Facial nerve function, recurrence-free and overall survival were evaluated. Adequate statistics were used for data analysis.

Results

The final cohort included 63 SGC patients, with adenoid cystic carcinoma the most common pathological type (27%, n = 17), followed by adenocarcinoma (17.4% n = 11). T1 and T2 patients accounted for majority cases (n = 46). The lymph node metastases were confirmed with the histopathology in 31.7% (n = 20). Distant metastases were observed in 4.8% of cases (n = 3). 38% (n = 24) of SGC were treated selectively with surgery, 49.2% (n = 31) had postoperative radiotherapy and 15.9% (n = 10)—radio-chemotherapy. The final facial nerve function was impaired in 38% of patients. Mean overall survival (OS) for all patients was 108.7 (± 132.1) months, and was the most favorable for acinar cell carcinoma (118.9 ± 45.4) and the poorest for squamous cell carcinoma (44 ± 32). Cox regression analysis of disease-free survival and OS identified significant association only with patients’ age over 65 years, the hazard ratio of 7.955 and 6.486, respectively.

Conclusions

The efficacy of treatment modalities for SGC should be verified with regard to the histopathological type, but also the patients’ age should be taken into account.

Tyagi R, Dey P (2015) Diagnostic problems of salivary gland tumors. Diagn Cytopathol 43:495–509. https://doi.org/10.1002/dc.23255CrossRefPubMed

Skálová A, Hyrcza MD, Leivo I (2022) Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: salivary glands. Head Neck Pathol 16:40–53. https://doi.org/10.1007/s12105-022-01420-1CrossRefPubMedPubMedCentral

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O (2022) Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endoc Pathol 33:27–63. https://doi.org/10.1007/s12022-022-09707-3CrossRef

Reinheimer A, Vieira DS, Cordeiro MM, Rivero ER (2019) Retrospective study of 124 cases of salivary gland tumors and literature review. J Clin Exp Dent 11:e1025–e1032. https://doi.org/10.4317/jced.55685CrossRefPubMedPubMedCentral

Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA (2005) Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg 34:533–536. https://doi.org/10.1016/j.ijom.2005.02.005CrossRefPubMed

Sood S, McGurk M, Vaz F (2016) Management of salivary gland tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 130(S2):S142–S149. https://doi.org/10.1017/S0022215116000566CrossRefPubMedPubMedCentral

De Felice F, de Vincentiis M, Valentini V, Musio D, Mezi S, Lo Mele L, Della Monaca M, D’Aguanno V, Terenzi V, Di Brino M, Brauner E, Bulzonetti N, Tenore G, Pomati G, Cassoni A, Tombolini M, Battisti A, Greco A, Pompa G, Minni A, Tombolini V (2017) Management of salivary gland malignant tumor: the Policlinico Umberto I, “Sapienza” University of Rome Head and Neck Unit clinical recommendations. Crit Rev Oncol Hematol 120:93–97. https://doi.org/10.1016/j.critrevonc.2017.10.010CrossRefPubMed

Dostalova L, Kalfert D, Jechova A, Koucky V, Novak S, Kuchar M, Zabrodsky M, Novakova Kodetova D, Ludvikova M, Kholova I, Plzak J (2020) The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls. Eur Arch Otorhinolaryngol 277:1763–1769. https://doi.org/10.1007/s00405-020-05868-1CrossRefPubMed

Liu Y, Li J, Tan YR, Xiong P, Zhong LP (2015) Accuracy of diagnosis of salivary gland tumors with the use of ultrasonography, computed tomography, and magnetic resonance imaging: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 119:238-245.e2. https://doi.org/10.1016/j.oooo.2014.10.020CrossRefPubMed

10.

Rossi ED, Wong LQ, Bizzarro T, Petrone G, Mule A, Fadda G, Baloch ZM (2016) The impact of FNAC in the management of salivary gland lesions: Institutional experiences leading to a risk-based classification scheme. Cancer Cytopathol 124:388–396. https://doi.org/10.1002/cncy.21710CrossRefPubMed

11.

Griffith CC, Pai RK, Schneider F, Duvvuri U, Ferris RL, Johnson JT, Seethala RR (2015) Salivary gland tumor fine-needle aspiration cytology: a proposal for a risk stratification classification. Am J Clin Pathol 143:839–853. https://doi.org/10.1309/AJCPMII6OSD2HSJACrossRefPubMed

12.

Wei S, Layfield LJ, LiVolsi VA, Montone KT, Baloch ZW (2017) Reporting of fine needle aspiration (FNA) specimens of salivary gland lesions: a comprehensive review. Diagn Cytopathol 45:820–827. https://doi.org/10.1002/dc.23716CrossRefPubMed

13.

Carlson ER, Schlieve T (2019) Salivary gland malignancies. Oral Maxillofac Surg Clin North Am 31(1):125–144. https://doi.org/10.1016/j.coms.2018.08.007CrossRefPubMed

14.

Wang X, Luo Y, Li M, Yan H, Sun M, Fan T (2017) Management of salivary gland carcinomas—a review. Oncotarget 8:3946–3956. https://doi.org/10.18632/oncotarget.13952CrossRefPubMed

15.

