Issue 1/2024
Content (74 Articles)
Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
Y. Schneider, C. Gauer, M. Andert, A. Hoffmann, M. J. Riemenschneider, W. Krebs, N. Chalmers, C. Lötzsch, U. J. Naumann, W. Xiang, V. Rothhammer, R. Beckervordersandforth, J. C. M. Schlachetzki, J. Winkler
Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park et al. (2022)
Huihui Luo, Emil K. Gustavsson, Hannah Macpherson, Natalia Dominik, Kristina Zhelcheska, Kylie Montgomery, Claire Anderson, Wai Yan Yau, Stephanie Efthymiou, Chris Turner, Michael DeTure, Dennis W. Dickson, Keith A. Josephs, Tamas Revesz, Tammaryn Lashley, Glenda Halliday, Dominic B. Rowe, Emily McCann, Ian Blair, Andrew J. Lees, Pentti J. Tienari, Anu Suomalainen, Laura Molina-Porcel, Gabor G. Kovacs, Ellen Gelpi, John Hardy, Matti J. Haltia, Arianna Tucci, Zane Jaunmuktane, Mina Ryten, Henry Houlden, Zhongbo Chen
Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways
Daniel C. Xu, Hanna Sas-Nowosielska, Greg Donahue, Hua Huang, Naemeh Pourshafie, Charly R. Good, Shelley L. Berger
Regional differences in synaptic degeneration are linked to alpha-synuclein burden and axonal damage in Parkinson’s disease and dementia with Lewy bodies
Irene Frigerio, Maud M. A. Bouwman, Ruby T. G. M. M. Noordermeer, Ema Podobnik, Marko Popovic, Evelien Timmermans, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg, Laura E. Jonkman
Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease
Min Hak Lee, Ki-Hwan Um, Seok Won Lee, Ye Ji Sun, Da-Hye Gu, Young Ok Jo, Sung Hyun Kim, Wongi Seol, Hyorin Hwang, Kyunghwa Baek, Jin Woo Choi
Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients
Marc Vervuurt, Joseph M. Schrader, Anna M. de Kort, Iris Kersten, Hans J. C. T. Wessels, Catharina J. M. Klijn, Floris H. B. M. Schreuder, H. Bea Kuiperij, Jolein Gloerich, William E. Van Nostrand, Marcel M. Verbeek
Enhancing mitosis quantification and detection in meningiomas with computational digital pathology
Hongyan Gu, Chunxu Yang, Issa Al-kharouf, Shino Magaki, Nelli Lakis, Christopher Kazu Williams, Sallam Mohammad Alrosan, Ellie Kate Onstott, Wenzhong Yan, Negar Khanlou, Inma Cobos, Xinhai Robert Zhang, Neda Zarrin-Khameh, Harry V. Vinters, Xiang Anthony Chen, Mohammad Haeri
CNS tumor with CREBBP::BCORL1 Fusion and pathogenic mutations in BCOR and CREBBP: expanding the spectrum of BCOR-altered tumors
Valeria Barresi, Antonello Cardoni, Evelina Miele, Lucia Pedace, Barbara Masotto, Claudia Nardini, Sabina Barresi, Sabrina Rossi
Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
Richard Drexler, Florian Brembach, Jennifer Sauvigny, Franz L. Ricklefs, Alicia Eckhardt, Helena Bode, Jens Gempt, Katrin Lamszus, Manfred Westphal, Ulrich Schüller, Malte Mohme
MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects
Jenni E. Anttila, Olli S. Mattila, Hock-Kean Liew, Kert Mätlik, Eero Mervaala, Päivi Lindholm, Maria Lindahl, Perttu J. Lindsberg, Kuan-Yin Tseng, Mikko Airavaara
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy
Nicole J. Corbin-Stein, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms
CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions
Arnault Tauziède-Espariat, Lucille Lew-Derivry, Samuel Abbou, Alice Métais, Gaëlle Pierron, Stéphanie Reynaud, Julien Masliah-Planchon, Cassandra Mariet, Lauren Hasty, Volodia Dangouloff-Ros, Nathalie Boddaert, Marie Csanyi, Aude Aline-Fardin, Claire Lamaison, Fabrice Chrétien, Kévin Beccaria, Stéphanie Puget, Pascale Varlet
The genomic alterations in glioblastoma influence the levels of CSF metabolites
