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Journal of Cancer Research and Clinical Oncology

Issue 7/2023

Content (115 Articles)

Quality of life in Tunisian colorectal cancer patients: a cross-sectional study

Imtinene Belaid, Chaimaa Ben Moussa, Rihab Melliti, Manel Limam, Tarek Ben Ahmed, Faten Ezzaari, Mohamed Amine Elghali, Amal Bouazzi, Mohamed Ben Mabrouk, Rym Bourigua, Nouha Ammar, Makrem Hochlaf, Leila Ben Fatma, Imene Chabchoub, Slim Ben Ahmed

Open Access Gastric Cancer Research

Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer

Han-Yuan Liu, Fu-Hui Wang, Jian-Ming Liang, Yuan-Yuan Xiang, Shu-Hao Liu, Shi-Wei Zhang, Cheng-Ming Zhu, Yu-Long He, Chang-Hua Zhang

Lymphoma Research

A novel antibody-TCR (AbTCR) T-cell therapy is safe and effective against CD19-positive relapsed/refractory B-cell lymphoma

Pengcheng He, Haibo Liu, Bryan Zimdahl, Jie Wang, Minna Luo, Qi Chang, Fangzhou Tian, Fan Ni, Duo Yu, Huasheng Liu, Limei Chen, Huaiyu Wang, Mei Zhang, Stephan A. Grupp, Cheng Liu

In search of effective therapies: the current landscape of phase II trials in patients with advanced soft tissue sarcoma

Paweł Sobczuk, Huber Bątruk, Paulina Wójcik, Krzysztof Iwaniak, Katarzyna Kozak, Piotr Rutkowski

Open Access Lymphoma Research

Predicting time to treatment in follicular lymphoma on watchful waiting using baseline metabolic tumour burden

Lucia Leccisotti, Daria Maccora, Rosalia Malafronte, Francesco D’Alò, Elena Maiolo, Salvatore Annunziata, Vittoria Rufini, Alessandro Giordano, Stefan Hohaus

Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors

Stine Overvad Fredslund, Agnethe Berglund, Anders Bonde Jensen, Britt Elmedal Laursen, Svend Juul, Kirstine Stochholm, Claus Højbjerg Gravholt

ß-Blockers Research

Effect of concurrent beta-blocker use in patients receiving immune checkpoint inhibitors for advanced solid tumors

George Mellgard, Vaibhav G. Patel, Xiaobo Zhong, Himanshu Joshi, Qian Qin, Bo Wang, Anish Parikh, Tomi Jun, Parissa Alerasool, Philip Garcia, Mahalya Gogerly-Moragoda, Amanda Leiter, Emily J. Gallagher, William K. Oh, Matthew D. Galsky, Che-Kai Tsao

Rare benign liver tumors that require differentiation from hepatocellular carcinoma: focus on diagnosis and treatment

Laihui Luo, Tao Wang, Mengting Cheng, Xian Ge, Shengjiang Song, Guoqing Zhu, Yongqiang Xiao, Wei Deng, Jin Xie, Renfeng Shan

Research

Complementary and alternative medicine in cancer patients: characteristics of use and interactions with antineoplastic agents

Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Patricia Gómez Martínez-Sagrera, Cristina Villanueva-Bueno, José Luis Revuelta-Herrero, Eva Gonzalez-Haba, Ángela Hoyo-Muñoz, Yolanda Jerez Gilarranz, Belén Marzal-Alfaro, Ana Herranz, Miguel Martin, María Sanjurjo

Vaccination Research

Seroprevalence study prior and post vaccination in cancer patients in principality of Andorra (COVONCO study)

Cristina Royo-Cebrecos, Ïa Robert-Montaner, David Vilanova, Eva Bailles, Jordi Serrano-Pons, Oliver Valero, Josep Maria Buldon, Leticia Bermudez-de-Castro, Eva Mahia, Jaume Pujadas, Francesc Cobo, Josep Maria Piqué, Santiago Albiol

Open Access Neutropenia Research

Nurses’ knowledge of chemotherapy-induced neutropenia and its management: a cross-sectional survey

Mohammad Al Qadire, Cherry Ann C. Ballad, Ma’en Aljezawi, Omar Al Omari, Fawwaz Alaloul, Ahmad Musa, Sulaiman Al Sabei, Atika Khalaf

Open Access Research

Decision-making by cancer patients and the role of a counselling facility for complementary and alternative medicine: a cohort study

