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Experimental Hematology & Oncology

Issue 1/2022

Content (108 Articles)

A Pig-a conditional knock-out mice model mediated by Vav-iCre: stable GPI-deficient and mild hemolysis

Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu

Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis

Xiaoman Li, Qi Jia, Yinyin Zhou, Xuan Jiang, Li Song, Yuanyuan Wu, Aiyun Wang, Wenxing Chen, Shijun Wang, Yin Lu

Research progress on dendritic cell vaccines in cancer immunotherapy

Jifeng Yu, Hao Sun, Weijie Cao, Yongping Song, Zhongxing Jiang

Correction to: Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

  • Open Access
  • Correction

Shuangli Zhu, Ming Yi, Yuze Wu, Bing Dong, Kongming Wu

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma

Staci L. Haney, Michelle L. Varney, Jacob T. Williams, Lynette M. Smith, Geoffrey Talmon, Sarah A. Holstein

Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome

Valentin Lacombe, Annaelle Beucher, Geoffrey Urbanski, Yannick Le Corre, Laurane Cottin, Anne Croué, Anne Bouvier

HOXA13 promotes gastric cancer progression partially via the FN1-mediated FAK/Src axis

Zhiwei Qin, Chongzhi Zhou

Progression patterns in monoclonal gammopathy of undetermined significance and multiple myeloma outcome: a cohort study in 42 patients

Widad Tahiru, Antonio Izarra Santamaria, Johan Hultdin, Wendy Yi-Ying Wu, Florentin Späth

A multicenter phase II study of bendamustine, rituximab, and cytarabine (BRAC) for relapsed or refractory patients with follicular lymphoma or mantle cell lymphoma

  • Open Access
  • Lymphoma
  • Letter to the Editor

Nobuhiko Nakamura, Senji Kasahara, Junichi Kitagawa, Hiroshi Nakamura, Michio Sawada, Kenji Fukuno, Yuhei Shibata, Yuto Kaneda, Takeshi Hara, Nobuhiro Kanemura, Hisashi Tsurumi, Masahito Shimizu

Successful administration of chimeric antigen receptor (CAR) T-cell therapy in patients requiring hemodialysis

Bradley D. Hunter, Daanish Hoda, Andy Nguyen, Launce Gouw, Bryan Huber, Ryan R. Jensen, Justine Preedit, Andrew Evens, Esther Huang, Jiyeon Park, Dennis L. Cooper

Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia

Xingcheng Yang, Ling Ma, Xiaoying Zhang, Liang Huang, Jia Wei

Increased TOX expression associates with exhausted T cells in patients with multiple myeloma

Yujie Zhao, Pengjun Liao, Shuxin Huang, Tairan Deng, Jiaxiong Tan, Youxue Huang, Huien Zhan, Yangqiu Li, Shaohua Chen, Liye Zhong

Distinct outcomes, ABL1 mutation profile, and transcriptome features between p190 and p210 transcripts in adult Philadelphia-positive acute lymphoblastic leukemia in the TKI era

Ting Shi, Mixue Xie, Li Chen, Wei Yuan, Yungui Wang, Xin Huang, Wanzhuo Xie, Haitao Meng, Yinjun Lou, Wenjuan Yu, Hongyan Tong, Xiujin Ye, Jinyan Huang, Jie Jin, Honghu Zhu

METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression

  • Open Access
  • Research

Yu-qing Guo, Qiang Wang, Jun-guo Wang, Ya-jun Gu, Pan-pan Song, Shou-yu Wang, Xiao-yun Qian, Xia Gao

A novel and efficient CD22 CAR-T therapy induced a robust antitumor effect in relapsed/refractory leukemia patients when combined with CD19 CAR-T treatment as a sequential therapy

Yu Zhang, Saisai Li, Ying Wang, Yang Lu, Yingxi Xu, Qing Rao, Huijun Wang, Haiyan Xing, Zheng Tian, Kejing Tang, Lulu Lv, Min Wang, Jianxiang Wang

