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Experimental Hematology & Oncology

Issue 1/2024

Content (123 Articles)

Recent updates on central nervous system prophylaxis in patients with high-risk diffuse large B-cell lymphoma

Bernard Ji Guang Chua, Chen Ee Low, Chun En Yau, Ya Hwee Tan, Jianbang Chiang, Esther Wei Yin Chang, Jason Yongsheng Chan, Eileen Yi Ling Poon, Nagavalli Somasundaram, Mohamed Farid Bin Harunal Rashid, Miriam Tao, Soon Thye Lim, Valerie Shiwen Yang

Molecular profiling of biliary tract cancers reveals distinct genomic landscapes between circulating and tissue tumor DNA

Clémence Astier, Carine Ngo, Léo Colmet-Daage, Virginie Marty, Olivia Bawa, Claudio Nicotra, Maud Ngo-Camus, Antoine Italiano, Christophe Massard, Jean-Yves Scoazec, Cristina Smolenschi, Michel Ducreux, Antoine Hollebecque, Sophie Postel-Vinay

The roles of tissue resident macrophages in health and cancer

  • Open Access
  • Review

Minmin Cao, Zihao Wang, Wanying Lan, Binghua Xiang, Wenjun Liao, Jie Zhou, Xiaomeng Liu, Yiling Wang, Shichuan Zhang, Shun Lu, Jinyi Lang, Yue Zhao

Outcomes of allogeneic hematopoietic stem cell transplantation in R/R DLBCL patients with failure of CAR-T therapy

Mengya Cong, Sicheng Ai, Liqing Kang, Mao Jin, Ying Zhu, Caixia Li, Zhengming Jin, Lei Yu, Depei Wu, Haiwen Huang

ZMIZ2 facilitates hepatocellular carcinoma progression via LEF1 mediated activation of Wnt/β-catenin pathway

Yang Ding, Yumei Ning, Hui Kang, Yuan Yuan, Kun Lin, Chun Wang, Yun Yi, Jianghua He, Lurao Li, Xingxing He, Ying Chang

Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs

Qi Zhao, Hong Zong, Pingping Zhu, Chang Su, Wenxue Tang, Zhenzhen Chen, Shuiling Jin

Correction: Breast cancer heterogeneity and its implication in personalized precision therapy

  • Open Access
  • Correction

Liantao Guo, Deguang Kong, Jianhua Liu, Ling Zhan, Lan Luo, Weijie Zheng, Qingyuan Zheng, Chuang Chen, Shengrong Sun

METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control

Pan Zhao, Lin Xia, Dan Chen, Wei Xu, Huanping Guo, Yinying Xu, Bingbing Yan, Xiao Wu, Yuxia Li, Yunfang Zhang, Xi Zhang

A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia

Wei Zhou, Siying Li, Hong Wang, Jingfeng Zhou, Shuyi Li, Guofeng Chen, Wei Guan, Xianli Fu, Clara Nervi, Li Yu, Yonghui Li

Cancer metabolism and carcinogenesis

  • Open Access
  • Review

Jianqiang Yang, Chloe Shay, Nabil F. Saba, Yong Teng

Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment

  • Open Access
  • Research

Meng Qiao, Fei Zhou, Xinyu Liu, Tao Jiang, Haowei Wang, Xuefei Li, Chao Zhao, Lei Cheng, Xiaoxia Chen, Shengxiang Ren, Zaiqi Wang, Caicun Zhou

Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance

Jianche Liu, Penglei Jiang, Zezhen Lu, Zebin Yu, Pengxu Qian

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

Charles H. Williams, Leif R. Neitzel, Jessica Cornell, Samantha Rea, Ian Mills, Maya S. Silver, Jovanni D. Ahmad, Konstantin G. Birukov, Anna Birukova, Henry Brem, Betty Tyler, Eli E. Bar, Charles C. Hong

The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma

Fangfang Yan, Vivian Jiang, Alexa Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yu Xue, Yijing Li, Joseph McIntosh, Zhihong Chen, Jovanny Vargas, Lei Nie, Yixin Yao, Heng-Huan Lee, Wei Wang, JohnNelson R. Bigcal, Maria Badillo, Jitendra Meena, Christopher Flowers, Jia Zhou, Zhongming Zhao, Lukas M. Simon, Michael Wang

