Issue 1/2020
Content (37 Articles)
The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells
- Open Access
- Research
Brianna M. Craver, Thanh Kim Nguyen, Jenny Nguyen, Hellen Nguyen, Christy Huynh, Sarah J. Morse, Angela G. Fleischman
Gene mutational analysis by NGS and its clinical significance in patients with myelodysplastic syndrome and acute myeloid leukemia
- Open Access
- Myelodysplastic Syndrome
- Research
Jifeng Yu, Yingmei Li, Tao Li, Yafei Li, Haizhou Xing, Hui Sun, Ling Sun, Dingming Wan, Yanfang Liu, Xinsheng Xie, Zhongxing Jiang
Indirect comparison of azacitidine and decitabine for the therapy of elderly patients with acute myeloid leukemia: a systematic review and network meta-analysis
- Open Access
- Acute Myeloid Leukemia
- Review
Bingbing Wen, Weiwen You, Sitian Yang, Xin Du
Clinical implications of recurrent gene mutations in acute myeloid leukemia
- Open Access
- Acute Myeloid Leukemia
- Review
Jifeng Yu, Yingmei Li, Danfeng Zhang, Dingming Wan, Zhongxing Jiang
Alternative donor peripheral blood stem cell transplantation for the treatment of high-risk refractory and/or relapsed childhood acute leukemia: a randomized trial
- Open Access
- Acute Myeloid Leukemia
- Research
Binglei Zhang, Jian Zhou, Fengkuan Yu, Tianxin Lv, Baijun Fang, Dandan Fan, Zhenyu Ji, Yongping Song
Efficacy and safety of rituximab in autoimmune and microangiopathic hemolytic anemia: a systematic review and meta-analysis
- Open Access
- Thrombotic Thrombocytopenic Purpura
- Research
Shih-Hsuan Chao, Yuh-Lih Chang, Jiin-Cherng Yen, Hsien-Tzung Liao, Tsai-Hung Wu, Chia-Li Yu, Chang-Youh Tsai, Yueh-Ching Chou
Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial
- Open Access
- NSCLC
- Research
Vivek Subbiah, Ecaterina Ileana Dumbrava, Yunfang Jiang, Kyaw Z. Thein, Aung Naing, David S. Hong, Siqing Fu, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Filip Janku, Funda Meric-Bernstam, Razelle Kurzrock, Gerald Falchook
Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma
- Multiple Myeloma
- Research
Xi Yun Zhang, Deepa Rajagopalan, Tae-Hoon Chung, Lissa Hooi, Tan Boon Toh, Johann Shane Tian, Masturah Bte Mohd Abdul Rashid, Noor Rashidha Bte Meera Sahib, Mengjie Gu, Jhin Jieh Lim, Wilson Wang, Wee Joo Chng, Sudhakar Jha, Edward Kai-Hua Chow
The effects of B cell depletion on immune related adverse events associated with immune checkpoint inhibition
- Lymphoma
- Letter to the Editor
Rasmus Strøm Risbjerg, Mie Vennize Hansen, Anne Sofie Sørensen, Tue Wenzel Kragstrup
Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma
- Open Access
- Hepatocellular Carcinoma
- Research
Furong Liu, Lu Qin, Zhibin Liao, Jia Song, Chaoyi Yuan, Yachong Liu, Yu Wang, Heze Xu, Qiaofeng Zhang, Youliang Pei, Hongwei Zhang, Yonglong Pan, Xiaoping Chen, Zhanguo Zhang, Wanguang Zhang, Bixiang Zhang
Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes
- Open Access
- CAR T-Cell Therapy
- Research
Liqing Kang, Xiaowen Tang, Jian Zhang, Minghao Li, Nan Xu, Wei Qi, Jingwen Tan, Xiaoyan Lou, Zhou Yu, Juanjuan Sun, Zhenkun Wang, Haiping Dai, Jia Chen, Guoqing Lin, Depei Wu, Lei Yu
Development of human prostate cancer stem cells involves epigenomic alteration and PI3K/AKT pathway activation
- Prostate Cancer
- Short report
Jingjing Wu, Shundong Cang, Christina Liu, Whitman Ochiai, Jen Wei Chiao
