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Open Access 01-12-2024 | Matters Arising

Does inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients? Unleashing the potential of individualized functional electrical stimulation-cycling in critical illness

Authors: Murillo Frazão, Gerson Cipriano Jr., Paulo Eugênio Silva

Published in: Critical Care | Issue 1/2024

Excerpt

Jameson et al. [1] recently published a study demonstrating intramuscular inflammation and altered substrate utilization in skeletal muscle in the first week of critical illness, with no effect following functional electrical stimulation-cycling (FES-cycling) intervention; these findings were also supported by two previous studies from the same group [2, 3]. Conversely, FES-cycling has been shown to promote a higher increase in cardiac output and peripheral oxygen extraction compared to other routine early mobilization methods used in critical illness [4], suggesting its potential for maintaining metabolic and physical function in these patients. The claimed ineffectiveness of FES-cycling by Jameson et al. [1] may be based on biased assumptions described in the subsequent. …

Jameson TSO, Caldow MK, Stephens F, et al. Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients. Crit Care. 2023;27(1):428. https://doi.org/10.1186/s13054-023-04664-7.CrossRefPubMedPubMedCentral

Waldauf P, Hruskova N, Blahutova B, et al. Functional electrical stimulation—assisted cycle ergometry-based progressive mobility programme for mechanically ventilated patients: randomised controlled trial with 6 months follow-up. Thorax. 2021;76(7):664–71.CrossRefPubMed

Berney S, Hopkins RO, Rose JW, et al. Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial. Thorax. 2021;76(7):656–63.CrossRefPubMed

Medrinal C, Combret Y, Prieur G, Quesada AR, Bonnevie T, Gravier FE, et al. Comparison of exercise intensity during four early rehabilitation techniques in sedated and ventilated patients in ICU: a randomised crossover trial. Crit Care. 2018;22(1):1–8.CrossRef

Maffiuletti NA, Gondin J, Place N, et al. Clinical use of neuromuscular electrical stimulation for neuromuscular rehabilitation: what are we overlooking? Arch Phys Med Rehabil. 2018;99(4):806–12.CrossRefPubMed

Silva PE, Maldaner V, Vieira L, et al. Neuromuscular electrophysiological disorders and muscle atrophy in mechanically-ventilated traumatic brain injury patients: new insights from a prospective observational study. J Crit Care. 2018;44:87–94.CrossRefPubMed

Silva PE, Martins HR, de Deus Macedo JR, et al. Towards innovative electrodiagnosis tests to investigate neuromuscular excitability dysfunction in critically ill patients: an agreement study. Res Biomed Eng. 2023. https://doi.org/10.1007/s42600-023-00318-3.CrossRef

Figueiredo TG, Frazão M, Werlang LA, et al. Functional electrical stimulation cycling-based muscular evaluation method in mechanically ventilated patients. Artif Organs. 2023. https://doi.org/10.1111/aor.14677.CrossRef

Parry S, Barney S, Warrillow S, El-Ansary D, Bryant A, Hart N, et al. Functional electrical stimulation with cycling in the critically ill: a pilot case-matched control study. J Crit Care. 2014;29(4):695.e1-7.CrossRefPubMed

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Volkers ME, Mouton LJ, Jeneson JA, Hettinga FJ. active muscle mass affects endurance physiology: a review on single versus double-leg cycling. Kinesiology. 2018;50(1):19–32.

Title: Does inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients? Unleashing the potential of individualized functional electrical stimulation-cycling in critical illness
Authors: Murillo Frazão
Gerson Cipriano Jr.
Paulo Eugênio Silva
Publication date: 01-12-2024
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2024
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-023-04788-w

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Does inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients? Unleashing the potential of individualized functional electrical stimulation-cycling in critical illness

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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