Trends in platelet count among cancer patients

Vasily Giannakeas

Matching-adjusted indirect treatment comparison of chimeric antigen receptor T-cell therapies for third-line or later treatment of relapsed or refractory large B-cell lymphoma: lisocabtagene maraleucel versus tisagenlecleucel

Guillaume Cartron, Christopher P. Fox, Fei Fei Liu, Ana Kostic, Jens Hasskarl, Daniel Li, Ashley Bonner, Yixie Zhang, David G. Maloney, John Kuruvilla

RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation

Dalia Quwaider, Luis A. Corchete, Marta Martín-Izquierdo, Jesús M. Hernández-Sánchez, Elizabeta A. Rojas, Ignacio J. Cardona-Benavides, Ramón García-Sanz, Ana B. Herrero, Norma C. Gutiérrez

The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis

Gerd Bendas, Martin Schlesinger

Physical activity improves outcomes of combined lenvatinib plus anti-PD-1 therapy in unresectable hepatocellular carcinoma: a retrospective study and mouse model

Xue-Feng Liu, Xiao-Dong Zhu, Long-Hai Feng, Xiao-Long Li, Bin Xu, Kang-Shuai Li, Nan Xiao, Ming Lei, Hui-Chuan Sun, Zhao-You Tang

m6A binding protein YTHDF2 in cancer

  • Open Access
  • Review

Xiaomin Chen, Xiangxiang Zhou, Xin Wang

The clinical characteristics and prognosis in adult Ph negative acute lymphoblastic leukemia with TP53 aberrations

Qiuyun Fang, Xiaoyuan Gong, Kaiqi Liu, Yujiao Jia, Yang Song, Guangji Zhang, Yan Li, Qishan Hao, Yueshen Ma, Shuning Wei, Bingcheng Liu, Ying Wang, Hui Wei, Jianxiang Wang, Yingchang Mi

Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways

Qinwei Chen, Suqi Deng, Manman Deng, Yuanfei Shi, Mengya Zhong, Lihong Ding, Yuelong Jiang, Yong Zhou, Bing Z. Carter, Bing Xu

Heterogeneity of the tumor immune microenvironment and its clinical relevance

Qingzhu Jia, Aoyun Wang, Yixiao Yuan, Bo Zhu, Haixia Long

A comprehensive model to predict severe acute graft-versus-host disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation

Meng-Zhu Shen, Shen-Da Hong, Rui Lou, Rui-Ze Chen, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Dong Mo

CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model

Xavier Chauchet, Laura Cons, Laurence Chatel, Bruno Daubeuf, Gérard Didelot, Valéry Moine, Didier Chollet, Pauline Malinge, Guillemette Pontini, Krzysztof Masternak, Walter Ferlin, Vanessa Buatois, Limin Shang

Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells

  • Open Access
  • Review

Rongqun Guo, Wei Li, Yadan Li, Yingmei Li, Zhongxing Jiang, Yongping Song

Myelodysplastic syndromes are multiclonal diseases derived from hematopoietic stem and progenitor cells

Bingqing Luo, Fang Dong, Tiejun Qin, Qingyun Zhang, Haitao Bai, Jinhong Wang, Yujiao Jia, Shihui Ma, Erlie Jiang, Tao Cheng, Zhijian Xiao, Hideo Ema

Chidamide and apatinib are therapeutically synergistic in acute myeloid leukemia stem and progenitor cells

Haijun Zhao, Yuelong Jiang, Fusheng Lin, Mengya Zhong, Jinshui Tan, Yong Zhou, Long Liu, Guowei Li, Manman Deng, Bing Xu

The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

  • Open Access
  • Review

Ze Zhang, Furong Liu, Wei Chen, Zhibin Liao, Wanguang Zhang, Bixiang Zhang, Huifang Liang, Liang Chu, Zhanguo Zhang

