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Experimental Hematology & Oncology

Issue 1/2023

Content (105 Articles)

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu

The role of etoposide in the treatment of adult patients with hemophagocytic lymphohistiocytosis

Timo C. E. Zondag, Aglina Lika, Jan A. M. van Laar

Breast cancer heterogeneity and its implication in personalized precision therapy

Liantao Guo, Deguang Kong, Jianhua Liu, Ling Zhan, Lan Luo, Weijie Zheng, Qingyuan Zheng, Chuang Chen, Shengrong Sun

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna

The emerging scenario of immunotherapy for T-cell Acute Lymphoblastic Leukemia: advances, challenges and future perspectives

Daniele Caracciolo, Antonia Mancuso, Nicoletta Polerà, Caterina Froio, Giuseppe D’Aquino, Caterina Riillo, Pierosandro Tagliaferri, Pierfrancesco Tassone

CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia

Xinting Hu, Yang Han, Jiarui Liu, Hua Wang, Zheng Tian, Xin Zhang, Ya Zhang, Xin Wang

Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism

  • Open Access
  • Research

Zhihua Gong, Qingzhu Jia, Jinming Guo, Chongyi Li, Shouxia Xu, Zheng Jin, Han Chu, Yisong Y. Wan, Bo Zhu, Yi Zhou

Immune-related gene index predicts metastasis for prostate cancer patients undergoing radical radiotherapy

Dechao Feng, Weizhen Zhu, Xu Shi, Zhihong Wang, Wuran Wei, Qiang Wei, Lu Yang, Ping Han

CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway

Erbao Chen, Yu He, Jing Jiang, Jing Yi, Zhilin Zou, Qiuzi Song, Qingqi Ren, Zewei Lin, Yi Lu, Jikui Liu, Jian Zhang

Increasing cure rates of solid tumors by immune checkpoint inhibitors

  • Open Access
  • NSCLC
  • Review

Weijie Ma, Ruobing Xue, Zheng Zhu, Hizra Farrukh, Wenru Song, Tianhong Li, Lei Zheng, Chong-xian Pan

Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism

  • Open Access
  • Research

Deyu Huang, Yingli Han, Tian Tang, Lin Yang, Penglei Jiang, Wenchang Qian, Zhaoru Zhang, Xinyue Qian, Xin Zeng, Pengxu Qian

CircFBXW7 in patients with T-cell ALL: depletion sustains MYC and NOTCH activation and leukemia cell viability

Alessia Buratin, Cristina Borin, Caterina Tretti Parenzan, Anna Dal Molin, Silvia Orsi, Andrea Binatti, Katharina Simon, Maddalena Paganin, Valentina Serafin, Enrico Gaffo, Geertruij te Kronnie, Pieter Van Vlierberghe, Silvia Bresolin, Stefania Bortoluzzi

Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia

Najmeh Bozorgmehr, Mark Hnatiuk, Anthea C. Peters, Shokrollah Elahi

Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment

Ting Yan, Lingfeng Zhu, Jin Chen

GPR109A controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis

Wenjin Guo, Qian Gong, Xiaofeng Zong, Dianjun Wu, Yuhang Li, Huijie Xiao, Jie Song, Sheng Zhang, Shoupeng Fu, Zhichun Feng, Lu Zhuang

Hetrombopag plus porcine ATG and cyclosporine for the treatment of aplastic anaemia: early outcomes of a prospective pilot study

  • Open Access
  • Correspondence

Wenrui Yang, Xin Zhao, Xu Liu, Youzhen Xiong, Huihui Fan, Li Zhang, Jianping Li, Lei Ye, Kang Zhou, Yuan Li, Yang Yang, Guangxin Peng, Liping Jing, Fengkui Zhang

Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma

Zhi-Qiang Chen, Xue-Liang Zuo, Juan Cai, Yao Zhang, Guo-Yong Han, Long Zhang, Wen-Zhou Ding, Jin-Dao Wu, Xue-Hao Wang