Revealing the role of the gut microbiota in enhancing targeted therapy efficacy for lung adenocarcinoma

Ting Jiang, Meng Zhang, Shaoyu Hao, Shi Huang, Xin Zheng, Zheng Sun

Outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: validation, comparison and improvement of 2022 ELN genetic risk system

Haixiao Zhang, Xinhui Zheng, Wenwen Guo, Yonghui Xia, Rongli Zhang, Weihua Zhai, Xin Chen, Qiaoling Ma, Donglin Yang, Jialin Wei, Aiming Pang, Yi He, Sizhou Feng, Jianxiang Wang, Mingzhe Han, Erlie Jiang

Venetoclax-based therapy for relapsed or refractory acute myeloid leukemia: latest updates from the 2023 ASH annual meeting

Xubo Gong, Xin He, Lin Wang, Teng Yu, Weiwei Liu, Huiying Xu, Lan Jin, Xiang Li, Bin Zhang, Zhihua Tao, Wenbin Qian

Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins

Tian-Qi Chen, Heng-Jing Huang, Shun-Xin Zhu, Xiao-Tong Chen, Ke-Jia Pu, Dan Wang, Yan An, Jun-Yi Lian, Yu-Meng Sun, Yue-Qin Chen, Wen-Tao Wang

Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia

Shuya Feng, Yigang Yuan, Zihan Lin, Min Li, Daijiao Ye, Liuzhi Shi, Danyang Li, Min Zhao, Chen Meng, Xiaofei He, Shanshan Wu, Fang Xiong, Siyu Ye, Junjun Yang, Haifeng Zhuang, Lili Hong, Shenmeng Gao

Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma

Xiao-Tian Shen, Sun-Zhe Xie, Xin Zheng, Tian-Tian Zou, Bei-Yuan Hu, Jing Xu, Lu Liu, Yun-Feng Xu, Xu-Feng Wang, Hao Wang, Shun Wang, Le Zhu, Kang-Kang Yu, Wen-Wei Zhu, Lu Lu, Ju-Bo Zhang, Jin-Hong Chen, Qiong-Zhu Dong, Lu-Yu Yang, Lun-Xiu Qin

Targeting natural killer cells: from basic biology to clinical application in hematologic malignancies

Juanjuan Shang, Shunfeng Hu, Xin Wang

Challenges and strategies associated with CAR-T cell therapy in blood malignancies

Zhaoyun Liu, Wenhui Lei, Hao Wang, Xiaohan Liu, Rong Fu

Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency

Ikuo Hirano, Kanako Abe, James Douglas Engel, Masayuki Yamamoto, Ritsuko Shimizu

The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice

Daishi Ishihara, Atsushi Hasegawa, Ikuo Hirano, James Douglas Engel, Masayuki Yamamoto, Ritsuko Shimizu

Dual-targeted CAR T-cell immunotherapies for hematological malignancies: latest updates from the 2023 ASH annual meeting

Jingyi Yang, Hao Guo, Lu Han, Yongping Song, Keshu Zhou

Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice

Ling Zhou, Yunlong Lu, Wei Liu, Shanglong Wang, Lingling Wang, Pengdou Zheng, Guisha Zi, Huiguo Liu, Wukun Liu, Shuang Wei

The multi-CDK inhibitor dinaciclib reverses bromo- and extra-terminal domain (BET) inhibitor resistance in acute myeloid leukemia via inhibition of Wnt/β-catenin signaling

Alexander R. Marr, Madeline Halpin, Dominique L. Corbin, Yerdanos Asemelash, Steven Sher, Britten K. Gordon, Ethan C. Whipp, Shaneice Mitchell, Bonnie K. Harrington, Shelley Orwick, Samon Benrashid, Virginia M. Goettl, Vedat Yildiz, Andrew D. Mitchell, Olivia Cahn, Alice S. Mims, Karilyn T. M. Larkin, Meixao Long, James Blachly, Jennifer A. Woyach, Rosa Lapalombella, Nicole R. Grieselhuber

Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies

Linqin Wang, Yuqi Lv, Linghui Zhou, Shenghao Wu, Yuanyuan Zhu, Shan Fu, Shuyi Ding, Ruimin Hong, Mingming Zhang, Hanjing Yu, Alex H. Chang, Guoqing Wei, Yongxian Hu, He Huang

MSCsDB: a database of single-cell transcriptomic profiles and in-depth comprehensive analyses of human mesenchymal stem cells

  • Open Access
  • Correspondence

Miao Yu, Ke Sui, Zheng Wang, Xi Zhang

Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Houhong Wang, Xiaoyu Wei, Lu Liu, Junfeng Zhang, Heng Li

Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects

Jing Zeng, Xianghong Zhang, Zhengjun Lin, Yu Zhang, Jing Yang, Pengcheng Dou, Tang Liu

Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis

Liang Liu, Xiaodong Chen, Leilei Wu, Kaizong Huang, Zhenyi Wang, Yaolin Zheng, Cheng Zheng, Zhenshan Zhang, Jiayan Chen, Jiaming Wei, Song Chen, Weilin Jin, Jinfei Chen, Dongping Wei, Yaping Xu

Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment

Yifan Zhou, Yao Qin, Jingjing Ma, Zhiyuan Li, Weiwei Heng, Lei Zhang, Hong Liu, Ruowei Li, Miaomiao Zhang, Qiao Peng, Pei Ye, Ning Duan, Ting Liu, Wenmei Wang, Xiang Wang

Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion

Diana Malarikova, Radek Jorda, Kristyna Kupcova, Jana Senavova, Alexandra Dolnikova, Eva Pokorna, Dmitry Kazantsev, Kristina Nozickova, Dana Sovilj, Celine Bellanger, David Chiron, Ladislav Andera, Vladimir Krystof, Miroslav Strnad, Karel Helman, Magdalena Klanova, Marek Trneny, Ondrej Havranek, Pavel Klener

VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses

Yusheng Lin, Ghizlane Choukrani, Lena Dubbel, Lena Rockstein, Jimena Alvarez Freile, Yuzhu Qi, Valerie Wiersma, Hao Zhang, Karl-Wilhelm Koch, Emanuele Ammatuna, Jan Jacob Schuringa, Tom van Meerten, Gerwin Huls, Edwin Bremer

Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells

Alaa M. Khalifa, Takashi Nakamura, Yusuke Sato, Hideyoshi Harashima

Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy

Weihuan Shao, Yiran Yao, Ludi Yang, Xiaoran Li, Tongxin Ge, Yue Zheng, Qiuyi Zhu, Shengfang Ge, Xiang Gu, Renbing Jia, Xin Song, Ai Zhuang

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma

Gabriel Gallo-Oller, Guillem Pons, Júlia Sansa-Girona, Natalia Navarro, Patricia Zarzosa, Lia García-Gilabert, Paula Cabré-Fernandez, Gabriela Guillén Burrieza, Lorena Valero-Arrese, Miguel F. Segura, José M. Lizcano, José Sánchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma

Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion

Junli Lu, Yiming Luo, Dean Rao, Tiantian Wang, Zhen Lei, Xiaoping Chen, Bixiang Zhang, Yiwei Li, Bifeng Liu, Limin Xia, Wenjie Huang

Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review

Yating Shen, Dexter Kai Hao Thng, Andrea Li Ann Wong, Tan Boon Toh

A Fab of trastuzumab to treat HER2 overexpressing breast cancer brain metastases

Eurydice Angeli, Justine Paris, Olivier Le Tilly, Céline Desvignes, Guillaume Gapihan, Didier Boquet, Frédéric Pamoukdjian, Diaddin Hamdan, Marthe Rigal, Florence Poirier, Didier Lutomski, Feriel Azibani, Alexandre Mebazaa, Amaury Herbet, Aloïse Mabondzo, Géraldine Falgarone, Anne Janin, Gilles Paintaud, Guilhem Bousquet