Daniel H. Wang, Yoko Fujita, Antonio Dono, Ana G. Rodriguez Armendariz, Mauli Shah, Nagireddy Putluri, Pavel S. Pichardo-Rojas, Chirag B. Patel, Jay-Jiguang Zhu, Jason T. Huse, Brittany C. Parker Kerrigan, Frederick F. Lang, Yoshua Esquenazi, Leomar Y. Ballester
Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis
Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu, Akinori Miyashita, Daiken Satake, Yoshihiro Mouri, Jun Tsukano, Keita Kawabe, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Akihiko Yuki, Hajime Umezu, Akiyoshi Kakita, Takeshi Ikeuchi, Makoto Oishi
A rare non-gadolinium enhancing sarcoma brain metastasis with microenvironment dominated by tumor-associated macrophages
David Rogawski, Joshua Wheeler, Esther Nie, William Zhu, Eleanor Villanueva, Gwen Coffey, Qian Ma, Kristen Ganjoo, Nancy Fischbein, Michael Iv, Hannes Vogel, Seema Nagpal
Progesterone receptor distribution in the human hypothalamus and its association with suicide
Lin Zhang, Ronald W.H. Verwer, Joop van Heerikhuize, Paul J. Lucassen, Peter W. Nathanielsz, Elly M. Hol, Eleonora Aronica, Waljit S. Dhillo, Gerben Meynen, Dick F. Swaab
Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor
Frank M. Mezzacappa, Frankie K. Smith, Weiwei Zhang, Andrew Gard, Fatmagul Kusku Cabuk, Ignancio Gonzalez-Gomez, Hector L. Monforte, Jiancong Liang, Omkar Singh, Martha M. Quezado, Kenneth D. Aldape, Murat Gokden, Julia A. Bridge, Jie Chen
Interplay between androgen and CXCR4 chemokine signaling in myelin repair
Narimène Asbelaoui, Charly Abi-Ghanem, Géraldine Schlecht-Louf, Hania Oukil, Michael Schumacher, Abdel Mouman Ghoumari
Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography
Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A. Sajitha, Xinlei Wang, Gadi Wollstein, Joel S. Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M. Sappington, Kevin C. Chan
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, Osamu Onodera, Hideki Mochizuki, Toshiki Mizuno, Keiji Wada, Yoshitaka Nagai
Brain injury drives optic glioma formation through neuron-glia signaling
Jit Chatterjee, Joshua P. Koleske, Astoria Chao, Andrew D. Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G. Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T. Kummer, David H. Gutmann
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma
Huilan Zeng, Jordan E. Mayberry, David Wadkins, Nathan Chen, Daniel W. Summers, Markus H. Kuehn
The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Ana-Caroline Raulin, Sydney V. Doss, Michael G. Heckman, Emily C. Craver, Zonghua Li, Tadafumi C. Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A. Martens, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Michael DeTure, R. Ross Reichard, Aivi T. Nguyen, Eleni Constantopoulos, Rachel A. Larsen, Emmaline K. Kounaves, Melissa E. Murray, Dennis W. Dickson, Ronald C. Petersen, Guojun Bu, Takahisa Kanekiyo
Correction: Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease
Sonia George, Annica Rönnbäck, Gunnar K. Gouras, Géraldine H. Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff, Patrik Brundin
Correction to: Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian‑Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez‑Pinilla, Zhen Zhao
Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer’s disease
Lauren Walker, Harry Simpson, Alan J. Thomas, Johannes Attems
Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion
Yoshiki Hase, Dan Jobson, Jeremy Cheong, Kelvin Gotama, Luciana Maffei, Mai Hase, Alhafidz Hamdan, Ren Ding, Tuomo Polivkoski, Karen Horsburgh, Raj N. Kalaria
