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Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Oncology Solid Tumor

Solid Tumor
Open Access Lung Cancer Case Study

A challenging diagnosis of lung cancer

Read more

Lung cancer is uncommon in patients with granulomatosis with polyangiitis but can pose a diagnostic challenge due to the similarities in imaging findings.

Editor's Choice

Management of dysphagia in head and neck cancer

Open Access Head and Neck Cancer Review

Speech and language therapists play a key role in the assessment and management of dysphagia following head and neck cancer radiotherapy. What are the current therapeutic approaches and the areas of unmet need?

GLP-1 receptor agonists not associated with increased risk for thyroid cancer

02-05-2024 Incretin Mimetics News

Treatment with a GLP-1 receptor agonist does not raise the risk for thyroid cancer 'substantially', compared with beginning DPP-4 inhibitor treatment.

Arrhythmia secondary to abiraterone treatment

Open Access Adverse Effects of Cancer Therapy Case Study

A man receiving abiraterone for prostate cancer developed severe hypokalemia, which led to polymorphic ventricular tachycardia and cardiac arrest. It is important to consider iatrogenic causes in cases of arrhythmia.

No reduction in breast cancer recurrence with aspirin

30-04-2024 Breast Cancer News

The Alliance A011502 trial has ruled out the adjuvant use of aspirin for the prevention of breast cancer recurrence in people with high-risk nonmetastatic disease.

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Latest News

Plant-based diets linked to reduced risk for prostate cancer progression

03-05-2024 Prostate Cancer News

GLP-1 receptor agonists not associated with increased risk for thyroid cancer

02-05-2024 Incretin Mimetics News

No reduction in breast cancer recurrence with aspirin

30-04-2024 Breast Cancer News

Some reassurance on ICI use in pregnancy from VigiBase analysis

23-04-2024 Checkpoint Inhibitors News

Postoperative pembrolizumab improves OS in high-risk RCC

18-04-2024 Kidney Cancer News

Potential of T-cell therapy shown for rare types of soft-tissue sarcomas

15-04-2024 Sarcoma News
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine

Case Studies

A challenging diagnosis of lung cancer

Open Access Lung Cancer Case Study

Lung cancer is uncommon in patients with granulomatosis with polyangiitis but can pose a diagnostic challenge due to the similarities in imaging findings.

Arrhythmia secondary to abiraterone treatment

Open Access Adverse Effects of Cancer Therapy Case Study

A man receiving abiraterone for prostate cancer developed severe hypokalemia, which led to polymorphic ventricular tachycardia and cardiac arrest. It is important to consider iatrogenic causes in cases of arrhythmia.

Insulinoma misidentified as schizophrenia

Insulinoma Case Study

Intermittently scanning CGM detected hypoglycemia in a woman previously diagnosed with schizophrenia and treated with antipsychotic medication. Insulinoma was diagnosed and resected, resolving her neuropsychiatric symptoms.
Cancer Biomarker Video

Next-generation sequencing

Watch now

Next-generation sequencing is a powerful tool that can identify mutations or fusions in a wide range of cancers, enabling physicians to provide targeted therapy to patients and improve outcomes. 

In this vodcast, Professor Andrew Beggs discusses practical aspects of this technique from the clinical viewpoint. 

Supported by: Illumina, Inc., and Eli Lilly and Company

Prof. Andrew Beggs
Developed by: Springer Healthcare

Current Reviews

Risk factors for lymph node metastasis in T2 colorectal cancer: a systematic review and meta-analysis

Colorectal Cancer Review Article

The introduction of colorectal cancer (CRC) screening programs has resulted in an increase in the detection of early-stage cancers. The indication for endoscopic treatment of CRC is limited to submucosal invasive (T1) cancer, while surgical …

Effect of adjuvant chemotherapy on localized dedifferentiated low-grade osteosarcoma: a systematic review

Osteosarcoma Review

Parosteal and low-grade central osteosarcomas comprise 4% and 1–2%, respectively, of all osteosarcomas, which are primary malignant bone tumors with several histological subtypes [ 1 , 2 ]. Parosteal osteosarcomas arise at the cortical bone …

Past, Present, and Future Therapeutic Strategies for NF-1-Associated Tumors

Open Access Neurofibromatosis Type 1 REVIEW

Neurofibromatosis type 1 (NF-1) is an autosomal dominant genetic disorder affecting 1 in 3000 individuals caused by germline mutation of the NF1 gene. The NF1 gene product neurofibromin is a Ras GTPase-activating protein (RAS-GAP) that converts …

Effectiveness of dietetic care for cancer survivors in the primary care setting: A systematic review and meta-analysis of randomized controlled trials

Open Access Breast Cancer Review

The incidence of cancer is rapidly increasing worldwide [ 1 ] and the number of people living with and beyond a cancer diagnosis has risen proportionately [ 2 ]. A cancer survivor is defined as someone who has received a cancer diagnosis, starting …
NSCLC Podcast

Episode 7: A deep dive into ADAURA

Listen now

The ADAURA trial has, as of this year, demonstrated an overall survival benefit with the adjuvant use of osimertinib in people with resectable NSCLC. 