Vanessa Hack, Lena Josfeld, Jutta Hübner, Christian Keinki, Jens Büntzel

SARS-CoV-2 Research

Effects of SARS-CoV-2 infections in patients with cancer on mortality, ICU admission and incidence: a systematic review with meta-analysis involving 709,908 participants and 31,732 cancer patients

Mehmet Emin Arayici, Nazlican Kipcak, Ufuktan Kayacik, Cansu Kelbat, Deniz Keskin, Muhammed Emin Kilicarslan, Ahmet Veli Kilinc, Sumeyye Kirgoz, Anil Kirilmaz, Melih Alihan Kizilkaya, Irem Gaye Kizmaz, Enes Berkin Kocak, Enver Kochan, Begum Kocpinar, Fatmanur Kordon, Batuhan Kurt, Hulya Ellidokuz

Open Access Care Research

The OUTREACH study: oncologists of German university hospitals in rotation on a palliative care unit—evaluation of attitude and competence in palliative care and hospice

T. Biersching, A. Schweda, K. Oechsle, F. Nauck, J. Rosenbruch, U. Schuler, J. Hense, M. Neukirchen, M. Weber, C. Junghanss, T. Kramer, C. Ostgathe, P. Thuss-Patience, B. Van Oorschot, M. Teufel, M. Schuler, C. Bausewein, M. Tewes, C. Ostgathe, M. Tewes, S. Gahr, J. Berendt, K. Oechsle, F. Nauck, G. Benze, C. Bausewein, J. Rosenbruch, U. Schuler, J. Hense, M. Neukirchen, J. Schwarz, M. Weber, U. Reinholz, C. Junghanss, T. Kramer, P. Thuss-Patience, B. van Oorschot, C. Roch

NSCLC Research

Efficacy and safety of immune checkpoint inhibitors in post-TKI NSCLC patients harboring EGFR mutations

Si Sun, Chang Liu, Chunyan Duan, Songxia Yu, Qiao Zhang, Nana Xu, Bo Yu, Xianghua Wu, Jialei Wang, Xingjiang Hu, Hui Yu

NSCLC Research

Safety and efficacy of pembrolizumab for advanced nonsmall cell lung cancer: before and during the COVID-19 pandemic

Doran Ksienski, Sapna Gupta, Pauline T. Truong, Jeffrey Bone, Angela Chan, Deepu Alex, Jason Hart, Philip Pollock, Tiffany Patterson, Melissa Clarkson, Dushanthi Dissanayake, Eric Sonke, Mary Lesperance

NSCLC Research

Serum immune modulators associated with immune-related toxicities and efficacy of atezolizumab in patients with non-small cell lung cancer

Yusuke Inoue, Naoki Inui, Masato Karayama, Kazuhiro Asada, Shun Matsuura, Masaki Ikeda, Tomohiro Uto, Masato Fujii, Dai Hashimoto, Takashi Matsui, Hiroyuki Matsuda, Nao Inami, Mikio Toyoshima, Yusuke Kaida, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Takafumi Suda

Open Access Meningioma Research

The prognostic role of the immunohistochemical expression of S100 in meningiomas

Felix Behling, Christina Fodi, Marco Skardelly, Frank Paulsen, Ghazaleh Tabatabai, Jürgen Honegger, Marcos Tatagiba, Jens Schittenhelm

Open Access NSCLC Research

Selective RET inhibitors shift the treatment pattern of RET fusion-positive NSCLC and improve survival outcomes

Chang Lu, Xue-Wu Wei, Yi-Chen Zhang, Zhi-Hong Chen, Chong-Rui Xu, Ming-Ying Zheng, Jin-Ji Yang, Xu-Chao Zhang, Qing Zhou

Lung Cancer Research

Age-dependent genomic characteristics and their impact on immunotherapy in lung adenocarcinoma

Peng Li, Shuyu Che, Yingxue Qi, Ningning Luo, Qiuju Lin, Xiaofeng Zhu, Yunpeng Xuan, Mengmeng Li, Jinlong Li, Minghui Ge, Tingting Sun, Chuang Qi, Yongjie Wang

Open Access Colorectal Cancer Research

Contribution of TLR4 to colorectal tumor microenvironment, etiology and prognosis

Elise E. Crame, Saeed Nourmohammadi, Hannah R. Wardill, Janet K. Coller, Joanne M. Bowen