Pan-cancer transcriptional atlas of minimal residual disease links DUSP1 to chemotherapy persistence

Yuanhui Liu, Bi Peng, Ziqi Chen, Yimin Shen, Jingmin Zhang, Xianglin Yuan

Novel CAR T-cell therapies for relapsed/refractory B-cell malignancies: latest updates from 2023 ASH annual meeting

Wenjie Zhang, Sumei Li, Jinlan Long, Shufeng Xie, Minghui Wang, Han Liu, Zhenshu Xu

Novel agents and regimens in relapsed or refractory peripheral T-cell lymphoma: latest updates from 2023 ASH annual meeting

Huageng Huang, Wei Zhang, Xinyi Deng, He Huang, Zhao Wang, Huangming Hong, Tongyu Lin

Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives

Jingjing Pu, Ting Liu, Xuzhen Wang, Amit Sharma, Ingo G. H. Schmidt-Wolf, Liping Jiang, Jian Hou

Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways

  • Open Access
  • Review

Rong Wang, Shiwei He, Jun Long, Yian Wang, Xianjie Jiang, Mingfen Chen, Jie Wang

Enhanced cellular therapy: revolutionizing adoptive cellular therapy

Meng-Yao Xu, Na Zeng, Chen-Qian Liu, Jian-Xuan Sun, Ye An, Si-Han Zhang, Jin-Zhou Xu, Xing-Yu Zhong, Si-Yang Ma, Hao-Dong He, Jia Hu, Qi-Dong Xia, Shao-Gang Wang

NK cell transfer overcomes resistance to PD-(L)1 therapy in aged mice

  • Open Access
  • Research

Junlei Hou, Shuanglong Xie, Jianbao Gao, Tao Jiang, Enjian Zhu, Xuezhi Yang, Zheng Jin, Haixia Long, Anmei Zhang, Fei Yang, Lujing Wang, Haoran Zha, Qingzhu Jia, Bo Zhu, Xinxin Wang

Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis

Tianxiang Hu, Bo Cheng, Atsuko Matsunaga, Ting Zhang, Xiaocui Lu, Hui Fang, Stephanie F. Mori, Xuexiu Fang, Gavin Wang, Hongyan Xu, Huidong Shi, John K. Cowell

Highly immunosuppressive myeloid cells correlate with early relapse after allogeneic stem cell transplantation

Anne-Béatrice Notarantonio, Allan Bertrand, Romain Piucco, Ghislain Fievet, Hervé Sartelet, Laura Boulangé, Natalia de Isla, Marcelo De Carvalho Bittencourt, Sébastien Hergalant, Marie-Thérèse Rubio, Maud D’Aveni

CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison

  • Open Access
  • Research

Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke

Combination of percutaneous thermal ablation and adoptive Th9 cell transfer therapy against non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Hanbo Pan, Yu Tian, Siyu Pei, Wanlin Yang, Yanyang Zhang, Zenan Gu, Hongda Zhu, Ningyuan Zou, Jiaqi Zhang, Long Jiang, Yingjie Hu, Shengping Shen, Kai Wang, Haizhen Jin, Ziming Li, Yanyun Zhang, Yichuan Xiao, Qingquan Luo, Hui Wang, Jia Huang

Analysis of CD20 and PD-L1 levels on small extracellular vesicles (sEV) produced by DLBCL cells and EBV-transformed B cells, and potential role in T cell inhibition

Hussein Akil, Hafidha Bentayeb, Marine Aitamer, Chantal Vignoles, Julie Abraham, Nathalie Gachard, Agnès Olivrie, Anne Guyot, Jessica Gobbo, Jean Feuillard, Hamasseh Shirvani, Danielle Troutaud

Correction: ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer

  • Open Access
  • Correction

Shiyong Xin, Xiang Liu, Ziyao Li, Xianchao Sun, Rong Wang, Zhenhua Zhang, Xinwei Feng, Liang Jin, Weiyi Li, Chaozhi Tang, Wangli Mei, Qiong Cao, Haojie Wang, Jianguo Zhang, Lijin Feng, Lin Ye

Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells

Zheng Shi, Cuilan Hu, Xiaogang Zheng, Chao Sun, Qiang Li

Three-dimensional chromatin landscapes in MLLr AML

Pinpin Sui, Zhihong Wang, Peng Zhang, Feng Pan

Advances in nano-immunotherapy for hematological malignancies

Jian Xu, Wenqi Liu, Fengjuan Fan, Bo Zhang, Chunyan Sun, Yu Hu

Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion

Dongning Rao, Jiaxin Li, Mao Zhang, Siyuan Huang, Lu Meng, Guohe Song, Jiaqiang Ma, Yingcheng Wu, Yifei Cheng, Shuyi Ji, Gaohua Wu, Lv Chen, Yuming Liu, Yang Shi, Jian Zhou, Fan Jia, Xiaoming Zhang, Ruibin Xi, Qiang Gao

High efficacy of huCD20-targeted AcTaferon in humanized patient derived xenograft models of aggressive B cell lymphoma

Willem Daneels, Alexander Van Parys, Leander Huyghe, Elke Rogge, Steffi De Rouck, Ruben Christiaen, Lennart Zabeau, Sylvie Taveirne, Jo Van Dorpe, Niko Kley, Anje Cauwels, Erik Depla, Jan Tavernier, Fritz Offner

Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study

  • Open Access
  • NSCLC
  • Research

Yuankai Shi, Xiaohong Han, Qian Zhao, YuLong Zheng, Jianhua Chen, Xinmin Yu, Jian Fang, Yutao Liu, Dingzhi Huang, Tianshu Liu, Hong Shen, Suxia Luo, Hongsheng Yu, Yu Cao, Xi Zhang, Pei Hu

Reconstructed colorectal cancer model to dissect the anti-tumor effect of mesenchymal stromal cells derived extracellular vesicles

Edoardo D’Angelo, Sarah Tassinari, Andrea Biccari, Sara Crotti, Francesca Sensi, Asia Marangio, Ombretta Repetto, Giuseppe Corona, Linda Bellucci, Federica Antico, Federico Caicci, Gaya Spolverato, Giovanni Montini, Benedetta Bussolati, Marco Agostini, Federica Collino

The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases

  • Open Access
  • Review

Min-Jun Wang, Hai-Ling Zhang, Fei Chen, Xiao-Jing Guo, Qing-Gui Liu, Jin Hou

cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer

Jingyuan Li, Jun Tan, Tao Wang, Shan Yu, Guangliang Guo, Kan Li, Le Yang, Bin Zeng, Xueying Mei, Siyong Gao, Xiaomei Lao, Sien Zhang, Guiqing Liao, Yujie Liang

Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression

Yanyan Zhang, Charles Wang, Jian Jian Li

HIV associated lymphoma: latest updates from 2023 ASH annual meeting

Chaoyu Wang, Qing Xiao, Xiaomei Zhang, Yao Liu

Fueling CARs: metabolic strategies to enhance CAR T-cell therapy

Arne Van der Vreken, Karin Vanderkerken, Elke De Bruyne, Kim De Veirman, Karine Breckpot, Eline Menu

Anti-TIM3 chimeric antigen receptor-natural killer cells preferentially target primitive acute myeloid leukemia cells with minimal fratricide and exhaustion

Phatchanat Klaihmon, Parinya Samart, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong

Versatile function of NF-ĸB in inflammation and cancer

Qiang Ma, Shuai Hao, Weilong Hong, Vinay Tergaonkar, Gautam Sethi, Yu Tian, Chenyang Duan

CAR-T cell combination therapies in hematologic malignancies

Delian Zhou, Xiaojian Zhu, Yi Xiao

Infusion and delivery strategies to maximize the efficacy of CAR-T cell immunotherapy for cancers

Xinyu Gu, Yalan Zhang, Weilin Zhou, Fengling Wang, Feiyang Yan, Haozhan Gao, Wei Wang

Exploring whether ChatGPT-4 with image analysis capabilities can diagnose osteosarcoma from X-ray images