We take an in-depth look at the study with Dr. Luis Paz-Ares, who outlines the study findings, discusses the clinical implications, and addresses the pertinent questions raised by the trial.

Dr. Luis Paz-Ares

CME & eLearning

Webinar (Link opens in a new window)

Lung Cancer

1.25 AMA PRA Category 1 Credit(s)™

A collaborative program highlighting the importance of molecular assessments and targeted treatment selection in people with biomarker-positive disease. Submit your questions for the experts now.

Supported by:
  • Roche and Illumina
Developed by: Springer Healthcare IME

Webcast | Videos | Cases (Link opens in a new window)

Thyroid Cancer

Identifying molecular biomarkers is crucial in determining the best targeted treatment options for your patients with advanced thyroid cancer.

Join our expert-led multi-format educational program that explores the continuing discovery of new genomic targets and delivers the latest research in molecular testing and the application of targeted therapies for thyroid cancer.

Start by watching our webcast and short vodcasts.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME

eLearning | Interviews | Digital Treatment Map (Link opens in a new window)

NSCLC

1.0 AMA PRA Category 1 Credit(s)™

Expert-led, multiformat program which will address the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Will also include guidance on integrating shared decision making into your clinical practice, drawing on insights from a patient on how best to communicate.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.
Developed by: Springer Healthcare IME
Biomarkers Podcast

Episode 5: Next-generation sequencing

Listen now

Emerging biomarkers in thyroid and non-small cell lung cancers

Next-generation sequencing is a powerful tool that can identify mutations or fusions in a wide range of cancers, enabling physicians to provide targeted therapy to patients and improve outcomes. In this podcast, Professor Andrew Beggs discusses practical aspects of this technique from the clinical viewpoint.

This content is intended only for healthcare providers and was made possible by educational funding provided by Illumina, Inc., and Eli Lilly and Company.

Prof. Andrew Beggs
Developed by: Springer Healthcare

Further Reading

Surgical resection of advanced intrathoracic tumors through a combination of the hemiclamshell and transmanubrial approaches

Open Access Thymoma Original Article

Intrathoracic tumors are difficult to detect and often become large and invade the surrounding area. Surgical resection is the choice of treatment and complete resection improves the prognosis significantly [ 1 – 3 ]. Therefore, the surgical …

The CONUT score is associated with the pathologic grade in non-small cell lung cancer

Open Access NSCLC Original Article

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The 5-year overall survival (OS) rates for patients with pathological stage IA1/IA2/IA3/IB early-stage lung cancer are 90%, 85%, 80%, and 73%, respectively.

Robotic transanal minimally invasive surgery (r-TAMIS): perioperative and short-term outcomes for local excision of rectal cancers

Open Access Rectal Cancer

Past, Present, and Future Therapeutic Strategies for NF-1-Associated Tumors

Open Access Neurofibromatosis Type 1 REVIEW

Neurofibromatosis type 1 (NF-1) is an autosomal dominant genetic disorder affecting 1 in 3000 individuals caused by germline mutation of the NF1 gene. The NF1 gene product neurofibromin is a Ras GTPase-activating protein (RAS-GAP) that converts …

Related topics

Open Access Glioblastoma Review

Improving drug delivery in glioblastoma

Glioblastoma remains resistant to most conventional treatments. Emerging therapies target the blood–brain barrier and tumor microenvironment.

Read more

Novel therapies for glioblastoma

Glioblastoma Review

Antiepileptic strategies for patients with brain tumors

Open Access Central Nervous System Cancer Review

Childhood cancer survivors benefit from getting active

08-02-2024 Pediatric Cancer News

CNS tumors: what should the neonatologist know?

Open Access CNS Tumors in Pediatrics Review

Primary central nervous system lymphoma

Lymphoma of the Central Nervous System Review
02-05-2024 Incretin Mimetics News

GLP-1 receptor agonists not associated with increased risk for thyroid cancer

Treatment with a GLP-1 receptor agonist does not raise the risk for thyroid cancer 'substantially', compared with beginning DPP-4 inhibitor treatment.