Open Access Pancreatic Cancer Research

KNTC1 as a putative tumor oncogene in pancreatic cancer

Ling Liu, Hongwei Chen, Xinan Chen, Chenjie Yao, Weimin Shen, Changku Jia

Lymphoma Research

Modified DEP regimen as induction therapy for lymphoma-associated hemophagocytic lymphohistiocytosis: a prospective, multicenter study

Yubo Pi, Jingshi Wang, Hui Zhou, Xiujin Ye, Xiuhua Sun, Ligen Liu, Xueyi Pan, Zhao Wang

Interferon Research

Interferon-γ predicts the treatment efficiency of immune checkpoint inhibitors in cancer patients

Jing Liu, Jingtao Ma, Na Xing, Zhengzheng Ji, Jiasong Li, Shasha Zhang, Zhanjun Guo

Open Access Sarcopenia Research

Body composition dynamics and impact on clinical outcome in gastric and gastro-esophageal junction cancer patients undergoing perioperative chemotherapy with the FLOT protocol

Florian Huemer, Stefan Hecht, Bernhard Scharinger, Verena Schlintl, Gabriel Rinnerthaler, Konstantin Schlick, Ronald Heregger, Thomas Melchardt, Angela Wimmer, Iris Mühlbacher, Oliver Owen Koch, Daniel Neureiter, Eckhard Klieser, Sara Seyedinia, Mohsen Beheshti, Richard Greil, Lukas Weiss

Open Access Hepatocellular Carcinoma Research

Ipilimumab and nivolumab in advanced hepatocellular carcinoma after failure of prior immune checkpoint inhibitor-based combination therapies: a multicenter retrospective study

Daniel Roessler, Osman Öcal, Alexander B. Philipp, Daniel Markwardt, Stefan Munker, Julia Mayerle, Leonie S. Jochheim, Katharina Hammer, Christian M. Lange, Andreas Geier, Max Seidensticker, Florian P. Reiter, Enrico N. De Toni, Najib Ben Khaled

Vaccination Research

Immune response to anti-SARS-CoV-2 prime-vaccination in patients with cancer: a systematic review and meta-analysis

Diogo Martins-Branco, Guilherme Nader-Marta, Ana Tecic Vuger, Veronique Debien, Lieveke Ameye, Mariana Brandão, Kevin Punie, Angela Loizidou, Karen Willard-Gallo, Chloe Spilleboudt, Ahmad Awada, Martine Piccart, Evandro de Azambuja

Open Access Hepatitis B Research

Differential role of chronic liver diseases on the incidence of cancer: a longitudinal analysis among 248,224 outpatients in Germany

Sven H. Loosen, David Schöler, Mark Luedde, Johannes Eschrich, Tom Luedde, Karel Kostev, Christoph Roderburg

Clinical characteristics and long-term outcomes of rhabdomyosarcoma in Korean children, adolescents and young adults: a single-center experience

Meerim Park, Jun Ah Lee, Hye Young Jin, Joo-Young Kim, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Seog Yun Park, Eun Young Park, Hyeon Jin Park, Byung Kiu Park

Open Access Basalioma Research

Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study

Mohamed El-Khalawany, Hussein M. M. Hassab-El-Naby, Ahmed Mustafa Mousa, Ahmed Sameh, Mahmoud A. Rageh, Rasha Mahmoud Genedy, Aya Magdy Hosny, Marwa A. Aboelmagd, Soha Aboeldahab

Nephrectomy Research

Advantages of organ-sparing treatment approaches in metastatic kidney cancer

Iurii Vitruk, Oleg Voylenko, Oleksandr Stakhovsky, Oleksii Kononenko, Maksym Pikul, Sofiya Semko, Bohdan Hrechko, Denis Koshel, Eduard Stakhovsky

Open Access NSCLC Research

Early mortality factors in immune checkpoint inhibitor monotherapy for advanced or metastatic non-small cell lung cancer

Eiji Takeuchi, Kensuke Kondo, Yoshio Okano, Michihiro Kunishige, Yoshihiro Kondo, Naoki Kadota, Hisanori Machida, Nobuo Hatakeyama, Keishi Naruse, Hirokazu Ogino, Hiroshi Nokihara, Tsutomu Shinohara, Yasuhiko Nishioka

Open Access Brachytherapy Research

Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma

Verena Ellerkamp, Andreas Schmidt, Steven W. Warmann, Franziska Eckert, Juergen Schaefer, Frank Paulsen, Joerg Fuchs

Metastasis Research

Prognosis of different extrathoracic metastasis patterns in patients with M1c lung adenocarcinoma receiving immunotherapy

