Critical Care

• Open Access
• Laryngoscopy
• Research

Video versus direct laryngoscopy in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Beatriz Araújo, André Rivera, Suzany Martins, Renatha Abreu, Paula Cassa, Maicon Silva, Alice Gallo de Moraes

• Open Access
• Review

Analysis and applications of respiratory surface EMG: report of a round table meeting

A. H. Jonkman, R. S. P. Warnaar, W. Baccinelli, N. M. Carbon, R. F. D’Cruz, J. Doorduin, J. L. M. van Doorn, J. Elshof, L. Estrada-Petrocelli, J. Graßhoff, L. M. A. Heunks, A. A. Koopman, D. Langer, C. M. Moore, J. M. Nunez Silveira, E. Petersen, D. Poddighe, M. Ramsay, A. Rodrigues, L. H. Roesthuis, A. Rossel, A. Torres, M. L. Duiverman, E. Oppersma

• Open Access
• Comment

Expanding the scope of prehabilitation: reducing critical illness weakness across elective surgical patients scheduled for postoperative ICU care

Wen Gao, Jingfen Jin

• Open Access
• COVID-19
• Research

Invasive group A streptococcal infections requiring admission to ICU: a nationwide, multicenter, retrospective study (ISTRE study)

Arthur Orieux, Renaud Prevel, Margot Dumery, Jean-Baptiste Lascarrou, Noémie Zucman, Florian Reizine, Pierre Fillatre, Charles Detollenaere, Cédric Darreau, Nadiejda Antier, Mélanie Saint-Léger, Guillaume Schnell, Béatrice La Combe, Charlotte Guesdon, Franklin Bruna, Antoine Guillon, Caroline Varillon, Olivier Lesieur, Hubert Grand, Benjamin Bertrand, Shidasp Siami, Pierre Oudeville, Céline Besnard, Romain Persichini, Pierrick Bauduin, Martial Thyrault, Mathieu Evrard, David Schnell, Johann Auchabie, Adrien Auvet, Jean-Philippe Rigaud, Pascal Beuret, Maxime Leclerc, Asaël Berger, Omar Ben Hadj Salem, Julien Lorber, Annabelle Stoclin, Olivier Guisset, Léa Bientz, Pierre Khan, Vivien Guillotin, Jean-Claude Lacherade, Alexandre Boyer, Arthur Orieux, Renaud Prevel, Margot Dumery, Jean-Baptiste Lascarrou, Noémie Zucman, Florian Reizine, Pierre Fillatre, Charles Detollenaere, Cédric Darreau, Nadiejda Antier, Mélanie Saint-Léger, Guillaume Schnell, Béatrice La Combe, Charlotte Guesdon, Franklin Bruna, Antoine Guillon, Caroline Varillon, Olivier Lesieur, Hubert Grand, Benjamin Bertrand, Shidasp Siami, Pierre Oudeville, Céline Besnard, Romain Persichini, Pierrick Bauduin, Martial Thyrault, Mathieu Evrard, David Schnell, Johann Auchabie, Adrien Auvet, Jean-Philippe Rigaud, Pascal Beuret, Maxime Leclerc, Asaël Berger, Omar Ben Hadj Salem, Julien Lorber, Annabelle Stoclin, Olivier Guisset, Léa Bientz, Pierre Khan, Vivien Guillotin, Jean-Claude Lacherade, Alexandre Boyer

• Open Access
• Cerebral Ischemia
• Research

Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial

Sijie Li, Xiurong Xing, Lanjing Wang, Jiali Xu, Changhong Ren, Yalin Li, Jing Wang, Zhi Liu, Heng Zhao, Wenbo Zhao, Xunming Ji

• Open Access
• Septic Shock
• Correspondence

Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics

Rémy Coudereau, Muzhda Haem Rahimi, Anne-Claire Lukaszewicz, Martin Cour, Frank Bidar, Laurent Argaud, Fabienne Venet, Guillaume Monneret

• Open Access
• Acute Respiratory Distress Syndrome
• Correspondence

Lost in a number: concealed heterogeneity within the sequential organ failure assessment (SOFA) score

Neville Dusaj, Eleni Papoutsi, Katherine L. Hoffman, Ilias I. Siempos, Edward James Schenck

• Open Access
• Matters Arising

Does inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients? Unleashing the potential of individualized functional electrical stimulation-cycling in critical illness

Murillo Frazão, Gerson Cipriano Jr., Paulo Eugênio Silva

• Open Access
• Septicemia
• Matters Arising

Reply to “Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients”

Gabriel Jakobsson, Henrik Andersson, Michelle Chew, Alexandru Schiopu

• Open Access
• Nosocomial Pneumonia
• Research

Single-drug versus combination antimicrobial therapy in critically ill patients with hospital-acquired pneumonia and ventilator-associated pneumonia due to Gram-negative pathogens: a multicenter retrospective cohort study

François Barbier, Claire Dupuis, Niccolò Buetti, Carole Schwebel, Élie Azoulay, Laurent Argaud, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Jean-Marie Forel, Christophe Adrie, Étienne de Montmollin, Jean Reignier, Stéphane Ruckly, Jean-Ralph Zahar, Jean-François Timsit

• Open Access
• Correction

Correction to: Bayesian methods: a potential path forward for sepsis trials

George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul McCarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell, Paul M. Walker, John A. Kellum

• Open Access
• Septicemia
• Review

Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis

Vladimir Kuklin, Michael Sovershaev, Johan Bjerner, Philip Keith, L. Keith Scott, Owen Matthew Truscott Thomas, Wladimir Szpirt, Gail Rock, Bernd Stegmayr

• Open Access
• ECMO
• Correspondence

Fever or hypothermia following ECMO decannulation: the association of body temperature with survival

Markus Busch, Benjamin Seeliger, Jan Fuge, Marius M. Hoeper, Klaus Stahl, Christian Kühn, Julius Schmidt, Nina Rittgerodt, Christine Fegbeutel, Olaf Wiesner, Heiner Wedemeyer

• Open Access
• Blinatumomab
• Correspondence

Life-threatening complications and intensive care unit management in patients treated with blinatumomab for B-cell acute lymphoblastic leukemia

Irene Urbino, Etienne Lengliné, Sandrine Valade, Marco Cerrano, Marie Sebert, Emmanuel Raffoux, Florence Rabian, Elie Azoulay, Nicolas Boissel

• Open Access
• Acute Kidney Injury
• Research

The effects of higher versus lower protein delivery in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

Zheng-Yii Lee, Ellen Dresen, Charles Chin Han Lew, Julia Bels, Aileen Hill, M. Shahnaz Hasan, Lu Ke, Arthur van Zanten, Marcel C. G. van de Poll, Daren K. Heyland, Christian Stoppe

• Open Access
• ECMO
• Correspondence

To identify Harlequin syndrome in patients with venoarterial extracorporeal membrane oxygenation using radial near-infrared spectroscopy

Yongwei Yu, Xing Fang, Zhipeng Xu, Tong Li, Jueyue Yan

• Open Access
• Septicemia
• Review

Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies

Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner, Markus Alexander Weigand

• Open Access
• Septicemia
• Research

Gut mycobiome dysbiosis after sepsis and trauma

Gwoncheol Park, Jennifer A. Munley, Lauren S. Kelly, Kolenkode B. Kannan, Robert T. Mankowski, Ashish Sharma, Gilbert Upchurch, Gemma Casadesus, Paramita Chakrabarty, Shannon M. Wallet, Robert Maile, Letitia E. Bible, Bo Wang, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron, Ravinder Nagpal

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Driving pressure of respiratory system and lung stress in mechanically ventilated patients with active breathing

Vaia Stamatopoulou, Evangelia Akoumianaki, Katerina Vaporidi, Efstathios Stamatopoulos, Eumorfia Kondili, Dimitrios Georgopoulos

• Open Access
• Research

Combined effects of targeted blood pressure, oxygenation, and duration of device-based fever prevention after out-of-hospital cardiac arrest on 1-year survival: post hoc analysis of a randomized controlled trial

Martin A. S. Meyer, Christian Hassager, Simon Mølstrøm, Britt Borregaard, Johannes Grand, Benjamin Nyholm, Laust E. R. Obling, Rasmus P. Beske, Anna Sina P. Meyer, Ditte Bekker‑Jensen, Matilde Winther-Jensen, Vibeke L. Jørgensen, Henrik Schmidt, Jacob E. Møller, Jesper Kjaergaard

• Open Access
• Subarachnoid Hemorrhage
• Matters Arising

The importance of assessing left ventricular longitudinal function in presence of increased afterload

Cristina Santonocito, Ryota Sato, Siddharth Dugar, Filippo Sanfilippo

• Open Access
• Matters Arising

Rotten and gold apples: inside and outside the gray zone of a ROC curve

Antonio Messina, Michelle Chew, Maurizio Cecconi

• Open Access
• Intracranial Hypertension
• Research

The effect of passive leg raising test on intracranial pressure and cerebral autoregulation in brain injured patients: a physiological observational study

Antonio Messina, Agnieszka Uryga, Alberto Giardina, Pietro Ciliberti, Denise Battaglini, Nicolo’ Patroniti, Marek Czosnyka, Xavier Monnet, Maurizio Cecconi, Chiara Robba

• Open Access
• Research

Association between urea trajectory and protein dose in critically ill adults: a secondary exploratory analysis of the effort protein trial (RE-EFFORT)

Ryan W. Haines, John R. Prowle, Andrew Day, Danielle E. Bear, Daren K. Heyland, Zudin Puthucheary

• Open Access
• Septic Shock
• Correspondence

Potential correlation between hemodynamic improvement and an immune-modulation effect in pediatric patients with septic shock treated with renal replacement therapy and CytoSorb®: an insight from the PedCyto study

Gabriella Bottari, Corrado Cecchetti, Carmela Serpe, David Grimaldi, Fabio S. Taccone

• Open Access
• Nutrition
• Research

Enhanced exclusive enteral nutrition delivery during the first 7 days is associated with decreased 28-day mortality in critically ill patients with normal lactate level: a post hoc analysis of a multicenter randomized trial

Yizhe Chen, Zirui Liu, Qiuhui Wang, Fei Gao, Hongyang Xu, Lu Ke, Zheng-Yii Lee, Christian Stoppe, Daren K. Heyland, Fengming Liang, Jiajia Lin

• Open Access
• Laryngoscopy
• Matters Arising

A comparison of video laryngoscopy and direct laryngoscopy in critically ill patients

Yang Zhao, Qian Wang, Bin Zang

• Open Access
• Glucocorticoid
• Research

Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial

Laust E. R. Obling, Rasmus P. Beske, Martin A. S. Meyer, Johannes Grand, Sebastian Wiberg, Thomas Mohr, Anders Damm-Hejmdal, Julie L. Forman, Ruth Frikke-Schmidt, Fredrik Folke, Jacob E. Møller, Jesper Kjaergaard, Christian Hassager

• Open Access
• Septicemia
• Research

Societal costs of sepsis in the Netherlands

Erik C. N. Luijks, Elisabeth C. van der Slikke, Arthur R. H. van Zanten, Jan C. ter Maaten, Maarten J. Postma, Henk B. M. Hilderink, Robert H. Henning, Hjalmar R. Bouma

• Open Access
• Septicemia
• Research

Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings

Andrew Li, Lowell Ling, Hanyu Qin, Yaseen M. Arabi, Sheila Nainan Myatra, Moritoki Egi, Je Hyeong Kim, Mohd Basri Mat Nor, Do Ngoc Son, Wen-Feng Fang, Bambang Wahyuprajitno, Madiha Hashmi, Mohammad Omar Faruq, Boonsong Patjanasoontorn, Maher Jaffer Al Bahrani, Babu Raja Shrestha, Ujma Shrestha, Khalid Mahmood Khan Nafees, Kyi Kyi Sann, Jose Emmanuel M. Palo, Naranpurev Mendsaikhan, Aidos Konkayev, Khamsay Detleuxay, Yiong Huak Chan, Bin Du, Jigeeshu Vasishtha Divatia, Younsuck Koh, Jason Phua, Uzzal Kumar Mallick, Motiul Islam, Tarequl Hamid, A. K. M. Shirazul Islam, Rabiul Halim, Md Arifur Rahman Khan, Mohammad Asaduzzaman, Md Rezaul Karim, Nahim Sarwar, Shamsul Hoque Milon, Rashed Mahmud, A. K. M. Sirajul Islam Hirok, Ashraful Haque, Amina Sultana, Mir Atiqur Rahman Shajal, Farha Andalib, Rashedul Hasan, Khalid Mahmood Khan Nafees, Shah Sudhirchandra Dhansukhlal, Ning Li, Xiaowei Liu, Haiwei Yang, Ming Hou, Ying Li, Jian Zhang, Lifeng Huang, Wenxiong Li, Meili Duan, Taotao Liu, Wei He, Fangyu Ning, Xiaozhi Wang, Xiaoyan Zhou, Sun Yu, Xiang Xiang, Liang Pan, Feihu Zhou, Yaoli Wang, Jian Zhou, Tao Wang, Xuefei Yang, Yu Ma, Xuan Song, Haiying Wu, Chuanyun Qian, Lixin Zhou, Zuohang Xu, Kun Zhang, Zhenjie Hu, Xingsheng Lin, Songjing Shi, Xiaoguang Zhang, Rongguo Yu, Liqin Zhang, Yuan Yuan, Huiru Zhou, Xiandong Wang, Zhonghua Wang, Tiehe Qin, Xianqing Shi, Rui Li, Zhenyang He, Xiangrong Zuo, Quan Cao, Tao He, Yuanda Sui, Tiejun Wu, Ying Xu, Qin Gu, Weizheng Shuai, Hanyu Qin, Bin Du, Hong Qiao, Shuangling Li, Guiying Dong, Xiujuan Zhao, Fengxue Zhu, Junshi Wang, Lei Huang, Tianchang Wang, Hao Wang, Siqing Ma, Zhengping Yang, Yuan Gao, Ruoming Tan, Yun Xie, Ruilan Wang, Jia Jia, Bin Zang, Jun Wang, Ling Lin, Yuwen Wu, Yunfu Wu, Penglin Ma, Yanfang Li, Li Yu, Rui Guo, Jiuzhi Zhang, Xianyao Wan, Feng Shen, Qindong Shi, Jun Xu, Qiang Fang, Shaohua Liu, Tongwen Sun, Mian Zeng, Weiyun Pan, Zhongmin Liu, Qingling Lin, Nan Wang, Jing Pang, Bin Xiong, Deliang Wen, Fuxin Kang, Liuhui Chang, Yun Sun, Jingxiao Zhang, Yongjie Yin, Liu Qing, Jiajun Sun, Nahui Li, Yongqiang Wang, Songtao Shou, Yanfen Chai, Lei Xu, Xiaobo Yang, Xuelian Liao, Xian Kang, Shuangping Zhao, Liquan Huang, Run Zhang, Renhua Sun, Chao Shen, Yan He, Fu Loi Chow, Michele Tang, Philip Lam, Esther Cham, Kin Bong Tang, Lowell Ling, Manimala Dharmangadan, Pauline Yeung Ng, Kin Ho Ling, Vincent Lau, Samir Sahu, Sharmila Chatterjee, Sushmita Basu, Zubair Umer Mohamed, Sudeep Sirga, Siddhartha Reddy Kasireddy, M. A. Aleem, Swarna Deepak Kuragayala, Sai Praveen Haranath, Nagarajan Ramakrishnan, Pravin Amin, Joanne Mascarenhas, Radhika Dash, Venkat Raman Kola, R. Vaidyanathan, Siddharth Agarwal, Pradip K. Bhattacharya, Deepak Jeswani, Parshotum Lal Gautam, Abdul Samad Ansari, Vivek Nangia, Mrinal Sircar, V. M. Balasubramani, S. Maneendra, Sanghamitra Mishra, Anjeev Kumar, Rajesh Chawla, Trevor Francis Sequeira, Om Prakash Shrivastava, T. V. Sreevalsan, Rajesh Mohan Shetty, Manjunath Thimmappa, M. M. Harish, Yatin Mehta, Divya Saxena, Vipul Mishra, Rishi Kumar, Simnt Kumar Jha, Prashant Sakhavalkar, Dnyaneshwar Diwane, Subhal Dixit, Kalaiselvan, Manoranjan Pattnaik, Lalit Singh, Fareed Khan, Mehul Shah, Prasanna, Ziokov Joshi, Sheila Ninan Myatra, Manoj Gorade, Bharat G. Jagiasi, Amol Hartalkar, B. Saroj Kumar Prusty, Yogesh, Ade Winata, Maulydia, Surya Oto Wijaya, Hermin Prihartini, Shinta V. R. Hutajulu, Rudy Manalu, Christrijogo Sumartono, Chrisma Adryana Albandjar, Ira Pitaloka, Dewi Kusumawati, Arifin, Akhmad Yun Jufan, Bambang Pujo Semedi, Vanessy Theodora Silalahi, Yudianto, Erwin Pradian, Achsanuddin Hanafie, Mariza Fitriati, Tinni Trihartini Maskoen, Satriawan Abadi, Calcarina Fitriani Retno Wisudarti, Johan Arifin, Reza Widyanto Sudjud, Prananda Surya Airlangga, Rupi’i, I. Made Wiryana, Anang Achmadi, Patra Rijalul Harly, Edward Kusuma, Primartanto Wibowo, Ade Veronica HY, Jeni Sarah Mandang, Meriwijanti, I. Wayan Aryabiantara, Faisal Muchtar, Fachrul Jamal Isa, Dita Aditianingsiih, Nicolaas Parningotan Simamora, Moch. Hasyim, I. Gusti Putu Manuaba, Novita Anggraeni, Rudy Ariyanto Sanoesi, Arief Munandar, Duma Saurma Siahaan, Sri Rachmawati, Oky Susianto, Liliriawati Ananta Kahar, Zulkifli, Mordekhai Leopold Laihad, Nakada Takaaki, Yoshitaka Hara, Osamu Nishida, Kenji Uehara, Makoto Takatori, Shinichiro Ohshimo, Kazuya Kikutani, Nobuaki Shime, Shin Nunomiya, Shinshu Katayama, Bengo Atari, Takashi Ito, Yasuyuki Kakihana, Kohei Takimoto, Machi Yanai, Moritoki Egi, Tomoaki Yatabe, Yuki Kishiara, Ushio Higashijima, Motohiro Sekino, Kazuaki Atagi, Hiroshi Ogura, Tsunehiro Matsubara, Tadashi Kamio, Shigeki Fujitani, Toru Yoshida, Yukari Aoyagi, Shigehiko Uchino, Masatsugu Hasegawa, Jun Oto, Naoki Yamaguchi, Yuki Enomoto, Masaki Nakane, G. S. Amirova, Murat Daribaev, Markov Viktor Evgenievich, A. A. Vorobiev, A. V. Andrushenko, Aliya Torpakbaeva, M. E. Konkayeva, A. V. Galkin, P. A. Ostanin, Khamsay Detleuxay, Noryani Mohd Samat, Ismail Tan, Nahla Irtiza Ismail, Chew Har Lim, Wan Nasrudin Wan Ismail, Siti Rohayah Sulaiman, Anita Alias, Joanne Tiong Jia Wen, Azmin Huda Abdul Rahim, Asmah Zainudin, Nik Azman Nik Adib, Zihni Abdullah, Hafizah, Mohd Zulfakar Mazlan, Mohd Basri Mat Nor, Munkhasiakhan, Naranpurev, Cho Myint Tun, Thinzar Maw, Cho Cho, Han Sein, Myo Malar Win, Lwin Lwin Hnin, Cho Cho Lwin, Aye Su Mon, Yi Sandar Thein, Khin Le Le Yi, Myo Min Naing, Nu Nu May, Lun Naing, Khin Saw Yu Aung, Moe Thu Lin, Aung Kyi, Kyaw Min Min Tun, Suu New Khin, Khin Pyone Yi, Khin May Waan, Moe Thidar, Kyi Kyi Sann, Mu Mu Naing, Win Win Mar, Naing Naing Lin, Lalit Rajbanshi, Trishant Limbu, Baburaja Shrestha, Ujma Shrestha, Ashish Shrestha, Rosi Pradhan, Ravi Ram Shrestha, Sulav Acharya, Pramesh Sunder Shrestha, Puja Thapa Karki, Moosa Awladthani, Jacob Paul, Nadia Al Badi, Adil Al Kharusi, Khalil Al Kharousi, Sandeep Kantor, Yohannan John, Said Al Mandhari, Geetha Jacob, Amr Muhammad Esmat, B. M. J. Shetty, Ahmed Mostafa, Naveed Haroon Rashid, Muhammad Sohaib, Sonia Joseph, Safia Zafar, Ahmed Farooq, Muhammad Sheharyar Ashraf, Tanveer Hussain, Muhammad Hayat, Ataur Rehman, Syed Muneeb Ali, Saad ur Rehman, Ashok Kumar, Aaron Hernandez, Crystal Aperocho, Raymundo Resurreccion, Debbie Noblezada-Uy, Jose Emmanuel Palo, Julie Visperas, Amer Asiri, Ali Beshabshi, Fahad Al-Hameed, Ohoud Al Orabi, Yaseen Arabi, Eman Al Qasim, Masood Iqbal, Tharwat Aisa, Mohammed Saeed Al Shahrani, Laila Asonto, Ayman Kharaba, Abdullah al Mutairi, Khaild Al Ghamdi, Lama Hefni, Ahmad Al Qurashi, Galeb Al Makhlafi, Roshni Sadashiv Gokhale, Noelle Lim, Manjit Pawar, Venkatesan Kumaresh, Naville Chia Chi Hock, Tan Chee Keat, Tan Rou An, Jared De Souza, Andrew Li, Yip Hwee Seng, Jason Phua, Addy Tan YH, Melvin Tay Chee Kiang, Ng Shin Yi, Ho Vui Kian, Kiran Sharma, Sennen Lew, Lee Rui Min, Do Wan Kim, Yoon Mi Shin, Song-I. Lee, Kyung Chan Kim, Yun-Seong Kang, Soo Hwan Lee, Ho Cheol Kim, Yun Su Sim, Sunghoon Park, Tai Sun Park, Hongyeul Lee, Youjin Chang, Heung Bum Lee, Je Hyeong Kim, Young Seok Lee, Won Gun Kwack, In Byung Kim, Tae Yun Park, Young Jae Cho, Sang-Min Lee, Kyeongman Jeon, Jongmin Lee, Shin Young Kim, Jin-Won Huh, Jong Joon Ahn, Jae Hwa Cho, Won-Yeon Lee, Chin-Kuo Lin, Chang-Ke Chu, Jiun-Ting Wu, Chiung-Yu Lin, Yu-Mu Chen, Kuo-Tung Huang, Han-Chung Hu, Cong-tat Cia, Jung-Yien Chien, Chun-Te Huang, Pin-Kuei Fu, Nattachai Srisawas, Manasnun Kongwibulwut, Kaweesak Chittawatanarat, Worapot Daewtrakulchai, Anakapong Phunmanee, Anupol Panitchote, Boonsong Patjanasoontorn, Chaiwut Sawawiboon, Lê Minh Trung, Đỗ Ngọc Sơn, B. S. Bùi Nhật Hà, Dương Thiện Phước, Huỳnh Quang Đại, Nguyễn Tấn Hùng, Lê Thị Phương Thúy, Hoàng Bùi Hải, Hoàng Trọng Ái Quốc, Trần Hoài Linh, Vũ Hải Yến, Phạm Trà Giang, Nguyễn Thị Ngà, Nguyễn Đăng Tuân

• Open Access
• Lung Ultrasound
• Correspondence

Association between CA-125 and post-extubation respiratory failure: a cohort study

Fataki Lombuli, Tiago Hermes Maeso Montes, Márcio Manozzo Boniatti

• Open Access
• Research

Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)

Annika Reintam Blaser, Merli Mändul, Martin Björck, Stefan Acosta, Miklosh Bala, Zsolt Bodnar, Dumitru Casian, Zaza Demetrashvili, Mario D’Oria, Virginia Durán Muñoz-Cruzado, Alastair Forbes, Hanne Fuglseth, Moran Hellerman Itzhaki, Benjamin Hess, Karri Kase, Mikhail Kirov, Kristoffer Lein, Matthias Lindner, Cecilia Inés Loudet, Damian J. Mole, Marko Murruste, Alexandre Nuzzo, Sten Saar, Maximilian Scheiterle, Joel Starkopf, Peep Talving, Anna-Liisa Voomets, Kenneth K. T. Voon, Mohammad Alif Yunus, Kadri Tamme, Olivier Corcos, Yves Castier, Maxime Ronot, Alan Biloslavo, Lucia Paiano, Gunnar Elke, Denise Nagel, David I. Radke, Jacqueline Vilca Becerra, María Elina Abeleyra, Martin Cahenzli, Tatjana Semenkova, Anton Nikonov, Alexey Smetkin, Geir Ivar Nedredal, Øivind Irtun, Oded Cohen-Arazi, Asaf Keda, Gheorghe Rojnoveanu, Alexandr Ursu, Felipe Pareja Ciuró, Anabel García-Leon, Carlos Javier García-Sánchez, Lim Jia Hui, Loy Yuan Ling, Ilya Kagan, Pierre Singer, Edgar Lipping, Ana Tvaladze, Dimitrios Damaskos, Darja Clinch, Too Xiao Qing, Morten Vetrhus, Jacopo Martellucci, Giulia Cerino, Donghuang Hong, Jinsheng Liu, Ernest Ong, Kursat Kundogan, Tutkun Talih, Lovenish Bains, Diego Visconti, Lorenzo Gibello, Ruhi Fadzlyana Jailani, Muhammad Amirul Ashra, Andee Dzulkarnaen Zakaria, Ahmad Faiz Najmuddin Mohd Ghazi, Nur Suriyana Abd Ghani, Mohd Fadliyazid Ab Rahim, Goran Augustin, Damir Halužan, Mohan Gurjar, Rahul Rahul, Firdaus Hayati, Jin-Jiun Mah

• Open Access
• Intracranial Hypertension
• Research

Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups

Paolo Gritti, Marco Bonfanti, Rosalia Zangari, Ezio Bonanomi, Alessia Farina, Giulio Pezzetti, Isabella Pelliccioli, Luca Longhi, Maria Di Matteo, Andrea Viscone, Gabriele Lando, Gaia Cavalleri, Simonetta Gerevini, Francesco Biroli, Ferdinando Luca Lorini

• Open Access
• Post-Intensive Care Syndrome
• Brief Report

Time in ICU and post-intensive care syndrome: how long is long enough?