Progress in understanding the mechanisms of resistance to BCL-2 inhibitors

Yilan Xu, Haige Ye

Mutational landscape of chronic myelomonocytic leukemia in Chinese patients

Yanbo Nie, Liang Shao, Hong Zhang, Colin K. He, Hongyu Li, Junyan Zou, Long Chen, Huaiyue Ji, Hao Tan, Yani Lin, Kun Ru

The HSP90 inhibitor KW-2478 depletes the malignancy of BCR/ABL and overcomes the imatinib-resistance caused by BCR/ABL amplification

Dachuan Zeng, Miao Gao, Renren Zheng, Run Qin, Wei He, Suotian Liu, Wei Wei, Zhenglan Huang

IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity

Kangkang Lv, Bo Hu, Mingzhu Xu, Li Wan, Ziqi Jin, Mimi Xu, Yuanyuan Du, Kunpeng Ma, Quansheng Lv, Yang Xu, Lei Lei, Huanle Gong, Haiyan Liu, Depei Wu, Yuejun Liu

Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer

Xinliang Gu, Yu Zhang, Xinyue Qin, Shuo Ma, Yuejiao Huang, Shaoqing Ju

Modified dendritic cell-derived exosomes activate both NK cells and T cells through the NKG2D/NKG2D-L pathway to kill CML cells with or without T315I mutation

Zhuanyun Du, Zhenglan Huang, Xi Chen, Guoyun Jiang, Yuhang Peng, Wenli Feng, Ningshu Huang

Spliceosome inhibitor induces human hematopoietic progenitor cell reprogramming toward stemness

  • Open Access
  • Correspondence

Liaoliao Dong, Chuijin Wei, Shumin Xiong, Ping Yu, Ren Zhou, Lin Cheng

TCR engineered T cells for solid tumor immunotherapy

Yikai Zhang, Zhipeng Liu, Wei Wei, Yangqiu Li

Targeting metabolic reprogramming in chronic lymphocytic leukemia

Yu Nie, Xiaoya Yun, Ya Zhang, Xin Wang

A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells

Walter Hanel, Pushpa Lata, Youssef Youssef, Ha Tran, Liudmyla Tsyba, Lalit Sehgal, Bradley W. Blaser, Dennis Huszar, JoBeth Helmig-Mason, Liwen Zhang, Morgan S. Schrock, Matthew K. Summers, Wing Keung Chan, Alexander Prouty, Bethany L. Mundy-Bosse, Selina Chen-Kiang, Alexey V. Danilov, Kami Maddocks, Robert A. Baiocchi, Lapo Alinari

A novel E-cadherin/SOX9 axis regulates cancer stem cells in multiple myeloma by activating Akt and MAPK pathways

Parinya Samart, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong

JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression

Hu Lei, Li Yang, Yingying Wang, Zhihui Zou, Meng Liu, Hanzhang Xu, Yingli Wu

Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin

Shunjie Yu, Xiaotong Ren, Lijuan Li

Current insight into the regulation of PD-L1 in cancer

  • Open Access
  • NSCLC
  • Review

Zhuandi Liu, Xibao Yu, Ling Xu, Yangqiu Li, Chengwu Zeng

Role of m6A writers, erasers and readers in cancer

  • Open Access
  • Review

Zhen Fang, Wentong Mei, Chang Qu, Jiongdi Lu, Liang Shang, Feng Cao, Fei Li

Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis

Chenghao Ge, Kelei Du, Mingjie Luo, Kaini Shen, Yangzhong Zhou, Kaiyuan Guo, Yang Liu, Chen Yin, Yi Li, Guanqiao Li, Xiaoyuan Chen

The genomic analysis brings a new piece to the molecular jigsaw of idiopathic erythrocytosis