Fang Hu, Jin Peng, Xiaowei Mao, Yanjie Niu, Meili Ma, Yizhuo Zhao, Aiqin Gu, Liyan Jiang

Open Access NSCLC Research

Non-specific symptoms as a prodrome of immune-related adverse events in patients with non-small cell lung cancer receiving nivolumab: a consecutive analysis of 200 patients

Ryoko Inaba Higashiyama, Hidehito Horinouchi, Aya Kuchiba, Yuji Matsumoto, Shuji Murakami, Yasushi Goto, Shintaro Kanda, Yutaka Fujiwara, Noboru Yamamoto, Yuichiro Ohe

Open Access Salivary Gland Cancer Research

The expression of the adenosine pathway markers CD39 and CD73 in salivary gland carcinomas harbors the potential for novel immune checkpoint inhibition

Arthur Bauer, Niklas Gebauer, Juliana Knief, Lars Tharun, Nele Arnold, Armin Riecke, Konrad Steinestel, Hanno M. Witte

Lung Cancer Research

Burden of lung cancer along with attributable risk factors in China from 1990 to 2019, and projections until 2030

Yuan Fang, Zhen Li, Hui Chen, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Xiaorong Yang, Ming Lu

Breast cancer patient-reported outcomes on level 1 and level 2 oncoplastic procedures using BREAST-Q®

C. A. Pinto, B. Peleteiro, C. S. Pinto, F. Osório, S. Costa, A. Magalhães, H. Mora, J. Amaral, D. Gonçalves, J. L. Fougo

COVID-19 Research

Incidence of asymptomatic COVID-19 positivity in cancer patients and effects on therapy

Lisa Liu, Nicole M. Ross, Elizabeth A. Handorf, Caitlin R. Meeker, Giana Chen, Donald Baldwin, Namrata Vijayvergia

Open Access Kidney Cancer Research

Real world data on IO-based therapy for metastatic renal cell carcinoma

Viktoria Stühler, Lisa Herrmann, Steffen Rausch, Arnulf Stenzl, Jens Bedke

Clinical application of next-generation sequencing-based monitoring of minimal residual disease in childhood acute lymphoblastic leukemia

Huirong Mai, Qin Li, Guobing Wang, Ying Wang, Shilin Liu, Xue Tang, Fen Chen, Guichi Zhou, Yi Liu, Tonghui Li, Lulu Wang, Chunyan Wang, Feiqiu Wen, Sixi Liu

Open Access NSCLC Research

Treatment patterns and prognosis of patients with inoperable stage III NSCLC after completion of concurrent chemoradiotherapy ± immune checkpoint inhibition: a decade-long single-center historical analysis

Benedikt Flörsch, Julian Taugner, Lukas Käsmann, Saskia Kenndoff, Julian Guggenberger, Amanda Tufman, Niels Reinmuth, Thomas Duell, Claus Belka, Chukwuka Eze, Farkhad Manapov

Clinical utility of psoas muscle volume in assessment of sarcopenia in patients with early-stage non-small cell lung cancer

Yuki Yamada, Yoshihisa Shimada, Yojiro Makino, Yujin Kudo, Sachio Maehara, Takafumi Yamada, Masaru Hagiwara, Masatoshi Kakihana, Tatsuo Ohira, Norihiko Ikeda

Research

Uncertainty-aware dynamic integration for multi-omics classification of tumors

Ling Du, Chaoyi Liu, Ran Wei, Jinmiao Chen

Open Access Rhabdomyosarcoma Research

Anticancer bioactivity of zerumbone on pediatric rhabdomyosarcoma cells

Cristian Urla, Matias Julian Stagno, Jörg Fuchs, Steven W. Warmann, Evi Schmid

Pancreatic cancer among solid organ transplant recipients in the United States

Tomohiro Tanaka, Charles F. Lynch, Kelly J. Yu, Bozena M. Morawski, Mei-Chin Hsieh, Georgetta Alverson, April A. Austin, Yun Zeng, Eric A. Engels

Metastasis Research

Genome-wide CRISPR knockout screening identified G protein pathway suppressor 2 as a novel tumor suppressor for uveal melanoma metastasis

Shuangshuang Shi, Haojie Chen, Hanqing Wang, JianFeng Wan, Yi Shi, Jia Li, Shuo Wang, Jie Shi, Jianying Lv, Tong Wu, Longlong Wang, Fengyuan Sun