Spiro RH, Koss LG, Hajdu SI, Strong EW (1973) Tumors of minor salivary origin. A clinicopathologic study of 492 cases. Cancer 31:117–129. https://doi.org/10.1002/1097-0142(197301)31:1%3c117::aid-cncr2820310116%3e3.0.co;2-7CrossRefPubMed

16.

Eveson JW, Cawson RA (1985) Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol 14:500–509. https://doi.org/10.1111/j.1600-0714.1985.tb00522.xCrossRefPubMed

17.

Cheraghlou S, Kuo P, Mehra S, Agogo GO, Bhatia A, Husain ZA, Yarbrough WG, Burtness BA, Judson BL (2018) Adjuvant therapy in major salivary gland cancers: analysis of 8580 patients in the National Cancer Database. Head Neck 40:1343–1355. https://doi.org/10.1002/hed.24984CrossRefPubMed

18.

Satko I, Stanko P, Longauerová I (2000) Salivary gland tumours treated in the stomatological clinics in Bratislava. J Craniomaxillofac Surg 28:56–61. https://doi.org/10.1054/jcms.1999.0092CrossRefPubMed

19.

Lima SS, Soares AF, de Amorim RF, Freitas R (2005) Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases. Braz J Otorhinolaryngol 71:335–340. https://doi.org/10.1016/s1808-8694(15)31332-xCrossRefPubMed

20.

de Oliveira FA, Duarte EC, Taveira CT, Máximo AA, de Aquino EC, Alencar R, Vencio EF (2009) Salivary gland tumor: a review of 599 cases in a Brazilian population. Head Neck Pathol 3:271–275. https://doi.org/10.1007/s12105-009-0139-9CrossRefPubMedPubMedCentral

21.

Sando Z, Fokouo JV, Mebada AO, Djomou F, NDjolo A, Oyono JL (2016) Epidemiological and histopathological patterns of salivary gland tumors in Cameroon. Pan Afr Med J 23:66. https://doi.org/10.11604/pamj.2016.23.66.5105CrossRefPubMedPubMedCentral

22.

Kamulegeya A, Kasangaki A (2004) Neoplasms of the salivary glands: a descriptive retrospective study of 142 cases-Mulago Hospital Uganda. J Contemp Dent Pract 5:16–27CrossRefPubMed

23.

Bjørndal K, Krogdahl A, Therkildsen MH, Overgaard J, Johansen J, Kristensen CA, Homøe P, Sørensen CH, Andersen E, Bundgaard T, Primdahl H, Lambertsen K, Andersen LJ, Godballe C (2011) Salivary gland carcinoma in Denmark 1990–2005: a national study of incidence, site and histology Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncol 47:677–682. https://doi.org/10.1016/j.oraloncology.2011.04.020CrossRefPubMed

24.

Terhaard CH, Lubsen H, Van der Tweel I, Hilgers FJ, Eijkenboom WM, Marres HA, Tjho-Heslinga RE, de Jong JM, Roodenburg JL, Dutch Head and Neck Oncology Cooperative Group (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 26:681–693. https://doi.org/10.1002/hed.10400CrossRefPubMed

25.

Speight PM, Barrett AW (2002) Salivary gland tumours. Oral Dis 8:229–240. https://doi.org/10.1034/j.1601-0825.2002.02870.xCrossRefPubMed

26.

Therkildsen MH, Christensen M, Andersen LJ, Schiødt T, Hansen HS (1998) Salivary gland carcinomas–prognostic factors. Acta Oncol 37:701–713. https://doi.org/10.1080/028418698430089CrossRefPubMed

27.

Al-Khateeb TH, Ababneh KT (2007) Salivary tumors in north Jordanians: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(5):e53–e59. https://doi.org/10.1016/j.tripleo.2006.11.017CrossRefPubMed

28.

Huang CC, Tseng FY, Chen ZC, Hsu CJ, Ko JY, Lou PJ, Chen YS (2007) Malignant parotid tumor and facial palsy. Otolaryngol Head Neck Surg 136:778–782. https://doi.org/10.1016/j.otohns.2006.10.043CrossRefPubMed

29.

Langdon JD (1985) Tumors of the salivary glands: clinical analysis of 68 cases. J Oral Maxillofac Surg 43:688–692. https://doi.org/10.1016/0278-2391(85)90195-8CrossRefPubMed

30.

Theriault C, Fitzpatrick PJ (1986) Malignant parotid tumors. Prognostic factors and optimum treatment. Am J Clin Oncol 9:510–516. https://doi.org/10.1097/00000421-198612000-00009CrossRefPubMed

31.

Spiro JD, Spiro RH (2003) Cancer of the parotid gland: role of 7th nerve preservation. World J Surg 27:863–867. https://doi.org/10.1007/s00268-003-7112-7CrossRefPubMed

32.

Pedersen D, Overgaard J, Søgaard H, Elbrønd O, Overgaard M (1992) Malignant parotid tumors in 110 consecutive patients: treatment results and prognosis. Laryngoscope 102:1064–1069. https://doi.org/10.1288/00005537-199209000-00019CrossRefPubMed

33.

