Issue 1/2021
Content (60 Articles)
Case report of combination therapy with Azacytidine, Enasidenib and Venetoclax in primary refractory AML
Sakshi Jasra, Mohammed Kazemi, Nishi Shah, Jiahao Chen, Karen Fehn, Yanhua Wang, Ioannis Mantzaris, Noah Kornblum, Alejandro Sica, LizaMarie Bachier, Mendel Goldfinger, Kira Gritsman, Ira Braunschweig, Ulrich Steidl, Aditi Shastri, Amit Verma
The degree of microsatellite instability predicts response to PD-1 blockade immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancers
Qiao-Xuan Wang, Chun-Hua Qu, Yuan-Hong Gao, Pei-Rong Ding, Jing-Ping Yun, Dan Xie, Mu-Yan Cai
Targeting phosphoglycerate dehydrogenase in multiple myeloma
Samah Elsaadi, Ida Steiro, Pegah Abdollahi, Esten N. Vandsemb, Rui Yang, Tobias S. Slørdahl, Torstein Baade Rø, Eline Menu, Anne-Marit Sponaas, Magne Børset
AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL
Zuoqiao Wu, Mary Nicoll, Robert J. Ingham
Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients
Changqian Bao, Xiandong Tao, Wei Cui, Yuanyuan Hao, Shuaike Zheng, Bin Yi, Tiewen Pan, Ken H. Young, Wenbin Qian
COVID-19-associated coagulopathy: thromboembolism prophylaxis and poor prognosis in ICU
Runhui Zheng, Jing Zhou, Bin Song, Xia Zheng, Ming Zhong, Li Jiang, Chun Pan, Wei Zhang, Jiaan Xia, Nanshan Chen, Wenjuan Wu, Dingyu Zhang, Yin Xi, Zhimin Lin, Ying Pan, Xiaoqing Liu, Shiyue Li, Yuanda Xu, Yimin Li, Huo Tan, Nanshan Zhong, Xiaodan Luo, Ling Sang
Multiplexed single‐cell mass cytometry reveals distinct inhibitory effects on intracellular phosphoproteins by midostaurin in combination with chemotherapy in AML cells
Emma Rörby, Jörgen Adolfsson, Erik Hultin, Thomas Gustafsson, Kourosh Lotfi, Jörg Cammenga, Jan-Ingvar Jönsson
MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3′UTR
Daniel T. Johnson, Amanda G. Davis, Jie-Hua Zhou, Edward D. Ball, Dong-Er Zhang
Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas
Yingying Ye, Ning Ding, Lan Mi, Yunfei Shi, Weiping Liu, Yuqin Song, Shaokun Shu, Jun Zhu
Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide
Yu Zheng, Yuan-Fei Mao, Hui-Jin Zhao, Li Chen, Li-Ning Wang, Yun-Xiang Zhang, Jiong Hu, Jun-Min Li, Xiao-Yang Li, Hong-Ming Zhu
A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990–2017
Mohammad Keykhaei, Masood Masinaei, Esmaeil Mohammadi, Sina Azadnajafabad, Negar Rezaei, Sahar Saeedi Moghaddam, Nazila Rezaei, Maryam Nasserinejad, Mohsen Abbasi-Kangevari, Mohammad-Reza Malekpour, Seyyed-Hadi Ghamari, Rosa Haghshenas, Kamyar Koliji, Farzad Kompani, Farshad Farzadfar
MiRNA-mediated EMT and CSCs in cancer chemoresistance
Bing Dong, Shiyu Li, Shuangli Zhu, Ming Yi, Suxia Luo, Kongming Wu
Circulating RNA biomarkers in diffuse large B-cell lymphoma: a systematic review
Philippe Decruyenaere, Fritz Offner, Jo Vandesompele
Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
Roberto Crocchiolo, Clara Cesana , Debora Girgenti , Giambattista Bertani, Claudia Barba , Giuseppa Liga , Ursula Ferri , Lara Crucitti , Giovanni Grillo, Silvano Rossini , Roberto Cairoli
Belinostat in combination with standard cyclophosphamide, doxorubicin, vincristine and prednisone as first-line treatment for patients with newly diagnosed peripheral T-cell lymphoma
Patrick B. Johnston, Amanda F. Cashen, Petros G. Nikolinakos, Anne W. Beaven, Stefan Klaus Barta, Gajanan Bhat, Steven J. Hasal, Sven De Vos, Yasuhiro Oki, Changchun Deng, Francine M. Foss
Etanercept as a new therapeutic option for cytokine release syndrome following chimeric antigen receptor T cell therapy
Lina Zhang, Shuai Wang, Ji Xu, Run Zhang, Han Zhu, Yujie Wu, Liying Zhu, Jianyong Li, Lijuan Chen
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion
Shu Yang, Hongying Zhang, Hua Yang, Jin Zhang, Jiao Wang, Ting Luo, Yangfu Jiang, Hui Hua
Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC
Mengke Niu, Ming Yi, Ning Li, Suxia Luo, Kongming Wu
Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma
Seiichi Okabe, Yuko Tanaka, Akihiko Gotoh
Tumor mutation burden estimated by a 69-gene-panel is associated with overall survival in patients with diffuse large B-cell lymphoma
Cunte Chen, Sichu Liu, Xinmiao Jiang, Ling Huang, Feili Chen, Xiaojun Wei, Hanguo Guo, Yang Shao, Yangqiu Li, Wenyu Li
Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
Yuwen Chen, Jianda Hu, Yingyu Chen
Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
Roberto Crocchiolo, Clara Cesana, Debora Girgenti, Giambattista Bertani, Claudia Barba, Giuseppa Liga, Ursula Ferri, Lara Crucitti, Giovanni Grillo, Silvano Rossini, Roberto Cairoli
VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder
Huijun Huang, Wenjun Zhang, Wenyu Cai, Jinqin Liu, Huijun Wang, Tiejun Qin, Zefeng Xu, Bing Li, Shiqiang Qu, Lijuan Pan, Gang Huang, Robert Peter Gale, Zhijian Xiao
Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4
Tianxin Lyu, Yinuo Wang, Ding Li, Hui Yang, Bin Qin, Wenli Zhang, Zhiyue Li, Cheng Cheng, Binglei Zhang, Rongqun Guo, Yongping Song
PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma
Shi-Zhe Zhang, Xiao-Dong Zhu, Long-Hai Feng, Xiao-Long Li, Xue-Feng Liu, Hui-Chuan Sun, Zhao-You Tang
Evaluation of acute myeloid leukemia blast percentage on MethylC-Capture Sequencing results
Erna Yang, Desheng Gong, Wei Guan, Jieying Li, Xuefeng Gao, Yonghui Li, Li Yu
Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns
Wei Guan, Lei Zhou, Yan Li, Erna Yang, Yangyang Liu, Na Lv, Lin Fu, Yi Ding, Nan Wang, Nan Fang, Qian Liu, Binan Wang, Fuwei Li, Juan Zhang, Maoquan Wang, Lili Wang, Yu Jing, Yonghui Li, Li Yu
Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells
Hyunsoo Cho, Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong, Yoo Hong Min
Histological verification of the treatment effect of tirabrutinib for relapsed/refractory primary central nervous system lymphoma
Yoshiko Okita, Rieko Kano-Fujiwara, Shin-Ichi Nakatsuka, Keiichiro Honma, Manabu Kinoshita
The metabolic adaptation mechanism of metastatic organotropism
Chao Wang, Daya Luo
Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment
Linbang Wang, Tao He, Jingkun Liu, Jiaojiao Tai, Bing Wang, Zhiyu Chen, Zhengxue Quan
Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine
Sophie Voruz, Laurence de Leval, Anne Cairoli
Comprehensive analysis of clinical, pathological, and genomic characteristics of follicular helper T-cell derived lymphomas
Sang Eun Yoon, Junhun Cho, Yeon Jeong Kim, Young Hyeh Ko, Woong-Yang Park, Seok Jin Kim, Won Seog Kim
Platelet-driven coagulopathy in COVID-19 patients: in comparison to seasonal influenza cases
Jianguo Zhang, Xing Huang, Daoyin Ding, Zhimin Tao
YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition
Xiangyuan Luo, Mengdie Cao, Fan Gao, Xingxing He
Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma
Nan Xiao, Xiaodong Zhu, Kangshuai Li, Yifan Chen, Xuefeng Liu, Bin Xu, Ming Lei, Jiejie Xu, Hui-Chuan Sun
Whole exome sequencing reveals a novel LRBA mutation and clonal hematopoiesis in a common variable immunodeficiency patient presented with hemophagocytic lymphohistiocytosis
Yanling Ren, Feng Xiao, Fei Cheng, Xin Huang, Jianhu Li, Xiaogang Wang, Wei Lang, Xinping Zhou, Jianping Lan, Hongyan Tong
Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development
Yiyi Yao, Fenglin Li, Jiansong Huang, Jie Jin, Huafeng Wang
Function and clinical significance of N6-methyladenosine in digestive system tumours
Junchao Huang, Yingjie Shao, Wendong Gu
Progress in molecular feature of smoldering mantle cell lymphoma
Panruo Jiang, Aakash Desai, Haige Ye
COVID-19 vaccination associated severe immune thrombocytopenia
Syed Raza Ali Shah, Sherpa Dolkar, Jacob Mathew, Prakash Vishnu
Genetic pathogenesis of immunoglobulin light chain amyloidosis: basic characteristics and clinical applications
Linchun Xu, Yongzhong Su