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis
Bert M. Verheijen, Claire Chung, Ben Thompson, Hyunjin Kim, Asa Nakahara, Jasper J. Anink, James D. Mills, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. MacGowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos A. Patsopoulos, Oleg Butovsky, Joshua Dubnau, Avindra Nath, Robert Bowser, Matthew Harms, Eleonora Aronica, Mary Poss, Jennifer Phillips-Cremins, John Crary, Nazem Atassi, Dale J. Lange, Darius J. Adams, Leonidas Stefanis, Marc Gotkine, Robert H. Baloh, Suma Babu, Towfique Raj, Sabrina Paganoni, Ophir Shalem, Colin Smith, Bin Zhang, Brent Harris, University of Maryland Brain and Tissue Bank and NIH NeuroBioBank, Iris Broce, Vivian Drory, John Ravits, Corey McMillan, Vilas Menon, Lani Wu, Steven Altschuler, Yossef Lerner, Rita Sattler, Kendall Van Keuren-Jensen, Orit Rozenblatt-Rosen, Kerstin Lindblad-Toh, Katharine Nicholson, Peter Gregersen, Jeong-Ho Lee, Maze Therapeutics, Bristol-Myers Squibb, Sulev Koks, Stephen Muljo, Bryan J. Traynor, Pfizer, Regeneron, Insitro, Jeong H. Lee, Eleonora Aronica, Kiyomitsu Oyanagi, Akiyoshi Kakita, Jean-Francois Gout, Marc Vermulst
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias
Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E. Flanagan, Hui Zhang, Rudolph Castellani, Eileen H. Bigio, M.-Marsel Mesulam, Changiz Geula, Tamar Gefen
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller
CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours
Sze Jet Aw, Enrica Ee Kar Tan, Sharon Yin Yee Low, Chik Hong Kuick, Jian Yuan Goh, Kenneth Tou En Chang
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Khalid Eltom, Tobias Mothes, Sylwia Libard, Martin Ingelsson, Anna Erlandsson
Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche
Kelin Gonçalves de Oliveira, Anna Bång-Rudenstam, Sarah Beyer, Axel Boukredine, Hugo Talbot, Valeria Governa, Maria C. Johansson, Ann-Sofie Månsson, Karin Forsberg-Nilsson, Johan Bengzon, Johan Malmström, Charlotte Welinder, Mattias Belting
Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Amin Otmani, Gauti Jóhannesson, Rune Brautaset, James R. Tribble, Pete A. Williams
Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosis
Zhen Guo, Chen Tian, Yang Shi, Xue-Ru Song, Wei Yin, Qing-Qing Tao, Jie Liu, Guo-Ping Peng, Zhi-Ying Wu, Yan-Jiang Wang, Zhen-Xin Zhang, Jing Zhang
Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth
Shahbaz Khan, Jeffrey A. Zuccato, Vladimir Ignatchenko, Olivia Singh, Meinusha Govindarajan, Matthew Waas, Salvador Mejia-Guerrero, Andrew Gao, Gelareh Zadeh, Thomas Kislinger
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer’s disease
Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Felipe Andreiuolo, Christina K. Ferrone, Sharika Rajan, Arie Perry, Ekin Guney, Elaine Cham, Caterina Giannini, Angus Toland, Nicholas Willard, Andrea Silveira de Souza, Karen Dazelle, Hye-Jung Chung, Omkar Singh, Kyle Conway, Nicholas Coley, Christopher Dampier, Zied Abdullaev, Drew Pratt, Patrick J. Cimino, Martha Quezado, Kenneth Aldape
CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology
Martina Glavan, Ana Jelic, Damien Levard, Juhana Frösen, Sara Keränen, Bart A. A. Franx, Ana-Rita Bras, Estelle R. Louet, Ádám Dénes, Mario Merlini, Denis Vivien, Marina Rubio
Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling
Shangli Ji, Yanfang Peng, Jian Liu, Pang Xu, Shibo Tang
β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
Sebok K. Halder, Arjun Sapkota, Richard Milner
Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
