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Open Access 01-12-2024 | Glioma | Research

Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma

Authors: Fatih Yalcin, Hannah Haneke, Ibrahim E. Efe, Leonard D. Kuhrt, Edyta Motta, Bernadette Nickl, Charlotte Flüh, Michael Synowitz, Omar Dzaye, Michael Bader, Helmut Kettenmann

Published in: Acta Neuropathologica Communications | Issue 1/2024

Abstract

Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB in the in vivo tumor microenvironment results in significantly smaller tumor volumes and generates a pro-inflammatory innate and adaptive immune cell microenvironment. The impact of host-derived GPNMB on tumor growth was confirmed in two distinct murine glioma cell lines in organotypic brain slices from GPNMB-KO and control mice. Using published data bases of human glioma, the elevated levels in TAMs could be confirmed and the GPNMB expression correlated with a poorer survival.

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Title: Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma
Authors: Fatih Yalcin
Hannah Haneke
Ibrahim E. Efe
Leonard D. Kuhrt
Edyta Motta
Bernadette Nickl
Charlotte Flüh
Michael Synowitz
Omar Dzaye
Michael Bader
Helmut Kettenmann
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Glioma
Glioma
Glioma
Glioblastoma
Glioblastoma
Glioblastoma
Published in: Acta Neuropathologica Communications / Issue 1/2024
Electronic ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-024-01754-7

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Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma

Abstract

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Abstract

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