Dylan Flaws, John F. Fraser, Kevin Laupland, Jayshree Lavana, Sue Patterson, Alexis Tabah, Oystein Tronstad, Mahesh Ramanan

• Open Access
• Post Traumatic Stress Disorder
• Perspective

Trajectories of post-traumatic stress in sepsis survivors two years after ICU discharge: a secondary analysis of a randomized controlled trial

Konrad F. R. Schmidt, Jochen S. Gensichen, Maya Schroevers, Martina Kaufmann, Friederike Mueller, Gustav Schelling, Sabine Gehrke-Beck, Monique Boede, Christoph Heintze, Michel Wensing, Daniel Schwarzkopf

• Open Access
• Septicemia
• Research

The protective effect of apolipoprotein H in paediatric sepsis

Zhicai Yu, Changxue Xiao, Rong Liu, Dandan Pi, Bian Jin, Zhen Zou, Feng Xu

• Open Access
• Tracheostomy
• Matters Arising

Response to: the association between time definition of reintubation and patient outcomes in critically ill patients—several topics should be noticed

Aiko Tanaka, Tetsuhisa Kitamura, Akinori Uchiyama, Yusuke Enokidani, Yukiko Koyama, Takeshi Yoshida, Yuji Fujino

• Open Access
• Nutrition
• Review

Combining proteins with n-3 PUFAs (EPA + DHA) and their inflammation pro-resolution mediators for preservation of skeletal muscle mass

Renée Blaauw, Philip C. Calder, Robert G. Martindale, Mette M. Berger

• Open Access
• Research

Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial

François Jardot, Robert G. Hahn, Dominique Engel, Christian M. Beilstein, Patrick Y. Wuethrich

• Open Access
• Pneumonia
• Research

Antibiotic definitive treatment in ventilator associated pneumonia caused by AmpC-producing Enterobacterales in critically ill patients: a prospective multicenter observational study

Matthieu Petit, Frank Bidar, Quentin Fosse, Lucie Lefevre, Marine Paul, Tomas Urbina, Paul Masi, Florent Bavozet, Jérémie Lemarié, Etienne de Montmollin, Chloé Andriamifidy-Berti, Julien Dessajan, Benjamin Zuber, Lara Zafrani, Edwige Peju, Paris Meng, Liliane Charrier, Loic Le Guennec, Marie Simon, Charles-Edouard Luyt, Luc Haudebourg, Guillaume Geri

• Open Access
• Septic Shock
• Brief Report

Thiamine administration in septic shock: a post hoc analysis of two randomized trials

Jacob Vine, John H. Lee, Max S. Kravitz, Anne V. Grossestreuer, Lakshman Balaji, Shannon B. Leland, Noa Berlin, Ari Moskowitz, Michael W. Donnino

• Open Access
• Meropenem
• Research

qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial

Maria Evangelia Adami, Antigone Kotsaki, Nikolaos Antonakos, Efthymia Giannitsioti, Stamatios Chalvatzis, Maria Saridaki, Christina Avgoustou, Karolina Akinosoglou, Konstantina Dakou, Georgia Damoraki, Konstantina Katrini, Panagiotis Koufargyris, Vasileios Lekakis, Antonia Panagaki, Asimina Safarika, Jesper Eugen-Olsen, Evangelos J. Giamarellos-Bourboulis

• Open Access
• Septicemia
• Research

Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study

Paul Gabarre, Cyrielle Desnos, Alexandra Morin, Louai Missri, Tomas Urbina, Vincent Bonny, Matthieu Turpin, Jean-Luc Baudel, Laurence Berard, Melissa Montil, Bertrand Guidet, Guillaume Voiriot, Jérémie Joffre, Eric Maury, Hafid Ait-Oufella

• Open Access
• Heart Surgery
• Research

Procalcitonin for the diagnosis of postoperative bacterial infection after adult cardiac surgery: a systematic review and meta-analysis

Davide Nicolotti, Silvia Grossi, Valeria Palermo, Federico Pontone, Giuseppe Maglietta, Francesca Diodati, Matteo Puntoni, Sandra Rossi, Caterina Caminiti

• Open Access
• Central Nervous System Trauma
• Perspective

Transforming research to improve therapies for trauma in the twenty-first century

Nicole P. Juffermans, Tarik Gözden, Karim Brohi, Ross Davenport, Jason P. Acker, Michael C. Reade, Marc Maegele, Matthew D. Neal, Philip C. Spinella

• Open Access
• Septic Shock
• Perspective

Administration of methylene blue in septic shock: pros and cons

Julian Arias-Ortiz, Jean-Louis Vincent

• Open Access
• Review

Trauma systems in Asian countries: challenges and recommendations

Dinesh Bagaria, Amila S. Ratnayake, Aireen Madrid, Tamara J. Worlton

• Open Access
• Ketamine
• Research

Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis

Takatoshi Koroki, Yuki Kotani, Takahiko Yaguchi, Taisuke Shibata, Motoki Fujii, Stefano Fresilli, Mayuko Tonai, Toshiyuki Karumai, Todd C. Lee, Giovanni Landoni, Yoshiro Hayashi

• Open Access
• Antibiotic
• Perspective

Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies

Jayesh Dhanani, Jason A. Roberts, Antoine Monsel, Antoni Torres, Marin Kollef, Jean-Jacques Rouby, Kostoula Arvaniti, Mona Assefi, Matteo Bassetti, Stijn Blot, Matthieu Boisson, Adrien Bouglé, Jean-Michel Constantin, Jayesh Dhanani, George Dimopoulos, Jonathan Dugernier, Pauline Dureau, Timothy Felton, Marin Kollef, Antonia Koutsoukou, Anna Kyriakoudi, Pierre-François Laterre, Marc Leone, Victoria Lepère, Gianluigi Li Bassi, Xuelian Liao, Olivier Mimoz, Antoine Monsel, Girish B. Nair, Michael Niederman, Lucy B. Palmer, Paolo Pelosi, Jose Manuel Pereira, Konstantinos Pontikis, Garyphalia Poulakou, Jérôme Pugin, Chuanyun Qian, Jie-ming Qu, Jordi Rello, Jason Roberts, Jean-Jacques Rouby, Christina Routsi, Gerald C. Smaldone, Antoni Torres, Melda Türkoğlu, Tobias Welte, Michel Wolff, Xia Jing, Li Yang, Ting Yang, Ying-gang Zhu

• Open Access
• Acute Kidney Injury
• Brief Report

Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury

Niklas Bruse, Katerina Pardali, Maarten Kraan, Matthijs Kox, Peter Pickkers

• Open Access
• Correspondence

The administration of four-factor prothrombin complex concentrate exacerbates thrombin generation in trauma patients at risk of massive transfusion: an ancillary study of the PROCOAG trial

Jules Greze, Raphael Marlu, Mariette Baud, Landry Seyve, Tobias Gauss, Pierre Bouzat

• Open Access
• Acute Kidney Injury
• Research

Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study

Felipe Muñoz, Pablo Born, Mario Bruna, Rodrigo Ulloa, Cecilia González, Valerie Philp, Roberto Mondaca, Juan Pablo Blanco, Emilio Daniel Valenzuela, Jaime Retamal, Francisco Miralles, Pedro D. Wendel-Garcia, Gustavo A. Ospina-Tascón, Ricardo Castro, Philippe Rola, Jan Bakker, Glenn Hernández, Eduardo Kattan

• Open Access
• Cardiogenic Shock
• Comment

Cardiogenic shock: all hail the RCT, long live the registry

A. Warren, D. Morrow, Alastair G. Proudfoot

• Open Access
• ECMO
• Research

Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study

Nicolas Nesseler, Alexandre Mansour, Matthieu Schmidt, Marylou Para, Alizée Porto, Pierre-Emmanuel Falcoz, Nicolas Mongardon, Claire Fougerou, James T. Ross, Antoine Beurton, Lucie Gaide-Chevronnay, Pierre-Grégoire Guinot, Guillaume Lebreton, Erwan Flecher, André Vincentelli, Nicolas Massart, Olivier Fouquet, Marc Pierrot, Sidney Chocron, Guillaume Flicoteaux, Philippe Mauriat, Alexandre Ouattara, Hadrien Roze, Olivier Huet, Marc-Olivier Fischer, Raphel Bellaïche, Ophélie Constant, Quentin De Roux, L. Y. André, Arnaud Meffert, Jean-Claude Merle, Lucile Picard, Elena Skripkina, Thierry Folliguet, Antonio Fiore, Nicolas D’ostrevy, Marie-Catherine Morgan, Maxime Nguyen, Nicolas Terzi, Gwenhaël Colin, Olivier Fabre, Arash Astaneh, Justin Issard, Elie Fadel, Dominique Fabre, Julien Guihaire, Iolande Ion, Jean Baptiste Menager, Delphine Mitilian, Olaf Mercier, François Stephan, Jacques Thes, Jerôme Jouan, Thibault Duburcq, Valentin Loobuyck, Mouhammed Moussa, Sabrina Manganiello, Agnes Mugnier, Natacha Rousse, Olivier Desebbe, Jean-Luc Fellahi, Roland Henaine, Matteo Pozzi, Zakaria Riad, Christophe Guervilly, Sami Hraiech, Laurent Papazian, Matthias Castanier, Charles Chanavaz, Cyril Cadoz, Sebastien Gette, Guillaume Louis, Erick Portocarrero, Philippe Gaudard, Kais Brini, Nicolas Bischoff, Antoine Kimmoun, Bruno Levy, Pierre Perez, Alexandre Bourdiol, Yannick Hourmant, Pierre-Joachim Mahé, Bertrand Rozec, Mickaël Vourc’h, Stéphane Aubert, Florian Bazalgette, Claire Roger, Pierre Jaquet, Brice Lortat-Jacob, Pierre Mordant, Patrick Nataf, Juliette Patrier, Sophie Provenchere, Morgan Roué, Romain Sonneville, Alexy Tran-Dinh, Paul-Henri Wicky, Charles Al Zreibi, Bernard Cholley, Yannis Guyonvarch, Sophie Hamada, Claudio Barbanti, Astrid Bertier, Anatole Harrois, Jordi Matiello, Thomas Kerforne, Corentin Lacroix, Nicolas Brechot, Alain Combes, Juliette Chommeloux, Cosimo D’alessandro, Pierre Demondion, Alexandre Demoule, Martin Dres, Guillaume Fadel, Muriel Fartoukh, Guillaume Hekimian, Charles Juvin, Pascal Leprince, David Levy, Charles Edouard Luyt, Thibaut Schoell, Pierre Fillâtre, Nicolas Massart, Maud Jonas, Nicolas Allou, Salvatore Muccio, Dario Di Perna, Vito-Giovanni Ruggieri, Bruno Mourvillier, Amedeo Anselmi, Karl Bounader, Yoann Launey, Thomas Lebouvier, Alessandro Parasido, Florian Reizine, Maxime Esvan, Philippe Seguin, Emmanuel Besnier, Dorothée Carpentier, Thomas Clavier, Anne Olland, Marion Villard, Fanny Bounes, François Labaste, Vincent Minville, Antoine Guillon, Yannick Fedun

• Open Access
• Community-Acquired Pneumonia
• Correspondence

Evidence supports the use of hydrocortisone for patients with community-acquired pneumonia

De-En Lu, Cheng-Yi Chang, Sheng-Wei Cheng, Enoch Kang, Chih-Hsin Lee, Kee-Hsin Chen

• Open Access
• COVID-19
• Research

Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial

Narges Alipanah-Lechner, James Hurst-Hopf, Kevin Delucchi, Lamorna Swigart, Andrew Willmore, Benjamin LaCombe, Robin Dewar, H. Clifford Lane, Perrine Lallemand, Kathleen D. Liu, Laura Esserman, Michael A. Matthay, Carolyn S. Calfee, Neil R. Aggarwal, Timothy Albertson, Sara Auld, Jeremy R. Beitler, Paul Berger, Ellen L. Burnham, Nathan Cobb, Alessio Crippa, Andrea Discacciati, Martin Eklund, D. Clark Files, Eliot Friedman, Sheetal Gandotra, Kashif Khan, Jonathan Koff, Santhi Kumar, Thomas R. Martin, Nuala J. Meyer, Timothy Obermiller, Philip Robinson, Derek Russell, Karl Thomas, Se Fum Wong, Richard G. Wunderink, Mark M. Wurfel, Albert Yen, Fady A. Youssef, Anita Darmanian, Amy L. Dzierba, Ivan Garcia, Katarzyna Gosek, Purnema Madahar, Aaron M. Mittel, Justin Muir, Amanda Rosen, John Schicchi, Alexis L. Serra, Romina Wahab, Kevin W. Gibbs, Leigha Landreth, Mary LaRose, Lisa Parks, Adina Wynn, Caroline A. G. Ittner, Nilam S. Mangalmurti, John P. Reilly, Donna Harris, Abhishek Methukupally, Siddharth Patel, Lindsie Boerger, John Kazianis, Carrie Higgins, Jeff McKeehan, Brian Daniel, Scott Fields, Alejandra Jauregui, Daniel Belvins, Catherine Nguyen, Alexis Suarez, Maged A. Tanios, Farjad Sarafian, Usman Shah, Max Adelman, Christina Creel-Bulos, Joshua Detelich, Gavin Harris, Katherine Nugent, Christina Spainhour, Philip Yang, Angela Haczku, Erin Hardy, Richart Harper, Brian Morrissey, Christian Sandrock, G. R. Scott Budinger, Helen K. Donnelly, Benjamin D. Singer, Ari Moskowitz, Melissa Coleman, Joseph Levitt, Ruixiao Lu, Paul Henderson, Adam Asare, Imogene Dunn, Alejandro Botello Barragan

• Open Access
• Cardiopulmonary Resuscitation
• Brief Report

Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis

Christopher Jer Wei Low, Ryan Ruiyang Ling, Kollengode Ramanathan, Ying Chen, Bram Rochwerg, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong, Yohei Okada

• Open Access
• Acute Respiratory Distress Syndrome
• Perspective

Improving management of ARDS: uniting acute management and long-term recovery

Nicola Latronico, M. Eikermann, E. W. Ely, D. M. Needham

• Open Access
• Matters Arising

Reflections on epidemiological investigations of sepsis in the Asian Region

Mingqiang Wang, Lin Zhong

• Open Access
• Acute Respiratory Distress Syndrome
• Correspondence

How often do we need to update PEEP setting during prone positioning in ARDS?

Ling Sang, Zhimin Lin, Zhanqi Zhao

• Open Access
• Research

Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures

Sebastian Berger, Pascale Grzonka, Anja I. Frei, Sabina Hunziker, Sira M. Baumann, Simon A. Amacher, Caroline E. Gebhard, Raoul Sutter

• Open Access
• COVID-19
• Correspondence

The use of mechanical CPR for IHCA during the COVID-19 pandemic as compared to the pre-pandemic period

Conor Crowley, Justin Salciccioli, Yuxiu Lei, Christopher Hansen, Tomoyoshi Tamura, Edy Y. Kim, Ari Moskowitz, Anne Grossestreuer, Ari Moskowitz, Joseph Ornato, Matthew Churpek, Monique Anderson Starks, Paul Chan, Saket Girotra, Sarah Perman

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia

Chel Hee Lee, Mohammad M. Banoei, Mariam Ansari, Matthew P. Cheng, Francois Lamontagne, Donald Griesdale, David E. Lasry, Koray Demir, Vinay Dhingra, Karen C. Tran, Terry Lee, Kevin Burns, David Sweet, John Marshall, Arthur Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Todd C. Lee, John H. Boyd, Keith R. Walley, Robert Fowler, Greg Haljan, Donald C. Vinh, Alison Mcgeer, David Maslove, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, Genevieve Rocheleau, Uriel Trahtemberg, Anand Kumar, Ma Lou, Claudia dos Santos, Andrew Baker, James A. Russell, Brent W. Winston, J. A. Russell, K. R. Walley, J. Boyd, T. Lee, J. Singer, D. Sweet, K. Tran, S. Reynolds, G. Haljan, M. Cheng, D. Vinh, T. Lee, F. Lamontagne, B. Winston, O. Rewa, J. Marshall, A. Slutsky, A. McGeer, V. Sivanantham, R. Fowler, D. Maslove, S. Perez Patrigeon, K. D. Burns

• Open Access
• Heart Surgery
• Research

Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial

Olivier Huet, Thomas Gargadennec, Jean-Ferréol Oilleau, Bertrand Rozec, Nicolas Nesseler, Adrien Bouglé, Thomas Kerforne, Sigismond Lasocki, Vedat Eljezi, Géraldine Dessertaine, Julien Amour, Xavier Chapalain, Grégoire Le Gac, Nima Djavidi, Emmanuel Rineau, Dauphou Eddi, Emmanuel Novak, Maëlys Consigny, Karim Ashenoune, Antoine Roquilly, Philippe Seguin, Claire Dayot-Fitzellier, Francis Remerand, Marc Laffon

• Open Access
• Imatinib
• Brief Report

Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial

Erik Duijvelaar, Xiaoke Pan, Harm Jan Bogaard, Etto C. Eringa, Jurjan Aman

• Open Access
• ECMO
• Review

Impact of hyperoxia on the gut during critical illnesses

Ninan Dai, Juan Gu, Yanhong Luo, Yuanfa Tao, Yuehting Chou, Ying He, Han Qin, Tao Chen, Xiaoyun Fu, Miao Chen, Zhouxiong Xing

• Open Access
• Matters Arising

The acute mesenteric ischaemia (AMESI) study: a matter of incidence

Lorenzo Garzelli, Mathieu Nacher

• Open Access
• Diffuse Large B-Cell Lymphoma
• Review

Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update

Mathieu Bellal, Jolan Malherbe, Gandhi Damaj, Damien Du Cheyron

• Open Access
• Research

Accuracy of respiratory muscle assessments to predict weaning outcomes: a systematic review and comparative meta-analysis

Diego Poddighe, Marine Van Hollebeke, Yasir Qaiser Choudhary, Débora Ribeiro Campos, Michele R. Schaeffer, Jan Y. Verbakel, Greet Hermans, Rik Gosselink, Daniel Langer

• Open Access
• Traumatic Brain Injuries
• Review

Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis

Mairi Ziaka, Aristomenis Exadaktylos

• Open Access
• Status Epilepticus
• Research

Long-term outcome in new onset refractory status epilepticus: a retrospective study

Federica Stretti, Stefan Yu Bögli, Francesca Casagrande, Amanda Eisele, Marian Galovic, Emanuela Keller, Giovanna Brandi

• Open Access
• Anakinra
• Research

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

Evdoxia Kyriazopoulou, Yehudit Hasin-Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios Kotsis, Dionysios G. Tsoukalas, Carlo Selmi, Alexandra Konstantinou, Michael Samarkos, Michael Doumas, Aikaterini Masgala, Konstantinos Pagkratis, Aikaterini Argyraki, Karolina Akinosoglou, Styliani Symbardi, Mihai G. Netea, Periklis Panagopoulos, George N. Dalekos, Oliver Liesenfeld, Timothy E. Sweeney, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis

• Open Access
• Acute Kidney Injury
• Correspondence

Mean arterial pressure during cardiopulmonary bypass: A modifiable risk factor for acute kidney injury in cardiac surgery patients?

Nikolaus Schreiber, Simon Orlob, Stephanie Fida, Christoph Klivinyi, Alexander H. Kirsch, Michael Kolland, Michael Schörghuber

• Open Access
• Artificial Intelligence
• Research

Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques

Candelaria de Haro, Verónica Santos-Pulpón, Irene Telías, Alba Xifra-Porxas, Carles Subirà, Montserrat Batlle, Rafael Fernández, Gastón Murias, Guillermo M. Albaiceta, Sol Fernández-Gonzalo, Marta Godoy-González, Gemma Gomà, Sara Nogales, Oriol Roca, Tai Pham, Josefina López-Aguilar, Rudys Magrans, Laurent Brochard, Lluís Blanch, Leonardo Sarlabous, Laurent Brochard, Irene Telias, Felipe Damiani, Ricard Artigas, Cesar Santis, Tài Pham, Tommaso Mauri, Elena Spinelli, Giacomo Grasselli, Savino Spadaro, Carlo Alberto Volta, Francesco Mojoli, Dimitris Georgopoulos, Eumorfia Kondili, Stella Soundoulounaki, Tobias Becher, Norbert Weiler, Dirk Schaedler, Oriol Roca, Manel Santafe, Jordi Mancebo, Nuria Rodríguez, Leo Heunks, Heder de Vries, Chang-Wen Chen, Jian-Xin Zhou, Guang-Qiang Chen, Nuttapol Rit-tayamai, Norberto Tiribelli, Sebastian Fredes, Ricard Mellado Artigas, Carlos Ferrando Ortolá, François Beloncle, Alain Mercat, Jean-Michel Arnal, Jean-Luc Diehl, Alexandre Demoule, Martin Dres, Quentin Fossé, Sébastien Jochmans, Jonathan Chelly, Nicolas Terzi, Claude Guérin, E. Baedorf Kassis, Jeremy Beitler, Davide Chiumello, Erica Ferrari Luca Bol-giaghi, Arnaud W. Thille, Rémi Coudroy, Laurent Papazian

• Open Access
• Research

Real-time machine learning model to predict short-term mortality in critically ill patients: development and international validation

Leerang Lim, Ukdong Gim, Kyungjae Cho, Dongjoon Yoo, Ho Geol Ryu, Hyung-Chul Lee

• Open Access
• COVID-19
• Research

Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study

Pierre Kalfon, Wissam El-Hage, Marie-Agnès Geantot, Constance Favier, Laetitia Bodet-Contentin, Khaldoun Kuteifan, Pierre-Yves Olivier, Didier Thévenin, Julien Pottecher, Jullien Crozon-Clauzel, Bénédicte Mauchien, Arnaud Galbois, Roland de Varax, Sabine Valera, Philippe Estagnasie, Audrey Berric, Martine Nyunga, Nathalie Revel, Georges Simon, Benjamin Kowalski, Achille Sossou, Thomas Signouret, Marc Leone, Charles Delalé, Aurélien Seemann, Sigismond Lasocki, Jean-Pierre Quenot, Antoine Monsel, Olivier Michel, Mathieu Page, René-Gilles Patrigeon, Walid Nicola, Arnaud W. Thille, Guillaume Hekimian, Pascal Auquier, Karine Baumstarck, Hortense Catry, Anne-Laure Dubus, Léa Laugery, Marion Lintaff, Mélanie Lourseyre, Lou Merigard, Lisa Michel, Nawal Ouhmad, Solenn Petit, Laurence Tricoche, Florent Beaumale, Anne-Sylvie Scholastique, Emmanuelle Mougenot, Céline Delerue, Marc Feller, Julien Grouille, Charles-Edouard Rochon, Juliette Audibert, Gaëtan Badre, Cécile Jourdain, Leslie Lehaie, Hasni Si Abdelkader, Emilie Henry, Marie Labruyere, Claire Boulle-Geronimi, Stéphanie Beaussard, Olivier Nigeon, Anthea Loiez, Valérie Cerro, Laetitia Marchand, Charlotte Arbelot, Karine Buzelier, Deborah Levy, Pascale Leloup, Karim Messaoudi, Camille Alzina, Lee Nguyen, Steve Nowak, Carole Ichai, Aminata Diop, Hélène Brisson, Jean-Michel Constantin, Samia Lakhal, Madjid Oudihat, Rémi Coudroy, Carole Guyon, Jean-Pierre Frat, René Robert, Nadine Lubango, Lisa Villequey, Stéphane Hecketsweiler, Nicolas Partouche, Laurent Ducros, Vincent Gardan, Julie Rivoire, Stéphanie Deparis-Dusautois, Lamia Lamri, Alexandra Lavalart

• Open Access
• Central Nervous System Trauma
• Research

Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study

Alwyn Gomez, Logan Froese, Donald Griesdale, Eric P. Thelin, Rahul Raj, Levi van Iperenburg, Jeanette Tas, Marcel Aries, Kevin Y. Stein, Clare Gallagher, Francis Bernard, Andreas H. Kramer, Frederick A. Zeiler

• Open Access
• Matters Arising

Albumin for sepsis-related peripheral tissue hypoperfusion

Mingqiang Wang, Lin Zhong

• Open Access
• ECMO
• Comment

Scrutinizing mechanical circulatory support in cardiogenic shock: Have we jumped the gun?