Single-cell transcriptome analysis reveals stem cell-like subsets in the progression of Waldenström’s macroglobulinemia

  • Open Access
  • Correspondence

Yu Qiu, Xiao-shuang Wang, Yuan Yao, Yan-min Si, Xue-zhu Wang, Ming-nan Jia, Dao-bin Zhou, Jia Yu, Xin-xin Cao, Jian Li

Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene

Xuehong Zhang, Zhijie Hou, Dan Huang, Furong Wang, Beibei Gao, Chengtao Zhang, Dong Zhou, Jiacheng Lou, Haina Wang, Yuan Gao, Zhijie Kang, Ying Lu, Quentin Liu, Jinsong Yan

Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML

Yuming Zhao, Chunxiao He, Dengyang Zhang, Yao Guo, Zhiyong Peng, Liuting Yu, Na Li, Chun Chen, Zhizhuang Joe Zhao, Yun Chen

Emerging roles of m6A RNA modification in cancer therapeutic resistance

Wei-Wei Liu, Zhong-Yuan Zhang, Fei Wang, Hao Wang

Complement-related molecular classification and a gene signature for lung adenocarcinoma

  • Open Access
  • Correspondence

Lin Zhang, Yannan Yang, Weihao Lin, Fei Shao, Yibo Gao, Jie He

Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Siyu Gu, Yue Hou, Katarina Dovat, Sinisa Dovat, Chunhua Song, Zheng Ge

Age-related accumulation of B-1 cell progenitors in mice reflects changes in miR15a/16-1 expression and radioresistance capacity

Olívia F Souza, Vivian C de Oliveira, Gabriel J. F. Rodrigues, Lucas V. S. Costa, Fernanda Corado, Ana F. Popi

Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencing

Wenqi Wu, Zeyan Shi, Zhongyuan Tang, Huiqun Li, Xiaoke Huang, Xiaolin Liang, Jing Li, Yibin Yao, Weihua Zhao, Meiqing Wu, Jun Luo, Zhenfang Liu

Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load

Zhao-Yun Liu, Nan-Hao Meng, Pan-Pan Cao, Feng-Ping Peng, Jing-Yi Luo, Hao Wang, Feng-Juan Jiang, Jin Lu, Rong Fu

Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development

  • Open Access
  • Review

Xiaoya Ren, Menglong Jiang, Peng Ding, Xiaoyan Zhang, Xin Zhou, Jian Shen, Dong Liu, Xiaolong Yan, Zhiqiang Ma

p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma

Yingtong Chen, Ping Yang, Jing Wang, Shuang Gao, Shiyu Xiao, Weilong Zhang, Mingxia Zhu, Yanfang Wang, Xiaoyan Ke, Hongmei Jing

Secretogranin II influences the assembly and function of MHC class I in melanoma

Tamara Steinfass, Juliane Poelchen, Qian Sun, Giovanni Mastrogiulio, Daniel Novak, Marlene Vierthaler, Sandra Pardo, Aniello Federico, Laura Hüser, Thomas Hielscher, Rafael Carretero, Rienk Offringa, Peter Altevogt, Viktor Umansky, Jochen Utikal

Targeted treatment of T-cell acute lymphoblastic leukemia: latest updates from the 2022 ASH Annual Meeting

Jieyu Xu, Hong-Hu Zhu

LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma

Xiaoting Liang, Jieyu Liu, Xingyuan Liu, Yi Jin, Minna Xu, Zhenyu Han, Ke Wang, Chunting Zhang, Fei Zou, Liang Zhou

PD-L1+ macrophages are associated with favorable features in primary mediastinal (thymic) large B-cell lymphoma

Raphael E. Steiner, Edwin R. Parra, Francisco Vega, Lei Feng, Jason R. Westin, Sattva S. Neelapu, Paolo Strati, Michael R. Green, Christopher R. Flowers, Luisa M. Solis, Ignacio I. Wistuba, Sairah Ahmed, Ranjit Nair, Fredrick B. Hagemeister, Mansoor Noorani, Mario L. Marques-Piubelli

