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3122 search results for:

Acute Promyelocytic Leukemia 

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  1. 17-04-2024 | Acute Promyelocytic Leukemia | Online First

    JSH practical guidelines for hematological malignancies, 2023: leukemia-2—acute promyelocytic leukemia (APL)

    Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) and referred to as APL with recurrent genetic abnormality PML::RARA in the 2017 WHO classification. 1 The cytogenetic abnormality t(15;17)(q24.1;q21.2) is typically …

  2. Open Access 01-12-2024 | Acute Promyelocytic Leukemia | ReviewPaper

    Natural products as potential drug treatments for acute promyelocytic leukemia

    Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) as clinical treatments. ATO …

  3. 27-03-2024 | Hematology | Erratum

    Correction to: Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia

  4. Open Access 26-03-2024 | Acute Promyelocytic Leukemia | OriginalPaper

    The influence of hospital volume and physician volume on early mortality in acute promyelocytic leukemia patients

    Acute promyelocytic leukemia (APL) is a highly curable hematologic malignancy in the era of all-trans retinoic acid (ATRA) combination treatment. However, only a modest change in early mortality rate has been observed despite the wide availability …

  5. 01-03-2024 | Acute Promyelocytic Leukemia | Online First

    Cystatin F a potential diagnostic biomarker in acute promyelocytic leukemia

  6. 31-01-2024 | Acute Promyelocytic Leukemia | OriginalPaper

    Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia

    Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid …

  7. 11-02-2024 | Acute Promyelocytic Leukemia | Online First

    Dysregulated hemostasis in acute promyelocytic leukemia

    Acute promyelocytic leukemia (APL) is associated with a high incidence of early death, which occurs within 30 days of diagnosis. The major cause of early death in APL is severe bleeding, particularly intracranial bleeding. Although APL is known to …

  8. 22-02-2024 | Acute Promyelocytic Leukemia | Online First

    Risk factors and remaining challenges in the treatment of acute promyelocytic leukemia

    The treatment of acute promyelocytic leukemia (APL) has evolved with the introduction of all-trans retinoic acid (ATRA) and subsequent arsenic trioxide (ATO), particularly in standard-risk APL with an initial white blood cell count …

  9. 30-12-2023 | Acute Promyelocytic Leukemia | Online First

    Treating Pediatric Acute Promyelocytic Leukemia in India – Key Challenges and Lessons Learned

  10. Open Access 19-12-2023 | Acute Promyelocytic Leukemia | OriginalPaper

    Incidence, risk factors, and outcomes of second neoplasms in patients with acute promyelocytic leukemia: the PETHEMA-PALG experience

    The most important challenges in acute promyelocytic leukemia (APL) is preventing early death and reducing long-term events, such as second neoplasms (s-NPLs). We performed a retrospective analysis of 2670 unselected APL patients, treated with …

  11. 15-08-2023 | Acute Promyelocytic Leukemia | Letter

    The Frequency, Clinico-Hematological Features, and Outcome of Acute Promyelocytic Leukemia with Variant RARA Rearrangements: A Single Center Experience from India

  12. Open Access 01-12-2023 | Acute Promyelocytic Leukemia | OriginalPaper

    Effects of peripheral blood leukocyte count and tumor necrosis factor-alpha on early death in acute promyelocytic leukemia

    Acute promyelocytic leukemia (APL) has become a highly curable hematologic neoplastic disease with a 10-year overall survival (OS) rate of 93.9% [ 1 ] due to the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). With increasingly …

  13. 25-07-2023 | Trisomy 21 | Online First

    Microgranular Acute Promyelocytic Leukemia in a Patient with Down Syndrome

  14. 29-06-2023 | Acute Promyelocytic Leukemia | Online First

    Treatment of Pediatric Acute Promyelocytic Leukemia with Retinoic Acid and Arsenic Trioxide along with Chemotherapy

    Acute promyelocytic leukemia (APL) is one of the success stories in oncology in the last decade, with a remarkable improvement in survival after the introduction of differentiating agents, all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) …

  15. Open Access 01-12-2022 | Acute Promyelocytic Leukemia | Letter

    Oral arsenic and retinoic acid for high-risk acute promyelocytic leukemia

    Acute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemotherapy has proven feasible in high-risk …

  16. 16-08-2022 | Acute Promyelocytic Leukemia | ReviewPaper

    Treatment for relapsed acute promyelocytic leukemia

    The advent of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has significantly improved the outcomes of acute promyelocytic leukemia (APL); nevertheless, a small fraction of patients still experience relapse. Due to the infrequency of …

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