Enzo Lüsebrink, Hugo Lanz, Holger Thiele

• Open Access
• Research

Trends in pre-hospital volume resuscitation of blunt trauma patients: a 15-year analysis of the British (TARN) and German (TraumaRegister DGU®) National Registries

M. F. Bath, J. Schloer, J. Strobel, W. Rea, R. Lefering, M. Maegele, H. De’Ath, Z. B. Perkins

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Effects of prone positioning on lung mechanical power components in patients with acute respiratory distress syndrome: a physiologic study

Christoph Boesing, Joerg Krebs, Alice Marguerite Conrad, Matthias Otto, Grietje Beck, Manfred Thiel, Patricia R. M. Rocco, Thomas Luecke, Laura Schaefer

• Open Access
• Matters Arising

The elusive relationship between cardiac filling and fluid responsiveness

Jon-Emile S. Kenny, Ross Prager, Korbin Haycock

• Open Access
• Perspective

Trauma systems in high socioeconomic index countries in 2050

Tobias Gauss, Mariska de Jongh, Marc Maegele, Elaine Cole, Pierre Bouzat

• Open Access
• Matters Arising

The incidences of acute mesenteric ischaemia vary greatly depending on the population and diagnostic activity

Annika Reintam Blaser, Kadri Tamme, Joel Starkopf, Alastair Forbes, Marko Murruste, Peep Talving, Stefan Acosta, Martin Björck

• Open Access
• Cardiopulmonary Resuscitation
• Matters Arising

A comparison of extracorporeal and conventional cardiopulmonary resuscitation for cardiac arrest

Yang Zhao, Qian Wang, Bin Zang

• Open Access
• Brief Report

Effect of a self-developed fixation device on preventing endotracheal intubation-related pressure injury: a randomised controlled trial

Xiaodong Zhang, Qibing Zhang, Jiqin You, Rong Xu, Zhaojie Zhang, Yunlan Shi, Chunrong Han, Shiyan Zhao, Bangtao Yao, Yan Geng, Songqiao Liu

• Open Access
• Septicemia
• Research

Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response

Giuseppe G. F. Leite, Justin de Brabander, Erik H. A. Michels, Joe M. Butler, Olaf L. Cremer, Brendon P. Scicluna, Timothy E. Sweeney, Miguel Reyes, Reinaldo Salomao, Hessel Peters-Sengers, Tom van der Poll

• Open Access
• Tranexamic Acid
• Research

Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan

Jotaro Tachino, Shigeto Seno, Hisatake Matsumoto, Tetsuhisa Kitamura, Atsushi Hirayama, Shunichiro Nakao, Yusuke Katayama, Hiroshi Ogura, Jun Oda

• Open Access
• ECMO
• Correspondence

Feasibility of 3D-EIT in identifying lung perfusion defect and V/Q mismatch in a patient with VA-ECMO

Yelin Gao, Ke Zhang, Maokun Li, Siyi Yuan, Qianlin Wang, Yi Chi, Yun Long, Zhanqi Zhao, Huaiwu He

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Adrian Ceccato, Carles Forne, Lieuwe D. Bos, Marta Camprubí-Rimblas, Aina Areny-Balagueró, Elena Campaña-Duel, Sara Quero, Emili Diaz, Oriol Roca, David De Gonzalo-Calvo, Laia Fernández-Barat, Anna Motos, Ricard Ferrer, Jordi Riera, Jose A. Lorente, Oscar Peñuelas, Rosario Menendez, Rosario Amaya-Villar, José M. Añón, Ana Balan-Mariño, Carme Barberà, José Barberán, Aaron Blandino-Ortiz, Maria Victoria Boado, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Nieves Franco, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Ángel Estella, Elena Gallego, José Luis García-Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge-García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, María Cruz Martin-Delgado, Ignacio Martínez-Varela, Juan Lopez Messa, Guillermo Muñiz-Albaiceta, María Teresa Nieto, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Felipe Pérez-García, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Victor Sagredo, Angel Sánchez-Miralles, Susana Sancho-Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suarez-Sipmann, Luis Tamayo-Lomas, José Trenado, Alejandro Úbeda, Luis Jorge Valdivia, Pablo Vidal, Jesus Bermejo, Jesica Gonzalez, Ferran Barbe, Carolyn S. Calfee, Antonio Artigas, Antoni Torres, Berta Adell-Serrano, María Aguilar Cabello, Luciano Aguilera, Victoria Alcaraz-Serrano, Cesar Aldecoa, Cynthia Alegre, Raquel Almansa, Sergio Álvarez, Antonio Álvarez Ruiz, Rosario Amaya Villar, Ruth Andrea, Mariana Andrea Novo, José Ángel, Jose Manuel Añon, Marta Arrieta, JIgnacio Ayestarán, Joan Ramon Badia, Mariona Badía, Orville Báez Pravia, Ana Balan Mariño, Begoña Balsera, Carme Barberà, José Barberán, Laura Barbena, Enric Barbeta, Tommaso Bardi, Patricia Barral Segade, Marta Barroso, José Ángel Berezo García, Jesús F. Bermejo-Martin, Belén Beteré, Judit Bigas, Aaron Blandino Ortiz, Rafael Blancas, María Luisa Blasco Cortés, María Boado, María Bodi Saera, Neus Bofill, María Teresa Bouza Vieiro, Leticia Bueno, Elena Bustamante-Munguira, Juan Bustamante-Munguira, Cecilia del Busto Martínez, Jesús Caballero, David Campi Hermoso, Sandra Campos Fernández, Cristina Carbajales, Iosune Cano, Maria Luisa Cantón-Bulnes, Nieves Carbonell, Pablo Cardina Fernández, Laura Carrión García, Sulamita Carvalho, Núria Casacuberta-Barberà, Manuel Castellà, Andrea Castellví, Pedro Castro, Mercedes Catalán-González, Ramon Cicuendez Ávila, Catia Cillóniz, Luisa Clar, Cristina Climent, Jordi Codina, Pamela Conde, Sofía Contreras, María Cruz Martin, Raul de Pablo Sánchez, Diego De Mendoza, Emili Díaz, Yolanda Díaz, María Digna Rivas Vilas, Cristina Dólera Moreno, Irene Dot, Pedro Enríquez Giraudo, Inés Esmorís Arijón, Angel Estella, Teresa Farre Monjo, Javier Fernández, Carlos Ferrando, Albert Figueras, Eva Forcadell-Ferreres, Lorena Forcelledo Espina, Nieves Franco, Enric Franquesa, Àngels Furro, Albert Gabarrus, Cristóbal Galbán, Elena Gallego, Felipe García, Beatriz García, José Luis García Garmendia, Dario Garcia-Gasulla, Emilio García Prieto, Carlos García Redruello, Amaia García Sagastume, José Garnacho-Montero, Maria Luisa Gascón Castillo, Gemma Gomà, José M. 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Mantellini, Gregorio Marco Naya, Pilar Marcos, Judith Marin-Corral, Enrique Marmol Peis, Paula Martín Vicente, María Martínez, Carmen Eulalia Martínez Fernández, Amalia Martínez de la Gándara, Maria Dolores Martínez Juan, Basilisa Martínez Palacios, Ignacio Martínez Varela, Juan Fernando Masa Jimenez, Joan Ramon Masclans, Emilio Maseda, Eva María Menor Fernández, Mar Miralbés, Josman Monclou, Juan Carlos Montejo-González, Neus Montserrat, María Mora Aznar, Dulce Morales, Sara Guadalupe Moreno Cano, David Mosquera Rodríguez, Rosana Muñoz-Bermúdez, Guillermo Muñiz Albaiceta, José María Nicolás, Maria Teresa NIeto, Ramon Nogue Bou, Rafaela Nogueras Salinas, Marta Ocón, Ana Ortega, Sergio Ossa, Pablo Pagliarani, Francisco Parrilla, Jose Pedregosa-Díaz, Yhivian Peñasco, Oscar Peñuelas, Leire Pérez Bastida, Purificación Pérez, Felipe Pérez-García, Gloria Pérez Planelles, Eva Pérez Rubio, David Pestaña Laguna, Àngels Piñol-Tena, Javier Prados, Andrés Pujol, Juan Carlos Pozo, Núria Ramon Coll, Gloria Renedo Sanchez-Giron, Jordi Riera, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Laura Rodriguez, Felipe Rodríguez de Castro, Silvia Rodríguez, Covadonga Rodríguez Ruiz, Jorge Rubio, Alberto Rubio López, Ángela Leonor Ruiz-García, Miriam Ruiz Miralles, Pablo Ryan Murúa, Eva Saborido Paz, Victor Sagredo, Ana Salazar Degracia, Inmaculada Salvador-Adell, Miguel Sanchez, Ana Sánchez, Angel Sánchez-Miralles, Susana Sancho Chinesta, Bitor Santacoloma, Miguel Sanchez, Maria Teresa Sariñena, Marta Segura Pensado, Lidia Serra, Mireia Serra-Fortuny, Ainhoa Serrano Lázaro, Lluís Servià, Lorenzo Socias, Laura Soliva, Jordi Solé-Violan, Fernando Suarez Sipmann, Carla Speziale, Luis Tamayo Lomas, Adrián Tormos, Maria del Carmen de la Torre, Gerard Torres, Mateu Torres, Sandra Trefler, Josep Trenado, Javier Trujillano, Alejandro Úbeda, Luis Urrelo-Cerrón, Estela Val, Manuel Valledor, Luis Valdivia Ruiz, Montserrat Vallverdú, Maria Van der Hofstadt Martin-Montalvo, Sabela Vara Adrio, Nil Vázquez, Javier Vengoechea, Pablo Vidal, Clara Vilà-Vilardel, Judit Vilanova, Tatiana Villada Warrington, Hua Yang, Minlan Yang, Ana Zapatero

• Open Access
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Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials

Matthieu Legrand, Sean M. Bagshaw, Pavan K. Bhatraju, Azra Bihorac, Ellen Caniglia, Ashish K. Khanna, John A. Kellum, Jay Koyner, Michael O. Harhay, Fernando G. Zampieri, Alexander Zarbock, Kevin Chung, Kathleen Liu, Ravindra Mehta, Peter Pickkers, Abigail Ryan, Juliane Bernholz, Laura Dember, Martin Gallagher, Patrick Rossignol, Marlies Ostermann

• Open Access
• Intra-Aortic Balloon
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Intra-aortic balloon pump in patients undergoing VA-ECMO: an analysis of the Chinese Extracorporeal Life Support Registry

Liangshan Wang, Xing Hao, Chenglong Li, Haixiu Xie, Feng Yang, Hong Wang, Zhongtao Du, Xiaotong Hou

• Open Access
• Emergency Medicine
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Correction : Selected articles from the annual update in intensive care and emergency medicine 2020

• Open Access
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The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial

Adriana C. Panayi, Daren K. Heyland, Christian Stoppe, Marc G. Jeschke, Oliver Didzun, Dany Matar, Christian Tapking, Alen Palackic, Björn Bliesener, Leila Harhaus, Samuel Knoedler, Valentin Haug, Amir K. Bigdeli, Ulrich Kneser, Dennis P. Orgill, Gabriel Hundeshagen

• Open Access
• Acute Respiratory Distress Syndrome
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Breath metabolomics for diagnosis of acute respiratory distress syndrome

Shiqi Zhang, Laura A. Hagens, Nanon F. L. Heijnen, Marry R. Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel, Lieuwe D. J. Bos, Lieuwe D. J. Bos, Laura A. Hagens, Marcus J. Schultz, Marry R. Smit, Dennis C. J. J. Bergmans, Nanon F. L. Heijnen, Ronny M. Schnabel, Inge Geven, Tamara M. E. Nijsen, Alwin R. M. Verschueren

• Open Access
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Vascular leak in sepsis: physiological basis and potential therapeutic advances

Ross R. McMullan, Daniel F. McAuley, Cecilia M. O’Kane, Jonathan A. Silversides

• Open Access
• Septicemia
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Physical activity is associated with a lower risk of contracting and dying in infection and sepsis: a Swedish population-based cohort study

Karl Stattin, Mikael Eriksson, Robert Frithiof, Rafael Kawati, Michael Hultström, Miklos Lipcsey

• Open Access
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Association between intensive care unit nursing grade and mortality in patients with cardiogenic shock and its cost-effectiveness

Ki Hong Choi, Danbee Kang, Jin Lee, Hyejeong Park, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Juhee Cho, Jeong Hoon Yang

• Open Access
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Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

Hang Ruan, Qin Zhang, You-ping Zhang, Shu-sheng Li, Xiao Ran

• Open Access
• Acute Respiratory Distress Syndrome
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Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS

Antoine Guillon, Youenn Jouan, Arthur Kassa-Sombo, Christophe Paget, Pierre-François Dequin

• Open Access
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Quality of life-related and non-quality of life-related issues in ICU survivors and non-ICU-treated controls: a multi-group exploratory factor analysis

Johan Malmgren, Stefan Lundin, Ann-Charlotte Waldenström, Christian Rylander, Elias Johannesson

• Open Access
• CSF Drainage
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Response to commentary “The importance of assessing left ventricular longitudinal function in presence of increased afterload”

Hugues de Courson, Alexandre Loiseau, Grégoire Chadefaux, Matthieu Biais

• Open Access
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“NeuroVanguard”: a contemporary strategy in neuromonitoring for severe adult brain injury patients

Edith Elianna Rodriguez, Mario Zaccarelli, Elda Diletta Sterchele, Fabio Silvio Taccone

• Open Access
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The management of heart failure cardiogenic shock: an international RAND appropriateness panel

Stefan Williams, Antonis Kalakoutas, Segun Olusanya, Benedict Schrage, Guido Tavazzi, Anthony P. Carnicelli, Santiago Montero, Christophe Vandenbriele, Adriana Luk, Hoong Sern Lim, Sai Bhagra, Sascha C. Ott, Marta Farrero, Marc D. Samsky, Jamie L. W. Kennedy, Sounok Sen, Richa Agrawal, Penelope Rampersad, Amanda Coniglio, Federico Pappalardo, Christopher Barnett, Alastair G. Proudfoot

• Open Access
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Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study

Eline G. M. Cox, Bas C. T. van Bussel, Nerea Campillo Llamazares, Jan-Willem E. M. Sels, Marisa Onrust, Iwan C. C. van der Horst, Jacqueline Koeze, Geert Koster, Jacqueline Koeze, Renske Wiersema, Frederik Keus, Iwan C. C. van der Horst, Willem Dieperink, Marisa Onrust, Nynke van der Veen, Alexander Irk, Arlinde Roelofs, Leonie Tijsma, Eline Cox, Nerea Campillo Llamazares, Lesley Holzhauer

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Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients

Benjamin Coiffard, Jose Dianti, Irene Telias, Laurent J. Brochard, Arthur S. Slutsky, Jennifer Beck, Christer Sinderby, Niall D. Ferguson, Ewan C. Goligher

• Open Access
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Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study

Lynda K. Cameron, Lesedi Ledwaba-Chapman, Kieran Voong, Geeta Hampson, Lui G. Forni, Nina Seylanova, Dominic J. Harrington, Rosario Lim, Aneta Bociek, Wang Yanzhong, Marlies Ostermann

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GFAP point-of-care measurement for prehospital diagnosis of intracranial hemorrhage in acute coma

Sabina Zylyftari, Sebastian Luger, Kristaps Blums, Stephan Barthelmes, Sebastian Humm, Hannsjörg Baum, Stephan Meckel, Jörg Braun, Gregor Lichy, Andreas Heilgeist, Love-Preet Kalra, Christian Foerch

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Correction: Selected articles from the annual update in Intensive Care and Emergency Medicine 2021

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Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial

Armin Niklas Flinspach, Florian Jürgen Raimann, Philipp Kaiser, Michaela Pfaff, Kai Zacharowski, Vanessa Neef, Elisabeth Hannah Adam

• Open Access
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Effects of robotic-assisted early mobilization versus conventional mobilization in intensive care unit patients: prospective interventional cohort study with retrospective control group analysis

Lucas Huebner, Angelika Warmbein, Christina Scharf, Ines Schroeder, Kirsi Manz, Ivanka Rathgeber, Marcus Gutmann, Johanna Biebl, Amrei Mehler-Klamt, Jana Huber, Inge Eberl, Eduard Kraft, Uli Fischer, Michael Zoller

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Use of artificial intelligence in critical care: opportunities and obstacles

Michael R. Pinsky, Armando Bedoya, Azra Bihorac, Leo Celi, Matthew Churpek, Nicoleta J. Economou-Zavlanos, Paul Elbers, Suchi Saria, Vincent Liu, Patrick G. Lyons, Benjamin Shickel, Patrick Toral, David Tscholl, Gilles Clermont

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Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies

Madelief Bolscher, Stephanie C. E. Koster, Matty Koopmans, Jelle L. G. Haitsma Mulier, Lennie P. G. Derde, Nicole P. Juffermans

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Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study

Weizhuo Liu, Rongjiao Shao, Shen Zhang, Lei Jin, Rongchen Liu, Peidong Chen, Jintao Hu, Haocheng Ma, Bangwei Wu, Weiguo Liang, Xinping Luo, Jian Li, Weiming Chen, Nanqing Xiong, Bin He

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Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest

Isabelle Arctaedius, Helena Levin, Bergthóra Thorgeirsdóttir, Marion Moseby-Knappe, Tobias Cronberg, Martin Annborn, Niklas Nielsen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Attila Frigyesi, Hans Friberg, Anna Lybeck, Niklas Mattsson-Carlgren

• Open Access
• Chronic Obstructive Lung Disease
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Correction: Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort

Louis‑Marie Galerneau, Sebastien Bailly, Nicolas Terzi, Stephane Ruckly, Maite Garrouste‑Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean‑Marie Forel, Anais Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran‑Toledano, Virginie Laurent, Laurent Argaud, Jean Reignier, Jean‑Louis Pepin, Michael Darmon, Jean‑Francois Timsit

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Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images

Hsinhan Tsai, Chien-Yu Chi, Liang-Wei Wang, Yu-Jen Su, Ya-Fang Chen, Min-Shan Tsai, Chih-Hung Wang, Cheyu Hsu, Chien-Hua Huang, Weichung Wang

• Open Access
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Job description and perception of clinical research personnel working in a network of French intensive care units

Mireille Adda, Claire Dupuis, Gérald Gouby, Claude Dubray, Jean Reignier, Bertrand Souweine, Christian Dualé

• Open Access
• Septic Shock
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Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study

YiWen Fan, Jill Moser, Matijs van Meurs, Dorien Kiers, Jannie Marie Bülow Sand, Diana Julie Leeming, Peter Pickkers, Janette K. Burgess, Matthijs Kox, Janesh Pillay

• Open Access
• Correction

Correction to: Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study

Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizio Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao, Rajesh Mishra

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Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis

Lujia Zhang, Jiahuan Xu, Yue Li, Fanqi Meng, Wei Wang

• Open Access
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Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis

Milo Gatti, Pier Giorgio Cojutti, Federico Pea

• Open Access
• Acute Respiratory Distress Syndrome
• Brief Report

Contribution of electrical impedance tomography to personalize positive end-expiratory pressure under ECCO2R

Benjamin Pequignot, Alain Combes, Mickael Lescroart, Bruno Levy, Matthieu Koszutski

• Open Access
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Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial

Daniel Rob, Klaudia Farkasovska, Marketa Kreckova, Ondrej Smid, Petra Kavalkova, Jaromir Macoun, Michal Huptych, Petra Havrankova, Juraj Gallo, Jan Pudil, Milan Dusik, Stepan Havranek, Ales Linhart, Jan Belohlavek

• Open Access
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Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: be aware of the temporal selection bias

Romain Jouffroy, Anne-Cécile Vie, Benoît Vivien

• Open Access
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Significance of critical closing pressures (starling resistors) in arterial circulation

Michael R. Pinsky, M. Ignacio Monge García, Arnaldo Dubin

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Policy framework for the utilization of generative AI

Kunming Cheng, Haiyang Wu

• Open Access
• Acute Respiratory Distress Syndrome
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Time-dependent effect of prone position in ARDS: considerations for future research

Yuxian Wang, Ming Zhong

• Open Access
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ACE inhibitors and angiotensin receptor blockers differentially alter the response to angiotensin II treatment in vasodilatory shock

Daniel E. Leisman, Damian R. Handisides, Laurence W. Busse, Mark C. Chappell, Lakhmir S. Chawla, Michael R. Filbin, Marcia B. Goldberg, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges, Rinaldo Bellomo

• Open Access
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Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis

Keyvan Razazi, Charles-Edouard Luyt, Guillaume Voiriot, Anahita Rouzé, Marc Garnier, Alexis Ferré, Laurent Camous, Nicholas Heming, Nathanaël Lapidus, Anais Charles-Nelson, Armand Mekontso-Dessap, Alain Mercat, Pierre Asfar, François Beloncle, Julien Demiselle, Tài Pham, Arthur Pavot, Xavier Monnet, Christian Richard, Alexandre Demoule, Martin Dres, Julien Mayaux, Alexandra Beurton, Cédric Daubin, Richard Descamps, Aurélie Joret, Damien Du Cheyron, Frédéric Pene, Jean-Daniel Chiche, Mathieu Jozwiak, Paul Jaubert, Guillaume Voiriot, Muriel Fartoukh, Marion Teulier, Clarisse Blayau, Erwen L’Her, Cécile Aubron, Laetitia Bodenes, Nicolas Ferriere, Johann Auchabie, Anthony Le Meur, Sylvain Pignal, Thierry Mazzoni, Jean-Pierre Quenot, Pascal Andreu, Jean-Baptiste Roudau, Marie Labruyère, Saad Nseir, Sébastien Preau, Julien Poissy, Daniel Mathieu, Sarah Benhamida, Rémi Paulet, Nicolas Roucaud, Martial Thyrault, Florence Daviet, Sami Hraiech, Gabriel Parzy, Aude Sylvestre, Sébastien Jochmans, Anne-Laure Bouilland, Mehran Monchi, Marc Danguy des Déserts, Quentin Mathais, Gwendoline Rager, Pierre Pasquier, Jean Reignier, Amélie Seguin, Charlotte Garret, Emmanuel Canet, Jean Dellamonica, Clément Saccheri, Romain Lombardi, Yanis Kouchit, Sophie Jacquier, Armelle Mathonnet, Mai-Ahn Nay, Isabelle Runge, Frédéric Martino, Laure Flurin, Amélie Rolle, Michel Carles, Rémi Coudroy, Arnaud W. Thille, Jean-Pierre Frat, Maeva Rodriguez, Pascal Beuret, Audrey Tientcheu, Arthur Vincent, Florian Michelin, Fabienne Tamion, Dorothée Carpentier, Déborah Boyer, Christophe Girault, Valérie Gissot, Stéphan Ehrmann, Charlotte Salmon Gandonniere, Djlali Elaroussi, Agathe Delbove, Yannick Fedun, Julien Huntzinger, Eddy Lebas, Grâce Kisoka, Céline Grégoire, Stella Marchetta, Bernard Lambermont, Laurent Argaud, Thomas Baudry, Pierre-Jean Bertrand, Auguste Dargent, Christophe Guitton, Nicolas Chudeau, Mickaël Landais, Cédric Darreau, Alexis Ferré, Antoine Gros, Guillaume Lacave, Fabrice Bruneel, Mathilde Neuville, Jérôme Devaquet, Guillaume Tachon, Richard Gallot, Riad Chelha, Arnaud Galbois, Anne Jallot, Ludivine Chalumeau Lemoine, Khaldoun Kuteifan, Valentin Pointurier, Louise-Marie Jandeaux, Joy Mootien, Charles Damoisel, Benjamin Sztrymf, Matthieu Schmidt, Alain Combes, Juliette Chommeloux, Charles Edouard Luyt, Frédérique Schortgen, Leon Rusel, Camille Jung, Florent Gobert, Damien Vimpere, Lionel Lamhaut, Bertrand Sauneuf, Liliane Charrrier, Julien Calus, Isabelle Desmeules, Benoît Painvin, Jean-Marc Tadie, Vincent Castelain, Baptiste Michard, Jean-Etienne Herbrecht, Mathieu Baldacini, Nicolas Weiss, Sophie Demeret, Clémence Marois, Benjamin Rohaut, Pierre-Henri Moury, Anne-Charlotte Savida, Emmanuel Couadau, Mathieu Série, Nica Alexandru, Cédric Bruel, Candice Fontaine, Sonia Garrigou, Juliette Courtiade Mahler, Maxime Leclerc, Michel Ramakers, Pierre Garçon, Nicole Massou, Ly Van Vong, Juliane Sen, Nolwenn Lucas, Franck Chemouni, Annabelle Stoclin, Alexandre Avenel, Henri Faure, Angélie Gentilhomme, Sylvie Ricome, Paul Abraham, Céline Monard, Julien Textoris, Thomas Rimmele, Florent Montini, Gabriel Lejour, Thierry Lazard, Isabelle Etienney, Younes Kerroumi, Claire Dupuis, Marine Bereiziat, Elisabeth Coupez, François Thouy, Clément Hofmann, Nicolas Donat, Anne Chrisment, Rose-Marie Blot, Antoine Kimmoun, Audrey Jacquot, Matthieu Mattei, Bruno Levy, Ramin Ravan, Loïc Dopeux, Jean-Mathias Liteaudon, Delphine Roux, Brice Rey, Radu Anghel, Deborah Schenesse, Vincent Gevrey, Jermy Castanera, Philippe Petua, Benjamin Madeux, Otto Hartman, Michael Piagnerelli, Anne Joosten, Cinderella Noel, Patrick Biston, Thibaut Noel, Gurvan L. 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Bouar, Messabi Boukhanza, Elsa Demarest, Marie-France Bajolet, Nathanaël Charrier, Audrey Quenet, Cécile Zylberfajn, Nicolas Dufour, Bruno Mégarbane, Sébastian Voicu, Nicolas Deye, Isabelle Malissin, François Legay, Matthieu Debarre, Nicolas Barbarot, Pierre Fillatre, Bertrand Delord, Thomas Laterrade, Tahar Saghi, Wilfried Pujol, Pierre Julien Cungi, Pierre Esnault, Mickael Cardinale, Vivien Hong Tuan Ha, Grégory Fleury, Marie-Ange Brou, Daniel Zafmahazo, David Tran-Van, Patrick Avargues, Lisa Carenco, Nicolas Robin, Alexandre Ouali, Lucie Houdou, Christophe Le Terrier, Noémie Suh, Steve Primmaz, Jérome Pugin, Emmanuel Weiss, Tobias Gauss, Jean-Denis Moyer, Catherine Paugam Burtz, Béatrice La Combe, Rolland Smonig, Jade Violleau, Pauline Cailliez, Jonathan Chelly, Antoine Marchalot, Cécile Saladin, Christelle Bigot, Pierre-Marie Fayolle, Jules Fatséas, Amr Ibrahim, Dabor Resiere, Rabih Hage, Clémentine Cholet, Marie Cantier, Pierre Trouiler, Philippe Montravers, Brice Lortat-Jacob, Sebastien Tanaka, Alexy Tran Dinh, Jacques Duranteau, Anatole Harrois, Guillaume Dubreuil, Marie Werner, Anne Godier, Sophie Hamada, Diane Zlotnik, Hélène Nougue, Armand Mekontso-Dessap, Guillaume Carteaux, Keyvan Razazi, Nicolas de Prost, Nicolas Mongardon, Nicolas Mongardon, Meriam Lamraoui, Claire Alessandri, Quentin de Roux, Charles de Roquetaillade, Benjamin G. Chousterman, Alexandre Mebazaa, Etienne Gayat, Marc Garnier, Emmanuel Pardo, Lea Satre-Buisson, Christophe Gutton, Elise Yvin, Clémence Marcault, Elie Azoulay, Michael Darmon, Hafid Ait Oufella, Geofroy Hariri, Tomas Urbina, Sandie Mazerand, Nicholas Heming, Francesca Santi, Pierre Moine, Djillali Annane, Adrien Bouglé, Edris Omar, Aymeric Lancelot, Emmanuelle Begot, Gaétan Plantefeve, Damien Contou, Hervé Mentec, Olivier Pajot, Stanislas Faguer, Olivier Cointault, Laurence Lavayssiere, Marie-Béatrice Nogier, Matthieu Jamme, Claire Pichereau, Jan Hayon, Hervé Outin, François Dépret, Maxime Coutrot, Maité Chaussard, Lucie Guillemet, Pierre Gofn, Romain Thouny, Julien Guntz, Laurent Jadot, Romain Persichini, Vanessa Jean-Michel, Hugues Georges, Thomas Caulier, Gaël Pradel, Marie-Hélène Hausermann, Thi My Hue Nguyen-Valat, Michel Boudinaud, Emmanuel Vivier, Sylvène Rosseli, Gaël Bourdin, Christian Pommier, Marc Vinclair, Simon Poignant, Sandrine Mons, Wulfran Bougouin, Franklin Bruna, Quentin Maestraggi, Christian Roth, Laurent Bitker, François Dhelft, Justine Bonnet-Chateau, Mathilde Filippelli, Tristan Morichau-Beauchant, Stéphane Thierry, Charlotte Le Roy, Mélanie Saint Jouan, Bruno Goncalves, Aurélien Mazeraud, Matthieu Daniel, Tarek Sharshar, Cyril Cadoz, Rostane Gaci, Sébastien Gette, Guillaune Louis, Sophie-Caroline Sacleux, Marie-Amélie Ordan, Aurélie Cravoisy, Marie Conrad, Guilhem Courte, Sébastien Gibot, Younès Benzidi, Claudia Casella, Laurent Serpin, Jean-Lou Setti, Marie-Catherine Besse, Anna Bourreau, Jérôme Pillot, Caroline Rivera, Camille Vinclair, Marie-Aline Robaux, Chloé Achino, Marie-Charlotte Delignette, Tessa Mazard, Frédéric Aubrun, Bruno Bouchet, Aurélien Frérou, Laura Muller, Charlotte Quentin, Samuel Degoul, Xavier Stihle, Claude Sumian, Nicoletta Bergero, Bernard Lanaspre, Hervé Quintard, Eve Marie Maiziere, Pierre-Yves Egreteau, Guillaume Leloup, Florin Berteau, Marjolaine Cottrel, Marie Bouteloup, Matthieu Jeannot, Quentin Blanc, Julien Saison, Isabelle Geneau, Romaric Grenot, Abdel Ouchike, Pascal Hazera, Anne-Lyse Masse, Suela Demiri, Corinne Vezinet, Elodie Baron, Deborah Benchetrit, Antoine Monsel, Grégoire Trebbia, Emmanuelle Schaack, Raphaël Lepecq, Mathieu Bobet, Christophe Vinsonneau, Thibault Dekeyser, Quentin Delforge, Imen Rahmani, Bérengère Vivet, Jonathan Paillot, Lucie Hierle, Claire Chaignat, Sarah Valette, Benoït Her, Jennifer Brunet, Mathieu Page, Fabienne Boiste, Anthony Collin, Florent Bavozet, Aude Garin, Mohamed Dlala, Kais Mhamdi, Bassem Beilouny, Alexandra Lavalard, Severine Perez, Benoit Veber, Pierre-Gildas Guitard, Philippe Gouin, Anna Lamacz, Fabienne Plouvier, Bertrand P. Delaborde, Aïssa Kherchache, Amina Chaalal, Jean-Damien Ricard, Marc Amouretti, Santiago Freita-Ramos, Damien Roux, Jean-Michel Constantin, Mona Assef, Marine Lecore, Agathe Selves, Florian Prevost, Christian Lamer, Ruiying Shi, Lyes Knani, Sébastien Pili Floury, Lucie Vettoretti, Michael Levy, Lucile Marsac, Stéphane Dauger, Sophie Guilmin-Crépon, Hadrien Winiszewski, Gael Piton, Thibaud Soumagne, Gilles Capellier, Jean-Baptiste Putegnat, Frédérique Bayle, Maya Perrou, Ghyslaine Thao, Guillaume Géri, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron, Mathieu Guilbart, Pierre-Alexandre Roger, Sébastien Hinard, Pierre-Yves Macq, Kevin Chaulier, Sylvie Goutte, Patrick Chillet, Anaïs Pitta, Barbara Darjent, Amandine Bruneau, Sigismond Lasocki, Maxime Leger, Soizic Gergaud, Pierre Lemarie, Nicolas Terzi, Carole Schwebel, Anaïs Dartevel, Louis-Marie Galerneau, Jean-Luc Diehl, Caroline Hauw-Berlemont, Nicolas Péron, Emmanuel Guérot, Abolfazl Mohebbi Amoli, Michel Benhamou, Jean-Pierre Deyme, Olivier Andremont, Diane Lena, Julien Cady, Arnaud Causeret, Arnaud De La Chapelle, Christophe Cracco, Stéphane Rouleau, David Schnell, Camille Foucault, Cécile Lory, Thibault Chapelle, Vincent Bruckert, Julie Garcia, Abdlazize Sahraoui, Nathalie Abbosh, Caroline Bornstain, Pierre Pernet, Florent Poirson, Ahmed Pasem, Philippe Karoubi, Virginie Poupinel, Caroline Gauthier, François Bouniol, Philippe Feuchere, Florent Bavozet, Anne Heron, Serge Carreira, Malo Emery, Anne Sophie Le Floch, Luana Giovannangeli, Nicolas Herzog, Christophe Giacardi, Thibaut Baudic, Chloé Thill, Said Lebbah, Jessica Palmyre, Florence Tubach, David Hajage, Nicolas Bonnet, Nathan Ebstein, Stéphane Gaudry, Yves Cohen, Julie Noublanche, Olivier Lesieur, Arnaud Sément, Isabel Roca-Cerezo, Michel Pascal, Nesrine Sma, Gwenhaël Colin, Jean-Claude Lacherade, Gauthier Bionz, Natacha Maquigneau, Pierre Bouzat, Michel Durand, Marie-Christine Hérault, Jean-Francois Payen

