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Ritonavir 

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  1. Open Access 12-04-2024 | Ritonavir | Online First

    Ritonavir: 25 Years’ Experience of Concomitant Medication Management. A Narrative Review

    Ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme and is commonly used as a pharmacokinetic (PK) enhancer in antiviral therapies because it increases bioavailability of concomitantly administered antivirals. Decades of experience …

  2. 10-04-2024 | Ritonavir | Online First

    Prevalence and Management of Medication Interactions with Nirmatrelvir-Ritonavir at a Large Urban Academic Medical Center: An Observational Study

    Nirmatrelvir-ritonavir received emergency use authorization by the U.S. Food and Drug Administration in December 2021 to treat ambulatory patients diagnosed with COVID-19 at risk of developing severe disease. 1 Ritonavir is an inhibitor of hepatic …

  3. 22-01-2024 | Ritonavir | Letter

    Nirmatrelvir-ritonavir (Paxlovid) Access, Use, and Eligibility Among Adults with COVID-19 in Los Angeles County: The LA Pandemic Surveillance Cohort Study

    Nirmatrelvir-ritonavir (Paxlovid), an effective treatment for COVID-19, was approved for emergency use authorization (EUA) in December 2021, for individuals at high risk of developing severe COVID-19. 1 Nirmatrelvir-ritonavir has been shown to …

  4. Open Access 01-12-2024 | Ritonavir | OriginalPaper

    A case report of drug interaction between co-packaged nirmatrelvir-ritonavir and tacrolimus causing hyponatremia in a lung transplant recipient

    The outcomes of lung transplant recipients infected with coronavirus disease 2019.

  5. 08-03-2024 | Ritonavir | Online First

    Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment

    Docetaxel is a taxane chemotherapeutic agent that is widely used in the clinic as single agent or in combination with other cytotoxic drugs for the treatment of a broad range of cancers, such as breast cancer, non-small cell lung cancer and …

  6. Open Access 23-02-2024 | Ritonavir | OriginalPaper

    Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers

    The COVID-19 pandemic affects people worldwide and can lead to hospitalization and death. Nirmatrelvir-ritonavir (Paxlovid ® ) has been available through an Emergency Use Authorization (EUA) since early 2022 and was approved by the US Food and Drug …

  7. 11-03-2024 | Ritonavir | Online First

    The Impacts of Nirmatrelvir–Ritonavir on Myocardial Injury and Long-Term Cardiovascular Outcomes in Hospitalized Patients with COVID-19 amid the Omicron Wave of the Pandemic

    Although the pathogenicity and clinical severity of omicron COVID-19 appear to be weakened compared with previous variants, it tends to evolve toward more transmissible, and the number of hospital admissions and cardiovascular complications might …

  8. 01-12-2024 | Ritonavir | OriginalPaper

    Red light-emitting diode therapy minimizes the functional deleterious effects of the antiretroviral ritonavir on osteoblasts in vitro

    Acquired immune deficiency syndrome (AIDS) is a serious public health issue worldwide [ 1 ]. Among the various medical concerns that HIV-positive patients face, stands out the high rates of impaired skeletal mineralization, clinically represented …

  9. 23-01-2024 | COVID-19 | News | Article

    Simnotrelvir plus ritonavir shortens duration of mild-to-moderate COVID-19 symptoms

    Early treatment with simnotrelvir used in combination with ritonavir significantly shortens the duration of COVID-19 symptoms versus placebo.

  10. Open Access 01-12-2024 | Ritonavir | OriginalPaper

    Real-world effectiveness of nirmatrelvir-ritonavir versus azvudine in hospitalized patients with COVID-19 during the omicron wave in Beijing: a multicenter retrospective cohort study

    In the context of the deadly COVID-19 pandemic, various developed or repurposed oral antiviral medications have been authorized for emergency use to treat SARS-CoV-2 infection [ 1 , 2 ]. Nirmatrelvir-ritonavir and azvudine are the main antivirus …

  11. 01-07-2023 | Ritonavir | News

    Ritonavir/tacrolimus

    Drug level increased following interaction: case report
  12. Open Access 19-12-2023 | Ritonavir | Online First

    Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin

    Nirmatrelvir/ritonavir (Paxlovid®) was approved in January 2022 for the early treatment of SARS-CoV-2-infected patients at high risk of severe courses. Its component ritonavir is used as a boosting agent to reach and maintain therapeutic drug …

  13. Open Access 01-12-2023 | Kidney Transplantation | OriginalPaper

    Switch from a ritonavir to a cobicistat containing antiretroviral regimen and impact on tacrolimus levels in a kidney transplant recipient

    The prevalence of chronic and end-stage kidney disease in people living with HIV (PLWH) is increasing with the improved life expectancy and the related aging of the HIV population [ 1 , 2 ]. As a consequence, kidney transplantation is increasingly …

  14. Open Access 01-12-2023 | Dyslipidemia | OriginalPaper

    Effects of pitavastatin on atherosclerotic-associated inflammatory biomarkers in people living with HIV with dyslipidemia and receiving ritonavir-boosted atazanavir: a randomized, double-blind, crossover study

    The use of antiretroviral therapy (ART) in people living with human immunodeficiency virus (PLHIV) has evidently reduced opportunistic infection-related morbidity and mortality [ 1 ]. Despite undetectable plasma viral load, immune activation and …

  15. 01-12-2021 | Ritonavir | News

    Ritonavir/tacrolimus interaction

    Various toxicities: case report
  16. Open Access 24-07-2023 | Ritonavir | OriginalPaper

    Is Azvudine Comparable to Nirmatrelvir-Ritonavir in Real-World Efficacy and Safety for Hospitalized Patients with COVID-19? A Retrospective Cohort Study

    This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.23608389 .

  17. 27-07-2022 | COVID-19 | ReviewPaper

    Clinically Relevant Interactions Between Ritonavir-Boosted Nirmatrelvir and Concomitant Antiseizure Medications: Implications for the Management of COVID-19 in Patients with Epilepsy

    Ritonavir-boosted nirmatrelvir (RBN) has been authorized recently in several countries as an orally active anti-SARS-CoV-2 treatment for patients at high risk of progressing to severe COVID-19 disease. Nirmatrelvir is the active component against …

  18. 01-12-2020 | Chloroquin | Letter

    Hydroxychloroquine and ritonavir for COVID-19 infection: a possible synergic toxicity for retinal pigmented epithelium

  19. 01-02-2023 | Ritonavir | ReviewPaper

    Nirmatrelvir plus ritonavir in COVID-19: a profile of its use

    Oral nirmatrelvir plus ritonavir (Paxlovid™) is an effective treatment option for coronavirus disease 2019 (COVID-19), the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nirmatrelvir inhibits the main protease of …

  20. 01-08-2019 | Ritonavir | News

    Ritonavir/lopinavir

    Renal stone: case report

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