The clinical impact of IKZF1 mutation in acute myeloid leukemia

Xiang Zhang, Aijie Huang, Lixia Liu, Jiayue Qin, Chengcheng Wang, Min Yang, Yinjun Lou, Lei Wang, Xiong Ni, Xiaoxia Hu, Gusheng Tang, Mengmeng Zhang, Shanbo Cao, Liping Mao, Jiejin Qian, Weilai Xu, Juying Wei, Gaixiang Xu, Haitao Meng, Wenyuan Mai, Chunmei Yang, Honghu Zhu, Hongyan Tong, Jianmin Yang, Wenjuan Yu, Jianmin Wang, Jie Jin

Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy

Xian-Miao Li, Zhen-Yu Zhao, Xiao Yu, Qi-Dong Xia, Peng Zhou, Shao-Gang Wang, Huan-Lei Wu, Jia Hu

Surface TREM2 on circulating M-MDSCs as a novel prognostic factor for adults with treatment-naïve diffuse large B-cell lymphoma

Hao-Yuan Wang, Fu-Chen Yang, Ching-Fen Yang, Yao-Chung Liu, Po-Shen Ko, Chien-Jung Li, Chun-Kuang Tsai, Yi-Lin Chung, Nien-Jung Chen

Decitabine in combination with fludarabine and cyclophosphamide as a lymphodepletion regimen followed by CD19/CD22 bispecific targeted CAR T-cell therapy significantly improves survival in relapsed/refractory B-ALL patients

Yunju Ma, Haiping Dai, Qingya Cui, Sining Liu, Liqing Kang, Xiaying Lian, Wei Cui, Jia Yin, Lingling Liu, Mengjie Cai, Lei Yu, Depei Wu, Xiaowen Tang

Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis

Po-Lung Cheng, Ping-Hsiu Wu, We-Yu Kao, Yen-Ting Lai, Jason C. Hsu, Jeng-Fong Chiou, Meng-Huang Wu, Hsin-Lun Lee

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma

Xiao-Lu Ma, Yan-Yan Nie, Su-Hong Xie, Hui Zheng, Ying Tong, Yan-Chun Wang, Tian-Qing Yan, Xin Meng, Jia-Zhen Cao, Wei-Guo Tang, Lin Guo, Ren-Quan Lu

Wdr5 is essential for fetal erythropoiesis and hematopoiesis

  • Open Access
  • Correspondence

Lulu Liu, Yanjia Fang, Xiaodan Ding, Weihua Zhou, Remi Terranova, Yan Zhang, He Wang

“Major pathologic response” in lymph nodes: a modified nodal classification for non-small cell lung cancer patients treated with neoadjuvant immunochemotherapy

  • Open Access
  • NSCLC
  • Correspondence

Hongsheng Deng, Shan Xiong, Ran Zhong, Yongmei Zheng, Hengrui Liang, Bo Cheng, Jianfu Li, Feng Li, Zhuxing Chen, Haixuan Wang, Jianxing He, Wenhua Liang

Bispecific antibodies as monotherapy or in combinations for non-hodgkin B-cell lymphoma: latest updates from the American society of hematology 2022 annual meeting

Zhijuan Lin, Long Liu, Zhifeng Li, Bing Xu

New approaches to idiopathic neutropenia in the era of clonal hematopoiesis

Olisaemeka D. Ogbue, Tariq Kewan, Waled S. Bahaj, Carmelo Gurnari, Valeria Visconte, Jaroslaw P. Maciejewski

ANXA6/TRPV2 axis promotes lymphatic metastasis in head and neck squamous cell carcinoma by inducing autophagy

Min Wang, Min Pan, Yanshi Li, Tao Lu, Zhihai Wang, Chuan Liu, Guohua Hu

Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

Wei Li, Binglei Zhang, Weijie Cao, Wenli Zhang, Tiandong Li, Lina Liu, LinPing Xu, Fengcai Gao, Yanmei Wang, Fang Wang, Haizhou Xing, Zhongxing Jiang, Jianxiang Shi, Zhilei Bian, Yongping Song