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Rapidly improving ARDS differs clinically and biologically from persistent ARDS

Patricia L. Valda Toro, Andrew Willmore, Nelson E. Wu, Kevin L. Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D. Liu, Carolyn M. Hendrickson, Aartik Sarma, Lucile P. A. Neyton, Aleksandra Leligdowicz, Charles R. Langelier, Hanjing Zhuo, Chayse Jones, Kirsten N. Kangelaris, Antonio D. Gomez, Michael A. Matthay, Carolyn S. Calfee

• Open Access
• Acute Respiratory Distress Syndrome
• Brief Report

Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes

Sébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Adrian Camino, Alexandre Massri, Laurent Villeneuve, Cédric Carrié, Laurent Petit, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes, Renaud Prével

• Open Access
• Cytokines
• Brief Report

Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure

Kazuki Sudo, Mao Kinoshita, Ken Kawaguchi, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Masaki Yamasaki, Tasuku Matsuyama, Kunihiko Kooguchi, Yasuo Takashima, Masami Tanaka, Kazumichi Matsumoto, Kei Tashiro, Tohru Inaba, Bon Ohta, Teiji Sawa

• Open Access
• Matters Arising

Transforming research to improve therapies for trauma in the twenty-first century: an alternative perspective

Geoffrey P. Dobson, Jodie L. Morris, Hayley L. Letson

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome

Elias Baedorf-Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M. Goodspeed, Michael A. Matthay, Michelle N. Gong, Deborah Cook, Stephen H. Loring, Daniel Talmor, Jeremy R. Beitler, Daniel Talmor, Todd Sarge, Valerie Goodspeed, Emily Fish, Sayuri Jinadasa, Ray Ritz, Joseph Previtera, Michelle N. Gong, Lawrence Lee, Jeremy R. Beitler, Deborah Cook, France Clarke, Tom Piraino, Joseph Levitt, Rosemary Vojnik, Pauline Park, Kristin Brierley, Carl Haas, Andrew Weirauch, Eddy Fan, Andrea Matte, R. Scott Harris, Mamary Kone, Stephen Heard, Karen Longtine, Franćois Lellouche, Pierre-Alexandre Bouchard, Lewis Rubinson, Jennifer McGrain, Donald E. G. Griesdale, Denise Foster, Richard Oeckler, Amy Amsbaugh, Edgar Jimenez, Valerie Danesh

• Open Access
• Neuromonitoring
• Matters Arising

Adapting NeuroVanguard to real-world challenges

Andres Giglio, Monserrat Pino, Andres Ferre, Andres Reccius

• Open Access
• Magnetic Resonance Imaging
• Research

Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal–external validation study

Jung A Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Jun Ahn, Hye Seon Jeong, Yong Hwan Kim, Byung Kook Lee, Dongha Kim

• Open Access
• ECMO
• Matters Arising

Beta-blockade in V-V ECMO

Aravind K. Bommiasamy, Bishoy Zakhary, Ran Ran

• Open Access
• Comment

Fluid responsiveness and venous congestion: unraveling the nuances of fluid status

Adrien Joseph, Matthieu Petit, Philippe Vignon, Antoine Vieillard-Baron

• Open Access
• Acute Respiratory Distress Syndrome
• Perspective

Stress & strain in mechanically nonuniform alveoli using clinical input variables: a simple conceptual model

John J. Marini, Patricia R. M. Rocco, Lauren T. Thornton, Philip S. Crooke

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Clinical validation of a capnodynamic method for measuring end-expiratory lung volume in critically ill patients

J. A. Sanchez Giralt, G. Tusman, M. Wallin, M. Hallback, A. Perez Lucendo, M. Sanchez Galindo, B. Abad Santamaria, E. Paz Calzada, P. Garcia Garcia, D. Rodriguez Huerta, A. Canabal Berlanga, Fernando Suarez-Sipmann

• Open Access
• Morphine
• Research

Intermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial

Gerdien Zeilmaker-Roest, Christine de Vries-Rink, Joost van Rosmalen, Monique van Dijk, Saskia N. de Wildt, Catherijne A. J. Knibbe, Erik Koomen, Nicolaas J. G. Jansen, Martin C. J. Kneyber, Sofie Maebe, Greet Van den Berghe, Renata Haghedooren, Dirk Vlasselaers, Ad J. J. C. Bogers, Dick Tibboel, Enno D. Wildschut

• Open Access
• Research

Assessing the safety of physical rehabilitation in critically ill patients: a Delphi study

Huw R. Woodbridge, Christopher J. McCarthy, Mandy Jones, Matthew Willis, David B. Antcliffe, Caroline M. Alexander, Anthony C. Gordon

• Open Access
• Research

The effectiveness of a brief intervention for intensive care unit patients with hazardous alcohol use: a randomized controlled trial

Eliisa Nissilä, Marja Hynninen, Ville Jalkanen, Anne Kuitunen, Minna Bäcklund, Outi Inkinen, Johanna Hästbacka

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis

Alexandra-Maria Stommel, Harald Herkner, Calvin Lukas Kienbacher, Brigitte Wildner, Alexander Hermann, Thomas Staudinger

• Open Access
• COVID-19
• Matters Arising

Bias caused by sample selection for lower respiratory tract microbiome research

Mingqiang Wang, Xiaojie Li

• Open Access
• Septicemia
• Research

Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000–2022: a binational cohort study

Aleece MacPhail, Claire Dendle, Monica Slavin, Robert Weinkove, Michael Bailey, David Pilcher, Zoe McQuilten

• Open Access
• Artificial Intelligence
• Correspondence

Generative artificial intelligence is infiltrating peer review process

Kunming Cheng, Zaijie Sun, Xiaojun Liu, Haiyang Wu, Cheng Li

• Open Access
• Cardiopulmonary Resuscitation
• Research

Critical care outcomes in decompensated cirrhosis: a United States national inpatient sample cross-sectional study

Spencer R. Goble, Abdellatif S. Ismail, Jose D. Debes, Thomas M. Leventhal

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study

Marleen A. Slim, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Olaf L. Cremer, Friso M. de Beer, Lieuwe D. J. Bos, Gerie J. Glas, Arie J. Hoogendijk, Roosmarijn T. M. van Hooijdonk, Janneke Horn, Mischa A. Huson, Laura R. A. Schouten, Marcus J. Schultz, Brendon P. Scicluna, Marleen Straat, Lonneke A. van Vught, Luuk Wieske, Maryse A. Wiewel, Esther Witteveen. Marc J. M. Bonten, Olaf M. Cremer, David S. Y. Ong, Jos F. Frencken, Peter M. C. Klein Klouwenberg, Maria E. Koster‐Brouwer, Kirsten van de Groep, Diana M. Verboom, W. Joost Wiersinga, Tom van der Poll, Lonneke A. van Vught

• Open Access
• Non-Invasive Ventilation
• Research

Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis

Tommaso Pettenuzzo, Annalisa Boscolo, Elisa Pistollato, Chiara Pretto, Tommaso Antonio Giacon, Sara Frasson, Francesco Maria Carbotti, Francesca Medici, Giovanni Pettenon, Giuliana Carofiglio, Marco Nardelli, Nicolas Cucci, Clara Letizia Tuccio, Veronica Gagliardi, Chiara Schiavolin, Caterina Simoni, Sabrina Congedi, Francesco Monteleone, Francesco Zarantonello, Nicolò Sella, Alessandro De Cassai, Paolo Navalesi

• Open Access
• Intracranial Hypertension
• Matters Arising

The neurovanguard concept and real-world embracement

Fabio Silvio Taccone, Edith Elianna Rodriguez, Mario Zaccarelli, Elda Diletta Sterchele

• Open Access
• Perspective

Past, present, and future of sustainable intensive care: narrative review and a large hospital system experience

Faisal N. Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E. Gooch, Konya Keeling-Johnson, Jukrin Moon, Jean-Louis Vincent

• Open Access
• Pneumonia
• Correspondence

Extent of microbial over-identification of endotracheal aspirate versus bronchoalveolar lavage in the diagnosis of ventilator-associated pneumonia

Alessandra Bisanti, Valentina Giammatteo, Giuseppe Bello, Domenico Luca Grieco, Gennaro De Pascale, Massimo Antonelli

• Open Access
• Acute Kidney Injury
• Research

Machine learning derived serum creatinine trajectories in acute kidney injury in critically ill patients with sepsis

Kullaya Takkavatakarn, Wonsuk Oh, Lili Chan, Ira Hofer, Khaled Shawwa, Monica Kraft, Neomi Shah, Roopa Kohli-Seth, Girish N. Nadkarni, Ankit Sakhuja

• Open Access
• Research

Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation

Ricard Mellado-Artigas, Xavier Borrat, Bruno L. Ferreyro, Christopher Yarnell, Sicheng Hao, Kerollos N. Wanis, Enric Barbeta, Antoni Torres, Carlos Ferrando, Laurent Brochard

• Open Access
• ECMO
• Research

Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis

Ali Ait Hssain, Amir Vahedian-Azimi, Abdulsalam Saif Ibrahim, Ibrahim Fawzy Hassan, Elie Azoulay, Michael Darmon

• Open Access
• Incretin Mimetics
• Correspondence

Potential implications of long-acting GLP-1 receptor agonists for critically ill

Luping Wang, Hao Yang, Xiaoxiao Xia, Bo Wang, Qin Wu

• Open Access
• Brain Death
• Research

Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study

Tetsuya Yumoto, Kohei Tsukahara, Takafumi Obara, Takashi Hongo, Tsuyoshi Nojima, Hiromichi Naito, Atsunori Nakao

• Open Access
• Antibiotic
• Matters Arising

qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in emergency department: a bit sweet and a bit sour randomized controlled trial

Bharat Paliwal, Nikhil Kothari, Trishita Saha, Pradeep Bhatia

• Open Access
• Urinary Tract Infection
• Research

Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial

Xingsong Qin, He Zhao, Wei Qin, Xinglei Qin, Songying Shen, Hongyu Wang

• Open Access
• Intracranial Hypertension
• Research

Predicting outcome after aneurysmal subarachnoid hemorrhage by exploitation of signal complexity: a prospective two-center cohort study

Stefan Yu Bögli, Ihsane Olakorede, Michael Veldeman, Erta Beqiri, Miriam Weiss, Gerrit Alexander Schubert, Jan Folkard Willms, Emanuela Keller, Peter Smielewski

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis

Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Kathleen D. Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V. Eric Kerchberger, Ann Zalucky, Michael A. Matthay, Lorraine B. Ware, Carolyn S. Calfee

• Open Access
• Acute Respiratory Distress Syndrome
• Review

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie, Ahmed H. Al Sharie, Denise Battaglini, Chiara Robba, John J. Marini, Lauren T. Thornton, Fernanda F. Cruz, Pedro L. Silva, Patricia R. M. Rocco

• Open Access
• Septic Shock
• Research

Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial

Anja Lindén, M. Spångfors, M. H. Olsen, J. Fisher, G. Lilja, F. Sjövall, M. Jungner, M. Lengquist, T. Kander, L. Samuelsson, J. Johansson, E. Palmnäs, J. Undén, J. Oras, M. Cronhjort, M. Chew, A. Linder, M. Lipcsey, N. Nielsen, J. C. Jakobsen, P. Bentzer, Jane Fisher, Maria Nelderup, Lisa Hassel, Eva Johnsson, Camilla Claesson, Anna Lybeck, Susann Schrey, Linda K. Andersson, Sandra Holmström, Marina Larsson, Katarina Bramell, Karin Aspholm, Karin Olne, Hanna Larsson, Miklos Lipscey, Region Skåne, Niklas Nielsen

• Open Access
• Addiction
• Matters Arising

Challenging ICU dogmas: a new perspective on venous congestion and preload dependency

Pierre-Grégoire Guinot, Dan Longrois

• Open Access
• Shock
• Research

Development and validation of the tic score for early detection of traumatic coagulopathy upon hospital admission: a cohort study

Louis Brac, Albrice Levrat, Charles-Hervé Vacheron, Pierre Bouzat, Tristan Delory, Jean-Stéphane David

• Open Access
• Acute Kidney Injury
• Research

Acute kidney injury after out-of-hospital cardiac arrest

Karoline Korsholm Jeppesen, Sebastian Buhl Rasmussen, Jesper Kjaergaard, Henrik Schmidt, Simon Mølstrøm, Rasmus Paulin Beske, Johannes Grand, Hanne Berg Ravn, Matilde Winther-Jensen, Martin Abild Stengaard Meyer, Christian Hassager, Jacob Eifer Møller

• Open Access
• Central Nervous System Trauma
• Guideline

Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations

Andrea Lavinio, Jonathan P. Coles, Chiara Robba, Marcel Aries, Pierre Bouzat, Dara Chean, Shirin Frisvold, Laura Galarza, Raimund Helbok, Jeroen Hermanides, Mathieu van der Jagt, David K. Menon, Geert Meyfroidt, Jean-Francois Payen, Daniele Poole, Frank Rasulo, Jonathan Rhodes, Emily Sidlow, Luzius A. Steiner, Fabio Silvio Taccone, Riikka Takala

• Open Access
• Obesity
• Research

Expiratory flow limitation during mechanical ventilation: real-time detection and physiological subtypes

Detajin Junhasavasdikul, Akarawut Kasemchaiyanun, Tanakorn Tassaneyasin, Tananchai Petnak, Frank Silva Bezerra, Ricard Mellado‐Artigas, Lu Chen, Yuda Sutherasan, Pongdhep Theerawit, Laurent Brochard

• Open Access
• Central Nervous System Trauma
• Research

Assessing the impact of early progressive mobilization on moderate-to-severe traumatic brain injury: a randomized controlled trial

Hsiao-Ching Yen, Hung-Jui Chuang, Wei-Ling Hsiao, Yun-Chen Tsai, Po-Min Hsu, Wen-Shiang Chen, Yin-Yi Han

• Open Access
• Cerebral Ischemia
• Research

Prognostic value of early EEG abnormalities in severe stroke patients requiring mechanical ventilation: a pre-planned analysis of the SPICE prospective multicenter study

Sarah Benghanem, Nathalie Kubis, Etienne Gayat, Ambre Loiodice, Estelle Pruvost-Robieux, Tarek Sharshar, Arnaud Foucrier, Samy Figueiredo, Viviane Bouilleret, Etienne De Montmollin, François Bagate, Jean-Pascal Lefaucheur, Bertrand Guidet, Emmanuelle Appartis, Alain Cariou, Olivier Varnet, Paul Henri Jost, Bruno Megarbane, Vincent Degos, Loic Le Guennec, Lionel Naccache, Stephane Legriel, France Woimant, Charles Gregoire, David Cortier, Isabelle Crassard, Jean-François Timsit, Mikael Mazighi, Romain Sonneville, Tiare Ader, Eric Barré, Hélène Bout, Perrine Boursin, Eric Bodiguel, Damien Bresson, Omar Ben Hadj Salem, Alain Combes, Anne Chrisment, Magalie Collet, Jacque Duranteau, Sophie Crozier, Daniel da Silva, Amexandre Demoule, Maxens Decavele, Eric Delpierre, Jean Luc Diehl, Martin Dres, Frédéric Faugeras, Marie-Céline Fournier, Tobias Gauss, Coralie Gernez, Guillaume Geri, Dominique Hurel, Matthieu Jamme, Laurence Josse, Igor Jurcisin, Lionel Kerhuel, Catherine Lamy, Fariza Lamara, Aymeric Lancelot, Bertrand Lapergue, Christophe Lenclud, Mathilde Lermuzeaux, Eric Magalhaes, Eric Mariotte, Isabelle Malissin, Alain Maldjian, Nathalie Marin, Jérôme Martin, Thibault Martinez, Armand Mekontso Dessap, Mehran Monchi, Giulia Naim, Hervé Outin, David Osman, Gregory Papin, Pierre Pasquier, Claire Pichereau, Matthieu Pissot, Keyvan Razazi, Danielle Reuter, Christian Richard, Stephane Ruckly, Damien Roux, Caroline Schimpf, Quentin Staiquly, Jérôme Servan, Sebastien Tanaka, Laurie-Anne Thion, Karim Toumert, Widad Traki, Marc Tran, Philippe Vassel, Bernard Vigué, Daniel Zafimahazo, Jonathan Zarka

• Open Access
• Dyspnea
• Research

Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure

Alexandre Demoule, Amandine Baptiste, Arnaud W. Thille, Thomas Similowski, Stephanie Ragot, Gwénael Prat, Alain Mercat, Christophe Girault, Guillaume Carteaux, Thierry Boulain, Sébastien Perbet, Maxens Decavèle, Lisa Belin, Jean-Pierre Frat

• Open Access
• Acute Kidney Injury
• Matters Arising

Vitamin D metabolism in critically ill patients with acute kidney injury: not a sole player

Alexandre Braga Libório

• Open Access
• Research

Prompt antimicrobial therapy and source control on survival and defervescence of adults with bacteraemia in the emergency department: the faster, the better

Ching-Chi Lee, Po-Lin Chen, Ching-Yu Ho, Ming-Yuan Hong, Yuan-Pin Hung, Wen-Chien Ko

• Open Access
• Acute Respiratory Distress Syndrome
• Review

Transpulmonary pressure monitoring in critically ill patients: pros and cons

Lorenzo Ball, Daniel Talmor, Paolo Pelosi

• Open Access
• Cytokines
• Matters Arising

The phenomenon of desorption: What are the best adsorber exchange intervals?

Alix Buhlmann, Rolf Erlebach, Mattia Müller, Sascha David, Eva-Maria Kleinert, Rolf Erlebach, Rea Andermatt, Daniel Andrea Hofmaenner, Mattia Mueller, Reto Schuepbach, Pedro David Wendel-Garcia, Christoph Camille Ganter, Klaus Stahl, Tobias Welte, Thorben Pape, Ann-Kathrin Rath, Bahar Nalbant, Jannik Ruwisch, Christian Bode, Benjamin Seeliger, Christian Putensen, Konrad Peukert, Andrea Sauer, Lennart Wild

• Open Access
• Acute Respiratory Distress Syndrome
• Review

Exploring the lung-gut direction of the gut-lung axis in patients with ARDS

Mairi Ziaka, Aristomenis Exadaktylos

• Open Access
• Septicemia
• Review

A scoping review of machine learning for sepsis prediction- feature engineering strategies and model performance: a step towards explainability

Sherali Bomrah, Mohy Uddin, Umashankar Upadhyay, Matthieu Komorowski, Jyoti Priya, Eshita Dhar, Shih-Chang Hsu, Shabbir Syed-Abdul

• Open Access
• Research

Triggers of intensive care patients with palliative care needs from nurses’ perspective: a mixed methods study

Manuela Schallenburger, Jacqueline Schwartz, Andrea Icks, Jürgen in der Schmitten, Yann-Nicolas Batzler, Stefan Meier, Miguel Mendez-Delgado, Theresa Tenge, Martin Neukirchen

• Open Access
• Human Cytomegalovirus
• Matters Arising

Comment to "Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis"

Zhihui Zhang, Xuesong Liu, Rong Zhang, Yimin Li, Xiaoqing Liu

• Open Access
• Septicemia
• Review

Towards personalized medicine: a scoping review of immunotherapy in sepsis

Marleen A. Slim, Niels van Mourik, Lieke Bakkerus, Katherine Fuller, Lydia Acharya, Tatiana Giannidis, Joanna C. Dionne, Simon J. W. Oczkowski, Mihai G. Netea, Peter Pickkers, Evangelos J. Giamarellos-Bourboulis, Marcella C. A. Müller, Tom van der Poll, W. Joost Wiersinga, Bart-Jan Kullberg, Aline Nooijer, Frank Veerdonk, Jaap Oever, Jacobien Hoogerwerf, Marlies Hulscher, Mihai Netea, Anke Oerlemans, Athanasios Ziogas, Julie Swillens, Lisa Berg, Nynke Bos, Matthijs Kox, Leda Estratiou, Evangelos Giamarellos-Bourboulis, Antigoni Kotsaki, Antonakos Nikolaos, Gregoriadis Spyros, Thierry Calandra, Sylvain Meylan, Tiia Snaka, Thierry Roger, Michael Bauer, Frank Brunkhorst, Frank Bloos, Sebastian Weis, Willy Hartman, Marleen Slim, Lonneke Vught, Alexander Vlaar, Marcela Muller, Joost Wiersinga, Mihaela Lupse, Grigore Santamarean, Thomas Rimmele, Filippo Conti, Guillaume Monneret, Anna Aschenbrenner, Joachim Schultze, Martina Uelft, Christoph Bock, Robert terHorst, Irit Gat-Viks, Einat Ron, Gal Yunkovitz, Sophie Ablott, Estelle Peronnet, Margaux Balezeaux, Adrien Saliou, Julie Hart, Alexander P. J. Vlaar, Lonneke A. van Vught

• Open Access
• Research

Composite outcome measures in high-impact critical care randomised controlled trials: a systematic review

Humphrey G. M. Walker, Alastair J. Brown, Ines P. Vaz, Rebecca Reed, Max A. Schofield, Jeffrey Shao, Vinodh B. Nanjayya, Andrew A. Udy, Toby Jeffcote

• Open Access
• Ceftriaxone
• Research

Biological effects of corticosteroids on pneumococcal pneumonia in Mice—translational significance

Hiroki Taenaka, Katherine D. Wick, Aartik Sarma, Shotaro Matsumoto, Rajani Ghale, Xiaohui Fang, Mazharul Maishan, Jeffrey E. Gotts, Charles R. Langelier, Carolyn S. Calfee, Michael A. Matthay

• Open Access
• Septicemia
• Review

Biological basis of critical illness subclasses: from the bedside to the bench and back again

Joseph Stevens, Oğuzhan Tezel, Valentina Bonnefil, Matthew Hapstack, Mihir R. Atreya

• Open Access
• Septicemia
• Research

The association of arterial partial oxygen pressure with mortality in critically ill sepsis patients: a nationwide observational cohort study

Dong-gon Hyun, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Chae-Man Lim

• Open Access
• Respiratory Microbiota
• Matters Arising

Sampling and processing matter in airway microbiota discovery

Sébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Laurence Delhaes, Renaud Prével

• Open Access
• Acute Kidney Injury
• Research

Development and external validation of a machine learning model for the prediction of persistent acute kidney injury stage 3 in multi-centric, multi-national intensive care cohorts

Simone Zappalà, Francesca Alfieri, Andrea Ancona, Fabio Silvio Taccone, Riccardo Maviglia, Valentina Cauda, Stefano Finazzi, Antonio Maria Dell’Anna

• Open Access
• Septicemia
• Matters Arising

Early sepsis recognition: how difficult can this be?

Maria-Evangelia Adami, Jesper Eugen-Olsen, Evangelos J. Giamarellos-Bourboulis

• Open Access
• Comment

A critical reappraisal of vasopressin and steroids in in-hospital cardiac arrest

Spyros D. Mentzelopoulos, Athanasios Chalkias

• Open Access
• Cardiogenic Shock
• Review

Sex differences in treatments and outcomes of patients with cardiogenic shock: a systematic review and epidemiological meta-analysis

Thomas Fisher, Nicole Hill, Antonis Kalakoutas, Assad Lahlou, Krishnaraj Rathod, Alastair Proudfoot, Alex Warren

• Open Access
• Morphine
• Matters Arising

Beyond opioids: revisiting pain management in post cardiac surgery infants

Siddannagoud Salotagi, Atul Jindal

• Open Access
• Review

Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials

Karen E. A. Burns, Behnam Sadeghirad, Maryam Ghadimi, Jeena Khan, Vorakamol Phoophiboon, Vatsal Trivedi, Carolina Gomez Builes, Benedetta Giammarioli, Kimberley Lewis, Dipayan Chaudhuri, Kairavi Desai, Jan O. Friedrich

• Open Access
• Research

Advanced waveform analysis of diaphragm surface EMG allows for continuous non-invasive assessment of respiratory effort in critically ill patients at different PEEP levels

R. S. P. Warnaar, A. D. Cornet, A. Beishuizen, C. M. Moore, D. W. Donker, E. Oppersma

• Open Access
• Artificial Intelligence
• Comment

Can artificial intelligence help for scientific illustration? Details matter

Julian Klug, Urs Pietsch

• Open Access
• Brief Report

Reliability and reproducibility of the venous excess ultrasound (VExUS) score, a multi-site prospective study: validating a novel ultrasound technique for comprehensive assessment of venous congestion

August A. Longino, Katharine C. Martin, Katarina R. Leyba, Luke McCormack, Gabriel Siegel, Vibhu M. Sharma, Matthew Riscinti, Carolina O. Lopez, Ivor S. Douglas, Edward A. Gill

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Standard vs. carbone dioxide adapted kidney replacement therapy in hypercapnic ARDS patients: a randomized controlled pilot trial (BigBIC)

Julius Valentin Kunz, Helena Hansmann, Mareike Fähndrich, Mareen Pigorsch, Nicole Bethke, Harm Peters, Anne Krüger, Tim Schroeder, Florian Marcy, Abakar Magomedov, Holger Müller-Redetzky, Kai-Uwe Eckardt, Dmytro Khadzhynov, Philipp Enghard

• Open Access
• Central Nervous System Trauma
• Research

Haemoglobin values, transfusion practices, and long-term outcomes in critically ill patients with traumatic brain injury: a secondary analysis of CENTER-TBI

Angelo Guglielmi, Francesca Graziano, Elisa Gouvêa Bogossian, Alexis F. Turgeon, Fabio Silvio Taccone, Giuseppe Citerio

• Open Access
• Correction

Correction to: Clinical validation of a capnodynamic method for measuring end‑expiratory lung volume in critically ill patients

J. A. Sanchez Giralt, G. Tusman, M. Wallin, M. Hallback, A. Perez Lucendo, M. Sanchez Galindo, B. Abad Santamaria, E. Paz Calzada, P. Garcia Garcia, D. Rodriguez Huerta, A. Canabal Berlanga, Fernando Suarez‑Sipmann

• Open Access
• Acute Respiratory Distress Syndrome
• Brief Report

Potential risk factors for reduced quality of life and increased health care utilization in ARDS survivors: results from the multicenter cohort study DACAPO

Hermann Szymczak, Susanne Brandstetter, Sebastian Blecha, Frank Dodoo-Schittko, Magdalena Rohr, Thomas Bein, Christian Apfelbacher

• Open Access
• Correspondence

Potential bias and misclassification of using continuous cardiac output to identify fluid responsiveness compared to calibrated measurements

Laurent Bitker, Guillaume Deniel, Jean-Christophe Richard

• Open Access
• ECMO
• Comment

Mechanical circulatory support in cardiogenic shock: microaxial flow pumps for all and VA-ECMO consigned to the museum?