Antonella Zagaria, Francesco Tarantini, Paola Orsini, Luisa Anelli, Cosimo Cumbo, Nicoletta Coccaro, Giuseppina Tota, Crescenzio Francesco Minervini, Elisa Parciante, Maria Rosa Conserva, Immacolata Redavid, Alessandra Ricco, Immacolata Attolico, Giorgina Specchia, Pellegrino Musto, Francesco Albano

Impaired mitochondria of Tregs decreases OXPHOS-derived ATP in primary immune thrombocytopenia with positive plasma pathogens detected by metagenomic sequencing

Yanxia Zhan, Jingjing Cao, Lili Ji, Miaomiao Zhang, Qi Shen, Pengcheng Xu, Xibing Zhuang, Shanshan Qin, Fanli Hua, Lihua Sun, Feng Li, Hao Chen, Yunfeng Cheng

Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma

Inge Oudaert, Arne Van der Vreken, Anke Maes, Elke De Bruyne, Kim De Veirman, Karin Vanderkerken, Eline Menu

Next-generation sequencing for MRD monitoring in B-lineage malignancies: from bench to bedside

Xinyue Deng, Meilan Zhang, Jianfeng Zhou, Min Xiao

CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis

Zijuan Wu, Danling Gu, Ruixin Wang, Xiaoling Zuo, Huayuan Zhu, Luqiao Wang, Xueying Lu, Yi Xia, Shuchao Qin, Wei Zhang, Wei Xu, Lei Fan, Jianyong Li, Hui Jin

The putative mechanistic insights on how SARS-CoV-2 might influence the outcomes in cancer patients

Jingwen Deng, Xiaopeng Cai, Zhi Chen

Novel treatment combining antiviral and neutralizing antibody-based therapies with monitoring of spike-specific antibody and viral load for immunocompromised patients with persistent COVID-19 infection

Daiki Wada, Yasushi Nakamori, Shuhei Maruyama, Haruka Shimazu, Fukuki Saito, Kazuhisa Yoshiya, Yasuyuki Kuwagata

Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia

Eugenio Morelli, Zachary R. Hunter, Mariateresa Fulciniti, Annamaria Gullà, Ida Daniela Perrotta, Valeria Zuccalà, Cinzia Federico, Giada Juli, Martina Manzoni, Domenica Ronchetti, Enrica Romeo, Maria Eugenia Gallo Cantafio, Debora Soncini, Lorenza Maltese, Marco Rossi, Aldo M. Roccaro, Michele Cea, Pierfrancesco Tassone, Antonino Neri, Steven C. Treon, Nikhil C. Munshi, Giuseppe Viglietto, Nicola Amodio

A pan-cancer analysis of the oncogenic role of leucine zipper protein 2 in human cancer

Dechao Feng, Xu Shi, Weizhen Zhu, Facai Zhang, Dengxiong Li, Ping Han, Qiang Wei, Lu Yang

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Lorenz Nierves, Jian Guo, Siyuan Chen, Janice Tsui, Anuli C. Uzozie, Jonathan W. Bush, Tao Huan, Philipp F. Lange

Rituximab, lenalidomide and BTK inhibitor as frontline treatment for elderly or unfit patients with diffuse large B-cell lymphoma: a real-world analysis of single center

Yanan Zhu, Xiang Zhang, Juying Wei, Chunmei Yang, Hongyan Tong, Wenyuan Mai, Min Yang, Jiejing Qian, Liping Mao, Haitao Meng, Jie Jin, Wenjuan Yu

Association between abnormal lipid profile and inflammation and progression of myelodysplastic syndrome to acute leukemia

Wei Qiao, Elliana Young, Chun Feng, Suyu Liu, Jeff Jin, Laila Noor, Cristhiam M. Rojas Hernandez, Gautam Borthakur, Olga Gorlova, Vahid Afshar-Kharghan

Chimeric antigen receptor T-cell therapy for relapsed and refractory thyroid cancer

Jing Ding, Deyu Li, Xingchen Liu, Hu Hei, Baoxi Sun, Dongmin Zhou, Keshu Zhou, Yongping Song

Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect

Haoran Wang, Hao Guo, Jingyi Yang, Yanyan Liu, Xingchen Liu, Qing Zhang, Keshu Zhou

Novel cellular immunotherapies for hematological malignancies: recent updates from the 2021 ASH annual meeting

Ji-nuo Wang, Tianning Gu, Yongxian Hu, He Huang

Calcium oxalate crystals trigger epithelial-mesenchymal transition and carcinogenic features in renal cells: a crossroad between kidney stone disease and renal cancer

Paleerath Peerapen, Wanida Boonmark, Pattaranit Putpeerawit, Visith Thongboonkerd

Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies

Anqiang Zhang, Dali Tong

Polyclonal evolution of Fanconi anemia to MDS and AML revealed at single cell resolution

Lixian Chang, Zejia Cui, Deyang Shi, Yajing Chu, Bichen Wang, Yang Wan, Qiuyi Ma, Ranran Zhang, Haoyuan Li, Xuelian Cheng, Tao Cheng, Xiaofan Zhu, Cheng Li, Weiping Yuan

Disease-free survival landmark analysis: a potential critical endpoint in triple-negative breast cancer

Fangchao Zheng, Tong Wei, Xue Wang, Feng Du, Jian Yue, Peng Yuan

p53 amyloid aggregation in cancer: function, mechanism, and therapy

  • Open Access
  • Review

Jingzhi Li, Ming Guo, Lin Chen, Zhuchu Chen, Ying Fu, Yongheng Chen

CD7-directed CAR T-cell therapy: a potential immunotherapy strategy for relapsed/refractory acute myeloid leukemia

Xuanqi Cao, Haiping Dai, Qingya Cui, Zheng Li, Wenhong Shen, Jinlan Pan, Hongjie Shen, Qinfen Ma, Mengyun Li, Sifan Chen, Juncheng Chen, Xiaming Zhu, Huimin Meng, Lin Yang, Depei Wu, Xiaowen Tang

MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer

  • Open Access
  • NSCLC
  • Research

Jae Heun Chung, Ho Jung Choi, Yong Jung Kang, Yun Seong Kim, Sang-Yull Lee, Ryuk Jun Kwon, Han-Sol Jeong, Su-Jung Park, Yeongmu Jeong, Dongwan Kang, Jeongin Ko, SangGyun Noh, Hae Young Chung, Hyung Ryong Moon, Seong Hoon Yoon

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

  • Open Access
  • Review

Nan Zhang, Hong‑Ping Zhu, Wei Huang, Xiang Wen, Xin Xie, Xian Jiang, Cheng Peng, Bo Han, Gu He

Identification of adenoid subtype characterized with immune-escaped phenotype in lung squamous carcinoma based on transcriptomics

  • Open Access
  • NSCLC
  • Correspondence

Jie Mei, Yun Cai, Ofek Mussafi, Mingfeng Zheng, Yongrui Xu, Ruo Chen, Guanyu Jiang, Wenjun Mao, Wei Xia, Yuan Wan

Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

Shan-Shan Li, Xiao-Hui Zhai, Hai-Ling Liu, Ting-Zhi Liu, Tai-Yuan Cao, Dong-Mei Chen, Le-Xin Xiao, Xiao-Qin Gan, Ke Cheng, Wan-Jia Hong, Yan Huang, Yi-Fan Lian, Jian Xiao

Autologous stem cell transplantation in tandem with Anti-CD30 CAR T-cell infusion in relapsed/refractory CD30+ lymphoma

Peiling Zhang, Xiuxiu Yang, Yang Cao, Jue Wang, Mi Zhou, Liting Chen, Jia Wei, Zekai Mao, Di Wang, Yi Xiao, Haichuan Zhu, Shangkun Zhang, Tongcun Zhang, Yicheng Zhang, Jianfeng Zhou, Liang Huang

IPSS-M has greater survival predictive accuracy compared with IPSS-R in persons ≥ 60 years with myelodysplastic syndromes