Venetoclax combined with daunorubicin and cytarabine (2 + 6) as induction treatment in adults with newly diagnosed acute myeloid leukemia: a phase 2, multicenter, single-arm trial

Xiaohui Suo, Fang Zheng, Dongmei Wang, Liyun Zhao, Jie Liu, Ling Li, Zhihua Zhang, Congcong Zhang, Yinling Li, Sisi Yang, Xuemei Zhao, Rui Shi, Yan Wu, Zongjiu Jiao, Jiaojie Song, Ling Zhang, Xinxiao Lu, Linyu Yuan, Sifeng Gao, Jilei Zhang, Xingli Zhao, Guanchen Bai, Kaiqi Liu, Yingchang Mi

Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment

Thi Oanh Bui, Eurydice Angeli, Morad El Bouchtaoui, Guillaume Gapihan, Van Tu Dao, Justine Paris, Christophe Leboeuf, Michael Soussan, Patrick Villarese, Marianne Ziol, Emmanuel Van Glabeke, Thi Huong Le, Jean-Paul Feugeas, Anne Janin, Guilhem Bousquet

Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis

Xin Liu, Shuxin Zhong, Kangjie Qiu, Xi Chen, Weiyue Wu, Jiamian Zheng, Yanwen Liu, Haolong Wu, Shiyun Fan, Dingrui Nie, Xianfeng Wang, Zhi Yu, Ziwei Liao, Mengjun Zhong, Yangqiu Li, Chengwu Zeng

The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury

Yuxi Yi, Weiqing Lu, Lijun Shen, Yang Wu, Zhen Zhang

ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer

Shiyong Xin, Xiang Liu, Ziyao Li, Xianchao Sun, Rong Wang, Zhenhua Zhang, Xinwei Feng, Liang Jin, Weiyi Li, Chaozhi Tang, Wangli Mei, Qiong Cao, Haojie Wang, Jianguo Zhang, Lijin Feng, Lin Ye

Utility of indium-111 platelet scintigraphy for understanding the mechanism of thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia

Pauline Durand, Valérie Pottier, Charles Mesguich, Frédéric Debordeaux, Estibaliz Lazaro, Jean-François Viallard, Etienne Rivière

Genome-wide CRISPR/Cas9 library screening identified ATM signaling network genes as critical drivers for resistance to ATR inhibition in soft-tissue sarcomas: synthetic lethality and therapeutic implications

M Spalato-Ceruso, A Laroche-Clary, R Perret, Y Valverde, V Chaire, Marie-Alix Derieppe, V Velasco, A Bourdon, A Italiano

EZH2 in hepatocellular carcinoma: progression, immunity, and potential targeting therapies

Bohan Wang, Yachong Liu, Zhibin Liao, Haofeng Wu, Bixiang Zhang, Lei Zhang

Molecular correlation of response to pyrotinib in advanced NSCLC with HER2 mutation: biomarker analysis from two phase II trials

  • Open Access
  • NSCLC
  • Research

Shiqi Mao, Shuo Yang, Xinyu Liu, Xingya Li, Qiming Wang, Yiping Zhang, Jianhua Chen, Yan Wang, Guanghui Gao, Fengying Wu, Tao Jiang, Jiao Zhang, Ying Yang, Xiang Lin, Xiaoyu Zhu, Caicun Zhou, Shengxiang Ren

Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma

Jianing Chen, Hainan Yang, Chao Zhao, Tao Lin, Da Liu, Weiping Hong, Changguo Shan, Cheng Zhou, Ling Bao, Caicun Zhou, Linbo Cai, Chunxia Su, Zhaoming Zhou, Lei Wen

A new dosing regimen of ropeginterferon alfa-2b is highly effective and tolerable: findings from a phase 2 study in Chinese patients with polycythemia vera