RDGN-based predictive model for the prognosis of breast cancer
- Open Access
- Metastasis
- Research
Bing Dong, Ming Yi, Suxia Luo, Anping Li, Kongming Wu
Leukemia incidence trends at the global, regional, and national level between 1990 and 2017
- Open Access
- Chronic Lymphocytic Leukemia
- Research
Ying Dong, Oumin Shi, Quanxiang Zeng, Xiaoqin Lu, Wei Wang, Yong Li, Qi Wang
Macrophage, the potential key mediator in CAR-T related CRS
- Tocilizumab
- Review
Zhaonian Hao, Ruyuan Li, Li Meng, Zhiqiang Han, Zhenya Hong
SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients
- Open Access
- Disseminated Intravascular Coagulation
- Research
Changqian Bao, Xiandong Tao, Wei Cui, Bin Yi, Tiewen Pan, Ken H. Young, Wenbin Qian
The frequency and inter-relationship of PD-L1 expression and tumour mutational burden across multiple types of advanced solid tumours in China
- Open Access
- NSCLC
- Research
Yanhui Chen, Yating Wang, Hongli Luo, Xue Meng, Wei Zhu, Di Wang, Hui Zeng, Henghui Zhang
Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models
- Open Access
- Cytostatic Therapy
- Letter to the Editor
Pei Pei Che, Alessandro Gregori, Omidreza Firuzi, Max Dahele, Peter Sminia, Godefridus J. Peters, Elisa Giovannetti
Primary chemoradiation with cisplatin versus cetuximab for locally advanced head and neck cancer: a retrospective cohort study
- Open Access
- Human Papillomavirus
- Letter to the Editor
Il Seok Daniel Jeong, Huan Mo, Anthony Nguyen, Esther G. Chong, Hsin Hsiang Clarence Tsai, Justin Moyers, Matthew Kim, Curtis Lacy, Vivek Shah, Eric Lau, Yi Xu, Huynh Cao
Two-year long safety and efficacy of deferasirox film-coated tablets in patients with thalassemia or lower/intermediate risk MDS: phase 3 results from a subset of patients previously treated with deferasirox in the ECLIPSE study
- Myelodysplastic Syndrome
- Research
Immacolata Tartaglione, Raffaella Origa, Antonis Kattamis, Michael Pfeilstöcker, Sibel Gunes, Susanne Crowe, Niamh Fagan, Beatrice Vincenzi, Giovan Battista Ruffo
Risk factors and outcome of COVID-19 in patients with hematological malignancies
- Open Access
- Stem Cell Transplantion
- Research
José Luis Piñana, Rodrigo Martino, Irene García-García, Rocío Parody, María Dolores Morales, Gonzalo Benzo, Irene Gómez-Catalan, Rosa Coll, Ignacio De La Fuente, Alejandro Luna, Beatriz Merchán, Anabelle Chinea, Dunia de Miguel, Ana Serrano, Carmen Pérez, Carola Diaz, José Luis Lopez, Adolfo Jesús Saez, Rebeca Bailen, Teresa Zudaire, Diana Martínez, Manuel Jurado, María Calbacho, Lourdes Vázquez, Irene Garcia-Cadenas, Laura Fox, Ana I. Pimentel, Guiomar Bautista, Agustin Nieto, Pascual Fernandez, Juan Carlos Vallejo, Carlos Solano, Marta Valero, Ildefonso Espigado, Raquel Saldaña, Luisa Sisinni, Josep Maria Ribera, Maria Jose Jimenez, Maria Trabazo, Marta Gonzalez-Vicent, Noemí Fernández, Carme Talarn, Maria Carmen Montoya, Angel Cedillo, Anna Sureda
Effects of decitabine on allogeneic immune reactions of donor lymphocyte infusion via activation of dendritic cells
- Open Access
- Graft-Versus-Host Disease
- Research
Yong-Rim Kwon, Hye Joung Kim, Min-Jung Sohn, Ji-Young Lim, Kyung-Shin Park, Seok Lee, Nack-Gyun Chung, Dae-Chul Jeong, Chang-Ki Min, Yoo-Jin Kim
Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer
- Open Access
- Pancreatic Cancer
