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Open Access 01-12-2024 | Ependymoma | Research

CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas

Authors: Arnault Tauziède-Espariat, Yvan Nicaise, Philipp Sievers, Felix Sahm, Andreas von Deimling, Delphine Guillemot, Gaëlle Pierron, Mathilde Duchesne, Myriam Edjlali, Volodia Dangouloff-Ros, Nathalie Boddaert, Alexandre Roux, Edouard Dezamis, Lauren Hasty, Benoît Lhermitte, Edouard Hirsch, Maria Paola Valenti Hirsch, François-Daniel Ardellier, Mélodie-Anne Karnoub, Marie Csanyi, Claude-Alain Maurage, Karima Mokhtari, Franck Bielle, Valérie Rigau, Thomas Roujeau, Marine Abad, Sébastien Klein, Michèle Bernier, Catherine Horodyckid, Clovis Adam, Petter Brandal, Pitt Niehusmann, Quentin Vannod-Michel, Corentin Provost, Nicolas Menjot de Champfleur, Lucia Nichelli, Alice Métais, Cassandra Mariet, Fabrice Chrétien, Thomas Blauwblomme, Kévin Beccaria, Johan Pallud, Stéphanie Puget, Emmanuelle Uro-Coste, Pascale Varlet, RENOCLIP-LOC

Published in: Acta Neuropathologica Communications | Issue 1/2024

Abstract

A novel methylation class, “neuroepithelial tumor, with PLAGL1 fusion” (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor with recurrent histopathological features suggesting an ependymal differentiation. Because of the recent identification of this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present a detailed series of nine cases of PLAGL1-fused supratentorial tumors, reclassified from a series of supratentorial ependymomas, non-ZFTA/non-YAP1 fusion-positive and subependymomas of the young. This study included extensive clinical, radiological, histopathological, ultrastructural, immunohistochemical, genetic and epigenetic (DNA methylation profiling) data for characterization. An important aim of this work was to evaluate the sensitivity and specificity of a novel fluorescent in situ hybridization (FISH) targeting the PLAGL1 gene. Using histopathology, immunohistochemistry and electron microscopy, we confirmed the ependymal differentiation of this new neoplastic entity. Indeed, the cases histopathologically presented as “mixed subependymomas-ependymomas” with well-circumscribed tumors exhibiting a diffuse immunoreactivity for GFAP, without expression of Olig2 or SOX10. Ultrastructurally, they also harbored features reminiscent of ependymal differentiation, such as cilia. Different gene partners were fused with PLAGL1: FOXO1, EWSR1 and for the first time MAML2. The PLAGL1 FISH presented a 100% sensitivity and specificity according to RNA sequencing and DNA methylation profiling results. This cohort of supratentorial PLAGL1-fused tumors highlights: 1/ the ependymal cell origin of this new neoplastic entity; 2/ benefit of looking for a PLAGL1 fusion in supratentorial cases of non-ZFTA/non-YAP1 ependymomas; and 3/ the usefulness of PLAGL1 FISH.

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Title: CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas
Authors: Arnault Tauziède-Espariat
Yvan Nicaise
Philipp Sievers
Felix Sahm
Andreas von Deimling
Delphine Guillemot
Gaëlle Pierron
Mathilde Duchesne
Myriam Edjlali
Volodia Dangouloff-Ros
Nathalie Boddaert
Alexandre Roux
Edouard Dezamis
Lauren Hasty
Benoît Lhermitte
Edouard Hirsch
Maria Paola Valenti Hirsch
François-Daniel Ardellier
Mélodie-Anne Karnoub
Marie Csanyi
Claude-Alain Maurage
Karima Mokhtari
Franck Bielle
Valérie Rigau
Thomas Roujeau
Marine Abad
Sébastien Klein
Michèle Bernier
Catherine Horodyckid
Clovis Adam
Petter Brandal
Pitt Niehusmann
Quentin Vannod-Michel
Corentin Provost
Nicolas Menjot de Champfleur
Lucia Nichelli
Alice Métais
Cassandra Mariet
Fabrice Chrétien
Thomas Blauwblomme
Kévin Beccaria
Johan Pallud
Stéphanie Puget
Emmanuelle Uro-Coste
Pascale Varlet
RENOCLIP-LOC
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Ependymoma
Ependymoma
Ependymoma
Fluorescence in Situ Hybridization
Published in: Acta Neuropathologica Communications / Issue 1/2024
Electronic ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-023-01695-7

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CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas

Abstract

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Abstract

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