Jie Jin, Lei Zhang, Albert Qin, Daoxiang Wu, Zonghong Shao, Jie Bai, Suning Chen, Minghui Duan, Hu Zhou, Na Xu, Sujiang Zhang, Xuelan Zuo, Xin Du, Li Wang, Pei Li, Xuhan Zhang, Yaning Li, Jingjing Zhang, Wei Wang, Weihong Shen, Oleh Zagrijtschuk, Raymond Urbanski, Toshiaki Sato, Zhijian Xiao

Outcome differences between PD-1/PD-L1 inhibitors-based monotherapy and combination treatments in NSCLC with brain metastases

Haowei Wang, Fangfang Liu, Xiaoxia Chen, Chao Zhao, Xuefei Li, Caicun Zhou, Jie Hu, Qian Chu, Tao Jiang

Venetoclax-based therapy for relapsed or refractory acute myeloid leukemia: latest updates from the 2022 ASH annual meeting

Xubo Gong, Yi Zhang, Xin He, Milad Moloudizargari, Teng Yu, Lin Wang, Weiwei Liu, Lan Jin, Huiying Xu, Yang Xu, Zhihua Tao, Wenbin Qian

The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications

  • Open Access
  • Review

Yunru Gu, Yuan Fang, Xi Wu, Tingting Xu, Tong Hu, Yangyue Xu, Pei Ma, Qiang Wang, Yongqian Shu

Advances in graft-versus-host disease prevention strategies: latest updates from the 2022 ASH annual meeting

Yiyin Chen, Yang Xu, Depei Wu

Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review

Charan Thej Reddy Vegivinti, Praneeth Reddy Keesari, Sindhusha Veeraballi, Catarina Maria Pina Martins Maia, Ansh Krishnachandra Mehta, Rohit Reddy Lavu, Rahul Kumar Thakur, Sri Harsha Tella, Riya Patel, Venkata Kiranmayi Kakumani, Yashwitha Sai Pulakurthi, Srinivas Aluri, Ritesh Kumar Aggarwal, Nandini Ramachandra, Rongbao Zhao, Srabani Sahu, Aditi Shastri, Amit Verma

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway

  • Open Access
  • NSCLC
  • Research

Fei Zhou, Jianguo Sun, Lingyun Ye, Tao Jiang, Wei Li, Chunxia Su, Shengxiang Ren, Fengying Wu, Caicun Zhou, Guanghui Gao

Targeting TIM-3 for hematological malignancy: latest updates from the 2022 ASH annual meeting

Jiaxiong Tan, Huo Tan, Yangqiu Li

DCF versus doublet chemotherapy as first-line treatment of advanced squamous anal cell carcinoma: a multicenter propensity score-matching study

Stefano Kim, Véronique Vendrely, Angélique Saint, Thierry André, Pauline Vaflard, Emmanuelle Samalin, Simon Pernot, Oliver Bouché, Mustapha Zubir, Jérôme Desrame, Christelle de la Fouchardière, Denis Smith, François Ghiringhelli, Angélique Vienot, Marion Jacquin, Elodie Klajer, Thierry Nguyen, Éric François, Julien Taieb, Karine Le Malicot, Dewi Vernerey, Aurélia Meurisse, Christophe Borg

Construction of CD19 targeted dual- and enhanced dual-antibodies and their efficiency in the treatment of B cell malignancy

Manling Chen, Xiaoyu Liu, Nan Peng, Ting Zhang, Junli Mou, Huizhen He, Ying Wang, Yingxi Xu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Runxia Gu, Shaowei Qiu, Min Wang, Jianxiang Wang

Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy

Xiaogang Zheng, Xiaodong Jin, Fei Ye, Xiongxiong Liu, Boyi Yu, Zheng Li, Ting Zhao, Weiqiang Chen, Xinguo Liu, Cuixia Di, Qiang Li

Multidisciplinary recommendations for the management of CAR-T recipients in the post-COVID-19 pandemic era