Daniel De Backer, Dirk W. Donker, Alain Combes, Alexandre Mebazaa, Jacob E. Moller, Jean-Louis Vincent

• Open Access
• Correspondence

What clinical practices for intensive care psychologists in France? A national survey

Alicia Landbeck, Arnaud Witt, Emilie Marty Petit, Emilie Aebischer, Anne-Laure Poujol, Stéphanie Nguyen, Etienne Simon, Pauline Bernigaud, Guillaume Thiery, Belaid Bouhemad, Alexandra Laurent

• Open Access
• ECMO
• Matters Arising

Practical considerations on hypoxemia and hypoxia in V-V ECMO patients

Dawid L. Staudacher, Matthieu Schmidt, Tobias Wengenmayer

• Open Access
• Nutrition
• Comment

Feeding critically ill patients at the right time of day

Hassan S. Dashti, YunZu Michele Wang, Melissa P. Knauert

• Open Access
• Cytokines
• Matters Arising

Desorption in hemoadsorption therapies: a call for more data

Aron Jansen, Nicole Waalders, Matthijs Kox, Peter Pickkers

• Open Access
• Review

Is comorbidity alone responsible for changes in health-related quality of life among critical care survivors? A purpose-specific review

Lotti Orwelius, Susanne Wilhelms, Folke Sjöberg

• Open Access
• Septicemia
• Research

Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis

Tobias Zimmermann, Philip Kaufmann, Simon A. Amacher, Raoul Sutter, Gregor Loosen, Hamid Merdji, Julie Helms, Atanas Todorov, Pimrapat Gebert, Vera Regitz-Zagrosek, Catherine Gebhard, Mervyn Singer, Martin Siegemund, Caroline E. Gebhard

• Open Access
• COVID-19
• Brief Report

Heterogeneity of treatment effect of vilobelimab in COVID-19: a secondary analysis of a randomised controlled trial

Rombout B. E. van Amstel, Marleen A. Slim, Endry H. T. Lim, Simon Rückinger, Christopher W. Seymour, Bruce P. Burnett, Lieuwe D. J. Bos, Lonneke A. van Vught, Niels C. Riedemann, Diederik van de Beek, Alexander P. J. Vlaar, Martin Witzenrath, Pieter van Paassen, Leo M. A. Heunks, Bruno Mourvillier, Sanne de Bruin, Matthijs C. Brouwer, Pieter R. Tuinman, José Francisco K. Saraiva, Gernot Marx, Suzana M. Lobo, Rodrigo Boldo, Jesus A. Simon-Campos, Alexander D. Cornet, Anastasia Grebenyuk, Johannes M. Engelbrecht, Murimisi Mukansi, Philippe G. Jorens, Robert Zerbib, Korinna Pilz, Renfeng Guo, Pierre Bulpa, Fabio S. Taccone, Greet Hermans, Marc Diltoer, Michael Piagnerelli, Nikolaas De Neve, Antonio T. Freire, Felipe D. Pizzol, Anna Karolina Marinho, Victor H. Sato, Clovis Arns da Cunha, Mathilde Neuville, Jean Dellamonica, Djillali Annane, Antoine Roquilly, Jean Luc Diehl, Francis Schneider, Jean Paul Mira, Jean Baptiste Lascarrou, Luc Desmedt, Claire Dupuis, Carole Schwebel, Guillaume Thiéry, Matthias Gründling, Marc Berger, Tobias Welte, Michael Bauer, Ulrich Jaschinski, Klaus Matschke, Roberto Mercado-Longoria, Belinda Gomez Quintana, Jorge Alberto Zamudio-Lerma, Juan Moreno Hoyos Abril, Angel Aleman Marquez, Peter Pickkers, Luuk Otterspoor, Luis Hercilla Vásquez, Carlos Rafael Seas Ramos, Alejandro Peña Villalobos, Gonzalo Gianella Malca, Victoria Chávez, Victor Filimonov, Vladimir Kulabukhov, Pinak Acharya, Sjoerd A. M. E. G. Timmermans, Matthias H. Busch, Floor L. F. van Baarle, Rutger Koning, Liora ter Horst, Nora Chekrouni, Thijs M. van Soest, Rombout B. E. van Amstel, Sabine E. Olie, Ingeborg E. van Zeggeren, Marcel C. G. van de Poll, Claus Thielert, Dorothee Neukirchen

• Open Access
• Pseudomonas
• Research

Gut colonization with multidrug resistant organisms in the intensive care unit: a systematic review and meta-analysis

Madison R. Heath, Weijia Fan, Cheng-Shiun Leu, Angela Gomez-Simmonds, Thomas Lodise, Daniel E. Freedberg

• Open Access
• Review

Vitamin K: a potential missing link in critical illness–a scoping review

Michelle Carmen Paulus, Marjolein Drent, Imre Willemijn Kehinde Kouw, Michiel Gerard Juliaan Balvers, Aalt Bast, Arthur Raymond Hubert van Zanten

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Integrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for ARDS

Mengna Lin, Feixiang Xu, Jian Sun, Jianfeng Song, Yao Shen, Su Lu, Hailin Ding, Lulu Lan, Chen Chen, Wen Ma, Xueling Wu, Zhenju Song, Weibing Wang

• Open Access
• Pneumonia
• Research

Unravelling the complexity of ventilator-associated pneumonia: a systematic methodological literature review of diagnostic criteria and definitions used in clinical research

Markus Fally, Faiuna Haseeb, Ahmed Kouta, Jan Hansel, Rebecca C. Robey, Thomas Williams, Tobias Welte, Timothy Felton, Alexander G. Mathioudakis

• Open Access
• Electroencephalography
• Research

Performance of the MRI lesion pattern score in predicting neurological outcome after out of hospital cardiac arrest: a retrospective cohort analysis

Manuela Iten, Antonia Moser, Franca Wagner, Matthias Haenggi

• Open Access
• Septic Shock
• Brief Report

The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients

Sebastian Morales, Pedro D. Wendel-Garcia, Miguel Ibarra-Estrada, Christian Jung, Ricardo Castro, Jaime Retamal, Luis I. Cortínez, Nicolás Severino, Greta Emilia Kiavialaitis, Gustavo Ospina-Tascón, Jan Bakker, Glenn Hernández, Eduardo Kattan

• Open Access
• Cardiopulmonary Resuscitation
• Research

Extracorporeal cardiopulmonary resuscitation versus standard treatment for refractory out-of-hospital cardiac arrest: a Bayesian meta-analysis

Samuel Heuts, Johannes F. H. Ubben, Michal J. Kawczynski, Andrea Gabrio, Martje M. Suverein, Thijs S. R. Delnoij, Petra Kavalkova, Daniel Rob, Arnošt Komárek, Iwan C. C. van der Horst, Jos G. Maessen, Demetris Yannopoulos, Jan Bělohlávek, Roberto Lorusso, Marcel C. G. van de Poll

• Open Access
• Central Nervous System Trauma
• Correspondence

Progressive hemorrhagic injury and ischemia after severe traumatic brain injury according to hemoglobin transfusion thresholds: a post-hoc analysis of the transfusion requirements after head trauma trial

André L. N. Gobatto, Davi Solla, Sérgio Brasil, Fabio S. Taccone, Carlos G. Carlotti Jr, Luiz Marcelo S. Malbouisson, Wellingson S. Paiva

• Open Access
• COVID-19
• Correspondence

Impact of the COVID-19 pandemic on lung-protective ventilation practice in critically ill patients with respiratory failure: a retrospective cohort study from a New England healthcare network

Ricardo Munoz-Acuna, Elena Ahrens, Aiman Suleiman, Luca J. Wachtendorf, Basit A. Azizi, Simone Redaelli, Tim M. Tartler, Guanqing Chen, Elias N. Baedorf-Kassis, Maximilian S. Schaefer, Shahla Siddiqui

• Open Access
• Acute Respiratory Distress Syndrome
• Review

Gut-derived immune cells and the gut-lung axis in ARDS

Mairi Ziaka, Aristomenis Exadaktylos

• Open Access
• Direct Oral Anticoagulant
• Review

Andexanet alpha versus four-factor prothrombin complex concentrate in DOACs anticoagulation reversal: an updated systematic review and meta-analysis

Daniele Orso, Federico Fonda, Alessandro Brussa, Irene Comisso, Elisabetta Auci, Marco Sartori, Tiziana Bove

• Open Access
• Hypocalcemia
• Research

Calcium supplementation during trauma resuscitation: a propensity score-matched analysis from the TraumaRegister DGU®

Dries Helsloot, Mark Fitzgerald, Rolf Lefering, Christopher Groombridge, Nathalie Becaus, Sandra Verelst, Carlo Missant

• Open Access
• Septic Shock
• Matters Arising

Trials and the importance of usual care

Kyle C. White, Kevin B. Laupland, Rinaldo Bellomo

• Open Access
• Lung Ultrasound
• Review

Diagnostic accuracy of lung ultrasound in diagnosis of ARDS and identification of focal or non-focal ARDS subphenotypes: a systematic review and meta-analysis

Maud M. A. Boumans, William Aerts, Luigi Pisani, Lieuwe D. J. Bos, Marry R. Smit, Pieter R. Tuinman

• Open Access
• Pneumonia
• Research

Clinical application of targeted next-generation sequencing in severe pneumonia: a retrospective review

Peng Zhang, Baoyi Liu, Shuang Zhang, Xuefei Chang, Lihe Zhang, Dejian Gu, Xin Zheng, Jiaqing Chen, Saiyin Xiao, Zhentao Wu, Xuemin Cai, Mingfa Long, Wenjie Lu, Mingzhu Zheng, Rongrong Chen, Rui Gao, Yan Zheng, Jinhua Wu, Qiujuan Feng, Gang He, Yantang Chen, Weihao Zheng, Wanli Zuo, Yanming Huang, Xin Zhang

• Open Access
• Septic Shock
• Matters Arising

Thiamine supplementation in septic shock patients: still looking for the target population

Amanda Gomes Pereira, Nara A. Costa, Mariana B. de Moraes, Marina P. Okoshi, Leonardo A. M. Zornoff, Paula S. Azevedo, Marcos F. Minicucci, Sérgio A. R. de Paiva, Bertha F. Polegato

• Open Access
• Acute Kidney Injury
• Research

Immune profiling of critically ill patients with acute kidney injury during the first week after various types of injuries: the REALAKI study

Frank Bidar, Louis Peillon, Maxime Bodinier, Fabienne Venet, Guillaume Monneret, Anne-Claire Lukaszewicz, Jean-François Llitjos, Julien Textoris, Thomas Rimmelé

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Physiological and clinical effects of trunk inclination adjustment in patients with respiratory failure: a scoping review and narrative synthesis

Martín H. Benites, Marcelo Zapata-Canivilo, Fabian Poblete, Francisco Labbe, Romina Battiato, Andrés Ferre, Jorge Dreyse, Guillermo Bugedo, Alejandro Bruhn, Eduardo L. V. Costa, Jaime Retamal

• Open Access
• Chronic Kidney Disease
• Matters Arising

Unveiling the hidden burden: the impact of undiagnosed comorbidities on health-related quality of life in ICU survivors

Jill Moser, Roos Mensink, Marisa Onrust, Fredrike Blokzijl, Jacqueline Koeze

• Open Access
• Septicemia
• Research

A proof of concept for microcirculation monitoring using machine learning based hyperspectral imaging in critically ill patients: a monocentric observational study

Judith Kohnke, Kevin Pattberg, Felix Nensa, Henning Kuhlmann, Thorsten Brenner, Karsten Schmidt, René Hosch, Florian Espeter

• Open Access
• Chronic Kidney Disease
• Research

Fluid management for sepsis-induced hypotension in patients with advanced chronic kidney disease: a secondary analysis of the CLOVERS trial

Anselm Jorda, Ivor S. Douglas, Thomas Staudinger, Gottfried Heinz, Felix Bergmann, Rainer Oberbauer, Gürkan Sengölge, Markus Zeitlinger, Bernd Jilma, Nathan I. Shapiro, Georg Gelbenegger

• Open Access
• Research

The paradox of workplace violence in the intensive care unit: a focus group study

Fredric Sjöberg, Martin Salzmann-Erikson, Eva Åkerman, Eva Joelsson-Alm, Anna Schandl

• Open Access
• Septic Shock
• Correspondence

Left and right atrial strain analysis to predicting new-onset atrial fibrillation in patients with septic shock: a single-center retrospective echocardiography study

Christophe Beyls, Alexis Hermida, Camille Daumin, Max-Paul Delmotte, Arnaud Nsiku, Pierre Huette, Camille Bunelle, Hervé Dupont, Osama Abou-Arab, Yazine Mahjoub

• Open Access
• Psychodynamic Regression
• Matters Arising

Bayesian networks may allow better performance and usability than logistic regression

Jared M. Wohlgemut, Erhan Pisirir, Rebecca S. Stoner, Evangelia Kyrimi, Barbaros Yet, William Marsh, Zane B. Perkins, Nigel R. M. Tai

• Open Access
• Research

Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study)

Lorena Bermúdez-Barrezueta, Juan Mayordomo-Colunga, María Miñambres-Rodríguez, Susana Reyes, Juan Valencia-Ramos, Yolanda Margarita Lopez-Fernandez, Mikel Mendizábal-Diez, Ana Vivanco-Allende, Alba Palacios-Cuesta, Lidia Oviedo-Melgares, José Luis Unzueta-Roch, Jorge López-González, María Teresa Jiménez-Villalta, Maite Cuervas-Mons Tejedor, Lourdes Artacho González, Ainhoa Jiménez Olmos, Martí Pons-Òdena, Marta Brezmes Raposo, María Asunción Pino Vázquez, Ana Vivanco-Allende, Juan Mayordomo-Colunga, María Miñambres-Rodríguez, Susana Beatriz Reyes-Domínguez, Yolanda López Fernández, Zaloa Gorostizaga, María Ángeles García Teresa, María Teresa Rives Ferreiro, Sarah N. Fernández-Lafever, José Manuel González-Gómez, Raúl Montero-Yéboles, Vicente Modesto i Alapont, Antonio Rodríguez-Núñez, Soraya Gutiérrez-Marqués, Aida González-Benavides, Sira Fernández de Miguel, Elcira González-Salas

• Open Access
• Candidiasis
• Research

Prognostic value of serial (1,3)-β-d-glucan measurements in ICU patients with invasive candidiasis

Simone Carelli, Brunella Posteraro, Riccardo Torelli, Elena De Carolis, Maria Sole Vallecoccia, Rikardo Xhemalaj, Salvatore Lucio Cutuli, Eloisa Sofia Tanzarella, Antonio Maria Dell’Anna, Gianmarco Lombardi, Fabiola Cammarota, Alessandro Caroli, Domenico Luca Grieco, Maurizio Sanguinetti, Massimo Antonelli, Gennaro De Pascale

• Open Access
• Post Traumatic Stress Disorder
• Research

Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA)

Alice Mathieu, Jean Reignier, Amélie Le Gouge, Gaetan Plantefeve, Jean-Paul Mira, Laurent Argaud, Pierre Asfar, Julio Badie, Nicolae-Vlad Botoc, Hoang-Nam Bui, Delphine Chatellier, Louis Chauvelot, Christophe Cracco, Michael Darmon, Agathe Delbove, Jérôme Devaquet, Louis-Marie Dumont, Olivier Gontier, Samuel Groyer, Yannick Hourmant, Samir Jaber, Fabien Lambiotte, Benjamin Madeux, Julien Maizel, Olivier Martinet, Virginie Maxime, Emmanuelle Mercier, Mai-Anh Nay, Saad Nseir, Gael Piton, Jean-Pierre Quenot, Anne Renault, Jean-Philippe Rigaud, Francis Schneider, Michel Sirodot, Bertrand Souweine, Fabienne Tamion, Didier Thévenin, Nathalie Thieulot-Rolin, Francois Tinturier, Patrice Tirot, Isabelle Vinatier, Christophe Vinsonneau, Jean-Baptiste Lascarrou, Alexandra Laurent

• Open Access
• Septicemia
• Review

Enhancing sepsis biomarker development: key considerations from public and private perspectives

Jean-Francois Llitjos, Enitan D. Carrol, Marcin F. Osuchowski, Marc Bonneville, Brendon P. Scicluna, Didier Payen, Adrienne G. Randolph, Stephan Witte, Jesus Rodriguez-Manzano, Bruno François

• Open Access
• Containing
• Review

Efficacy and safety of different polymyxin-containing regimens for the treatment of pneumonia caused by multidrug-resistant gram-negative bacteria: a systematic review and network meta-analysis

Yi Zhou, Guizhong Wang, Ying Zhao, Weijia Chen, Xuyan Chen, Yuqi Qiu, Yuanyu Liu, Shuqi Wu, Jianbin Guan, Ping Chang, Yong Liu, Zhanguo Liu

• Open Access
• Septicemia
• Research

Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients

Maxime Bodinier, Estelle Peronnet, Jean-François Llitjos, Louis Kreitmann, Karen Brengel-Pesce, Thomas Rimmelé, Aurore Fleurie, Julien Textoris, Fabienne Venet, Delphine Maucort-Boulch, Guillaume Monneret, Sophie Arnal, Caroline Augris-Mathieu, Frédérique Bayle, Liana Caruso, Charles-Eric Ber, Asma Ben-Amor, Anne-Sophie Bellocq, Farida Benatir, Anne Bertin-Maghit, Marc Bertin-Maghit, André Boibieux, Yves Bouffard, Jean-Christophe Cejka, Valérie Cerro, Jullien Crozon-Clauzel, Julien Davidson, Sophie Debord-Peguet, Benjamin Delwarde, Robert Deleat-Besson, Claire Delsuc, Bertrand Devigne, Laure Fayolle-Pivot, Alexandre Faure, Bernard Floccard, Julie Gatel, Charline Genin, Thibaut Girardot, Arnaud Gregoire, Baptiste Hengy, Laetitia Huriaux, Catherine Jadaud, Alain Lepape, Véronique Leray, Anne-Claire Lukaszewicz, Guillaume Marcotte, Olivier Martin, Marie Matray, Delphine Maucort-Boulch, Pascal Meuret, Céline Monard, Florent Moriceau, Guillaume Monneret, Nathalie Panel, Najia Rahali, Thomas Rimmele, Cyrille Truc, Thomas Uberti, Hélène Vallin, Fabienne Venet, Sylvie Tissot, Abbès Zadam, Sophie Blein, Karen Brengel-Pesce, Elisabeth Cerrato, Valérie Cheynet, Emmanuelle Gallet-Gorius, Audrey Guichard, Camille Jourdan, Natacha Koenig, François Mallet, Boris Meunier, Virginie Moucadel, Marine Mommert, Guy Oriol, Alexandre Pachot, Estelle Peronnet, Claire Schrevel, Olivier Tabone, Julien Textoris, Javier Yugueros Marcos, Jérémie Becker, Frédéric Bequet, Yacine Bounab, Florian Brajon, Bertrand Canard, Muriel Collus, Nathalie Garcon, Irène Gorse, Cyril Guyard, Fabien Lavocat, Philippe Leissner, Karen Louis, Maxime Mistretta, Jeanne Moriniere, Yoann Mouscaz, Laura Noailles, Magali Perret, Frédéric Reynier, Cindy Riffaud, Mary-Luz Rol, Nicolas Sapay, Trang Tran, Christophe Vedrine, Christophe Carre, Pierre Cortez, Aymeric de Monfort, Karine Florin, Laurent Fraisse, Isabelle Fugier, Sandrine PAYRARD, Annick Peleraux, Laurence Quemeneur, Andrew Griffiths, Stephanie Toetsch, Teri Ashton, Peter J. Gough, Scott B. Berger, David Gardiner, Iain Gillespie, Aidan Macnamara, Aparna Raychaudhuri, Rob Smylie, Lionel Tan, Craig Tipple

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Absolute values of regional ventilation-perfusion mismatch in patients with ARDS monitored by electrical impedance tomography and the role of dead space and shunt compensation

Marco Leali, Ines Marongiu, Elena Spinelli, Valentina Chiavieri, Joaquin Perez, Mauro Panigada, Giacomo Grasselli, Tommaso Mauri

• Open Access
• Cardiopulmonary Resuscitation
• Research

Early bolus epinephrine administration during pediatric cardiopulmonary resuscitation for bradycardia with poor perfusion: an ICU-resuscitation study

Amanda J. O’Halloran, Ron W. Reeder, Robert A. Berg, Tageldin Ahmed, Michael J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink, Deborah Franzon, Aisha H. Frazier, Stuart H. Friess, Kathryn Graham, Mark Hall, David A. Hehir, Christopher M. Horvat, Leanna L. Huard, Martha F. Kienzle, Todd J. Kilbaugh, Tensing Maa, Arushi Manga, Patrick S. McQuillen, Kathleen L. Meert, Peter M. Mourani, Vinay M. Nadkarni, Maryam Y. Naim, Daniel Notterman, Murray M. Pollack, Anil Sapru, Carleen Schneiter, Matthew P. Sharron, Neeraj Srivastava, Bradley Tilford, Alexis A. Topjian, Shirley Viteri, David Wessel, Heather A. Wolfe, Andrew R. Yates, Athena F. Zuppa, Robert M. Sutton, Ryan W. Morgan

• Open Access
• Graft-Versus-Host Disease
• Research

Clinical characteristics and outcomes of immunocompromised critically ill patients with cytomegalovirus end-organ disease: a multicenter retrospective cohort study

Sara Fernández, Ignacio Grafia, Olivier Peyrony, Emmanuel Canet, Clara Vigneron, Clément Monet, Nahéma Issa, Maxens Decavele, Anne-Sophie Moreau, Alexandre Lautrette, Guillaume Lacave, Guillaume Morel, Cyril Cadoz, Laurent Argaud, Liran Statlender, Karam Azem, Jean-Pierre Quenot, Olivier Lesieur, Javier Fernández, Marta Farrero, Mª Ángeles Marcos, Virgine Lemiale, Pedro Castro, Élie Azoulay

• Open Access
• Electroencephalography
• Review

Utility and rationale for continuous EEG monitoring: a primer for the general intensivist

Ribal Bitar, Usaamah M. Khan, Eric S. Rosenthal

• Open Access
• Research

Operator independent continuous ultrasound monitoring of diaphragm excursion predicts successful weaning from mechanical ventilation: a prospective observational study

Alexandre Demoule, Quentin Fossé, Alain Mercat, Daniel Bergum, Sara Virolle, Côme Bureau, Marit Mellemseter, Rafaël Guichou, Thomas Similowski, Martin Dres, Satar Mortaza

• Open Access
• Septic Shock
• Research

Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes

Mihir R. Atreya, Min Huang, Andrew R. Moore, Hong Zheng, Yehudit Hasin-Brumshtein, Julie C. Fitzgerald, Scott L. Weiss, Natalie Z. Cvijanovich, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Neal J. Thomas, Michael Quasney, Mary K. Dahmer, Torrey Baines, Bereketeab Haileselassie, Andrew J. Lautz, Natalja L. Stanski, Stephen W. Standage, Jennifer M. Kaplan, Basilia Zingarelli, Rashmi Sahay, Bin Zhang, Timothy E. Sweeney, Purvesh Khatri, L. Nelson Sanchez-Pinto, Rishikesan Kamaleswaran

• Open Access
• Psychodynamic Regression
• Research

Prioritising deteriorating patients using time-to-event analysis: prediction model development and internal–external validation

Robin Blythe, Rex Parsons, Adrian G. Barnett, David Cook, Steven M. McPhail, Nicole M. White

• Open Access
• COVID-19
• Brief Report

Early physical rehabilitation dosage in the intensive care unit associates with hospital outcomes after critical COVID-19

Kirby P. Mayer, Evan Haezebrouck, Lori M. Ginoza, Clarisa Martinez, Minnie Jan, Lori A. Michener, Lindsey E. Fresenko, Ashley A. Montgomery-Yates, Anna G. Kalema, Amy M. Pastva, Michelle Biehl, Matthew F. Mart, Joshua K. Johnson

• Open Access
• Shock
• Correspondence

Guiding resuscitation in shock: base excess or lactate?