Open Access Endometrial Cancer Research

Improved preoperative risk stratification in endometrial carcinoma patients: external validation of the ENDORISK Bayesian network model in a large population-based case series

Marcel Grube, Casper Reijnen, Peter J. F. Lucas, Frieder Kommoss, Felix K. F. Kommoss, Sara Y. Brucker, Christina B. Walter, Ernst Oberlechner, Bernhard Krämer, Jürgen Andress, Felix Neis, Annette Staebler, Johanna M. A. Pijnenborg, Stefan Kommoss

Open Access Prostate Cancer Research

Systemic inflammatory biomarkers as predictive and prognostic factors in men with metastatic castration-refractory prostate cancer treated with docetaxel therapy: a comprehensive analysis in a German real-world cohort

Manuel Neuberger, Nora Goly, Janina Skladny, Veronica Milczynski, Christel Weiß, Frederik Wessels, Katja Nitschke, Britta Grüne, Caelán M. Haney, Friedrich Hartung, Jonas Herrmann, Jonas Jarczyk, Karl F. Kowalewski, Frank Waldbillig, Maximilian C. Kriegmair, Niklas Westhoff, Thomas S. Worst, Philipp Nuhn

Open Access Human Papillomavirus Research

The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma

Mara Borgmann, Agnes Oetting, Felix Meyer, Nikolaus Möckelmann, Conrad Droste, Clara Marie von Bargen, Christina Möller-Koop, Melanie Witt, Kerstin Borgmann, Kai Rothkamm, Christian Betz, Adrian Münscher, Till Sebastian Clauditz, Thorsten Rieckmann

Radiomics based on enhanced CT for differentiating between pulmonary tuberculosis and pulmonary adenocarcinoma presenting as solid nodules or masses

Wenjing Zhao, Ziqi Xiong, Yining Jiang, Kunpeng Wang, Min Zhao, Xiwei Lu, Ailian Liu, Dongxue Qin, Zhiyong Li

Effects and mechanisms of GSG2 in esophageal cancer progression

Chong Geng, Qiang Wang, Peng-Fei Xing, Min Wang, Shao-Dong Tong, Ju-Ying Zhou

Open Access Care Research

Willingness, preferences, barriers, and facilitators of a multimodal supportive care intervention including exercise, nutritional and psychological approach in patients with cancer: a cross-sectional study

Alice Avancini, Ilaria Trestini, Daniela Tregnago, Lorenzo Belluomini, Marco Sposito, Jessica Insolda, Federico Schena, Michele Milella, Sara Pilotto

Association between secondhand smoke and cancers in adults in the US population

Zhongmian Zhang, Zhipeng Li, Xiyan Zhang, Wangyu Ye, JiaQin Chen, Lan Wang, Zili Lin, Jian Li, Zhihong Li

Open Access Breast Cancer Research

Evaluation of different imaging modalities for axillary lymph node staging in breast cancer patients to provide a personalized and optimized therapy algorithm

Joachim Diessner, Laura Anders, Saskia Herbert, Matthias Kiesel, Thorsten Bley, Tanja Schlaiss, Stephanie Sauer, Achim Wöckel, Catharina Bartmann

Open Access NSCLC Research

Fibroblast activation protein in the tumor microenvironment predicts outcomes of PD-1 blockade therapy in advanced non-small cell lung cancer

Yan Zhao, Yueping Liu, Yunlong Jia, Xiaoxiao Wang, Jiankun He, Shuman Zhen, Jiali Wang, Lihua Liu

Lung Cancer Research

The crosstalk between lung cancer cells and platelets promotes tumor angiogenesis in vivo and in vitro

Baikun Li, Ting Zhu, Xiaohong Wu, Shiyu Chen, Chen Lu, Jimin Zhu, Qinglin Li

Open Access Glioblastoma Research

Precision neuro-oncology: a pilot analysis of personalized treatment in recurrent glioma

Lazaros Lazaridis, Teresa Schmidt, Christoph Oster, Tobias Blau, Daniela Pierscianek, Jens T. Siveke, Sebastian Bauer, Hans-Ulrich Schildhaus, Ulrich Sure, Kathy Keyvani, Christoph Kleinschnitz, Martin Stuschke, Ken Herrmann, Cornelius Deuschl, Björn Scheffler, Sied Kebir, Martin Glas

Open Access Thyroidectomy Research

Role of surgery to the primary tumor in metastatic anaplastic thyroid carcinoma: pooled analysis and SEER-based study