Read more

Insulinoma misidentified as schizophrenia

Insulinoma Case Study

Advances in radionuclide therapies for neuroendocrine tumors

Open Access Neuroendocrine Tumor Review

An unusual pancreatic neuroendocrine microtumor

Open Access Neuroendocrine Tumor Case Study

Follicular adenoma with a papillary architecture originating from an ectopic thyroid gland

Open Access Thyroid Disease Case Study

Clinical use of thyroglobulin: Thyroid cancer and beyond

Open Access Thyroid Disease Review
Open Access Gastric Cancer Review

Consensus on the management of metastatic gastric cancer

Guidance on the diagnosis, treatment, and care of patients with metastatic gastric cancer, based on the findings of the international multidisciplinary Bertinoro workshop held in November 2022.

Read more

Insulinoma misidentified as schizophrenia

Insulinoma Case Study

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Profound hypotension induced by ICI treatment

Open Access Adverse Effects of Cancer Therapy Case Study

Clinical practice guidelines for esophagogastric junction cancer

Open Access Gastroesophageal Junction Cancer Review

An uncommon presentation of CRC

Open Access Colorectal Cancer Case Study
Open Access Adverse Effects of Cancer Therapy Case Study

Arrhythmia secondary to abiraterone treatment

A man receiving abiraterone for prostate cancer developed severe hypokalemia, which led to polymorphic ventricular tachycardia and cardiac arrest. It is important to consider iatrogenic causes in cases of arrhythmia.

Read more

Postoperative pembrolizumab improves OS in high-risk RCC

18-04-2024 Kidney Cancer News

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Three-phase screening approach promising for prostate cancer

11-04-2024 Prostate Cancer News

Lymph node dissection in testicular cancer

Open Access Testicular Cancer Review

Exercise may serve as a painkiller for cancer survivors

22-02-2024 Lifestyle Modifications News
30-04-2024 Breast Cancer News

No reduction in breast cancer recurrence with aspirin

The Alliance A011502 trial has ruled out the adjuvant use of aspirin for the prevention of breast cancer recurrence in people with high-risk nonmetastatic disease.

Read more

Vocal cord paralysis caused by metastasized endometrial cancer

Open Access Endometrial Cancer Case Study

ADCs in cancer: key data for currently approved agents

Open Access Cancer Therapy Review

Forgoing axillary surgery does not increase breast cancer recurrence

04-04-2024 Breast Cancer News

Ovarian suppression in breast cancer

Open Access Breast Cancer Review

Adding pembrolizumab to CRT boosts cervical cancer PFS

27-03-2024 Cervical Cancer News
Open Access Head and Neck Cancer Review

Management of dysphagia in head and neck cancer

Speech and language therapists play a key role in the assessment and management of dysphagia following head and neck cancer radiotherapy. What are the current therapeutic approaches and the areas of unmet need?

Read more

Stroke prevention measures warranted for head and neck cancer survivors

15-02-2024 Head and Neck Cancer News

An aggressive presentation of secretory carcinoma

Open Access Salivary Gland Cancer Case Study

Breast metastases in a male patient with nasopharyngeal carcinoma

Open Access Nasopharyngeal Cancer Case Study

Carcinosarcoma of the parotid gland

Open Access Salivary Gland Cancer Case Study

HER2-positive mucoepidermoid carcinoma of the breast

Open Access Breast Cancer Case Study
23-04-2024 Checkpoint Inhibitors News

Some reassurance on ICI use in pregnancy from VigiBase analysis

A study has found little over-reporting of adverse maternofetal outcomes among pregnant women with cancer using ICIs versus other anticancer agents.

Read more

Primary melanoma of the lung

Open Access Melanoma Case Study

Individualized neoantigen therapy may benefit people with resected melanoma

25-01-2024 Melanoma News

Treatment of melanoma brain and leptomeningeal metastases

Melanoma Review

Genetic counseling ‘should be considered’ for patients with early-onset MCC

05-01-2024 Merkel Cell Carcinoma News

Primary melanoma presenting in the cervical spine

Open Access Melanoma Case Study
Open Access Lung Cancer Case Study

A challenging diagnosis of lung cancer

Lung cancer is uncommon in patients with granulomatosis with polyangiitis but can pose a diagnostic challenge due to the similarities in imaging findings.

Read more

Development of bronchopleural fistula after neoadjuvant immunochemotherapy

Open Access Adverse Effects of Cancer Therapy Case Study

Severe megaloblastic anemia related to erlotinib

Open Access NSCLC Case Study

Trial reassures on SABR use in NSCLC patients with ILD

14-03-2024 NSCLC News

Managing malignant pleural effusion

Open Access Pleural Effusion Review

Lung cancer in a transplanted lung

Open Access Lung Cancer Case Study
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