Yi Ren, Yusheng Guo, Qingliu He, Zhixuan Cheng, Qiming Huang, Lian Yang

Immunosuppressive tumor microenvironment in the progression, metastasis, and therapy of hepatocellular carcinoma: from bench to bedside

Yue Yin, Weibo Feng, Jie Chen, Xilang Chen, Guodong Wang, Shuai Wang, Xiao Xu, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia

1q jumping translocation as a biomarker in myeloid malignancy: frequently mutated genes associated with bad prognosis and low survival

Eitan Halper-Stromberg, Victoria Stinnett, Laura Morsberger, Aparna Pallavajjala, Mark J. Levis, Amy E. DeZern, Michelle Lei, Brian Phan, Rena R. Xian, Christopher D. Gocke, Guilin Tang, Ying S. Zou

Role of CDK4 as prognostic biomarker in Soft Tissue Sarcoma and synergistic effect of its inhibition in dedifferentiated liposarcoma sequential treatment

Silvia Vanni, Giacomo Miserocchi, Graziana Gallo, Valentina Fausti, Sofia Gabellone, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Giovanni De Luca, Massimo Bassi, Manlio Gessaroli, Nicola Tomasetti, Angelo Campobassi, Federica Pieri, Giorgio Ercolani, Davide Cavaliere, Lorena Gurrieri, Nada Riva, Federica Recine, Toni Ibrahim, Laura Mercatali, Robin Jones, Alessandro De Vita

Cell membrane patches transfer CAR molecules from a cellular depot to conventional T cells for constructing innovative fused-CAR-T cells without necessitating genetic modification

  • Open Access
  • Correspondence

Jing Hu, Luyi Zhong, Yiqiu Wang, Shiyi Hu, Lijiaqi Zhang, Qingchang Tian

The next frontier in immunotherapy: potential and challenges of CAR-macrophages

Jing Li, Ping Chen, Wenxue Ma

Overexpression of ESYT3 improves radioimmune responses through activating cGAS-STING pathway in lung adenocarcinoma

Zan Luo, Ying Li, Bin Xu, Tenghua Yu, Mingming Luo, PeiMeng You, Xing Niu, Junyu Li

Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilities

  • Open Access
  • SCLC
  • Review

Jing Zhang, Xiaoping Zeng, Qiji Guo, Zhenxin Sheng, Yan Chen, Shiyue Wan, Lele Zhang, Peng Zhang

CD105+CAF-derived exosomes CircAMPK1 promotes pancreatic cancer progression by activating autophagy

Zhiwei He, Xiushen Li, Shiyu Chen, Kun Cai, Xiaowu Li, Hui Liu

Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies

  • Open Access
  • Review

Siwei Zheng, Wenwen Wang, Lesang Shen, Yao Yao, Wenjie Xia, Chao Ni

Hematopoietic stem/progenitor cell transplantation recovers immune defects and prevents lymphomas in Atm-deficient mice

Bruna Sabino Pinho de Oliveira, Alessandro Giovinazzo, Sabrina Putti, Matilde Merolle, Tiziana Orsini, Giuseppe D. Tocchini-Valentini, Christophe Lancrin, Fabio Naro, Manuela Pellegrini

Measurable therapeutic antibody in serum as potential predictive factor of response to anti-CD38 therapy in non-IgG-k myeloma patients

Emilia Gigliotta, Federica Plano, Giusy Corsale, Anna Maria Corsale, Cristina Aquilina, Maria Speciale, Andrea Rizzuto, Enrica Antonia Martino, Dario Leotta, Antonio Giovanni Solimando, Roberto Ria, Massimo Gentile, Sergio Siragusa, Cirino Botta

M2-like tumor-associated macrophage-secreted CCL2 facilitates gallbladder cancer stemness and metastasis

Weihong Chen, Mingyuan Chen, Lingju Hong, Abudukeremu Xiahenazi, Maotuan Huang, Nanhong Tang, Xinyue Yang, Feifei She, Yanling Chen

Enhanced depletion of MLL-fusion proteins in acute leukemia: potential for improved therapeutic outcomes