Dmytro Oliinyk, Teresa Augustin, Josefine Rauch, Viktoria Florentine Koehler, Claus Belka, Christine Spitzweg, Lukas Käsmann

Anti-PD-1 for the treatment of advanced cutaneous squamous cell carcinoma in elderly patients: a French multicenter retrospective survey

Quentin Samaran, Romain Samaran, Ernestine Ferreira, Naeda Haddad, Antoine Fottorino, Hervé Maillard, Brigitte Dreno, Nicolas Meyer, David Azria, Eve Maubec, Caroline Gaudy-Marqueste, Nicolas Molinari, Pierre-Emmanuel Stoebner, Olivier Dereure

Open Access Metastasis Research

Optical coherence tomography and convolutional neural networks can differentiate colorectal liver metastases from liver parenchyma ex vivo

Iakovos Amygdalos, Enno Hachgenei, Luisa Burkl, David Vargas, Paul Goßmann, Laura I. Wolff, Mariia Druzenko, Maik Frye, Niels König, Robert H. Schmitt, Alexandros Chrysos, Katharina Jöchle, Tom F. Ulmer, Andreas Lambertz, Ruth Knüchel-Clarke, Ulf P. Neumann, Sven A. Lang

The benefit of treatment beyond progression with immune checkpoint inhibitors: a multi-center retrospective cohort study

Deniz Can Guven, Emre Yekeduz, Enes Erul, Sati Coskun Yazgan, Taha Koray Sahin, Gokturk Karatas, Sercan Aksoy, Mustafa Erman, Suayib Yalcin, Yuksel Urun, Saadettin Kilickap

History of keratinocyte carcinoma and survival after a second primary malignancy: the Moffitt Cancer Center patient experience

Rossybelle P. Amorrortu, Yayi Zhao, Sandra Stewart, Kavita M. Ghia, Vonetta L. Williams, Vernon K. Sondak, Kenneth Y. Tsai, Javier Pinilla, Julio Chavez, Dana E. Rollison

Open Access Research

IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma

Ann-Kristin Struckmeier, Anne Radermacher, Michael Fehrenz, Tamara Bellin, Dalia Alansary, Philipp Wartenberg, Ulrich Boehm, Mathias Wagner, Anja Scheller, Jochen Hess, Julius Moratin, Christian Freudlsperger, Jürgen Hoffmann, Lorenz Thurner, Klaus Roemer, Kolja Freier, Dominik Horn

Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis

Barbara Hollander, Shruti Khurana, Jake S. Jacob, Melmet Altan, Jianbo Wang, Dan Zhao, Krishnavathana Varatharajalu, Mazen Alasadi, Anusha S. Thomas, Yinghong Wang

NSCLC Research

Circulating circular RNA hsa_circ_0023179 acts as a diagnostic biomarker for non-small-cell lung cancer detection

Qi Zhang, Shiyi Qin, Chunlei Peng, Yupeng Liu, Yuejiao Huang, Shaoqing Ju

Open Access Research

PD-1, PD-L1 and cAMP immunohistochemical expressions are associated with worse oncological outcome in patients with bladder cancer

Giorgio Ivan Russo, Nicolò Musso, Arturo Lo Giudice, Maria Giovanna Asmundo, Marina Di Mauro, Paolo G. Bonacci, Mariacristina Massimino, Dalida Bivona, Stefania Stefani, Elisabetta Pricoco, Matteo Ferro, Massimo Camarda, Sebastiano Cimino, Giuseppe Morgia, Rosario Caltabiano, Giuseppe Broggi

The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation

Raylane Adrielle Gonçalves Cambui, Fernanda Pereira Fernandes, Vinicius Nunes Cordeiro Leal, Edione Cristina Reis, Dhemerson Souza de Lima, Gilmar Ferreira do Espírito Santo, Rosa Maria Elias, Alessandra Pontillo

Open Access Multiple Myeloma Research

Impact of the changing landscape of induction therapy prior to autologous stem cell transplantation in 540 newly diagnosed myeloma patients: a retrospective real-world study

Song-Yau Wang, Tanja Holzhey, Simone Heyn, Thomas Zehrfeld, Susann Fricke, Franz Albert Hoffmann, Cornelia Becker, Leanthe Braunert, Thomas Edelmann, Inessa Paulenz, Marcus Hitzschke, Franziska Flade, Andreas Schwarzer, Klaus Fenchel, Georg-Nikolaus Franke, Vladan Vucinic, Madlen Jentzsch, Sebastian Schwind, Saskia Hell, Donata Backhaus, Thoralf Lange, Dietger Niederwieser, Markus Scholz, Uwe Platzbecker, Wolfram Pönisch