Allogeneic stem cell transplantation may overcome the adverse impact of myelofibrosis on the prognosis of myelodysplastic syndrome
Xiangzong Zeng, Li Xuan, Zhiping Fan, Yu Zhang, Ke Zhao, Ya Zhou, Jun Xu, Qifa Liu, Min Dai
Atezolizumab plus bevacizumab combination enables an unresectable hepatocellular carcinoma resectable and links immune exclusion and tumor dedifferentiation to acquired resistance
Yulei Wang, Li-Chun Lu, Yinghui Guan, Ming-Chih Ho, Shan Lu, Jessica Spahn, Chih-Hung Hsu
Efficacy of combination of venetoclax with azacitidine or chemotherapy in refractory/relapse acute leukemias of ambiguous lineage, not otherwise specified
Kaiqi Liu, Yan Li, Shaowei Qiu, Chunlin Zhou, Shuning Wei, Dong Lin, Guangji Zhang, Hui Wei, Ying Wang, Bingcheng Liu, Xiaoyuan Gong, Qiuyun Fang, Yang Song, Huijun Wang, Chengwen Li, Qinghua Li, Lihua Wu, Benfa Gong, Yuntao Liu, Jianxiang Wang, Yingchang Mi
Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm
Haotian Zhang, Melissa Castiglione, Lei Zheng, Huichun Zhan
19-Hydroxybufalin inhibits non-small cell lung cancer cell proliferation and promotes cell apoptosis via the Wnt/β-catenin pathway
Wei Yu, Xiao Zhang, Wei Zhang, Minggang Xiong, Yuhan Lin, Ming Chang, Lin Xu, Yi Lu, Yun Liu, Jian Zhang
Roles of the intestinal microbiota and microbial metabolites in acute GVHD
Dandan Lin, Bo Hu, Pengfei Li, Ye Zhao, Yang Xu, Depei Wu
Red blood cells differentiated in vitro using sequential liquid and semi-solid culture as a pre-clinical model
Matthew Cannon, Hannah Phillips, Sidney Smith, Shaneice Mitchell, Kristina Landes, Payal Desai, John Byrd, Rosa Lapalombella
Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment
Mohsen Valikhani, Elahe Rahimian, Seyed Esmaeil Ahmadi, Rouzbeh Chegeni, Majid Safa
MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors
Lun-Xi Peng, Guang-Ling Jie, An-Na Li, Si-Yang Liu, Hao Sun, Mei-Mei Zheng, Jia-Ying Zhou, Jia-Tao Zhang, Xu-Chao Zhang, Qing Zhou, Wen-Zhao Zhong, Jin-Ji Yang, Hai-Yan Tu, Jian Su, Hong-Hong Yan, Yi-Long Wu
Molecular subclassification of gastrointestinal cancers based on cancer stem cell traits
Mei-Mei Li, Jun Yuan, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu
CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
Jun Zhang, Xilin He, Yajie Wan, Honghong Zhang, Tao Tang, Meng Zhang, Shiyi Yu, Weiyong Zhao, Liming Chen
Elevated LDH greater than 400 U/L portends poorer overall survival in diffuse large B-cell lymphoma patients treated with CD19 CAR-T cell therapy in a real world multi-ethnic cohort
Emma Rabinovich, Kith Pradhan, R. Alejandro Sica, Lizamarie Bachier-Rodriguez, Ioannis Mantzaris, Noah Kornblum, Aditi Shastri, Kira Gritsman, Mendel Goldfinger, Amit Verma, Ira Braunschweig
Recent advances and challenges of bispecific antibodies in solid tumors
Yuze Wu, Ming Yi, Shuangli Zhu, Haiyong Wang, Kongming Wu
Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy
Eleni Gavriilaki, Vincent T. Ho, Wilhelm Schwaeble, Thomas Dudler, Mohamed Daha, Teizo Fujita, Sonata Jodele
IRF4 expression is low in Philadelphia negative myeloproliferative neoplasms and is associated with a worse prognosis
Cosimo Cumbo, Francesco Tarantini, Luisa Anelli, Antonella Zagaria, Immacolata Redavid, Crescenzio Francesco Minervini, Nicoletta Coccaro, Giuseppina Tota, Alessandra Ricco, Elisa Parciante, Maria Rosa Conserva, Giorgina Specchia, Pellegrino Musto, Francesco Albano
Selinexor in combination with standard chemotherapy in patients with advanced or metastatic solid tumors
Kyaw Z. Thein, Sarina A. Piha-Paul, Apostolia Tsimberidou, Daniel D. Karp, Filip Janku, Siqing Fu, Vivek Subbiah, David S. Hong, Timothy A. Yap, Jatin Shah, Denái R. Milton, Lacey McQuinn, Jing Gong, Yanyan Tran, Brett W. Carter, Rivka Colen, Funda Meric-Bernstam, Aung Naing
Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
Shuangli Zhu, Ming Yi, Yuze Wu, Bing Dong, Kongming Wu