Noelia Che, Sandra Cantilena, Remi Looi-Somoye, Danesh Sundar, Kent Fung, Jasper de Boer, Owen Williams

Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder

Qiusui Mai, Bailin He, Shikai Deng, Qing Zeng, Yanwen Xu, Cong Wang, Yunyi Pang, Sheng Zhang, Jinfeng Li, Jinfeng Zeng, Liqin Huang, Yongshui Fu, Chengyao Li, Tingting Li, Xiaojun Xu, Ling Zhang

Epigenetic alterations of TP53INP1 by EHMT2 regulate the cell cycle in gastric cancer

Tae Young Ryu, In Hwan Tae, Tae-Su Han, Jinkwon Lee, Kwangho Kim, Yunsang Kang, Solbi Kim, Hyo Jin Lee, Cho-Rok Jung, Jung Hwa Lim, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho

Current and future therapies for follicular lymphoma

Pier Luigi Zinzani, Javier Muñoz, Judith Trotman

Application patterns and outcomes of hematopoietic stem cell transplantation in peripheral T-cell lymphoma patients: a multicenter real-world study in China

Hongye Gao, Zhuoxin Zhang, Jiali Wang, Yannan Jia, Yawei Zheng, Xiaolei Pei, Weihua Zhai, Rongli Zhang, Xin Chen, Qiaoling Ma, Jialin Wei, Donglin Yang, Aiming Pang, Yi He, Sizhou Feng, Hao Zhang, Xin Du, Xianmin Song, Yao Liu, Dehui Zou, Erlie Jiang

Genetic factors, risk prediction and AI application of thrombotic diseases

Rong Wang, Liang V. Tang, Yu Hu

Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment

Huogang Wang, Mingo MH Yung, Yang Xuan, Fushun Chen, Waisun Chan, Michelle KY Siu, Runying Long, Shuo Jia, Yonghao Liang, Dakang Xu, Zhangfa Song, Stephen KW Tsui, Hextan YS Ngan, Karen KL Chan, David W Chan

Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets

Zihang Hong, Furong Liu, Zhanguo Zhang

Identifying ADGRG1 as a specific marker for tumor-reactive T cells in acute myeloid leukemia

Yihan Mei, Yu Liu, Wenbing Liu, Manling Chen, Xiaoyu Liu, Shangshang Wang, Junli Mou, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Runxia Gu, Shaowei Qiu, Jianxiang Wang

Correction: Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder

Qiusui Mai, Bailin He, Shikai Deng, Qing Zeng, Yanwen Xu, Cong Wang, Yunyi Pang, Sheng Zhang, Jinfeng Li, Jinfeng Zeng, Liqin Huang, Yongshui Fu, Chengyao Li, Tingting Li, Xiaojun Xu, Ling Zhang

Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers

  • Open Access
  • Correspondence

Hiroshi Kotani, Tomoyoshi Yamano, Justin C. Boucher, Shigeki Sato, Hiroyuki Sakaguchi, Koji Fukuda, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi, Takumi Nishiuchi, Hiroko Oshima, Masanobu Oshima, Marco L. Davila, Seiji Yano

Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response

Antonio Di Grazia, Eleonora Franzè, Rachele Frascatani, Federica Laudisi, Teresa Pacifico, Lorenzo Tomassini, Davide Di Fusco, Vincenzo Formica, Giuseppe Sica, Carmine Stolfi, Ivan Monteleone, Giovanni Monteleone

Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment

Xianjun Li, Tianjun Chen, Xuehan Li, Hanyu Zhang, Yingjing Li, Shuyuan Zhang, Shengnan Luo, Tongsen Zheng

Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer with concomitant aberrant MET activation

  • Open Access
  • NSCLC
  • Research

Shanshan Huang, Yaling Long, Yuan Gao, Wanling Lin, Lei Wang, Jizong Jiang, Xun Yuan, Yuan Chen, Peng Zhang, Qian Chu

Preclinical investigations and a first-in-human phase 1a trial of JS007, a novel anti-CTLA-4 antibody, in patients with advanced solid tumors

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Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma

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New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies

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Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia

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Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

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Developed by: Springer Healthcare IME
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Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

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Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare
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