Open Access Cytostatic Therapy Research

FLOT and CROSS chemotherapy regimens alter the frequency of CD27+ and CD69+ T cells in oesophagogastric adenocarcinomas: implications for combination with immunotherapy

Maria Davern, Noel E. Donlon, Andrew S. Sheppard, Klaudia D. Majcher, Fiona O’ Connell, Aisling B. Heeran, Malika Grant, Robert A. Farrell, Conall Hayes, Dara Bracken-Clarke, Melissa J. Conroy, Emma Foley, Dermot O’ Toole, Anshul Bhardwaj, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Jacintha O’ Sullivan, Joanne Lysaght

Research

Distinct cellular immune profiles in lung adenocarcinoma manifesting as pure ground glass opacity versus solid nodules

Rirong Qu, Fan Ye, Shaojie Hu, Boyu Wang, Shenghui Qin, Jing Xiong, Xiangning Fu, Lequn Li, Yixin Cai

Liposarcoma Research

A novel anti-CD47-targeted blockade promotes immune activation in human soft tissue sarcoma but does not potentiate anti-PD-1 blockade

Andrej Ozaniak, Jitka Smetanova, Robin Bartolini, Michal Rataj, Linda Capkova, Jaromir Hacek, Martina Fialova, Lenka Krupickova, Ilja Striz, Robert Lischke, Jirina Bartunkova, Zuzana Strizova

Clinical value and influencing factors of establishing stomach cancer organoids by endoscopic biopsy

Jie Li, Yan Chen, Yingyi Zhang, Xiaobo Peng, Meihong Wu, Ling Chen, Xianbao Zhan

Open Access Salivary Gland Cancer Research

Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany

Lisa Nachtsheim, M. Mayer, M. F. Meyer, F. Oesterling, H. Kajueter, C. Arolt, A. Quaas, J. P. Klussmann, P. Wolber

Open Access Nutrition Research

Nutrition and physical activity in cancer patients: a survey on their information sources

Sebastian Josef Boesenecker, V. Mathies, J. Buentzel, J. Huebner

Open Access Checkpoint Inhibitors Research

The role of immune checkpoint inhibitors in clinical practice: an analysis of the treatment patterns, survival and toxicity rates by sex

Murielle N. Wahli, Stefanie Hayoz, Dennis Hoch, Christoph O. Ryser, Michèle Hoffmann, Amina Scherz, Birgit Schwacha-Eipper, Simon Häfliger, Julian Wampfler, Martin D. Berger, Urban Novak, Berna C. Özdemir

Open Access Research

Cancer patients’ experiences and preferences when receiving bad news: a qualitative study

Theresia Krieger, Sandra Salm, Antje Dresen, Natalia Cecon

Open Access Ovarian Cancer Research

Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells

Xin Zhang, Jiandong Wang, Yali Fan, Ziyi Zhao, Sarah E. Paraghamian, Gabrielle M. Hawkins, Lindsey Buckingham, Jillian O’Donnell, Tianran Hao, Hongyan Suo, Yajie Yin, Wenchuan Sun, Weimin Kong, Delin Sun, Luyu Zhao, Chunxiao Zhou, Victoria L. Bae-Jump

NSCLC Research

Non-invasive early prediction of immune checkpoint inhibitor efficacy in non-small-cell lung cancer patients using on-treatment serum CRP and NLR

Reiko Matsuzawa, Masahiro Morise, Fumie Kinoshita, Ichidai Tanaka, Junji Koyama, Tomoki Kimura, Yasuhiro Kondoh, Taro Tanaka, Koichiro Shima, Tetsunari Hase, Keiko Wakahara, Makoto Ishii, Naozumi Hashimoto

Open Access NSCLC Research

Efficacy and safety of EGFR‑TKIs plus Shenqi Fuzheng injection for non-small cell lung cancer patients with EGFR-sensitive mutations

Jia-li Wang, Chuan-sheng Chen, Zhi-rong Jia, Li-yun Miao, Jun Xie, Zhen-zhen Pan, Ya-lei Duan, Shuo Liu, Meng-jun Hou, Xuan-sheng Ding

Technique to match mesorectal lymph nodes imaging findings to histopathology: node-by-node comparison