- Review
Mengqi Liu, Wensheng Liu, Yi Qin, Xiaowu Xu, Xianjun Yu, Qifeng Zhuo, Shunrong Ji
Frontiers in the COVID-19 vaccines development
- Open Access
- Adenovirus
- Letter to the Editor
Ehtisham Ul Haq, Jifeng Yu, Jiancheng Guo
miR-100 inhibits cell proliferation in mantle cell lymphoma by targeting mTOR
- Open Access
- Mantle Cell Lymphoma
- Research
Luhui Lin, Yiqun Huang, Wei Zhuang, Ping Lin, Xudong Ma
Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance
- Open Access
- Chronic Myeloid Leukemia
- Research
Theresa Klümper, Henrike Bruckmueller, Tobias Diewock, Meike Kaehler, Sierk Haenisch, Christiane Pott, Oliver Bruhn, Ingolf Cascorbi
The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017
- Open Access
- Kidney Cancer
- Research
Xianguang Bai, Ming Yi, Bing Dong, Xinhua Zheng, Kongming Wu
Molecular drivers and cells of origin in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine carcinoma
- Open Access
- Neuroendocrine Tumor
- Review
He-Li Gao, Wen-Quan Wang, Xian-Jun Yu, Liang Liu
Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
- Open Access
- Chronic Myeloid Leukemia
- Research
Liqing Ning, Chuanyu Hu, Pingfan Lu, Yimei Que, Xiaojian Zhu, Dengju Li
Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma
- Open Access
- Lymphoma
- Review
Caiqin Xie, Xian Li, Hui Zeng, Wenbin Qian
Advances of target therapy on NOTCH1 signaling pathway in T-cell acute lymphoblastic leukemia
- Open Access
- Acute Lymphoblastic Leukemia
- Review
Ruyue Zheng, Menglin Li, Shujuan Wang, Yanfang Liu
Complex roles of cAMP–PKA–CREB signaling in cancer
- Open Access
- Hepatocellular Carcinoma
- Review
Hongying Zhang, Qingbin Kong, Jiao Wang, Yangfu Jiang, Hui Hua
Recent updates for antibody therapy for acute lymphoblastic leukemia
- Open Access
- Acute Lymphoblastic Leukemia
- Review
Le Li, Ying Wang
Engineering better chimeric antigen receptor T cells
- Open Access
- Acute Lymphoblastic Leukemia
- Review
Hao Zhang, Pu Zhao, He Huang
Applications of gut microbiota in patients with hematopoietic stem-cell transplantation
- Open Access
- Probiotics
- Review
Jifeng Yu, Hao Sun, Weijie Cao, Lijie Han, Yongping Song, Dingming Wan, Zhongxing Jiang
CD44 as a tumor biomarker and therapeutic target
- Open Access
- Biomarkers
- Review
Hanxiao Xu, Mengke Niu, Xun Yuan, Kongming Wu, Aiguo Liu
Clinical characteristics and outcome of SARS-CoV-2 infection in admitted patients with chronic lymphocytic leukemia from a single European country
- Open Access
- Chronic Lymphocytic Leukemia
- Letter to the Editor
Ana Muntañola, Guillermo Villacampa, José Ángel Hernández-Rivas, Rosalía Alonso, Fátima Mirás, Santiago Osorio, Mónica Baile, Patricia Baltasar, Javier López Jiménez, Ines Hernandez-Rodriguez, Susana Valenciano, Ana Alfayate, Eva Gimeno, Abelardo Bárez, Ana C. Oliveira, Rosalía Riaza, Pilar Romero, Julio Delgado, Lucrecia Yáñez, Amaya Zabalza, Ana Torres, Mª Isabel Gómez-Roncero, Marta Crespo, Raúl Córdoba, Juan José Mateos-Mazón, Sonia Pérez, Rafael Andreu, Jorge Labrador, Mª Elena Ruiz, César Andrés Velasquez, Mª José Terol, Raquel Santiago, Mª Jesús Vidal, Fiz Campoy García, Lucía Villalón, Begoña S. Muiña, Joan Alfons Soler, Cristina Seri, Mª José Sánchez, Amalia Cuesta, Rafael Ramos, Adrián Sánchez-Montalvá, Isabel Ruiz-Camps, Marcos González, Pau Abrisqueta, Francesc Bosch
