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Open Access 01-12-2024 | Glaucoma | Letter to the Editor

Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

Authors: Cinzia Bocca, Judith Kouassi-Nzoughet, Juan Manuel Chao de la Barca, Dominique Bonneau, Christophe Verny, Philippe Gohier, Christophe Orssaud, Pascal Reynier

Published in: Acta Neuropathologica Communications | Issue 1/2024

Excerpt

Dear editor, …

Otmani A, Jóhannesson G, Brautaset R, Tribble JR, Williams PA (2024) Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume. Acta Neuropathol Commun 12(1):37. https://doi.org/10.1186/s40478-024-01724-zCrossRefPubMedPubMedCentral

Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V et al (2017) Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 355(6326):756–760. https://doi.org/10.1126/science.aal0092CrossRefPubMedPubMedCentral

Hui F, Tang J, Williams PA, McGuinness MB, Hadoux X, Casson RJ et al (2020) Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomized clinical trial. Clin Exp Ophthalmol 48(7):903–914. https://doi.org/10.1111/ceo.13818CrossRefPubMed

De Moraes CG, John SWM, Williams PA, Blumberg DM, Cioffi GA, Liebmann JM (2022) Nicotinamide and pyruvate for Neuroenhancement in Open-AngleGlaucoma: a phase 2 Randomized Clinical Trial. JAMA Ophthalmol 140(1):11–18. https://doi.org/10.1001/jamaophthalmol.2021.4576CrossRefPubMed

Bocca C, Le Paih V, Chao de la Barca JM, Kouassy Nzoughet J, Amati-Bonneau P, Blanchet O et al (2021) A plasma metabolomic signature of Leber hereditary optic neuropathy showing taurine and nicotinamide deficiencies. Hum Mol Genet 30(1):21–29. https://doi.org/10.1093/hmg/ddab013CrossRefPubMedPubMedCentral

Bocca C, Kouassi Nzoughet J, Leruez S, Amati-Bonneau P, Ferré M, Kane MS et al (2018) A plasma metabolomic signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related disorders. Invest Ophthalmol Vis Sci 59(1):185–195. https://doi.org/10.1167/iovs.17-23027CrossRefPubMed

Kouassi Nzoughet J, de la Chao JM, Guehlouz K, Leruez S, Coulbault L, Allouche S et al (2019) Nicotinamide Deficiency in Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci 60(7):2509–2514. https://doi.org/10.1167/iovs.19-27099CrossRefPubMed

Title: Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Authors: Cinzia Bocca
Judith Kouassi-Nzoughet
Juan Manuel Chao de la Barca
Dominique Bonneau
Christophe Verny
Philippe Gohier
Christophe Orssaud
Pascal Reynier
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Glaucoma
Published in: Acta Neuropathologica Communications / Issue 1/2024
Electronic ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-024-01768-1

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Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

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