J. G. Nicholson, S. Cirigliano, R. Singhania, C. Haywood, M. Shahidi Dadras, M. Yoshimura, D. Vanderbilt, B. Liechty, H. A. Fine
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome
Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Sanda Alexandrescu, Anna Pinto, Arin K. Greene, Donald E. Ingber, Joyce Bischoff
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Masanori Kurihara, Tomoyasu Matsubara, Satoru Morimoto, Akira Arakawa, Kensuke Ohse, Kazutomi Kanemaru, Atsushi Iwata, Shigeo Murayama, Yuko Saito
Correction to: The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
Dan‑Dan Wang, Mitali Katoch, Samir Jabari, Ingmar Blumcke, David B. Blumenthal, De‑Hong Lu, Roland Coras, Yu‑Jiao Wang, Jie Shi, Wen‑Jing Zhou, Katja Kobow, Yue‑Shan Piao
Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma
Fatih Yalcin, Hannah Haneke, Ibrahim E. Efe, Leonard D. Kuhrt, Edyta Motta, Bernadette Nickl, Charlotte Flüh, Michael Synowitz, Omar Dzaye, Michael Bader, Helmut Kettenmann
EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
Jürgen Hench, Claus Hultschig, Jon Brugger, Luigi Mariani, Raphael Guzman, Jehuda Soleman, Severina Leu, Miles Benton, Irenäus Maria Stec, Ivana Bratic Hench, Per Hoffmann, Patrick Harter, Katharina J Weber, Anne Albers, Christian Thomas, Martin Hasselblatt, Ulrich Schüller, Lisa Restelli, David Capper, Ekkehard Hewer, Joachim Diebold, Danijela Kolenc, Ulf C. Schneider, Elisabeth Rushing, Rosa della Monica, Lorenzo Chiariotti, Martin Sill, Daniel Schrimpf, Andreas von Deimling, Felix Sahm, Christian Kölsche, Markus Tolnay, Stephan Frank
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Cinzia Bocca, Judith Kouassi-Nzoughet, Juan Manuel Chao de la Barca, Dominique Bonneau, Christophe Verny, Philippe Gohier, Christophe Orssaud, Pascal Reynier
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
Tim Bathe, Gabriela P. Hery, Jonathan A. B. Villareal, Jennifer L. Phillips, Eric M. Cohen, Rohan V. Sharma, Wangchen Tsering, Stefan Prokop
CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas
Arnault Tauziède-Espariat, Yvan Nicaise, Philipp Sievers, Felix Sahm, Andreas von Deimling, Delphine Guillemot, Gaëlle Pierron, Mathilde Duchesne, Myriam Edjlali, Volodia Dangouloff-Ros, Nathalie Boddaert, Alexandre Roux, Edouard Dezamis, Lauren Hasty, Benoît Lhermitte, Edouard Hirsch, Maria Paola Valenti Hirsch, François-Daniel Ardellier, Mélodie-Anne Karnoub, Marie Csanyi, Claude-Alain Maurage, Karima Mokhtari, Franck Bielle, Valérie Rigau, Thomas Roujeau, Marine Abad, Sébastien Klein, Michèle Bernier, Catherine Horodyckid, Clovis Adam, Petter Brandal, Pitt Niehusmann, Quentin Vannod-Michel, Corentin Provost, Nicolas Menjot de Champfleur, Lucia Nichelli, Alice Métais, Cassandra Mariet, Fabrice Chrétien, Thomas Blauwblomme, Kévin Beccaria, Johan Pallud, Stéphanie Puget, Emmanuelle Uro-Coste, Pascale Varlet
Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson
Pediatric-type high-grade gliomas with PDGFRA amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases
Yuji Kibe, Fumiharu Ohka, Kosuke Aoki, Junya Yamaguchi, Kazuya Motomura, Eiji Ito, Kazuhito Takeuchi, Yuichi Nagata, Satoshi Ito, Nobuhiko Mizutani, Yoshiki Shiba, Sachi Maeda, Tomohide Nishikawa, Hiroki Shimizu, Ryuta Saito
Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Shruthi Karnam, Shubham Maurya, Elainna Ng, Amodini Choudhary, Arzin Thobani, John G Flanagan, Karsten Gronert
BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion
Azadeh Ebrahimi, Andreas Waha, Jens Schittenhelm, Georg Gohla, Martin U Schuhmann, Torsten Pietsch
Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
Yijun Cheng, Yuting Dai, Hao Tang, Xingyu Lu, Jing Xie, Wanqun Xie, Qianqian Zhang, Yanting Liu, Shaojian Lin, Hong Yao, Hanbing Shang, Kun Yang, Hongyi Liu, Xuefeng Wu, Jianming Zhang, Xun Zhang, Li Xue, Zhe Bao Wu
ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case
Claudio D’Incal, Anke Van Dijck, Joe Ibrahim, Kevin De Man, Lina Bastini, Anthony Konings, Ellen Elinck, lllana Gozes, Zlatko Marusic, Mirna Anicic, Jurica Vukovic, Nathalie Van der Aa, Ligia Mateiu, Wim Vanden Berghe, R. Frank Kooy
Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion
Nicholas Chapman, Joshua Greenwald, Jolee Suddock, Dong Xu, Alexander Markowitz, Maeve Humphrey, Jennifer A Cotter, Mark D Krieger, Debra Hawes, Jianling Ji
Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche
Mengyi Liu, Zhicheng Ji, Vaibhav Jain, Vanessa L. Smith, Emily Hocke, Anoop P. Patel, Roger E. McLendon, David M. Ashley, Simon G. Gregory, Giselle Y. López
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
Myungjin Kim, Jun Yong Kim, Won-Kyu Rhim, Gloria Cimaglia, Andrew Want, James E. Morgan, Pete A. Williams, Chun Gwon Park, Dong Keun Han, Seungsoo Rho
Mouse serum albumin induces neuronal apoptosis and tauopathies
Sheng-jie Hou, Ya-ru Huang, Jie Zhu, Ying-bo Jia, Xiao-yun Niu, Jin-ju Yang, Xiao-lin Yu, Xiao-yu Du, Shi-yu Liang, Fang Cui, Ling-jie Li, Chen Tian, Rui-tian Liu
Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs
Theresa Kraft, Konrad Grützmann, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert
Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response
Luuk E. de Vries, Aldo Jongejan, Jennifer Monteiro Fortes, Rawien Balesar, Annemieke J. M. Rozemuller, Perry D. Moerland, Inge Huitinga, Dick F. Swaab, Joost Verhaagen
LINC complex alterations are a key feature of sporadic and familial ALS/FTD
Riccardo Sirtori, Michelle J. Gregoire, Emily M. Potts, Alicia Collins, Liviana Donatelli, Claudia Fallini
Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19
Nathalie A. Lengacher, Julianna J. Tomlinson, Ann-Kristin Jochum, Jonas Franz, Omar Hasan Ali, Lukas Flatz, Wolfram Jochum, Josef Penninger, Benjamin Arenkiel, Zhandong Liu, Brit Mollenhauer, Josef Penninger, Maxime Rousseaux, Armen Saghatelyan, Natalina Salmaso, Christine Stadelmann, Michael G. Schlossmacher, Julianna J. Tomlinson, John M. Woulfe, Christine Stadelmann, John M. Woulfe, Michael G. Schlossmacher
Laminin-associated integrins mediate Diffuse Intrinsic Pontine Glioma infiltration and therapy response within a neural assembloid model
Sauradeep Sinha, Michelle S. Huang, Georgios Mikos, Yudhishtar Bedi, Luis Soto, Sarah Lensch, Manish Ayushman, Lacramioara Bintu, Nidhi Bhutani, Sarah C. Heilshorn, Fan Yang
Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors
Malgorzata Perycz, Michal J. Dabrowski, Marta Jardanowska-Kotuniak, Adria-Jaume Roura, Bartlomiej Gielniewski, Karolina Stepniak, Michał Dramiński, Iwona A. Ciechomska, Bozena Kaminska, Bartosz Wojtas
Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies
Janna van Wetering, Hanne Geut, John J. Bol, Yvon Galis, Evelien Timmermans, Jos W.R. Twisk, Dagmar H. Hepp, Martino L. Morella, Lasse Pihlstrom, Afina W. Lemstra, Annemieke J.M. Rozemuller, Laura E. Jonkman, Wilma D.J. van de Berg
Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas
Felix Ehret, Eilís Perez, Daniel Teichmann, Sandra Meier, Carola Geiler, Zeus Cosmas, Helene Franke, Siyer Roohani, David Wasilewksi, Julia Onken, Peter Vajkoczy, Leonille Schweizer, David Kaul, David Capper