Junying Wu, Yudi Zhang, Tiejun Qin, Zefeng Xu, Shiqiang Qu, Lijuan Pan, Bing Li, Yujiao Jia, Chengwen Li, Huijun Wang, Qingyan Gao, Wenyu Cai, Jingye Gong, Songyang Zhao, Fuhui Li, Robert Peter Gale, Zhijian Xiao

DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang, Yue Han

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

  • Open Access
  • Review

Ning Huang, Xiaolin Sun, Peng Li, Xin liu, Xuemei Zhang, Qian Chen, Hong Xin

Spindle and kinetochore-associated complex subunit 3 could serve as a prognostic biomarker for prostate cancer

Dechao Feng, Weizhen Zhu, Xu Shi, Qiao Xiong, Dengxiong Li, Wuran Wei, Ping Han, Qiang Wei, Lu Yang

G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

Rui Li, Mengying Ke, Mingming Qi, Zhenru Han, Yuhao Cao, Zhendong Deng, Jinjun Qian, Ye Yang, Chunyan Gu

Recall of reactive cutaneous capillary endothelial proliferation (RCCEP) induced by stereotactic body radiation therapy (SBRT) in a patient with lung squamous cell carcinoma

Rong Ma, Jia-Lin Wang, Yan-Yang Wang

Safe and effective treatment of venous Thromboembolism associated with Cancer: focus on direct Oral Anticoagulants in Asian patients

Lai Heng Lee, Pongwut Danchaivijitr, Noppacharn Uaprasert, Harinder Gill, Dennis Lee Sacdalan, Gwo Fuang Ho, Rajiv Parakh, Paresh Pai, Jen-Kuang Lee, Nannette Rey, Alexander T. Cohen

RNA binding proteins in MLL-rearranged leukemia

Tiffany M. Tran, Dinesh S. Rao

The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia

Binyan Xu, Ziying Zhou, Yueting Wen, Zhongwei Li, Zhongxi Huang, Yuhua Li

Introducing AI to the molecular tumor board: one direction toward the establishment of precision medicine using large-scale cancer clinical and biological information

Ryuji Hamamoto, Takafumi Koyama, Nobuji Kouno, Tomohiro Yasuda, Shuntaro Yui, Kazuki Sudo, Makoto Hirata, Kuniko Sunami, Takashi Kubo, Ken Takasawa, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Ken Asada, Masaaki Komatsu, Syuzo Kaneko, Yasushi Yatabe, Noboru Yamamoto

Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor

Shaima Jabbar, Parker Mathews, Xiaobei Wang, Pasupathi Sundaramoorthy, Emily Chu, Sadhna O. Piryani, Shengli Ding, Xiling Shen, Phuong L. Doan, Yubin Kang

The natural FGF-trap long pentraxin 3 inhibits lymphangiogenesis and lymphatic dissemination

Marta Turati, Arianna Giacomini, Sara Rezzola, Federica Maccarinelli, Giorgia Gazzaroli, Sonia Valentino, Barbara Bottazzi, Marco Presta, Roberto Ronca

Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

Xiao Wang, Xuejiao Yang, Xiang Yuan, Wenbo Wang, Yueying Wang

Follow our path with asparaginase activity: one technique, but different uses in clinical practice

Daiane Keller Cecconello, Ciliana Rechenmacher, Klerize Anecely de Souza Silva, Fernanda Fetter Scherer, Thomas Dal Bem Prates, Rebeca Ferreira Marques, Liane Esteves Daudt, Mariana Bohns Michalowski

Low expression of PEBP1P2 promotes metastasis of clear cell renal cell carcinoma by post-transcriptional regulation of PEBP1 and KLF13 mRNA

Lei Yang, Haoli Yin, Yi Chen, Chun Pan, Hexing Hang, Yanwen Lu, Wenliang Ma, Xin Li, Weidong Gan, Hongqian Guo, Dongmei Li

Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis

Zhiyong Zhang, Yaojun Zheng, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Yayi Hou, Sunan Shen, Mingming Lv, Tingting Wang

Pan-cancer landscape of aberrant DNA Methylation across childhood Cancers: Molecular Characteristics and Clinical relevance

Zheng Dong, Hongyu Zhou

RHO GTPase family in hepatocellular carcinoma

Tiantian Wang, Dean Rao, Chengpeng Yu, Jiaqi Sheng, Yiming Luo, Limin Xia, Wenjie Huang

Correction: Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

  • Open Access
  • Correction

Nan Zhang, Hong‑Ping Zhu, Wei Huang, Xiang Wen, Xin Xie, Xian Jiang, Cheng Peng, Bo Han, Gu He

circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma

Xia-Hui Lin, Zhi-Yong Liu, Dan-Ying Zhang, Si Zhang, Wen-Qing Tang, Dong-Ping Li, Feng Zhang, Rong-Xin Chen, Shu-Qiang Weng, Ru-Yi Xue, Ling Dong

Learn from antibody–drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy

Mo Wu, Wei Huang, Nan Yang, Yanyong Liu

Targeting Bruton’s tyrosine kinase in vitreoretinal lymphoma: an open-label, prospective, single-center, phase 2 study

Wenxue Guan, Liang Wang, Xiaoyan Peng

Targeting the integrated stress response in hematologic malignancies

Gus O. Nwosu, Jason A. Powell, Stuart M. Pitson

Fecal microbiota transplantation combined with ruxolitinib as a salvage treatment for intestinal steroid-refractory acute GVHD

Yin Liu, Ye Zhao, Jiaqian Qi, Xiao Ma, Xiaofei Qi, Depei Wu, Yang Xu

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside

Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang, Bixiang Zhang

Roles of N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting

Jiahua Chen, Bao Guo, Xiaojing Liu, Jing Zhang, Junhui Zhang, Yuan Fang, Suding Zhu, Bing Wei, Yunxia Cao, Lei Zhan

The role of neutrophil extracellular traps in cancer progression, metastasis and therapy

Yue Chen, Haoyue Hu, Songtao Tan, Qionglan Dong, Xue Fan, Yi Wang, Huan Zhang, Jun He

Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia

Weijun Zhou, Jinyi Yu, Yilu Li, Kankan Wang

New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

Mengyuan Dai, Miao Liu, Hua Yang, Can Küçük, Hua You

Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche

Chen Wang, Taiyang Ye, Wenjing Wang, Keqi Song, Jie Zhu, Lan Dai, Wen Di

Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA

Xubo Gong, Piaoping Kong, Teng Yu, Xibin Xiao, Lin Wang, Yiwen Sang, Xiang Li, Bin Zhang, Zhihua Tao, Weiwei Liu

Phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced breast cancer

Sophie Cousin, Maud Toulmonde, Michèle Kind, Jean-Philippe Guegan, Alban Bessede, Coralie Cantarel, Carine Bellera, Antoine Italiano

Immune related biomarkers for cancer metastasis to the brain

  • Open Access
  • NSCLC
  • Review

Wei-Wei Chen, Timothy Shun Man Chu, LiangLiang Xu, Cai-Ning Zhao, Wai-Sang Poon, Gilberto Ka-Kit Leung, Feng-Ming (Spring) Kong

Correction: New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

Mengyuan Dai, Miao Liu, Hua Yang, Can Küçük, Hua You

Increased expression of ECT2 predicts the poor prognosis of breast cancer patients

Ming Yi, Di Zhang, Bin Song, Bin Zhao, Mengke Niu, Yuze Wu, Zhijun Dai, Kongming Wu

Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches

Walter Hanel, Alex F. Herrera, Narendranath Epperla

Dec 21
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Elevate your expertise in aplastic anemia (Link opens in a new window)

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Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

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Chaired by: Prof. Martin Dreyling
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