Micah Liam Arthur Heldeweg, Thomas Langer, František Duška

• Open Access
• Non-Invasive Ventilation
• Research

High flow nasal cannula oxygen therapy versus non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: a randomized controlled non-inferiority trial

Dingyu Tan, Bingxia Wang, Peng Cao, Yunyun Wang, Jiayan Sun, Ping Geng, Joseph Harold Walline, Yachao Wang, Chenlong Wang

• Open Access
• Central Nervous System Trauma
• Research

Influence of health insurance on withdrawal of life sustaining treatment for patients with isolated traumatic brain injury: a retrospective multi-center observational cohort study

Armaan K. Malhotra, Husain Shakil, Ahmad Essa, Francois Mathieu, Shaurya Taran, Jetan Badhiwala, Yingshi He, Eva Y. Yuan, Abhaya V. Kulkarni, Jefferson R. Wilson, Avery B. Nathens, Christopher D. Witiw

• Open Access
• Septicemia
• Matters Arising

Hyperoxemia may be more beneficial for patients with sepsis

Liyuan Peng, Xiaoming Qin, Lvlin Chen

• Open Access
• Packed Red Blood Cell
• Research

Association between whole blood ratio and risk of mortality in massively transfused trauma patients: retrospective cohort study

Makoto Aoki, Toshikazu Abe, Akira Komori, Morihiro Katsura, Kazuhide Matsushima

• Open Access
• Septicemia
• Review

Plasma for prevention and treatment of glycocalyx degradation in trauma and sepsis

M. S. Kravitz, N. Kattouf, I. J. Stewart, A. A. Ginde, E. P. Schmidt, N. I. Shapiro

• Open Access
• Research

Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors

Lucy L. Porter, Koen S. Simons, Stijn Corsten, Brigitte Westerhof, Thijs C. D. Rettig, Esther Ewalds, Inge Janssen, Crétien Jacobs, Susanne van Santen, Arjen J. C. Slooter, Margaretha C. E. van der Woude, Johannes G. van der Hoeven, Marieke Zegers, Mark van den Boogaard

• Open Access
• Intracranial Hypertension
• Research

Critical thresholds of long-pressure reactivity index and impact of intracranial pressure monitoring methods in traumatic brain injury

Erik Hong, Logan Froese, Emeli Pontén, Alexander Fletcher-Sandersjöö, Charles Tatter, Emma Hammarlund, Cecilia A. I. Åkerlund, Jonathan Tjerkaski, Peter Alpkvist, Jiri Bartek Jr, Rahul Raj, Caroline Lindblad, David W. Nelson, Frederick A. Zeiler, Eric P. Thelin

• Open Access
• Lung Ultrasound
• Matters Arising

LUS me up: elevating ARDS diagnosis

Rogério da Hora Passos, Rafaella Maria da Cunha Lyrio, Igor Dovorake Lourenço, Evandro José de Almeida Figueiredo, Uri Adrian Prync Flato, Carmen Valente Barbas, Arnaldo Alves da Silva

• Open Access
• Artificial Intelligence
• Perspective

Artificial intelligence in acute medicine: a call to action

Maurizio Cecconi, Massimiliano Greco, Benjamin Shickel, Jean-Louis Vincent, Azra Bihorac

• Open Access
• Cardiopulmonary Resuscitation
• Review

Mechanical versus manual cardiopulmonary resuscitation (CPR): an umbrella review of contemporary systematic reviews and more

Ayman El-Menyar, Mashhood Naduvilekandy, Sandro Rizoli, Salvatore Di Somma, Basar Cander, Sagar Galwankar, Fatimah Lateef, Mohamed Alwi Abdul Rahman, Prabath Nanayakkara, Hassan Al-Thani

• Open Access
• Somatosensory Evoked Potential
• Research

Alteration in early resting‑state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study

Rui Shao, Tao Wang, Chenchen Hang, Le An, Xingsheng Wang, Luying Zhang, Jingfei Yu, Zhenyu Shan, Qi Yang, Ziren Tang

• Open Access
• Correspondence

STAB-5: an aide-mémoire for the efficient prehospital management of penetrating trauma by emergency medical services

M. Robinson, F. Rath, C. Sutton, M. Kinsella, E. ter Avest, L. Carenzo

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome

Louis Bouchant, Thomas Godet, Gauthier Arpajou, Lucie Aupetitgendre, Sophie Cayot, Renaud Guerin, Matthieu Jabaudon, Camille Verlhac, Raiko Blondonnet, Lucile Borao, Bruno Pereira, Jean-Michel Constantin, Jean-Etienne Bazin, Emmanuel Futier, Jules Audard

• Open Access
• Computed Tomography
• Research

Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan

Emanuele Rezoagli, Yi Xin, Davide Signori, Wenli Sun, Sarah Gerard, Kevin L. Delucchi, Aurora Magliocca, Giovanni Vitale, Matteo Giacomini, Linda Mussoni, Jonathan Montomoli, Matteo Subert, Alessandra Ponti, Savino Spadaro, Giancarla Poli, Francesco Casola, Jacob Herrmann, Giuseppe Foti, Carolyn S. Calfee, John Laffey, Giacomo Bellani, Maurizio Cereda, Ferdinando Luca Lorini, Pietro Bonaffini, Matteo Cazzaniga, Irene Ottaviani, Mario Tavola, Asia Borgo, Livio Ferraris, Filippo Serra, Stefano Gatti, Davide Ippolito, Beatrice Tamagnini, Marino Gatti, Massimo Arlotti, Emiliano Gamberini, Enrico Cavagna, Giuseppe Galbiati, Davide De Ponti

• Open Access
• Non-Invasive Ventilation
• Matters Arising

Probing the efficacy of high-flow nasal cannula in the treatment of acute exacerbations of COPD with acute-moderate hypercapnic respiratory failure

Ioannis Pantazopoulos, Georgios Mavrovouni

• Open Access
• Cerebral Ischemia
• Research

Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study

Giovanni Chiarini, Silvia Mariani, Anne-Kristin Schaefer, Bas C. T. van Bussel, Michele Di Mauro, Dominik Wiedemann, Diyar Saeed, Matteo Pozzi, Luca Botta, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Hergen Buscher, Leonardo Salazar, Bart Meyns, Daniel Herr, Sacha Matteucci, Sandro Sponga, Kollengode Ramanathan, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, I-wen Wang, Jae-Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, José P. Garcia, Kiran Shekar, Glenn J. R. Whitman, Roberto Lorusso, Samuel Heuts, Luca Conci, Jawad Khalil, Sven Lehmann, Jean-Francois Obadia, Antonio Loforte, Davide Pacini, Nikolaos Kalampokas, Agne Jankuviene, Karl Bounader, Erwan Flecher, Dinis Dos Reis Miranda, Kogulan Sriranjan, Michael A. Mazzeffi, Marco Di Eusanio, Igor Vendramin, Graeme MacLaren, Vitaly Sorokin, Alessandro Costetti, Chistof Schmid, Roberto Castillo, Tomas Grus, Marco Solinas

• Open Access
• Nutrition
• Debate

The kidney: the critical organ system for guiding nutrition therapy in the ICU-patient?

Wilfred Druml, Thomas Staudinger, Michael Joannidis

• Open Access
• COVID-19
• Brief Report

Longer ICU stay and invasive mechanical ventilation accelerate telomere shortening in COVID-19 patients 1 year after recovery

Ana Virseda-Berdices, Raquel Behar-Lagares, Oscar Martínez-González, Rafael Blancas, Soraya Bueno-Bustos, Oscar Brochado-Kith, Eva Manteiga, María J. Mallol Poyato, Blanca López Matamala, Carmen Martín Parra, Salvador Resino, María Á Jiménez-Sousa, Amanda Fernández-Rodríguez

• Open Access
• Septicemia
• Comment

Sex matters: Is it time for a SOFA makeover?

Emma Larsson

• Open Access
• Anesthetics
• Review

Volatile anesthetics for lung- and diaphragm-protective sedation

Lukas M. Müller-Wirtz, Brian O’Gara, Marcelo Gama de Abreu, Marcus J. Schultz, Jeremy R. Beitler, Angela Jerath, Andreas Meiser

• Open Access
• Septicemia
• Research

High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration

Stefan Rusev, Patrick Thon, Birte Dyck, Dominik Ziehe, Tim Rahmel, Britta Marko, Lars Palmowski, Hartmuth Nowak, Björn Ellger, Ulrich Limper, Elke Schwier, Dietrich Henzler, Stefan Felix Ehrentraut, Lars Bergmann, Matthias Unterberg, Michael Adamzik, Björn Koos, Katharina Rump

• Open Access
• Nutrition
• Brief Report

The role of lipid emulsions containing omega-3 fatty acids for medical and surgical critical care patients

Christian Stoppe, Robert G. Martindale, Stanislaw Klek, Philip C. Calder, Paul E. Wischmeyer, Jayshil J. Patel

• Open Access
• Acute Kidney Injury
• Research

Redefining urine output thresholds for acute kidney injury criteria in critically Ill patients: a derivation and validation study

Guido Dias Machado, Leticia Libório Santos, Alexandre Braga Libório

• Open Access
• ECMO
• Correction

Correction: A critical reappraisal of vasopressin and steroids in in-hospital cardiac arrest

Spyros D. Mentzelopoulos, Athanasios Chalkias

• Open Access
• ECMO
• Brief Report

Effects of different VV ECMO blood flow rates on lung perfusion assessment by hypertonic saline bolus-based electrical impedance tomography

Hongling Zhang, Yongran Wu, Xuehui Gao, Chengchao Peng, Ruirui Li, Azhen Wang, Jiancheng Zhang, Shiying Yuan, Le Yang, Xiaojing Zou, You Shang

• Open Access
• Acute Respiratory Distress Syndrome
• Matters Arising

Comment on the article “Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome”, from Bouchant et al.

Ricardo Castro, Eduardo Kattan, Glenn Hernández

• Open Access
• Artificial Intelligence
• Comment

Beware the self-fulfilling prophecy: enhancing clinical decision-making with AI

Taotao Liu, Yaocong Duan

• Open Access
• Acute Respiratory Distress Syndrome
• Review

Positive end-expiratory pressure management in patients with severe ARDS: implications of prone positioning and extracorporeal membrane oxygenation

Christoph Boesing, Patricia R. M. Rocco, Thomas Luecke, Joerg Krebs

• Open Access
• ECMO
• Brief Report

Role of age as eligibility criterion for ECMO in patients with ARDS: meta-regression analysis

Tommaso Tonetti, Rossana Di Staso, Laura Bambini, Martina Bordini, Rosanna D’Albo, Domenico Nocera, Irene Sbaraini Zernini, Ilaria Turriziani, Luciana Mascia, Paola Rucci, V. Marco Ranieri

• Open Access
• ECMO
• Research

Retrospective ANalysis of multi-drug resistant Gram-nEgative bacteRia on veno-venous extracorporeal membrane oxygenation. The multicenter RANGER STUDY

Annalisa Boscolo, Andrea Bruni, Marco Giani, Eugenio Garofalo, Nicolò Sella, Tommaso Pettenuzzo, Michela Bombino, Matteo Palcani, Emanuele Rezoagli, Matteo Pozzi, Elena Falcioni, Elisa Pistollato, Eugenio Biamonte, Francesco Murgolo, Graziella D’Arrigo, Mercedes Gori, Giovanni Luigi Tripepi, Leonardo Gottin, Federico Longhini, Salvatore Grasso, Paolo Navalesi, Giuseppe Foti

• Open Access
• Teicoplanin
• Correspondence

Effect of therapeutic plasma exchange on antimicrobials in critically ill patients

Ugur Balaban, Emre Kara, Esat Kivanc Kaya, Osman Ilhami Ozcebe, Murat Akova, Arzu Topeli, Kaya Yorganci, Kutay Demirkan

• Open Access
• Septicemia
• Research

Post-discharge functional outcomes in older patients with sepsis

Sanyu Ge, Ling Zha, Aiko Tanaka, Nobuhiro Narii, Yoshimitsu Shimomura, Masayo Komatsu, Sho Komukai, Fumiko Murata, Megumi Maeda, Kosuke Kiyohara, Tetsuhisa Kitamura, Haruhisa Fukuda

• Open Access
• Baricitinib
• Correspondence

Baricitinib versus tocilizumab in mechanically ventilated patients with COVID-19: a nationwide cohort study

Seung-Hun You, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim

• Open Access
• Long-COVID Syndrome
• Review

How are Long-Covid, Post-Sepsis-Syndrome and Post-Intensive-Care-Syndrome related? A conceptional approach based on the current research literature

Carolin Fleischmann-Struzek, Franka E. A. Joost, Mathias W. Pletz, Björn Weiß, Nicolas Paul, E. Wesley Ely, Konrad Reinhart, Norman Rose

• Open Access
• Perspective

The ventilator of the future: key principles and unmet needs

John J. Marini, Luciano Gattinoni

• Open Access
• Septic Shock
• Review

Septic shock in the immunocompromised cancer patient: a narrative review

Joseph L. Nates, Frédéric Pène, Michael Darmon, Djamel Mokart, Pedro Castro, Sascha David, Pedro Povoa, Lene Russell, Nathan D. Nielsen, Gabriel-Petre Gorecki, Kim O. Gradel, Elie Azoulay, Philippe R. Bauer

• Open Access
• Cardiopulmonary Resuscitation
• Research

Brief report: incidence and outcomes of pediatric tracheal intubation-associated cardiac arrests in the ICU-RESUS clinical trial

Akira Nishisaki, Ron W. Reeder, Elizabeth Laverriere McGovern, Tageldin Ahmed, Michael J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, Wesley Diddle, Myke Federman, Ericka L. Fink, Deborah Franzon, Aisha H. Frazier, Stuart H. Friess, Kathryn Graham, Mark Hall, David A. Hehir, Christopher M. Horvat, Leanna L. Huard, Tensing Maa, Arushi Manga, Patrick McQuillen, Kathleen L. Meert, Ryan W. Morgan, Peter M. Mourani, Vinay M. Nadkarni, Maryam Y. Naim, Daniel Notterman, Chella A. Palmer, Anil Sapru, Carleen Schneiter, Matthew P. Sharron, Neeraj Srivastava, Shirley Viteri, David Wessel, Heather A. Wolfe, Andrew R. Yates, Athena F. Zuppa, Robert M. Sutton, Robert A. Berg

• Open Access
• Brief Report

Variability in forgoing life-sustaining treatment practices in critically Ill patients with hospital-acquired bloodstream infections: a secondary analysis of the EUROBACT-2 international cohort

Hannah Wozniak, Alexis Tabah, Jan J. De Waele, Jean-François Timsit, Niccolò Buetti

• Open Access
• ICU-Acquired Weakness
• Research

Accelerometer-derived movement features as predictive biomarkers for muscle atrophy in neurocritical care: a prospective cohort study

Moritz L. Schmidbauer, Timon Putz, Leon Gehri, Luka Ratkovic, Andreas Maskos, Julia Zibold, Johanna Bauchmüller, Sophie Imhof, Thomas Weig, Max Wuehr, Konstantinos Dimitriadis

• Open Access
• Cerebral Ischemia
• Research

Assessment of fluid responsiveness using pulse pressure variation, stroke volume variation, plethysmographic variability index, central venous pressure, and inferior vena cava variation in patients undergoing mechanical ventilation: a systematic review and meta-analysis

Renato Carneiro de Freitas Chaves, Carmen Silvia Valente Barbas, Veronica Neves Fialho Queiroz, Ary Serpa Neto, Rodrigo Octavio Deliberato, Adriano José Pereira, Karina Tavares Timenetsky, João Manoel Silva Júnior, Flávio Takaoka, Daniel de Backer, Leo Anthony Celi, Thiago Domingos Corrêa

• Open Access
• Septicemia
• Research

Novel cortisol trajectory sub-phenotypes in sepsis

Fei Leng, Zhunyong Gu, Simeng Pan, Shilong Lin, Xu Wang, Ming Zhong, Jieqiong Song

• Open Access
• Septicemia
• Matters Arising

Association between arterial oxygen partial pressure and mortality in sepsis

Xinyuan Ding, Shangzhong Chen

• Open Access
• Septicemia
• Review

Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives

Dongxue Hu, Harshini Sheeja Prabhakaran, Yuan-Yuan Zhang, Gaoxing Luo, Weifeng He, Yih-Cherng Liou

• Open Access
• Septicemia
• Research

Divergent effects of tumor necrosis factor (TNF) in sepsis: a meta-analysis of experimental studies

Christian Kassasseya, Ligia Iulia Torsin, Caroline Musset, Marc Benhamou, Irshad H. Chaudry, Jean-Marc Cavaillon, Nathalie Grall, Renato Monteiro, Luc de Chaisemartin, Dan Longrois, Philippe Montravers, Christian de Tymowski

• Open Access
• Intracranial Hypertension
• Research

Cerebral physiologic insult burden in acute traumatic neural injury: a Canadian High Resolution-TBI (CAHR-TBI) descriptive analysis

Kevin Y. Stein, Alwyn Gomez, Donald Griesdale, Mypinder Sekhon, Francis Bernard, Clare Gallagher, Eric P. Thelin, Rahul Raj, Marcel Aries, Logan Froese, Andreas Kramer, Frederick A. Zeiler

• Open Access
• Glucocorticoid
• Research

Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function

Lauren De Bruyn, Arno Téblick, Tim Van Oudenhove, Sarah Vander Perre, Inge Derese, Lies Pauwels, Sarah Derde, Greet De Vlieger, Greet Van den Berghe, Lies Langouche

• Open Access
• ECMO
• Guideline

Neurological monitoring and management for adult extracorporeal membrane oxygenation patients: Extracorporeal Life Support Organization consensus guidelines

Sung-Min Cho, Jaeho Hwang, Giovanni Chiarini, Marwa Amer, Marta V. Antonini, Nicholas Barrett, Jan Belohlavek, Daniel Brodie, Heidi J. Dalton, Rodrigo Diaz, Alyaa Elhazmi, Pouya Tahsili-Fahadan, Jonathon Fanning, John Fraser, Aparna Hoskote, Jae-Seung Jung, Christopher Lotz, Graeme MacLaren, Giles Peek, Angelo Polito, Jan Pudil, Lakshmi Raman, Kollengode Ramanathan, Dinis Dos Reis Miranda, Daniel Rob, Leonardo Salazar Rojas, Fabio Silvio Taccone, Glenn Whitman, Akram M. Zaaqoq, Roberto Lorusso

• Open Access
• Septicemia
• Research

Impact of the timing of invasive mechanical ventilation in patients with sepsis: a multicenter cohort study

Gyungah Kim, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Chae-Man Lim

• Open Access
• Septicemia
• Matters Arising

Cytomegalovirus end-organ disease in immunocompromised critically ill patients: key concerns demanding attention

Zhihui Zhang, Junlu Sun, Xuesong Liu, Rong Zhang, Yimin Li, Xiaoqing Liu

• Open Access
• Shock
• Research

Exploration of different statistical approaches in the comparison of dopamine and norepinephrine in the treatment of shock: SOAP II

Fernando G. Zampieri, Sean M. Bagshaw, Hassane Njimi, Jean-Louis Vincent, Daniel DeBacker, P. Biston, J. Devriendt, C. Madl, D. Chochrad, C. Aldecoa, A. Brasseur, P. Defrance, P. Gottignies, R. Kitzberger, U. Holzinger, A. Roman, D. De Bels, S. Anane, S. Brimioulle, M. Van Nuffelen, M. VanCutsem, J. Rico, J. I. Gomez Herreras, C. Mélot

• Open Access
• ECMO
• Review

Cardiopulmonary bypass and VA-ECMO induced immune dysfunction: common features and differences, a narrative review

Mathieu Lesouhaitier, Félicie Belicard, Jean-Marc Tadié

• Open Access
• Artificial Intelligence
• Debate

Should AI models be explainable to clinicians?

Gwénolé Abgrall, Andre L. Holder, Zaineb Chelly Dagdia, Karine Zeitouni, Xavier Monnet

• Open Access
• ECMO
• Research

Sex differences in extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: nationwide multicenter retrospective study in Japan

Akira Kawauchi, Yohei Okada, Makoto Aoki, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda, Mitsunobu Nakamura

• Open Access
• Matters Arising

Scoring system: use and not use from the future to present

Charles-Hervé Vacheron, Louis Brac, Albrice Levrat, Jean Stéphane David

• Open Access
• Subacromiales Impingement
• Research

Intensive care unit caseload and workload and their association with outcomes in critically unwell patients: a large registry-based cohort analysis

Paul Zajic, Teresa Engelbrecht, Alexandra Graf, Barbara Metnitz, Rui Moreno, Martin Posch, Andrew Rhodes, Philipp Metnitz

• Open Access
• Research

Testing preload responsiveness by the tidal volume challenge assessed by the photoplethysmographic perfusion index

Chiara Bruscagnin, Rui Shi, Daniela Rosalba, Gaelle Fouqué, Julien Hagry, Christopher Lai, Katia Donadello, Tài Pham, Jean-Louis Teboul, Xavier Monnet

• Open Access
• Obesity
• Research

The pleural gradient does not reflect the superimposed pressure in patients with class III obesity

Stefano Spina, Lea Mantz, Yi Xin, David C. Moscho, Roberta Ribeiro De Santis Santiago, Luigi Grassi, Alice Nova, Sarah E. Gerard, Edward A. Bittner, Florian J. Fintelmann, Lorenzo Berra, Maurizio Cereda

• Open Access
• Lung Ultrasound
• Matters Arising

Lung ultrasound and ARDS: global collaboration is the way to go

Marry R. Smit, Maud Boumans, William Aerts, Pieter R. Tuinman

• Open Access
• Research

Time course of electrical activity of the diaphragm (EAdi) in the peri extubation period and its role as predictor of extubation failure in difficult to wean patients

Francisco José Parrilla-Gómez, Ferran Roche-Campo, Stefano Italiano, Andrés Parrilla-Gómez, Indalecio Morán, Jordi Mancebo, Tommaso Maraffi

• Open Access
• Pneumonia
• Perspective

Prevention of ventilator-associated pneumonia by metal-coated endotracheal tubes: a meta-analysis

Yuxin Yang, Xuan Xiong, Xiaofei Wang, Qionglan Dong, Lingai Pan

• Open Access
• Research

Post-insufflation diaphragm contractions in patients receiving various modes of mechanical ventilation

Antenor Rodrigues, Fernando Vieira, Michael C. Sklar, L. Felipe Damiani, Thomas Piraino, Irene Telias, Ewan C. Goligher, W. Darlene Reid, Laurent Brochard

• Open Access
• Intracranial Hypertension
• Correspondence

Further support for the intracranial compartmental syndrome concept

Daniel Agustin Godoy, Sergio Brasil, Andres M. Rubiano

• Open Access
• Septicemia
• Correspondence

The procalcitonin trajectory as an effective tool for identifying sepsis patients at high risk of mortality

Xu Wang, Shilong Lin, Ming Zhong, Jieqiong Song

• Open Access
• Non-Invasive Ventilation
• Matters Arising

High flow nasal cannula versus non-invasive ventilation in the treatment of acute exacerbations of COPD with acute-moderate hypercapnic respiratory failure

Rongpeng Xu, Ziqiang Shao

• Open Access
• Cardiopulmonary Resuscitation
• Research

Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest

Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. Zanier, Fabio Silvio Taccone

• Open Access
• Lymphopenia
• Review

Lymphopenia in sepsis: a narrative review

Zhibin Wang, Wenzhao Zhang, Linlin Chen, Xin Lu, Ye Tu

• Open Access
• Intoxication
• Research

The INTOXICATE study: methodology and preliminary results of a prospective observational study

Samanta M. Zwaag, Irma S. van den Hengel-Koot, Stuart Baker, Patrick Druwé, Muhammed Elhadi, Ana Ferrer Dufol, Sune Forsberg, Burcin Halacli, Christian Jung, Gabija Laubner Sakalauskienė, Elin Lindqvist, Rui Moreno, Christian Rabe, Nanna Reiter, Richard Rezar, Radu Țincu, Arzu Topeli, David M. Wood, Dylan W. de Lange, Claudine C. Hunault, Christian Aage Wamberg, Hazim Ababneh, Eman Abdulwahed, Sefanja Achterberg, Entisar Ahmed Ali Alshareea, Aiman Ahmed Hamed, Mahmoud Alali, Ali Najeh Al-Awwady, Amar Al-Jarrah, Maytham A. Al-Juaifari, Hazem Zuhair Hussain Alnatour, Khayry Al-Shami, Ahmed Altobal, Shimaa Ahmed Hamed Al-Touny, Mahmut Arslan, Theodoros Aslanidis, Avinash Aujayeb, Munire Babayigit, Robertas Badaras, Stuart Baker, Patricia Barral Segade, Najat Ben Hasan, Dennis C. J. J. Bergmans, Yeliz Bilir, Muhannud Binnawara, Patrick Biston, Dirk P. Boer, Hans Christian Boesen, Hella F. Borggreve, Helene Brix, Thirsa Brommer, Nestor Bueno-Vidales, Isabel Canas-Pérez, Maxim P. Carlier, Alba Castellanos Esparraguera, Deniz Cekic, Mario Chico-Fernández, Lisbeth Christiansen, Cristian Cobilinschi, Luis Coelho, Catalin Constantinescu, Alexander D. Cornet, Elena Crescioli, Cristina Cuenca-Rubio, Paul I. Dargan, Raluca Darie, Dylan W. de Lange, Francisco de Paula Delgado-Moya, Nicolas De Schryver, Bram Dewulf, Willem Dieperink, Patrick Druwé, Simon Dubler, Maree Duroux, Mohamed Elbahnasawy, Muhammed Elhadi, Ahmet Eroglu, Selin Eyüpoğlu, Raquel Feria Gil, Ana Silva Fernandes, Carolina Ferrer, Ana Ferrer Dufol, Sune Forsberg, Diego Franch-Llasat, Rik T. Gerritsen, Reem Ghmagh, Juliana Gonzalez Londoño, Christoffer Grant Sølling, Kjeld Gravgaard, Massimiliano Greco, Goncalo Guerreiro, Nicole Gustavsson, Seda Güzeldag, Burcin Halacli, Hytham K. S. Hamid, Philippe Hantson, Thijs T. W. van Herpt, Jantine van Holten, Femke van der Horst, Aletta P. I. Houwink, Claudine C. Hunault, Malene Hvass Renner Block, Christian Jung, Stavri Karasiali, Mohamed Karghul, Ebru Kaya, Almu’atasim Khamees, Justin Koh, Matty Koopmans, Vedran Kovacic, Gabija Laubner Sakalauskienė, Lenneke E. M. van Lelyveld-Haas, Elin Lindqvist, Meritxell Lladó Vilar, Mette Lolk, Beatriz Martín-Pérez, Eva Maria Mateo Rodríguez, Hélène P. Mattijsen, Ayman Meelad, Iris Miltenburg, Ahmed Ibrahim Mohamed Mohamed, Rui Moreno, Marwa Morgom, Mercedes Mucia-Anayaa, Khalid Mahmood Khan Nafees, Mohamed Nassredin, Binti Haji Abd Rashid Nurhikmahtul Aqilah, Huub L. A. van den Oever, Evelien A. N. Oostdijk, Ozlem Ozkan Kuscu, Catarina Pacheco, Dorte Palmqvist, Despoina Papachristou, David Pérez-Torres, Cristina Petrişor, Michael Piagnerelli, Wouter Pijper, Christian Rabe, Radu Țincu, Megan Ratcliffe, Nanna Reiter, Richard Rezar, Ferran Roche-Campo, Emilio Rodriguez-Ruiz, Harm Roetert, Jessica Ruiz-Izquierdo, Ana Maria Ruiz Mena, Vusala Rzayeva, Nick van Sabben, Elfayadh Saidahmed, Gustaf Sandström, Kemal Tolga Saracoglu, Clemens Seelmaier, Nicolas Serck, Carlos Serón-Arbeloa, Susanne Stads, Louise Stenbryggen Herløv, Ayca Sultan Sahin, Josefine Thomsen, Arzu Topeli, Yen Tran, Bas van den Bogaard, Irma S. van den Hengel-Koot, Klaas Vanderbiest, Liam van Dielen, Abram L. van Duijn, Jolien Van Hecke, Klaus Vennick Marcussen, Marie Vergotten, Wytze Vermeijden, Ester Viktorsdottir, Peter H. J. van der Voort, Evert-Jan Wils, Xavier Wittebole, Esther Wolthuis, David M. Wood, Max Wretman, Hana B. Yahya, Cengizhan Yavuz, Selcuk Yaylaci, Begoña Zalba Etayo, Samanta M. Zwaag

• Open Access
• Digital Health
• Research

Exploring the effectiveness of eHealth interventions in treating Post Intensive Care Syndrome (PICS) outcomes: a systematic review

