Published in:
Open Access
01-12-2024 | Alzheimer's Disease | Letter to the Editor
Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer’s disease
Authors:
Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Published in:
Acta Neuropathologica Communications
|
Issue 1/2024
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Excerpt
The prevalence of Alzheimer’s disease (AD) continues to increase, with projections estimating 70 million patients by 2030. While recent FDA approvals for Aducanumab and Lecanemab have generated optimism, these therapies offer only partial relief by slowing cognitive decline [
1‐
2], leaving us ill-equipped to face the looming AD epidemic. To better address AD, we must enhance our understanding of its pathophysiology, with a focus on utilizing animal models that closely replicate the human condition. …