Tingting Zhang, Weiwei Tian, Shuang Wei, Xinyi Lu, Jing An, Shaolong He, Jie Zhao, Zhilin Gao, Li Li, Ke Lian, Qiang Zhou, Huilai Zhang, Liang Wang, Liping Su, Huicong Kang, Ting Niu, Ailin Zhao, Jing Pan, Qingqing Cai, Zhenshu Xu, Wenming Chen, Hongmei Jing, Peng Li, Wanhong Zhao, Yang Cao, Jianqing Mi, Tao Chen, Yuan Chen, Ping Zou, Veronika Lukacs-Kornek, Christian Kurts, Jian Li, Xiansheng Liu, Qi Mei, Yicheng Zhang, Jia Wei

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer

Fei Wu, Minglei Wang, Tao Zhong, Changyan Xiao, Xiaozheng Chen, Yiheng Huang, Meng Wu, Jinming Yu, Dawei Chen

Novel agents and clinical trials in castration-resistant prostate cancer: latest updates from 2023 ASCO-GU Cancers Symposium

Yuanhong Jiang, Siyu Wu, Rong Li, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Zhenqun Xu, Shijie Li, Xiaonan Chen

The role of organoids in cancer research

  • Open Access
  • Review

Zhen Fang, Peijuan Li, Fengying Du, Liang Shang, Leping Li

Chimeric antigen receptor engineered natural killer cells for cancer therapy

  • Open Access
  • Review

Yalan Zhang, Weilin Zhou, Jiangping Yang, Jinrong Yang, Wei Wang

Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma

Cecilia Bandini, Elisabetta Mereu, Tina Paradzik, Maria Labrador, Monica Maccagno, Michela Cumerlato, Federico Oreglia, Lorenzo Prever, Veronica Manicardi, Elisa Taiana, Domenica Ronchetti, Mattia D’Agostino, Francesca Gay, Alessandra Larocca, Lenka Besse, Giorgio Roberto Merlo, Emilio Hirsch, Alessia Ciarrocchi, Giorgio Inghirami, Antonino Neri, Roberto Piva

The progress of novel strategies on immune-based therapy in relapsed or refractory diffuse large B-cell lymphoma

Tingxun Lu, Jie Zhang, Zijun Y. Xu-Monette, Ken H. Young

Current approaches to develop “off-the-shelf” chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review

Cristina Aparicio, Carlos Acebal, Margarita González-Vallinas

Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting

Jiangxue Hou, Yufu Li, Quande Lin

Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells

  • Open Access
  • Research

Juan-Juan Wang, Ding-Xiong Chen, Yu Zhang, Xin Xu, Yan Cai, Wen-Qiang Wei, Jia-Jie Hao, Ming-Rong Wang

Targeting NOTCH1 in combination with antimetabolite drugs prolongs life span in relapsed pediatric and adult T-acute lymphoblastic leukemia xenografts

Sonia Minuzzo, Valentina Agnusdei, Marica Pinazza, Adriana A. Amaro, Valeria Sacchetto, Ulrich Pfeffer, Roberta Bertorelle, Orietta Spinelli, Valentina Serafin, Stefano Indraccolo

CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression

Dakui Luo, Min Chen, Qingguo Li, Kangjunjie Wang, Kaihua Wang, Junqiang Li, Guoxiang Fu, Zezhi Shan, Qi Liu, Yufei Yang, Lei Liang, Yanlei Ma, Yi Qin, Jun Qin, Daming Gao, Xinxiang Li

Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma

  • Open Access
  • Sarcoma
  • Correspondence

Sonam Mittal, Ishaque Pulikkal Kadamberi, Hua Chang, Feng Wang, Sudhir Kumar, Shirng-Wern Tsaih, Christopher J. Walker, Pradeep Chaluvally-Raghavan, John Charlson, Yosef Landesman, Sunila Pradeep

A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models

Wing Keung Chan, Jessica Williams, Kinnari Sorathia, Betsy Pray, Kaled Abusaleh, Zehua Bian, Archisha Sharma, Ian Hout, Shamama Nishat, Walter Hanel, Shelby L. Sloan, Aneeq Yasin, Nathan Denlinger, Xiaoli Zhang, Natarajan Muthusamy, Sumithira Vasu, Marcos de Lima, Yiping Yang, Robert Baiocchi, Lapo Alinari