Daniel Jie Lai, Zhao Liu, Elaine Johnston, Lisa Dikomitis, Teresa D’Oliveira, Sukhi Shergill

• Open Access
• Pneumonia
• Correspondence

Prognostic role of early blood gas variables in critically ill patients with Pneumocystis jirovecii pneumonia: a retrospective analysis

Anouk Voutaz, Jean Bonnemain, Zied Ltaief, Oriol Manuel, Lucas Liaudet

• Open Access
• Cardiopulmonary Resuscitation
• Matters Arising

Comparison of mechanical versus manual cardiopulmonary resuscitation in cardiac arrest

Yang Zhao, Da Chen, Qian Wang

• Open Access
• COVID-19
• Research

Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study

Florian Reizine, Nicolas Massart, Alexandre Mansour, Yannick Fedun, Anaïs Machut, Charles-Hervé Vacheron, Anne Savey, Arnaud Friggeri, Alain Lepape, Serge Alfandari, Alexandra Allaire, Antonio Alvarez, Ammenouche Nacim, Laurent Argaus, Gérard Audibert, Caroline Aurel, Odile Bajolet, Frédéric Barbut, Genevieve Barjon, Patricia Baune, Sébastien Beague, Bassam Beilouny, Nicolas Bele, Nicolas Belin, Cécile Bernerd, Yasmina Berrouane, Aziz Berrouba, Julie Bertrand, Claire Bianchi, Sandrine Biangoma, Fabienne Birot Jaulin, Severine Bonjean, Stéphanie Bordes-Couecou, Abdenour Bouhara, Philippe Bouillard, Céline Bourigault, Sylvie Bourzeix, Sébastien Boutreux, Hanene Bouzidi, Julie Brochart, Stéphanie Bulyez, Marie Callanquin, Nathalie Canu, Matthieu Capron, Daniel Carbognani, Vincent Castelain, Vincent Catanese, Isabelle Cattaneo, Vanessa Chartier, Guillaume Chassaing, Robert Chausset, Mélanie Chauvet, Fabrice Chopin, Catherine Chubilleau, Céline Clayer, Agnès Cohen, Sylvie Comparot, Philippe Corne, Marie-Elisabeth Cornesse, Gaelle Corno, Esther Cortes, Patricia Courouble, Christian Crombe, Véronique Curnier, Monzer Dabbachi, Cédric Dananché, Abla Daroukh, Damien Dassant, Martine Daumas, Aurélien Daurat, Dominique Deffarges, Fanny Delanghe, Olivier Delastre, Joel Delhomme, Jean Paul Délias, Martine Delorme, Fabienne Derramond, Frédérique Diaw, Isabelle Dijols, Kamel Djedaini, Loic Dopeux, Sophie Duhoo, Thierry Dulac, Clarisse Dupin, Laurène Dupont, Michel Durand, Isabelle Durand Joly, Jean-Yves Dusseau, Pierre Yves Egreteau, Carole Eldin, Florence Espinasse, Eric Farfour, Abdelhamid Fatah, Yannick Fedun, Luis Ferreira, Pierre Fillatre, Toufic Finge, Véronique Fleurial, Arnaud Florentin, Agnès Fribourg, Severine Gallais-Hoff, Claude Galland, Richard Galliot, Sylvain Garnier, Gaelle Gasan, Julien Gaubert-Duclos, Valérie Gauzere, Thomas Geffriaud, Isabelle Geneau, Hughes Georges, Solweig Gerbier Colomban, Christophe Giacardi, Sebastien Gibot, Audrey Glanard, Marion Gleize, Marieline Goret, Michele Gourgues, Delphine Grau, Béatrice Grisi, Clotilde Groleau, Liliane Grolier-Bois, Catherine Guignabert, Fethi Hadj-Slimane, Emmanuelle Hammad, Catherine Haond, Marie Hélène Hausermann, Francoise Hayo, Christophe Henry, Alexandre Herbland, Julien Huntzinger, Hervé Hyvernat, Alexandre Jean, Boris Jolibois, Sylvie Joron, Gauthier Julien, Jean Kempf, Lyes Knani, Béatrice La Combe, Marie Labruyere, Sandrine Lacroix, Bruno Lafon, Katia Lamant, Peggy Larroudé, Anne Launoy, Bernadette Laurent, Thierry Lavigne, Christine Lawrence, Quoc Vien Le, Muriel Le Coq, Anne-Sophie Le Floch, Fanny Le Fall, Brigitte Le Tallec, Lucie Lecoutre, Stanislas Ledochowski, Rusel Leon, Claire Lepouse, Thomas Lescot, Mélanie Levrard, Marie Laure Lier, Anne Lignereux, Benjamin Louart, Claire Maheu, Aurélie Maindron, Francois Mallard, Marie Reine Mallaret, Bernard Mankikian, Christiane Manzon, Philippe Mardrus, Jacques Mariot, Audry Martin, Emmanuelle Martin, Maelle Martin, Pascale Martres, Virginie Maxime, Olivier Meunier, Ella-Pauline Meyer, Ferhat Meziani, Sébastien Moschietto, Céline Muller, Elodie Munier-Marion, Caroline Neulier, François Nicolas, Jacques-Yves Nizou, Christine Palitta, Michel Pascal, Olivier Passouant, René-Gilles Patrigeon, Frédérique Pavillard, Sabine Peghaire, Christophe Perdrix, Jean-Sebastien Petit, Judith Pibre, Walter Picard, Sylvie Picault, Santiago Picos Gil, Jérôme Pillot, Patrick Pina, Rémi Plattier, Laurent Poiron, Christian Pommier, Gaël Pradel, Cristian Prelipcean, Paul-Simon Pugliesi, Vincent Quenee, Olga Raposo, Eve Remy, Sabine Reynaud Deforges, Jean-Christophe Richard, Sylvie Ricome, Thomas Rimmele, Adrien Robine, Anne-Claude Roche, Laetitia Rohr, Gwenaël Rolland-Jacob, Adrien Roques, Catherine Rougier, Jérôme Roustan, Mélanie Saint-Leger, Faouzi Saliba, Dominique Sechaud, Amine Si-Ali, Catherine Simac, Georges Simon, Michel Sirodot, Vincent Stoeckel, Philippe Tagawa, Marine Tasle, Fabrice Thiollière, Benoit Thiphagne, Aurélie Thomas-Hervieu, François Tinturier, Alexandre Tonnelier, Alexandre Toro, David Tranvan, Dominique Trivier, Gilles Troché, Rémi Trusson, Lionel Ursulet, Marie Laure Valdeyron, Catherine Vallet, Vanessa Van Rossem, Laurence Vasse, Myriam Venelle, Christine Venot, Antoine Vieillard-Baron, Jean-François Vincent, Michel Vitris, Hussein Yassine, Lassane Zanre, Cecile Zylberfajn

• Open Access
• Septicemia
• Research

Derivation and validation of generalized sepsis-induced acute respiratory failure phenotypes among critically ill patients: a retrospective study

Tilendra Choudhary, Pulakesh Upadhyaya, Carolyn M. Davis, Philip Yang, Simon Tallowin, Felipe A. Lisboa, Seth A. Schobel, Craig M. Coopersmith, Eric A. Elster, Timothy G. Buchman, Christopher J. Dente, Rishikesan Kamaleswaran

• Open Access
• Comment

What criteria for neuropronostication: consciousness or ability? The neuro-intensivist’s dilemma

Nicolas Engrand, Armelle Nicolas-Robin, Pierre Trouiller, Stéphane Welschbillig

• Open Access
• Research

Consensus statements for the establishment of medical intensive care in low-resource settings: international study using modified Delphi methodology

Pedja Kovacevic, Jadranka Vidovic, Boris Tomic, Jihad Mallat, Ali Ait Hssain, Muyiwa Rotimi, Owoniya Temitope Akindele, Kent Doi, Rajesh Mishra, F. Joachim Meyer, Ivan Palibrk, Ranko Skrbic, Enrique Boloña, Oguz Kilickaya, Ognjen Gajic

• Open Access
• Antibiotic
• Matters Arising

Polymyxin-containing regimens for treating of pneumonia caused by multidrug-resistant gram-negative bacteria: Mind the breakpoints and the standardization of nebulization therapy

Lihui Wang, Chunhui Xu, Lining Si, Guifen Gan, Bin Lin, Yuetian Yu

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆PES in ventilated children

Meryl Vedrenne-Cloquet, Y. Ito, J. Hotz, M. J. Klein, M. Herrera, D. Chang, A. K. Bhalla, C. J. L. Newth, R. G. Khemani

• Open Access
• ECMO
• Review

A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation

Myeongji Kim, Maryam Mahmood, Lynn L. Estes, John W. Wilson, Nathaniel J. Martin, Joseph E. Marcus, Ankit Mittal, Casey R. O’Connell, Aditya Shah

• Open Access
• ECMO
• Correction

Correction to: Neurological monitoring and management for adult extracorporeal membrane oxygenation patients: Extracorporeal Life Support Organization consensus guidelines

Sung‑Min Cho, Jaeho Hwang, Giovanni Chiarini, Marwa Amer, Marta V. Antonini, Nicholas Barrett, Jan Belohlavek, Daniel Brodie, Heidi J. Dalton, Rodrigo Diaz, Alyaa Elhazmi, Pouya Tahsili‑Fahadan, Jonathon Fanning, John Fraser, Aparna Hoskote, Jae‑Seung Jung, Christopher Lotz, Graeme MacLaren, Giles Peek, Angelo Polito, Jan Pudil, Lakshmi Raman, Kollengode Ramanathan, Dinis Dos Reis Miranda, Daniel Rob, Leonardo Salazar Rojas, Fabio Silvio Taccone, Glenn Whitman, Akram M. Zaaqoq, Roberto Lorusso

• Open Access
• Lung Ultrasound
• Review

Nuts and bolts of lung ultrasound: utility, scanning techniques, protocols, and findings in common pathologies

Michael Beshara, Edward A. Bittner, Alberto Goffi, Lorenzo Berra, Marvin G. Chang

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation

Jason H. T. Bates, David W. Kaczka, Michaela Kollisch-Singule, Gary F. Nieman, Donald P. Gaver

• Open Access
• ECMO
• Research

Blood trauma in veno-venous extracorporeal membrane oxygenation: low pump pressures and low circuit resistance matter

Christopher Blum, Micha Landoll, Stephan E. Strassmann, Ulrich Steinseifer, Michael Neidlin, Christian Karagiannidis

• Open Access
• Polysomnography
• Research

Impact of sleep disturbances on outcomes in intensive care units

Laura Marchasson, Christophe Rault, Sylvain Le Pape, François Arrivé, Rémi Coudroy, Jean-Pierre Frat, Vanessa Bironneau, Etienne-Marie Jutant, Quentin Heraud, Xavier Drouot, Arnaud W. Thille

• Open Access
• ECMO
• Research

Extracorporeal membrane oxygenation for tuberculosis-related acute respiratory distress syndrome: An international multicentre retrospective cohort study

Ali Ait Hssain, Matthieu Petit, Clemens Wiest, Laura Simon, Abdulrahman A. Al-Fares, Ahmed Hany, Dafna I. Garcia-Gomez, Santiago Besa, Saad Nseir, Christophe Guervilly, Wael Alqassem, Mathieu Lesouhaitier, Adrian Chelaru, Simon WC Sin, Roberto Roncon-Albuquerque Jr., Marco Giani, Philipp M. Lepper, Jean-Rémi Lavillegrand, Sunghoon Park, Peter Schellongowski, Ibrahim Fawzy Hassan, Alain Combes, Romain Sonneville, Matthieu Schmidt

• Open Access
• Septicemia
• Brief Report

Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial

Mark C. Chappell, Christopher L. Schaich, Laurence W. Busse, Greg S. Martin, Jonathan E. Sevransky, Jeremiah K. Hinson, Ashish K. Khanna

• Open Access
• Sevoflurane
• Research

A systematic review on the use of sevoflurane in the management of status asthmaticus in adults

Gerald Wai Kit Ho, Thirumeninathan Thaarun, Neo Jean Ee, Teo Chong Boon, Koh Zheng Ning, Matthew Edward Cove, Will Ne-Hooi Loh

• Open Access
• Research

Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study

Fabio Silvio Taccone, Alain Cariou, Stefano Zorzi, Hans Friberg, Janus C. Jakobsen, Per Nordberg, Chiara Robba, Jan Belohlavek, Jan Hovdenes, Matthias Haenggi, Anders Åneman, Anders Grejs, Thomas R. Keeble, Filippo Annoni, Paul J. Young, Matt P. Wise, Tobias Cronberg, Gisela Lilja, Niklas Nielsen, Josef Dankiewicz

• Open Access
• Computed Tomography
• Research

Regional ventilation dynamics of electrical impedance tomography validated with four-dimensional computed tomography: single-center, prospective, observational study

Shinshu Katayama, Ken Tonai, Kie Nakamura, Misuzu Tsuji, Shinichiro Uchimasu, Atsuko Shono, Masamitsu Sanui

• Open Access
• ECMO
• Correspondence

Cefiderocol pharmacokinetics in critically ill patients undergoing ECMO support

María Marín-Cerezuela, Ruben Martín-Latorre, Juan Frasquet, Jesus Ruiz-Ramos, Sandra Garcia-Contreras, Mónica Gordón, María Jesús Broch, Álvaro Castellanos-Ortega, Paula Ramirez

• Open Access
• Septicemia
• Research

High-cost users after sepsis: a population-based observational cohort study

Kali A. Barrett, Fatima Sheikh, Victoria Chechulina, Hannah Chung, Peter Dodek, Laura Rosella, Kednapa Thavorn, Damon C. Scales

• Open Access
• CSF Drainage
• Research

Incidence, predictability, and outcomes of systemic venous congestion following a fluid challenge in initially fluid-tolerant preload-responders after cardiac surgery: a pilot trial

Bianca Morosanu, Cosmin Balan, Cristian Boros, Federico Dazzi, Adrian Wong, Francesco Corradi, Serban-Ion Bubenek-Turconi

• Open Access
• Cardiopulmonary Resuscitation
• Matters Arising

An update on the mechanical versus manual cardiopulmonary resuscitation in cardiac arrest patients

Ayman El-Menyar, Mashhood Naduvilekandy

• Open Access
• Correspondence

Comparison of electrical impedance tomography, blood gas analysis, and respiratory mechanics for positive end-expiratory pressure titration

Han Chen, Takeshi Yoshida, Jian-Xin Zhou

• Open Access
• Electroencephalography
• Comment

A plea for enhanced monitoring of depth of sedation in patients who are intubated and ventilated

Stefano Romagnoli, Basil Matta, Brian E. Driver, Lisbeth Evered

• Open Access
• ECMO
• Research

Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis

Mitsuaki Nishikimi, Shinichiro Ohshimo, Giacomo Bellani, Wataru Fukumoto, Tatsuhiko Anzai, Keibun Liu, Junki Ishii, Michihito Kyo, Kazuo Awai, Kunihiko Takahashi, Nobuaki Shime, Jun Hamaguchi, Kazuki Matsumura, Kenji Fujizuka, Yoshihiro Hagiwara, Ryuichi Nakayama, Naofumi Bunya, Junichi Maruyama, Takayuki Ogura, Mitsunobu Nakamura, Keiki Shimizu, Mamoru Masuda

• Open Access
• Non-Invasive Ventilation
• Research

Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study

Shahin Isha, Prasanth Balasubramanian, Abby J. Hanson, Sadhana Jonna, Lekhya Raavi, Subekshya Khadka, Ananya Vasudhar, Jorge Sinclair De Frias, Anna Jenkins, Arvind Balavenkataraman, Aysun Tekin, Vikas Bansal, Swetha Reddy, Sean M. Caples, Syed Anjum Khan, Nitesh K. Jain, Abigail T. LaNou, Rahul Kashyap, Rodrigo Cartin-Ceba, Ricardo Diaz Milian, Carla P. Venegas, Anna B. Shapiro, Anirban Bhattacharyya, Sanjay Chaudhary, Sean P. Kiley, Quintin J. Quinones, Neal M. Patel, Pramod K. Guru, Pablo Moreno Franco, Devang K. Sanghavi

• Open Access
• Research

Self-confidence as a mediator in the relationship between executive functioning and depression among ICU survivors: a latent variable analysis

Elias Johannesson, Johan Malmgren

• Open Access
• Septicemia
• Brief Report

Clinical impact of the implementation of monocyte distribution width (MDW) measurement on time to anti-infective administration in sepsis patients in the emergency department: a before/after cohort study

Marta Cancella de Abreu, Timothé Sala, Enfel Houas, Ilaria Cherubini, Martin Larsen, Pierre Hausfater

• Open Access
• ECMO
• Matters Arising

Lack of up-to-date studies and data conversion may lead to biased results

Guoying Wang, Fen Liu, Linqing Xu, Xiaoming Zhou

• Open Access
• Caspofungin
• Research

Rezafungin versus caspofungin for patients with candidaemia or invasive candidiasis in the intensive care unit: pooled analyses of the ReSTORE and STRIVE randomised trials

Patrick M. Honoré, Massimo Girardis, Marin Kollef, Oliver A. Cornely, George R. Thompson III, Matteo Bassetti, Alex Soriano, Haihui Huang, Jose Vazquez, Bart Jan Kullberg, Peter G. Pappas, Nick Manamley, Taylor Sandison, John Pullman, Saad Nseir

• Open Access
• Atrial Fibrillation
• Research

Interpretable machine learning model for new-onset atrial fibrillation prediction in critically ill patients: a multi-center study

Chengjian Guan, Angwei Gong, Yan Zhao, Chen Yin, Lu Geng, Linli Liu, Xiuchun Yang, Jingchao Lu, Bing Xiao

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Airway epithelium damage in acute respiratory distress syndrome

Ludovic Gerard, Marylene Lecocq, Bruno Detry, Caroline Bouzin, Delphine Hoton, Joao Pinto Pereira, François Carlier, Thomas Plante-Bordeneuve, Sophie Gohy, Valérie Lacroix, Pierre-François Laterre, Charles Pilette

• Open Access
• Septic Shock
• Research

Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock

Klaus Stahl, Georg F. Lehner, Pedro David Wendel-Garcia, Benjamin Seeliger, Thorben Pape, Bernhard M. W. Schmidt, Heiko Schenk, Julius Schmitt, Andrea Sauer, Lennart Wild, Konrad Peukert, Christian Putensen, Christian Bode, Michael Joannidis, Sascha David

• Open Access
• Respiratory Medicine
• Review

A narrative review on lung injury: mechanisms, biomarkers, and monitoring

Wenping Fan, Biyu Gui, Xiaolei Zhou, Li Li, Huaiyong Chen

• Open Access
• Non-Invasive Ventilation
• Correspondence

Development and functional characterization of a novel respiratory mask with full accordion cushioning to prevent air leaks and pressure injuries during non-invasive ventilation

Masahiko Hara, Masatake Tamaki

• Open Access
• Soft Tissue Infection
• Research

Biochemical analysis of soft tissue infectious fluids and its diagnostic value in necrotizing soft tissue infections: a 5-year cohort study

Kai-Hsiang Wu, Po-Han Wu, Hung-Sheng Wang, Hsiu-Mei Shiau, Yung-Sung Hsu, Chih-Yi Lee, Yin-Ting Lin, Cheng-Ting Hsiao, Leng-Chieh Lin, Chia-Peng Chang, Pey-Jium Chang

• Open Access
• Matters Arising

Transpulmonary pressure monitoring in critically ill patients: pros and cons—correction of description of the non-invasive PEEP-step method for separation of lung and chest wall mechanics

Ola Stenqvist

• Open Access
• Mpox
• Comment

What every intensivist needs to know about mpox

Siyao Zeng, Yue Li, Zhipeng Yao, Junbo Zheng, Hongliang Wang

• Open Access
• Tocilizumab
• Matters Arising

Commenting on baricitinib versus tocilizumab in mechanically ventilated patients with COVID-19: a nationwide cohort study

James Cheng Chung Wei, Poi Kuo, Po-Cheng Shih

• Open Access
• Perspective

Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction

Mattia Docci, Giuseppe Foti, Laurent Brochard, Giacomo Bellani

• Open Access
• Nutrition
• Review

The efficacy of fiber-supplemented enteral nutrition in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

Jana Larissa Koch, Charles Chin Han Lew, Felix Kork, Alexander Koch, Christian Stoppe, Daren K. Heyland, Ellen Dresen, Zheng-Yii Lee, Aileen Hill

• Open Access
• Research

Changes in central venous-to-arterial PCO2 difference and central venous oxygen saturation as markers to define fluid responsiveness in critically ill patients: a pot-hoc analysis of a multi-center prospective study

Jihad Mallat, Osama Abou-Arab, Malcolm Lemyze, Dahlia Saleh, Pierre-Grégoire Guinot, Marc-Olivier Fischer

• Open Access
• Caspofungin
• Research

Length of hospital and intensive care unit stay in patients with invasive candidiasis and/or candidemia treated with rezafungin: a pooled analysis of two randomised controlled trials

Patrick M. Honoré, Matteo Bassetti, Oliver A. Cornely, Herve Dupont, Jesús Fortún, Marin H. Kollef, Peter Pappas, John Pullman, Jose Vazquez, Inga Bielicka, Sara Dickerson, Nick Manamley, Taylor Sandison, George R. Thompson

• Open Access
• Prolonged Grief Disorder
• Research

Factors of prolonged-grief-disorder symptom trajectories for ICU bereaved family surrogates

Fur-Hsing Wen, Holly G. Prigerson, Li-Pang Chuang, Tsung-Hui Hu, Chung-Chi Huang, Wen-Chi Chou, Siew Tzuh Tang

• Open Access
• Artificial Intelligence
• Research

Representation of intensivists’ race/ethnicity, sex, and age by artificial intelligence: a cross-sectional study of two text-to-image models

Mia Gisselbaek, Mélanie Suppan, Laurens Minsart, Ekin Köselerli, Sheila Nainan Myatra, Idit Matot, Odmara L. Barreto Chang, Sarah Saxena, Joana Berger-Estilita

• Open Access
• Septic Shock
• Correspondence

Epidemiology of β-blocker use among critically iII patients during and after septic shock

Stuthi Iyer, Jason N. Kennedy, Peter C. Nauka, Mourad H. Senussi, Christopher W. Seymour

• Open Access
• Research

Based -evidence, an intervention study to improve sleep quality in awake adult ICU patients: a prospective, single-blind, clustered controlled trial

Yanting Zhang, Yihua Yang, Chong Cheng, Gui Hou, Xinbo Ding, Jing Ma

• Open Access
• Review

Predictors of weaning failure in ventilated intensive care patients: a systematic evidence map

Fritz Sterr, Michael Reintke, Lydia Bauernfeind, Volkan Senyol, Christian Rester, Sabine Metzing, Rebecca Palm

• Open Access
• Central Nervous System Trauma
• Research

Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis

Elisa Gouvêa Bogossian, Michele Salvagno, Marco Fiore, Marta Talamonti, Chiara Prezioso, Federica Montanaro, Sara Fratino, Sophie Schuind, Fabio Silvio Taccone

• Open Access
• Research

The long-term conditional mortality rate in older ICU patients compared to the general population

Anna Aronsson Dannewitz, Bodil Svennblad, Karl Michaëlsson, Miklos Lipcsey, Rolf Gedeborg

• Open Access
• Isoflurane
• Matters Arising

Volatile anaesthetics for ICU sedation: beyond hypnosis?

