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5221 search results for:

Gastroesophageal Junction Cancer 

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  1. 14-05-2024 | Online First

    Palliative Surgery for Patients with Gastroesophageal Junction or Gastric Cancer: A Report on Clinical Observational Outcomes

  2. 17-04-2024 | Targeted Therapy | Online First

    New therapeutic target molecules for gastric and gastroesophageal junction cancer

    Molecularly targeted therapy for receptor tyrosine kinases (RTKs) has faced limitations in gastric and gastroesophageal junction (G/GEJ) cancer except for HER2-targeted agents, possibly due to inappropriate assay selection that has hindered …

  3. Open Access 27-02-2024 | Esophageal Cancer | Online First

    Effectiveness of prehabilitation during neoadjuvant therapy for patients with esophageal or gastroesophageal junction cancer: a systematic review

    Progression of the physical weakness during neoadjuvant therapy (NAT) in patients with esophageal or gastroesophageal junction cancer is a serious problem; however, prehabilitation during NAT has the potential to overcome the unmet need.

  4. Open Access 28-01-2024 | Ramucirumab | OriginalPaper

    Rivoceranib, a VEGFR-2 inhibitor, monotherapy in previously treated patients with advanced or metastatic gastric or gastroesophageal junction cancer (ANGEL study): an international, randomized, placebo-controlled, phase 3 trial

    Although gastric cancer is declining in incidence, it is still the fifth most common type of cancer worldwide in terms of incidence, with over 1 million new cases in 2020, and globally it is the fourth most common cause of cancer death after lung …

  5. 23-11-2023 | Esophageal Cancer | ReviewPaper

    Current state of the art: immunotherapy in esophageal cancer and gastroesophageal junction cancer

    Esophageal cancers have a high mortality rate and limited treatment options especially in the advanced/metastatic setting. Squamous cell carcinoma (SCC) and adenocarcinoma are two distinct types of esophageal cancer. Esophageal SCC is more common …

  6. Open Access 31-03-2023 | Gastrectomy | OriginalPaper

    Two decades of gastric and gastroesophageal junction cancer surgery

    Gastric cancer incidence is continuously decreasing worldwide, but it remains the fourth most common cancer disease in males (683,754) and fifth in females (349,947) (Bray et al. 2018 ).

  7. Open Access 23-05-2023 | Gastric Cancer | ReviewPaper

    Clinical Outcomes for Previously Treated Patients with Advanced Gastric or Gastroesophageal Junction Cancer: A Systematic Literature Review and Meta-Analysis

    With over a million new cases per year worldwide, gastric cancer is one of the leading causes of cancer-related mortality [ 1 ]. Despite declining incidence rates, gastric cancer is the most frequently diagnosed cancer in men in many South Central …

  8. 28-07-2023 | Gastric Cancer | ReviewPaper

    Perioperative immune checkpoint inhibitor therapy for gastric and gastroesophageal junction cancers: a review of current approaches and future perspectives

    Metastatic gastric and gastroesophageal junction cancers have been treated with chemotherapy, but the landscape of cancer treatment is rapidly shifting towards immune-based therapies. As established by the CheckMate 649 and ATTRACTION-4 trials …

  9. Open Access 10-04-2023 | Gastric Cancer | OriginalPaper

    Efficacy of Pembrolizumab Monotherapy in Japanese Patients with Advanced Gastric or Gastroesophageal Junction Cancer

    Gastric cancer (GC) is the fifth most common cancer worldwide, and the geographic distribution of GC incidence and mortality is disproportionate, with the highest rates observed in east Asian countries, such as South Korea, Mongolia, and Japan [ 1 …

  10. Open Access 01-12-2023 | Esophagus Resection | OriginalPaper

    Neoadjuvant radiochemotherapy with cisplatin/5-flourouracil or carboplatin/paclitaxel in patients with resectable cancer of the esophagus and the gastroesophageal junction — comparison of postoperative mortality and complications, toxicity, and pathological tumor response

    Each year, more than 450,000 patients are newly diagnosed with esophageal cancer (EC) worldwide [ 1 ]. The national cancer registries in Germany report about 10 cases per population of 100,000 annually [ 2 ]. Kamangar et al. reported similar rates …