Recent advances and future perspectives in the therapeutics of prostate cancer

Ganji Lakshmi Varaprasad, Vivek Kumar Gupta, Kiran Prasad, Eunsu Kim, Mandava Bhuvan Tej, Pratik Mohanty, Henu Kumar Verma, Ganji Seeta Rama Raju, LVKS Bhaskar, Yun Suk Huh

Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia

Pauline Schneider, Nicholas T. Crump, Susan T.C.J.M. Arentsen-Peters, Alastair L. Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Anja de Jong, Stefan Nierkens, Bianca Koopmans, Thomas A. Milne, Rob Pieters, Ronald W. Stam

The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer

Arianna Giacomini, Marta Turati, Elisabetta Grillo, Sara Rezzola, Gaia Cristina Ghedini, Ander Churruca Schuind, Eleonora Foglio, Federica Maccarinelli, Jessica Faletti, Serena Filiberti, Angela Chambery, Mariangela Valletta, Laura Melocchi, Stephanie Gofflot, Barbara Chiavarina, Andrei Turtoi, Marco Presta, Roberto Ronca

Focal adhesion kinase: from biological functions to therapeutic strategies

Ximin Tan, Yuheng Yan, Bin Song, Shuangli Zhu, Qi Mei, Kongming Wu

Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target

Mengwei Zhang, Jinkai Liu, Qiang Xia

Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain

Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang, Long Zhao, Yang Yang, Yijian Zhang, Lei Xu, Yangyang Lei, Jie Du, Hu Chen, Lian Duan, Mingyi He, Lintao Shi, Lei Liu, Quanjun Wang, Liangding Hu, Bin Zhang

Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting

Jiangxue Hou, Yufu Li, Quande Lin

Identification of a novel NPM1 mutation in acute myeloid leukemia

Yiyi Yao, Xiangjie Lin, Chen Wang, Ying Gu, Jie Jin, Yinghui Zhu, Huafeng Wang

CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro

Ming Liu, Linlin Zhang, Mingtian Zhong, Yihao Long, Wenhui Yang, Ting Liu, Xingxu Huang, Xiaodong Ma

Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia

Agnieszka Goral, Marta Sledz, Aneta Manda-Handzlik, Adrianna Cieloch, Alicja Wojciechowska, Mieszko Lachota, Agnieszka Mroczek, Urszula Demkow, Radoslaw Zagozdzon, Katarzyna Matusik, Malgorzata Wachowska, Angelika Muchowicz

Targeting CD22 for B-cell hematologic malignancies

Jia Xu, Wenjing Luo, Chenggong Li, Heng Mei

New insight into circRNAs: characterization, strategies, and biomedical applications

  • Open Access
  • Review

Xin-Yi Feng, Shun-Xin Zhu, Ke-Jia Pu, Heng-Jing Huang, Yue-Qin Chen, Wen-Tao Wang

Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies

Yuqin Song, Shang-Ju Wu, Zhixiang Shen, Donglu Zhao, Thomas Sau Yan Chan, Huiqiang Huang, Lugui Qiu, Jianyong Li, Tran-der Tan, Jun Zhu, Yongping Song, Wei-Han Huang, Weili Zhao, Herman Sung Yu Liu, Wei Xu, Naizhi Chen, Jun Ma, Cheng-Shyong Chang, Eric Wai Choi Tse

The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC

  • Open Access
  • NSCLC
  • Review

Firas Batrash, Mahmoud Kutmah, Jun Zhang

Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling

  • Open Access
  • NSCLC
  • Research

Hao Luo, Qing Li, Ren-Tao Wang, Liang Zhang, Wei Zhang, Meng-Sheng Deng, Yuan-Yuan Luo, Xintong Ji, Yongheng Wen, Xuan-Rui Zhou, Bo Xu, Dong Wang, Bin Hu, Hua Jin, Cheng-Xiong Xu

CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy

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Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

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Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

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