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135120 search results for:

Targeted Therapy 

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  1. Open Access 01-12-2024 | Glioblastoma | ReviewPaper

    New insights into targeted therapy of glioblastoma using smart nanoparticles

    In recent times, the intersection of nanotechnology and biomedical research has given rise to nanobiomedicine, a captivating realm that holds immense promise for revolutionizing diagnostic and therapeutic approaches in the field of cancer. This …

  2. 01-05-2024 | Acute Myeloid Leukemia | Online First

    Evolution of natural killer cell-targeted therapy for acute myeloid leukemia

    In hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to conventional therapies. Despite advances in treatment, including intensive chemotherapy and hematopoietic …

  3. Open Access 01-05-2024 | Bevacizumab | ReviewPaper

    Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors

    Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of angiogenesis. The upregulation of VEGF-A facilitates the process of tumor vascularization, thereby fostering …

  4. 12-04-2024 | Targeted Therapy | Online First

    Exosomes for neurodegenerative diseases: diagnosis and targeted therapy

    Neurodegenerative diseases refer to a group of diseases caused by chronic progressive degeneration of the central nervous system (CNS), mainly including Alzheimer’s disease(AD), Parkinson’s disease(PD), amyotrophic lateral sclerosis(ALS) …

  5. 02-05-2024 | Craniopharyngioma | Online First

    Targeted therapy in BRAF mutated aggressive papillary craniopharyngioma: a case report and overview of the literature

    Craniopharyngioma is a histologically benign (grade 1 according to the World Health Organization classification) tumor, which accounts for 2–5% of all primary intracranial neoplasms [ 1 ]. Despite the benign histology, craniopharyngioma often …

  6. Open Access 27-04-2024 | Online First

    Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?

    Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these radionuclides, animal studies must be refined to produce the most translatable TAT agents with the greatest …

  7. 27-04-2024 | Online First

    Erratum to: Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

  8. Open Access 01-12-2024 | Sorafenib | OriginalPaper

    Assessment of disease control rate and safety of sorafenib in targeted therapy for advanced liver cancer

    Liver cancer (LC) is a malignant tumor that occurs in liver cells. It is commonly classified into two types: primary LC and metastatic LC [ 1 , 2 ]. The etiology of LC is diverse, but the most common risk factors include chronic viral hepatitis …

  9. Open Access 11-04-2024 | Targeted Therapy | Online First

    Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy

    Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major component of TME and exhibit heterogeneous properties in their …

  10. Open Access 01-12-2024 | Targeted Therapy | ReviewPaper

    Aptamers as an approach to targeted cancer therapy

    Conventional cancer treatments can cause serious side effects because they are not specific to cancer cells and can damage healthy cells. Aptamers often are single-stranded oligonucleotides arranged in a unique architecture, allowing them to bind …

  11. 20-02-2024 | Neuroendocrine Tumor | EditorialNotes

    Advances in targeted alpha therapy of cancer

  12. 16-03-2024 | Targeted Therapy | EditorialNotes

    From gene panel testing to new molecularly targeted therapy

  13. Open Access 01-12-2024 | Cancer Therapy | Letter

    Late cardiotoxicity related to HER2-targeted cancer therapy

    Long-term anti-HER2 therapy in metastatic HER2 + cancers is increasing, but data about the incidence and risk factors for developing late Cancer therapy-related cardiac dysfunction (CTRCD) are missing. We conducted a single-centre, retrospective …

  14. Open Access 30-03-2024 | Epilepsy | Online First

    The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

    Epilepsy is a multifaceted neurological syndrome characterized by recurrent, spontaneous, and synchronous seizures. The pathogenesis of epilepsy, known as epileptogenesis, involves intricate changes in neurons, neuroglia, and endothelium, leading …

  15. 21-03-2024 | Gastric Cancer | Erratum

    Correction: Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer

  16. Open Access 21-03-2024 | Hypoglycemia | OriginalPaper

    Real-World Outcomes of Individualized Targeted Therapy with Insulin Glargine 300 Units/mL in Insulin-Naïve Korean People with Type 2 Diabetes: TOBE Study

    This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.25273465 .

  17. Open Access 01-12-2024 | Melanoma | ReviewPaper

    Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance

    Melanoma is not as common as other skin cancers; however, it is more lethal, resulting in approximately 75% of skin cancer-related deaths [ 1 ]. The rapidly increasing incidence of melanoma and the high lethality of advanced disease have prompted …

  18. 11-04-2024 | Myasthenia Gravis | Online First

    Bispecific BCMA/CD19 targeted CAR-T cell therapy forces sustained disappearance of symptoms and anti-acetylcholine receptor antibodies in refractory myasthenia gravis: a case report

  19. Open Access 28-03-2024 | Prostate Cancer | OriginalPaper

    Manual on the proper use of the 211At-labeled PSMA ligand ([211At]PSMA-5) for clinical trials of targeted alpha therapy (1st edition)

    Recently, an astatine-labeled prostate-specific membrane antigen (PSMA) ligand ([211At]PSMA-5) has been developed for the targeted alpha therapy of patients with prostate cancer. This manual delineates its physicochemical characteristics to assist …

  20. Open Access 01-03-2024 | NSCLC | ReviewPaper

    BRAF/MEK-targeted therapy in BRAF ex15 p.T599dup mutation-driven NSCLC: a case report

    BRAF mutations are found in 1–5% of non-small-cell lung cancer (NSCLC), with V600 and non-V600 accounting for approximately 50% each. It has been confirmed that targeted therapy with dabrafenib + trametinib is effective in patients with metastatic …

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