  11. Open Access 01-12-2023 | Gastrectomy | OriginalPaper

    Trans-pacific multicenter collaborative study of minimally invasive proximal versus total gastrectomy for proximal gastric and gastroesophageal junction cancers

    The current standard surgical procedure used to treat proximal gastric and gastroesophageal junction (P/GEJ) cancers with limited esophageal extension is total gastrectomy (TG), unless the tumor is small (< 3 cm in diameter) and contained in the …

  12. 15-04-2023 | Neutropenia | OriginalPaper

    A Multicenter, Phase II Trial of Schedule Modification for Nab-Paclitaxel in Combination with Ramucirumab for Patients with Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer: The B-RAX Trial (JACCRO GC-09)

    Taxanes inhibit the disassembly of microtubules, thereby causing cell death by disrupting the normal microtubule dynamics required for cell division and vital interphase processes [ 1 – 3 ]. Solvent-based (sb) paclitaxel (PTX) is an important drug …

  13. 30-08-2022 | Surgery | OriginalPaper

    Combined Prophylactic Hyperthermic Intraperitoneal Chemotherapy and Intraoperative Radiotherapy for Localized Gastroesophageal Junction and Gastric Cancer: A Comparative Nonrandomized Study

    This retrospective study reviewed the medical records of patients with a confirmed diagnosis of gastric or gastroesophageal junction adenocarcinoma managed at a tertiary care institution. The inclusion criteria specified adult patients 18 years of …

  14. Open Access 01-12-2022 | Neutropenia | OriginalPaper

    Biweekly oxaliplatin plus S1 for Chinese elderly patients with advanced gastric or gastroesophageal junction cancer as the first-line therapy: a single-arm, phase 2 study

    Gastric cancer is the second most common cancer and the third leading cause of cancer related deaths in China [ 1 , 2 ]. The incidence of gastric cancer is 63.92 per 100, 000 among the population aged 50–59 years, and 143.10 per 100, 000 among …

  15. 01-05-2022 | Cytostatic Therapy | EditorialNotes

    ASO Perspectives: Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer: Never Stop Questioning

    This ASO perspective reviews the findings of a randomized placebo-controlled, clinical trial evaluating adjuvant nivolumab in esophageal or gastroesophageal junction carcinoma, reported recently by the Checkmate 577 investigators. The use of …

  16. 09-05-2022 | Gastric Cancer | ReviewPaper

    Essential news and practice changing trials in oesophageal, gastroesophageal junction and gastric cancer in 2021

    In this short review we aim to summarize the highlights in gastric, gastroesophageal junction and oesophageal cancer in 2021. We will discuss practice changing studies and potential guideline changes based on these trials, with focus on the latest …

  17. Open Access 06-01-2023 | Gastric Cancer | OriginalPaper

    Immunological effects and activity of multiple doses of zolbetuximab in combination with zoledronic acid and interleukin-2 in a phase 1 study in patients with advanced gastric and gastroesophageal junction cancer

    Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer death globally (Sung et al. 2021 ). As gastric adenocarcinomas are typically detected at an advanced stage, treatment outcomes are dismal (Bilici 2014 ; …

  18. 01-06-2023 | OriginalPaper

    Laparoscopic and Thoracoscopic Total Gastrectomy and Esophagectomy with a Roux-en-Y Long Loop Esophagojejunostomy for Gastroesophageal Junction Cancers (with Video)

  19. 01-04-2022 | Gastric Cancer

    Cost-effectiveness analysis of nivolumab plus standard chemotherapy versus chemotherapy alone for the first-line treatment of unresectable advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma

    Background Nivolumab plus standard chemotherapy has significant clinical benefits for unresectable advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC/GEJC/EAC). However, nivolumab is …

  20. 03-04-2023 | Esophagus Resection | OriginalPaper

    Oesophagectomy or Total Gastrectomy for the Management of Siewert II Gastroesophageal Junction Cancer: a Systematic Review and Meta-analysis

    The most recent data from the UK shows that over 15,000 people were diagnosed with oesophagogastric cancer between 2016 and 2018 [ 1 ]. Data from UK resectional units shows that within this time frame, there were 4112 oesophagectomies and 2163 …

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