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Pancreatic Cancer 

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  1. Open Access 15-04-2024 | Metastasis | Online First

    Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a propensity for early metastatic spread [ 1 ]. Approximately 80% of PDAC patients are diagnosed at an advanced stage with a dismal prognosis [ 2 , 3 ].

  2. 03-05-2024 | Pancreatic Cancer | Online First

    Harnessing Plant Flavonoids to Fight Pancreatic Cancer

    Pancreatic cancer is an exceptionally lethal malignancy for which mortality closely parallels incidence [ 1 ]. Due to the lack of early symptoms coupled with the unavailability of early efficient non-invasive screening and diagnostic markers …

  3. 19-04-2024 | Autoimmune Pancreatitis | Online First

    Quantitative MR imaging biomarkers for distinguishing inflammatory pancreatic mass and pancreatic cancer—a systematic review and meta-analysis

    Inflammatory pancreatic masses (IPM) primarily encompass mass-forming pancreatitis (MFP) and autoimmune pancreatitis (AIP). The imaging appearance of both tumors mimics pancreatic cancer (PC) [ 1 , 2 ]. However, PC is a highly fatal disease and …

  4. Open Access 01-12-2024 | Pancreatectomy | OriginalPaper

    Adjuvant chemotherapy omission after pancreatic cancer resection: a French nationwide study

    Despite tremendous efforts to improve prognosis, pancreatic ductal adenocarcinoma (PDAC) is expected to be the second leading cause of cancer [ 1 ]. After curative resection, adjuvant chemotherapy (AC) can significantly improve disease-free and …

  5. Open Access 25-04-2024 | Pancreatectomy | Online First

    Surgical aspects related to hereditary pancreatic cancer

    The goal of surveillance programs for individuals at risk (IAR) from familial pancreatic cancer (FPC) families or families with other inherited tumor syndromes predisposing to the development of pancreatic adenocarcinoma (PDAC), such as hereditary …

  6. Open Access 19-03-2024 | Metastasis | ReviewPaper

    Surgery for Oligometastatic Pancreatic Cancer: Defining Biologic Resectability

    Pancreatic ductal adenocarcinoma (PDAC) is most often metastatic at diagnosis. As systemic therapy continues to improve alongside advanced surgical techniques, the focus has shifted toward defining biologic, rather than technical, resectability.

  7. 09-05-2024 | Online First

    Changing Trends in the Global Disease Burden of Pancreatic Cancer from 1990 to 2030

    Pancreatic cancer (PC) is a rare malignant tumour that originates in the pancreas. This cancer can be classified into different histological types, including ductal adenocarcinoma (accounting for approximately 90% of PC cases), cystadenocarcinoma …

  8. 09-05-2024 | Online First

    ASO Author Reflections: Radical Resection for Locally Advanced Pancreatic Cancer: Arterial Resection Versus Divestment?

    The treatment approaches for locally advanced pancreatic cancer (LAPC) in terms of systemic (both neoadjuvant and adjuvant setting) and local therapy were not standardized in the past. LAPC with vascular involvement were deemed unresectbale.

  9. 26-04-2024 | Pancreatic Cancer | Online First

    The Role of Neoadjuvant and Adjuvant Chemotherapy in Pancreatic Cancer

    Pancreatic cancer is an aggressive malignancy. Recurrences are very high despite high-quality surgery necessitating adjuvant therapy. The evolution of adjuvant therapy took several decades and gradually evolved from single-agent chemotherapy to …

  10. Open Access 01-12-2024 | Pancreatic Cancer | OriginalPaper

    circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer

    Pancreatic cancer is one of the most lethal malignancies, ranking as the fourth leading cause of cancer-related mortality [ 1 ]. Pancreatic ductal adenocarcinoma (PDAC) comprises more than 95% of PC [ 2 ]. PC still remains a deadly malignancy with …

  11. Open Access 01-12-2024 | Cytostatic Therapy | OriginalPaper

    Physical function as a predictor of chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer

    Pancreatic cancer is one of the most common cancers worldwide, with a poor 5-year survival rate of just 6% and a rank of seven among the leading causes of cancer death worldwide [ 1 , 2 ]. However, a combination of surgery and adjuvant chemotherapy …

  12. Open Access 07-05-2024 | Online First

    Periarterial and Sub-adventitial Divestment Along with Triangle Operation and RAMPS for Pancreatic Body Cancer

  13. 25-04-2024 | Pancreatic Cancer | Online First

    The role of biomarkers in the early detection of pancreatic cancer

    Pancreatic surveillance can detect early-stage pancreatic cancer and achieve long-term survival, but currently involves annual endoscopic ultrasound and MRI/MRCP, and is recommended only for individuals who meet familial/genetic risk criteria. To …

  14. Open Access 01-12-2024 | Pancreatic Cancer | Erratum

    Retraction Note: Palmitoyl transferases act as novel drug targets for pancreatic cancer

  15. 02-05-2024 | Pancreatic Cancer | Online First

    CAR-T Cell Therapy in Pancreatic and Biliary Tract Cancers: An Updated Review of Clinical Trials

    Pancreatic cancer currently ranks as the fourth leading cause of cancer-related deaths in the USA and it is indicated that it is anticipated to reach the second rank in terms of cancer-related mortality by the year 2030 [ 1 ]. Around 60% of …

  16. Open Access 01-12-2024 | Pancreatic Cancer | OriginalPaper

    The clinical significance and oncogenic function of LRRFIP1 in pancreatic cancer

    Pancreatic cancer is one of the most lethal cancers in the world, with a 5-year survival rate of approximately 10% [ 1 ]. Surgical intervention is a top priority in the treatment of pancreatic cancer, but most of the patients are diagnosed at an …

  17. 22-04-2024 | Pancreatic Cancer | Online First

    Management of malignant Gastric Outlet Obstruction (mGOO) due to pancreatic cancer in the era of EUS-Gastrojejunostomy: an international practice survey and case vignette study by Pancreas 2000 from the European Pancreatic Club

  18. Open Access 01-12-2024 | OriginalPaper

    A clinical-radiomics nomogram based on dual-layer spectral detector CT to predict cancer stage in pancreatic ductal adenocarcinoma

    Pancreatic cancer remains a highly lethal digestive system disease, with a 5-year survival rate of under 10%. It ranks as the seventh leading cause of cancer-related mortality worldwide [ 1 – 3 ]. Pancreatic ductal adenocarcinoma (PDAC) …

  19. Open Access 01-12-2024 | Azelastine | OriginalPaper

    Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells

    Pancreatic ductal adenocarcinoma (PDAC) ranks as the third leading cause of cancer-related deaths, with significantly worse survival rates than other solid malignancies [ 1 , 2 ] due to late-stage diagnosis and multidrug resistance [ 3 ]. Recent …

  20. 24-03-2024 | Online First

    Commentary on ‘‘The postoperative platelet‑to‑lymphocyte ratio predicts the outcome of patients undergoing pancreaticoduodenectomy for pancreatic head cancer’’

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