Renehan A, Gleave EN, Hancock BD, Smith P, McGurk M (1996) Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg 83:1750–1754. https://doi.org/10.1002/bjs.1800831228CrossRefPubMed

34.

Borthne A, Kjellevold K, Kaalhus O, Vermund H (1986) Salivary gland malignant neoplasms: treatment and prognosis. Int J Radiat Oncol Biol Phys 1986(12):747–754. https://doi.org/10.1016/0360-3016(86)90032-5CrossRef

35.

Cheraghlou S, Yu PK, Otremba MD, Mehra S, Yarbrough WG, Judson BL (2018) Extracapsular extension is not a significant prognostic indicator in non-squamous cancers of the major salivary glands. Cancers Head Neck 3(3):5. https://doi.org/10.1186/s41199-018-0032-xCrossRefPubMedPubMedCentral

36.

Gao M, Hao Y, Huang MX, Ma DQ, Luo HY, Gao Y, Peng X, Yu GY (2013) Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma. Int J Oral Maxillofac Surg 42:923–928. https://doi.org/10.1016/j.ijom.2013.04.006CrossRefPubMed

37.

Kane WJ, McCaffrey TV, Olsen KD, Lewis JE (1991) Primary parotid malignancies. A clinical and pathologic review. Arch Otolaryngol Head Neck Surg 1991(117):307–315. https://doi.org/10.1001/archotol.1991.01870150075010CrossRef

38.

Magnano M, Gervasio CF, Cravero L, Machetta G, Lerda W, Beltramo G, Orecchia R, Ragona R, Bussi M (1999) Treatment of malignant neoplasms of the parotid gland. Otolaryngol Head Neck Surg 121:627–632. https://doi.org/10.1016/S0194-5998(99)70070-7CrossRefPubMed

39.

Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Loftus-Coll BM, Keus RB, van Leeuwen FE, Hart AA (1999) The development of a prognostic score for patients with parotid carcinoma. Cancer 85:2057–2067CrossRefPubMed

40.

Zbären P, Schüpbach J, Nuyens M, Stauffer E, Greiner R, Häusler R (2003) Carcinoma of the parotid gland. Am J Surg 186:57–62. https://doi.org/10.1016/s0002-9610(03)00105-3CrossRefPubMed

41.

Bhattacharyya N, Fried MP (2005) Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol 26:39–44. https://doi.org/10.1016/j.amjoto.2004.06.017CrossRefPubMed

42.

Terakedis BE, Hunt JP, Buchmann LO, Avizonis VN, Anker CJ, Hitchcock YJ (2017) The prognostic significance of facial nerve involvement in carcinomas of the parotid gland. Am J Clin Oncol 40:323–328. https://doi.org/10.1097/COC.0000000000000157CrossRefPubMed

43.

Olsen KD, Quer M, de Bree R, Vander Poorten V, Rinaldo A, Ferlito A (2017) Deep lobe parotidectomy-why, when, and how? Eur Arch Otorhinolaryngol 274:4073–4078. https://doi.org/10.1007/s00405-017-4767-5CrossRefPubMed

44.

Régis De Brito Santos I, Kowalski LP, Cavalcante De Araujo V, Flávia Logullo A, Magrin J (2001) Multivariate analysis of risk factors for neck metastases in surgically treated parotid carcinomas. Arch Otolaryngol Head Neck Surg 127:56–60. https://doi.org/10.1001/archotol.127.1.56CrossRefPubMed

45.

Ali S, Palmer FL, DiLorenzo M, Shah JP, Patel SG, Ganly I (2014) Treatment of the neck in carcinoma of the parotid gland. Ann Surg Oncol 21:3042–3048. https://doi.org/10.1245/s10434-014-3681-yCrossRefPubMed

46.

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology Head and Neck Cancers Version 2. 2022. https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf (access on December 2023).

47.

Kucharska E, Rzepakowska A, Cieślik M, Wilemska S, Bara M, Osuch-Wójcikiewicz E, Niemczyk K (2022) Indications for surgical treatment of major salivary glands pathologies with epidemiology analysis in adults—cohort study of 1173 cases. Otolaryngol Pol 76:1–5. https://doi.org/10.5604/01.3001.0015.8056CrossRefPubMed

Title: Oncologic outcomes of the most prevalent major salivary gland cancers: retrospective cohort study from single center
Authors: Ewa Kucharska
Anna Rzepakowska
Michał Żurek
Julia Pikul
Piotr Daniel
Angelika Oleszczak
Kazimierz Niemczyk
Publication date: 23-04-2024
Publisher: Springer Berlin Heidelberg
Keywords: Salivary Gland Cancer
Salivary Gland Cancer
Parotidectomy
Metastasis
Published in: European Archives of Oto-Rhino-Laryngology
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-024-08650-9

At a glance: The STEP trials

Springer Medicine

Oncologic outcomes of the most prevalent major salivary gland cancers: retrospective cohort study from single center

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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