Zixuan Zhuang, Xueqin Ma, Yang Zhang, Xuyang Yang, Mingtian Wei, Xiangbing Deng, Ziqiang Wang

Association of birth weight with cancer risk: a dose–response meta-analysis and Mendelian randomization study

Chao Chen, Xiaoying Chen, Donghong Wu, Huiting Wang, Chuqiao Wang, Jieni Shen, Yiran An, Ran Zhong, Caichen Li, Wenhua Liang

Open Access Breast Cancer Research

Deciphering clinical significance of BCL11A isoforms and protein expression roles in triple-negative breast cancer subtype

Andrea Angius, Giovanna Pira, Paolo Cossu-Rocca, Giovanni Sotgiu, Laura Saderi, Maria Rosaria Muroni, Patrizia Virdis, Daniela Piras, Rallo Vincenzo, Ciriaco Carru, Donatella Coradduzza, Maria Gabriela Uras, Pierina Cottu, Alessandro Fancellu, Sandra Orrù, Paolo Uva, Maria Rosaria De Miglio

Solid Tumor Research

Clinical characteristics and outcomes of tyrosine kinase inhibitor-related lower GI adverse effects

Cynthia Liu, Rajan Amin, Malek Shatila, Nicholas Short, Mehmet Altan, Amishi Shah, Omar Alhalabi, Pablo Okhuysen, Anusha S. Thomas, Yinghong Wang

Real-world evidence of ABVD-like regimens compared with ABVD in classical Hodgkin lymphoma: a 10-year study from China

Qing Wen, Jingjing Ge, Yaxin Lei, Yue Zhang, Xiaoshuang Kong, Wenhua Wang, Huting Hou, Zeyuan Wang, Siyu Qian, Mengjie Ding, Meng Dong, Linan Zhu, Mingzhi Zhang, Xudong Zhang, Qingjiang Chen

Obesity Research

Association between oral cavity cancer and metabolic syndrome

Gang Won Choi, Hyeon-Kyoung Cheong, Soo Young Choi, Young Chan Lee, In-Hwan Oh, Young-Gyu Eun

Metastasis Research

Repeat hepatectomy for pediatric recurrent chemotherapy-resistant hepatoblastoma: a report of 18 cases

Xiaoran Li, Zheng Wang, Dongpo Zhang, Di Zhao, Jindong Ye, Weihong Duan, Liuxin Duan, Quanda Liu

Open Access Fatigue Research

Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post treatment

Marlou-Floor Kenkhuis, Mo Klingestijn, Anne-Marie Fanshawe, Stéphanie O. Breukink, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Sabina Rinaldi, Paolo Vineis, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg, Martijn J. L. Bours, Eline H. van Roekel

Ramucirumab Research

Does HER2 status influence in the benefit of ramucirumab and paclitaxel as second line treatment of advanced gastro-esophageal adenocarcinoma? Data from the AGAMENON-SEOM registry

Sena Valcarcel, Javier Gallego, Paula Jimenez-Fonseca, Marc Diez, Eva Martínez de Castro, Raquel Hernandez, Virginia Arrazubi, Ana Custodio, Juana María Cano, Ana Fernández Montes, Ismael Macias, Laura Visa, Aitana Calvo, Rosario Vidal Tocino, Nieves Martínez Lago, María Luisa Limón, Mónica Granja, Mireia Gil, Paola Pimentel, Lola Macia-Rivas, Carolina Hernández Pérez, Montserrat Mangas, Alfonso Martín Carnicero, Paula Cerdà, Lucía Gomez Gonzalez, Francisco Garcia Navalon, Mª Dolores Mediano Rambla, Marta Martin Richard, Alberto Carmona-Bayonas

Vaccination Research

Preventive cancer stem cell-based vaccination modulates tumor development in syngeneic colon adenocarcinoma murine model

Leila Eini, Marzieh Naseri, Feridoun Karimi-Busheri, Mahmood Bozorgmehr, Roya Ghods, Zahra Madjd

CRISPR/Cas9 mediated knocking out of OPN gene enhances radiosensitivity in MDA-MB-231 breast cancer cell line

Rahil Ghanbarnasab Behbahani, Amir Danyaei, Ali Teimoori, Mohammad Javad Tahmasbi, Niloofar Neisi

Open Access Kidney Cancer Research

Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus

Łukasz Zapała, Michał Kunc, Sumit Sharma, Rafał Pęksa, Marta Popęda, Wojciech Biernat, Piotr Radziszewski

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.