José Manuel Añón, Fernando Suarez-Sipmann, María Paz Escuela, Aris Perez-Lucendo, Andoni García-Muñoz

• Open Access
• Matters Arising

Inhalation NO in the HFNC group may result in a meaningless extension of survival time

Lin Zhong, Lingtong Huang

• Open Access
• Pneumothorax
• Correspondence

Pitfall of lung ultrasound in the quantification of pneumothorax

Haotian Zhao, Kai Liu, Li Li, Heling Zhao

• Open Access
• Nutrition
• Correspondence

How to define parenteral nutrition

Annika Reintam Blaser, Antonella Cotoia, Mette M. Berger, Martin Padar, Yaseen M. Arabi, Michael P. Casaer, Jan Gunst, Imre W. K. Kouw, Manu L. N. G. Malbrain, Stefan J. Schaller, Joel Starkopf, Martin Sundström Rehal, Arthur R. H. van Zanten, Kaspar F. Bachmann, Yvonnen Swaen-Dekkers, Anna-Liisa Voomets, Rebecca Lindström, Jonas Blixt, Benjamin Hess, Olivier Pantet, Yasir Alzoubi, Liese Mebis, Linus O. Warner, Kristina Fuest, Francesco Cardinale, Zhigang Chang, Ramprasad Matsa, Cecilia Loudet, Maria Theodorakopoulou, Giuliano Bolondi, František Duška, Juan Carlos Lopez-Delgado, Varsha Asrani, Natalija Vukovic, Oskar Appelberg, Raul Sanchez Leon, Guillaume Besch, Sirak Petros, Rebecka Rubenson Wahlin, Qin Wu, Jovana Stanisavljevic, Zhang Dong

• Open Access
• Comment

The effects between andexanet alpha and four-factor prothrombin complex concentrate on DOACs anticoagulation reversal

Tengfei Yang, Bo Zhao

• Open Access
• Septicemia
• Research

Three-year mortality of ICU survivors with sepsis, an infection or an inflammatory illness: an individually matched cohort study of ICU patients in the Netherlands from 2007 to 2019

Sesmu M. Arbous, Fabian Termorshuizen, Sylvia Brinkman, Dylan W. de Lange, Rob J. Bosman, Olaf M. Dekkers, Nicolette F. de Keizer

• Open Access
• Septicemia
• Research

A multicentre prospective registry of one thousand sepsis patients admitted in Indian ICUs: (SEPSIS INDIA) study

Subhash Todi, Yatin Mehta, Kapil Zirpe, Subhal Dixit, Atul P. Kulkarni, Sushma Gurav, Shweta Ram Chandankhede, Deepak Govil, Amitabha Saha, Arpit Kumar Saha, Sumalatha Arunachala, Kapil Borawake, Shilpushp Bhosale, Sumit Ray, Ruchi Gupta, Swarna Deepak Kuragayala, Srinivas Samavedam, Mehul Shah, Ashit Hegde, Palepu Gopal, Abdul Samad Ansari, Ajoy Krishna Sarkar, Rahul Pandit, Fehmeena Begum, Mubeena Qadir, Sourabh S. Ambapkar, Saanvi S. Ambapkar, D. Soma Sekhar, Ramesh Shanmugam, P. Ashok, K. B. Chetak, Abhijit Deshmukh, Anand Tiwari, Anita Salgar, Puja Kaushik, Sushmita Basu, Mayur Shah, Chitra Mehta, Sweta J. Patel, Rahul Hurne, Anjana Srivastav, Gaurav Kochhar

• Open Access
• Pharmacokinetics
• Review

The relation between inflammatory biomarkers and drug pharmacokinetics in the critically ill patients: a scoping review

Letao Li, Julia Zinger, Sebastiaan D. T. Sassen, Nicole P. Juffermans, Birgit C. P. Koch, Henrik Endeman

• Open Access
• Review

Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions

Gaetano Scaramuzzo, Bertrand Pavlovsky, Andy Adler, Walter Baccinelli, Dani L. Bodor, L. Felipe Damiani, Guillaume Franchineau, Juliette Francovich, Inéz Frerichs, Juan A. Sánchez Giralt, Bartłomiej Grychtol, Huaiwu He, Bhushan H. Katira, Alette A. Koopman, Steffen Leonhardt, Luca S. Menga, Amne Mousa, Mariangela Pellegrini, Thomas Piraino, Paolo Priani, Peter Somhorst, Elena Spinelli, Claas Händel, Fernando Suárez-Sipmann, Jantine J. Wisse, Tobias Becher, Annemijn H. Jonkman

• Open Access
• Research

Central venous catheter-related infections: a systematic review, meta-analysis, trial sequential analysis and meta-regression comparing ultrasound guidance and landmark technique for insertion

Nicolas Boulet, Joris Pensier, Bob-Valéry Occean, Pascale Fabbro Peray, Olivier Mimoz, Claire M. Rickard, Niccolò Buetti, Jean-Yves Lefrant, Laurent Muller, Claire Roger

• Open Access
• Acute Kidney Injury
• Matters Arising

New definition of AKI: shifting the focus beyond mortality

Lihong Zhu, Juan Lin

• Open Access
• Septicemia
• Comment

Do prolonged infusions of β-lactam antibiotics improve outcomes in critically ill patients with sepsis? It is time to say yes

Xiaoming Li, Zhengying Jiang

• Open Access
• Nosocomial Pneumonia
• Research

D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care

Luis Felipe Reyes, Cristian C. Serrano-Mayorga, Zhongheng Zhang, Isabela Tsuji, Gennaro De Pascale, Valeria Enciso Prieto, Mervyn Mer, Elyce Sheehan, Prashant Nasa, Goran Zangana, Kostoula Avanti, Alexis Tabah, Gentle Sunder Shrestha, Hendrik Bracht, Arie Zainul Fatoni, Khalid Abidi, Helmi bin Sulaiman, Vandana Kalwaje Eshwara, Liesbet De Bus, Yoshiro Hayashi, Pervin Korkmaz, Ali Ait Hssain, Niccolò Buetti, Qing Yuan Goh, Arthur Kwizera, Despoina Koulenti, Nathan D. Nielsen, Pedro Povoa, Otavio Ranzani, Jordi Rello, Andrew Conway Morris, Luis Felipe Reyes, Zhongheng Zhang, Mervyn Mer, Alexis Tabah, Arthur Kwizera, Despoina Koulenti, Nathan D. Nielsen, Pedro Povoa, Otavio Ranzani, Jordi Rello, Andrew Conway Morris, Wilson Mphandi, Adrian Ceccato, Alexis Tabah, Ahsina Jahan, Liesbet De Bus, Isabela Tsuji, Zhongheng Zhang, Luis Felipe Reyes, Manuel Jibaja, Adel Alsisi, Antoine Roquilly, Hendrik Bracht, Kostoula Arvaniti, Nancy Sandoval, Vandana Kalwaje Eshwara, Arie Zainul, Faird Zand, Gennaro De Pascale, Yoshiro Hayashi, Dimitry Viderman, Helmi bin Sulaiman, Leonel Lagunes, Prashant Nasa, Goran Zangana, Khalid Abidi, Gentle Shrestha, Jeroen Schouten, Dabota Buowari, Madiha Hashmi, Nestor Luque, David Nora, Ali Ait Hssain, Artem Kuzovlev, Qing Yuan Goh, Mervyn Mer, Jordi Rello, Rashan Hanifa, Fredrik Sjovall, Niccollò Buetti, Tony Yeh, Pervin Korkmaz, Arthur Kwizera, Nesreen Shaban, Islam Hamed, Elyce Sheehan

• Open Access
• Central Nervous System Trauma
• Research

Evaluation of severe rhabdomyolysis on day 30 mortality in trauma patients admitted to intensive care: a propensity score analysis of the Traumabase registry

Thibault Martinez, Anatole Harrois, Anaïs Codorniu, Nicolas Mongardon, Matthieu Pissot, Benjamin Popoff, Marc Leone, Nathalie Delhaye, Eric Vicaut, Quentin Mathais, Vincent Legros, Jean-Luc Hanouz, Nicolas Gatulle, Véronique Ramonda, Benjamin Cohen, Mathieu Boutonnet, Julien Pottecher, Nicolas Libert, Jean Denis Moyer, Arthur James, Fanny Bounes, Gérard Audibert, Mickael Cardinale, Anne Galland, Alexandre Bourgeois, Philippe Laitselart, Marie Werner, Caroline Jeantrelle, Thomas Geeraerts, Sebastien Gette, Elisabeth Gaertner, Claire Jaillette, Mathieu Willig

• Open Access
• Septicemia
• Research

Epidemiology of sepsis-associated acute kidney injury in critically ill patients: a multicenter, prospective, observational cohort study in South Korea

Myung Jin Song, Yeonhoon Jang, Matthieu Legrand, Sunghoon Park, RyoungEun Ko, Gee Young Suh, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Chae-Man Lim, Se Young Jung, Sung Yoon Lim

• Open Access
• Matters Arising

Inhaled nitric oxide clinical confusions: population types, duration, and responsiveness

Kai Liu, Shi-Min Zhang, Jing-chao Luo, Min-jie Ju

• Open Access
• Septicemia
• Research

Culture-negative sepsis may be a different entity from culture-positive sepsis: a prospective nationwide multicenter cohort study

Youjin Chang, Ju Hyun Oh, Dong Kyu Oh, Su Yeon Lee, Dong-gon Hyun, Mi Hyeon Park, Chae-Man Lim, Chae-Man Lim, Sang-Bum Hong, Dong Kyu Oh, Su Yeon Lee, Gee Young Suh, Kyeongman Jeon, Ryoung-Eun Ko, Young-Jae Cho, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Jeongwon Heo, Jae-myeong Lee, Kyung Chan Kim, Yeon Joo Lee, Youjin Chang, Kyeongman Jeon, Sang-Min Lee, Chae-Man Lim, Suk-Kyung Hong, Woo Hyun Cho, Sang Hyun Kwak, Heung Bum Lee, Jong-Joon Ahn, Gil Myeong Seong, Song-I Lee, Sunghoon Park, Tai Sun Park, Su Hwan Lee, Eun Young Choi, Jae Young Moon, Hyung Koo Kang

• Open Access
• Pediatric Intensive Care
• Research

Cost-effectiveness of high flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care

Zia Sadique, Silvia Moler Zapata, Richard Grieve, Alvin Richards-Belle, Izabella Lawson, Robert Darnell, Julie Lester, Kevin P. Morris, Lyvonne N. Tume, Peter J. Davis, Mark J. Peters, Richard G. Feltbower, Paul R. Mouncey, David A. Harrison, Kathryn M. Rowan, Padmanabhan Ramnarayan

• Open Access
• Antibiotic
• Review

Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis

Nicolò Sella, Tommaso Pettenuzzo, Alessandro De Cassai, Francesco Zarantonello, Sabrina Congedi, Andrea Bruni, Eugenio Garofalo, Honoria Ocagli, Dario Gregori, Federico Longhini, Paolo Navalesi, Annalisa Boscolo, Carlo Albero Bertoncello, Nicola Franchetti, Chiara Schiavolin, Giuliana Carofiglio, Chiara Guidotto, Giovanni De Lorenzi, Christian Legnaro, Marco Nardelli, Elisa Pistollato, Giulia Mormando, Arianna Peralta, Enrico Petranzan, Luisa Muraro, Paolo Persona, Giorgia Pacchiarini

• Open Access
• Matters Arising

Passive leg raising uncovers venous congestion: dynamic fluid intolerance and the Doppler Starling curve

Jon-Emile S. Kenny

• Open Access
• Septic Shock
• Research

The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

Matthieu Legrand, Ashish K. Khanna, Marlies Ostermann, Yuki Kotani, Ricard Ferrer, Massimo Girardis, Marc Leone, Gennaro DePascale, Peter Pickkers, Pierre Tissieres, Filippo Annoni, Katarzyna Kotfis, Giovanni Landoni, Alexander Zarbock, Patrick M. Wieruszewski, Daniel De Backer, Jean-Louis Vincent, Rinaldo Bellomo

• Open Access
• Packed Red Blood Cell
• Matters Arising

Time-dependent intervention in the database study examining the efficacy of whole blood transfusion in traumatic patients

Taisuke Shibata, Saburo Minami, Atsushi Shiraishi

• Open Access
• Lung Ultrasound
• Research

Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial

Jean-Jacques Rouby, Sébastien Perbet, Jean-Pierre Quenot, Mao Zhang, Pascal Andreu, Mona Assefi, Yuzhi Gao, Romain Deransy, Jie Lyu, Charlotte Arbelot, Youzhong An, Antoine Monsel, Xia Jing, Philippe Guerci, Chuanyun Qian, Luiz Malbouisson, Dominique Morand, Louis Puybasset, Emmanuel Futier, Jean-Michel Constantin, Bruno Pereira, Nicolas Adam, Marine Lecorre, Hélène Brisson, Matthieu Jabaudon, Russel Chabanne, Sylvia Collomb, Marie Labruyère, Jean-Baptiste Roudaut, Marine Jacquier, Shan Lyu, Yang Ting, Julien Birckener, Laura Chenard, Benoît Longère, Pierre-Eric Danin, Jean-François Payen, Florent Wallet, Felippe Dexheimer

• Open Access
• Esmolol
• Research

Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials

Mihai-Gabriel Alexandru, Patrick Niewald, Stefan Krüger, Rainer Borgstedt, Tony Whitehouse, Mervyn Singer, Sebastian Rehberg, Sean S. Scholz

• Open Access
• Anesthetics
• Matters Arising

Reply to “volatile anaesthetics for ICU sedation: beyond hypnosis?”: A comment on “volatile anesthetics for lung- and diaphragm-protective sedation”

Lukas M. Müller-Wirtz, Marcus J. Schultz, Andreas Meiser

• Open Access
• ECMO
• Research

Intra-aortic balloon pump after VA-ECMO reduces mortality in patients with cardiogenic shock: an analysis of the Chinese extracorporeal life support registry

Kexin Wang, Liangshan Wang, Jiawang Ma, Haixiu Xie, Chenglong Li, Xing Hao, Zhongtao Du, Hong Wang, Xiaotong Hou

• Open Access
• Matters Arising

Association between whole blood transfusion and mortality

Shangzhong Chen

• Open Access
• Septicemia
• Research

Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis

David Legouis, Céline Monard, Aimad Ourahmoune, Sebastian Sgardello, Hervé Quintard, Gilles Criton, Frederic Sangla, Antoine Schneider

• Open Access
• Septicemia
• Matters Arising

Timing of mechanical ventilation in sepsis

Juqin Shao, Juan Lin

• Open Access
• Septicemia
• Matters Arising

Angiotensinogen: a new era beyond lactate as a biomarker?

Yanfei Shen, Xinyuan Ding

• Open Access
• Septicemia
• Correspondence

Lymphocyte count trajectories are associated with the prognosis of sepsis patients

Jiale Yang, Binli Ma, Huasheng Tong

• Open Access
• Research

Nailfold videocapillaroscopy – a novel method for the assessment of hemodynamic incoherence on the ICU

Sebastian Kintrup, Lukasz Listkiewicz, Philip-Helge Arnemann, Nana-Maria Wagner

• Open Access
• Septic Shock
• Research

Epidemiology and outcomes of septic shock in Thai children: a nationwide retrospective study from 2015 to 2022

Sirapoom Niamsanit, Phanthila Sitthikarnkha, Leelawadee Techasatian, Suchaorn Saengnipanthkul, Rattapon Uppala

• Open Access
• Leukopenia
• Matters Arising

Relationship between leukopenia and mortality among patients with hematological malignancies

Caibao Hu, Qian Li, Xinyuan Ding

• Open Access
• ECMO
• Research

The effects of blood cell salvage on transfusion requirements after decannulation from veno-venous extracorporeal membrane oxygenation: an emulated trial analysis

Valentina Camarda, Barnaby Sanderson, Nicholas A. Barrett, Patrick Duncan Collins, Benjamin Garfield, Luciano Gattinoni, Lorenzo Giosa, Teddy Tun Win Hla, Ruth H. Keogh, Claire Laidlaw, Francesca Momigliano, Brijesh V. Patel, Andrew Retter, Emilia Tomarchio, Daniel McAuley, Louise Rose, Luigi Camporota

• Open Access
• Artificial Intelligence
• Review

Roadmap for the evolution of monitoring: developing and evaluating waveform-based variability-derived artificial intelligence-powered predictive clinical decision support software tools

Andrew J. E. Seely, Kimberley Newman, Rashi Ramchandani, Christophe Herry, Nathan Scales, Natasha Hudek, Jamie Brehaut, Daniel Jones, Tim Ramsay, Doug Barnaby, Shannon Fernando, Jeffrey Perry, Sonny Dhanani, Karen E. A. Burns

• Open Access
• Community-Acquired Pneumonia
• Research

Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia

Emma Rademaker, Lisette M. Vernooij, Tom van der Poll, Marc J. M. Bonten, Helen Leavis, Olaf L. Cremer, Lennie P. G. Derde

• Open Access
• Cytokines
• Research

REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial

Andreas Hohn, Nathalie M. Malewicz-Oeck, Dirk Buchwald, Thorsten Annecke, Peter K. Zahn, Andreas Baumann

• Open Access
• Septic Shock
• Matters Arising

Reply to: angiotensinogen: a new era beyond lactate as a biomarker?

Mark C. Chappell, Christopher L. Schaich, Ashish K. Khanna

• Open Access
• Insulins
• Research

Management of diabetic keto-acidosis in adult patients admitted to intensive care unit: an ESICM-endorsed international survey

Mathieu Jozwiak, Margaret M. Hayes, Emmanuel Canet, Alexandre Lautrette, Maël-Morvan Duroyon, Nicolas Molinari, Boris Jung

• Open Access
• Baricitinib
• Matters Arising

Baricitinib therapy in critical COVID-19: plenty of promise, but no hard evidence yet

Seung-Hun You, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim

• Open Access
• Acute Kidney Injury
• Matters Arising

Structural, physiological or clinical outcomes to define urine output threshold in acute kidney injury

Guido Dias Machado, Leticia Libório Santos, Alexandre Braga Libório

• Open Access
• Septicemia
• Matters Arising

Associations between oxygenation status and prognosis in sepsis

Lihong Zhu, Juan Lin

• Open Access
• Carbapenem Antibiotic
• Research

Seven versus 14 days of antimicrobial therapy for severe multidrug-resistant Gram-negative bacterial infections in intensive care unit patients (OPTIMISE): a randomised, open-label, non-inferiority clinical trial

Beatriz Arns, Andre C. Kalil, Guilherme G. L. Sorio, Emerson Boschi, Ana Carolina Peçanha Antonio, Juliana Peçanha Antonio, Daniella Cunha Birriel, Daniel Haase Lanziotti, Frederico da Cunha Abbott, Glecia Carla Rocha, Vanildes de Fátima Fernandes, Vicente Cés de Souza Dantas, Graciele Fátima da Silva Medeiros, Verônica de França Diniz Rocha, Francielle Constantino Pereira, André Luiz Nunes Gobatto, Valéria Paes Lima, Fábio Holanda Lacerda, Cláudia Maria Dantas de Maio Carrilho, Kairo Daniel Nunes de Oliveira Cardozo, Vivian Menezes Irineu, Pedro Kurtz, Jaqueline Driemeyer Correia Horvath, Guilhermo Prates Sesin, Crepin Aziz Jose Oluwafoumi Agani, Tiago Marcon dos Santos, Liliane Spencer Bittencourt Brochier, Bruna Silveira da Rosa, Bruno Martins Tomazini, Bruno Adler Maccagnan Pinheiro Besen, Adriano Jose Pereira, Viviane Cordeiro Veiga, Giovana Marssola Nascimento, Alexandre P. Zavascki, Jaysa Pizzi, Thaissa Torrezini, Euclimeire da Silva Neves, Jamile Freire Barreto dos Santos, Jaime Paula Pessoa Linhares Filho, Marcos de Almeida e Pontes Vieira, René Rodrigues Pereira, Cassia Righy, Ricardo Turon, Bruno Gonçalves

• Open Access
• Delirium
• Brief Report

Sex specific differences in short-term mortality after ICU-delirium

Nikolaus Schreiber, Michael Eichlseder, Simon Orlob, Christoph Klivinyi, Philipp Zoidl, Alexander Pichler, Michael Eichinger, Simon Fandler-Höfler, Laura Scholz, Jekaterina Baumgartner, Michael Schörghuber, Philipp Eller

• Open Access
• Intracranial Hypertension
• Correspondence

Aggressive therapies for intracranial hypertension after aneurysmal subarachnoid hemorrhage: a single-center experience

Tommaso Zoerle, Elisa Zoe Battistelli, Valeria Conte, Silvia Pifferi, Alessandra Merrino, Anna Zanetti, Marco Locatelli, Fabrizio Ortolano, Nino Stocchetti

• Open Access
• Septicemia
• Matters Arising

Timing of invasive mechanical ventilation in patients with sepsis: the impact of excluding non-intubated patients

Yun Ji, Libin Li

• Open Access
• Shock
• Perspective

Are crystalloid-based fluid expansion strategies still relevant in the first hours of trauma induced hemorrhagic shock?

Perrine Tubert, Alexandre Kalimouttou, Pierre Bouzat, Jean-Stéphane David, Tobias Gauss

• Open Access
• ECMO
• Correspondence

VExUS score in V-V ECMO: the B-wave

Dion O. Gajadin, Wouter A. van der Heijden, Maarten van den Berg

• Open Access
• Dyspnea
• Matters Arising

Relationships between dyspnea, oxygenation and prognosis in hypoxemic respiratory failure

Yanfei Shen, Xinyuan Ding

• Open Access
• Acute Kidney Injury
• Research

Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes

Ian B. Stanaway, Eric D. Morrell, F. Linzee Mabrey, Neha A. Sathe, Zoie Bailey, Sarah Speckmaier, Jordan Lo, Leila R. Zelnick, Jonathan Himmelfarb, Carmen Mikacenic, Laura Evans, Mark M. Wurfel, Pavan K. Bhatraju

• Open Access
• Nutrition
• Research

Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI)

Kaspar F. Bachmann, Bethan Jenkins, Varsha Asrani, Danielle E. Bear, Giuliano Bolondi, Sabrina Boraso, Michael P. Casaer, Zhigang Chang, Craig M. Coopersmith, Antonella Cotoia, Thomas Davies, Angelique De Man, Gunnar Elke, Kursat Gundogan, Jan Gunst, Slavica Kvolik, Marcus Laube, Matthias Lindner, Juan Carlos Lopez-Delgado, Cecilia Loudet, Ram Matsa, Emmanuel Pardo, Simone Piva, Zudin Puthucheary, Todd W. Rice, Sergio Ruiz-Santana, Stefan J. Schaller, Joel Starkopf, Christian Stoppe, Arthur Van Zanten, Annika Reintam Blaser

• Open Access
• ICU-Acquired Weakness
• Research

Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients

Sara Virolle, Baptiste Duceau, Elise Morawiec, Quentin Fossé, Marie-Cécile Nierat, Mélodie Parfait, Maxens Decavèle, Alexandre Demoule, Julie Delemazure, Martin Dres

• Open Access
• Septic Shock
• Matters Arising

Thiamine administration in septic shock: towards finding the target population

Jacob Vine, John H. Lee, Ari Moskowitz, Michael W. Donnino

• Open Access
• Acute Respiratory Distress Syndrome
• Obituary

Luciano Gattinoni: a tribute to a pioneer in intensive care medicine

Antonio Pesenti, Gaetano Iapichino, Jean Louis Vincent

• Open Access
• Tracheostomy
• Correspondence

Application and safety of speaking valves in tracheostomy patients

Hao Wang, Hongying Jiang, Zhanqi Zhao, Jia Liu, Chenxi Zhang

• Open Access
• Lice
• Research

Comparison of methods to normalize urine output in critically ill patients: a multicenter cohort study

Céline Monard, Nicolas Tebib, Bastien Trächsel, Tatiana Kelevina, Antoine Guillaume Schneider

• Open Access
• ECMO
• Brief Report

Veno-venous extracorporeal membrane oxygenation as a bridge in central airway obstruction: experience from a high-volume center

Xiao-xiu Luo, Jia-jia Li, Fu-xun Yang, Yu Lei, Fan Zeng, Yun-ping Lan, Chun Pan, Xiao-bo Huang, Rong-an Liu, Jing-chao Luo

• Open Access
• Neuromonitoring
• Consensus Article

Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus

Sami Barrit, Mejdeddine Al Barajraji, Salim El Hadwe, Alexandre Niset, Brandon Foreman, Soojin Park, Christos Lazaridis, Lori Shutter, Brian Appavu, Matthew P. Kirschen, Felipe A. Montellano, Verena Rass, Nathan Torcida, Daniel Pinggera, Emily Gilmore, Nawfel Ben-Hamouda, Nicolas Massager, Francis Bernard, Chiara Robba, Fabio Silvio Taccone, Mejdeddine Al Barajraji, Ionel Alb, Edilberto Amorim, Brian Appavu, Baptiste Balanca, Sami Barrit, Nawfel Ben-Hamouda, Francis Bernard, Giorgio Giovanni Carrabba, Russell Chabanne, Giuseppe Citerio, Salim El Hadwe, Brandon Foreman, Emily Gilmore, Maria Isabel Gonzalez, Adrien Guenego, Steven David Hajdu, Raimund Helbok, Peter John Ashton Hutchinson, Kristaps Jurjans, Matthew P. Kirschen, Alfonso Lagares, Christos Lazaridis, Joshua Mark Levine, Teemu M. Luoto, Niklas Marklund, Nicolas Massager, Aurélien Mazeraud, Mahmoud Messerer, Felipe Montellano, Laura Benjamin Ngwenya, Alexandre Niset, Soojin Park, Daniel Pinggera, Verena Rass, Thibault Yves Remacle, Chiara Robba, Sergio Aguilera Rodriguez, Lori Shutter, Fabio Silvio Taccone, Nicole Angela Terpolilli, Nathan Torcida Sedano, Parmenion P. Tsitsopoulos, Thomas Arjan Van Essen, Dmitar Vlahovic, Allen Waziri, Jan Folkard Willms, Alexander Younsi

• Open Access
• Baricitinib
• Matters Arising

Comments on “Baricitinib versus tocilizumab in mechanically ventilated patients with COVID-19: a nationwide cohort study”

Rong Li, JuanJuan Wang, Qian Li, QianYue Guo, Jun Kang Zhao, James Cheng-Chung Wei, Li-Yun Zhang

• Open Access
• Septic Shock
• Research

Impact on fluid balance of an optimized restrictive strategy targeting non-resuscitative fluids in intensive care patients with septic shock: a single-blind, multicenter, randomized, controlled, pilot study

Nicolas Boulet, Jean-Pierre Quenot, Chris Serrand, Nadiejda Antier, Sylvain Garnier, Aurèle Buzancais, Laurent Muller, Claire Roger, Jean-Yves Lefrant, Saber Davide Barbar

• Open Access
• Comment

Red blood cell transfusion in brain injury: Is it solely a matter of hemoglobin threshold?

Lamamri Myriam, Arnaud Foucrier, Emmanuel Weiss

• Open Access
• Septicemia
• Research

Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality

Beulah Augustin, Dongyuan Wu, Lauren Page Black, Andrew Bertrand, Dawoud Sulaiman, Charlotte Hopson, Vinitha Jacob, Jordan A. Shavit, Daniel A. Hofmaenner, Guillaume Labilloy, Leslie Smith, Emilio Cagmat, Kiley Graim, Susmita Datta, Srinivasa T. Reddy, Faheem W. Guirgis

• Open Access
• Renal Replacement Procedures
• Review

Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives

Gabriella Bottari, Vito Marco Ranieri, Can Ince, Antonio Pesenti, Filippo Aucella, Anna Maria Scandroglio, Claudio Ronco, Jean-Louis Vincent

• Open Access
• Acute Respiratory Distress Syndrome
• Research

Feasibility and safety of ultra-low volume ventilation (≤ 3 ml/kg) combined with extra corporeal carbon dioxide removal (ECCO2R) in acute respiratory failure patients

Clément Monet, Thomas Renault, Yassir Aarab, Joris Pensier, Albert Prades, Ines Lakbar, Clément Le Bihan, Mathieu Capdevila, Audrey De Jong, Nicolas Molinari, Samir Jaber

• Open Access
• Research

Family concerns in organ donor conversations: a qualitative embedded multiple-case study

Sanne P. C. van Oosterhout, Anneke G. van der Niet, Wilson F. Abdo, Marianne Boenink, Jelle L. P. van Gurp, Gert Olthuis

• Open Access
• Review

Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice

Hiroyuki Ohbe, Kasumi Satoh, Takaaki Totoki, Atsushi Tanikawa, Kasumi Shirasaki, Yoshihide Kuribayashi, Miku Tamura, Yudai Takatani, Hiroyasu Ishikura, Kensuke Nakamura

• Open Access
• Central Nervous System Trauma
• Research

Dynamic assessment of signal entropy for prognostication and secondary brain insult detection after traumatic brain injury

Stefan Yu Bögli, Ihsane Olakorede, Erta Beqiri, Xuhang Chen, Ari Ercole, Peter Hutchinson, Peter Smielewski

• Open Access
• Heart Surgery
• Correspondence

Hemoadsorption in cardiac surgery, limitations of low-risk patient selection and minimal cytokine levels

Gonzalo Ramírez-Guerrero, Cristian Pedreros-Rosales

• Open Access
• Pharmacokinetics
• Correspondence

High rates of cefidercol plasma target attainment: results of a retrospective cohort study in 31 critically ill ICU patients

Hans Theodor Naumann, Rainer Höhl, Martina Kinzig, Sophie Salat, Vanessa Bartsch, Fritz Sörgel, Ralph Bertram, Joerg Steinmann, Arnim Geise, Golo-Sung Haarmeyer, Matthias Baumgärtel, Jens Nentwich, Axel von Fragstein, Anke Jensen

• Open Access
• Heart Surgery
• Research

Non-adrenergic vasopressors for vasodilatory shock or perioperative vasoplegia: a meta-analysis of randomized controlled trials

Yuki Kotani, Alessandro Belletti, Filippo D’Amico, Alessandra Bonaccorso, Patrick M. Wieruszewski, Tomoko Fujii, Ashish K. Khanna, Giovanni Landoni, Rinaldo Bellomo

• Open Access
• Polymerase Chain Reaction
• Review

The role of rapid multiplex molecular syndromic panels in the clinical management of infections in critically ill patients: an experts-opinion document

Francisco Javier Candel, Miguel Salavert, Rafael Cantón, José Luis del Pozo, Fátima Galán-Sánchez, David Navarro, Alejandro Rodríguez, Juan Carlos Rodríguez, Montserrat Rodríguez-Aguirregabiria, Borja Suberviola, Rafael Zaragoza

• Open Access
• ECMO
• Matters Arising

Lack of up-to-date studies and data conversion may lead to biased results: a response to Wang et al

Ali Ait Hssain, Amir Vahedian-Azimi, Abdulsalam Saif Ibrahim, Ibrahim Fawzy Hassan, Elie Azoulay, Michael Darmon

• Open Access
• Septicemia
• Review

Megakaryocyte in sepsis: the trinity of coagulation, inflammation and immunity

Tianzhen Hua, Fenghua Yao, Haitao Wang, Wei Liu, Xiaomei Zhu, Yongming Yao