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ICU-Acquired Weakness 

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  1. Open Access 01-12-2022 | Diseases of the neuromuscular synapses and muscles | OriginalPaper

    Early detection of ICU-acquired weakness in septic shock patients ventilated longer than 72 h

    Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are part of a clinical entity called intensive care unit ( ICU) acquired weakness (ICUAW) , a frequent complication of critical illnesses [ 1 ] shown to delay ventilator …

    Author:
    Caroline Attwell, Laurent Sauterel, Jane Jöhr, Lise Piquilloud, Thierry Kuntzer, Karin Diserens
    Published in:
    BMC Pulmonary Medicine > Issue: 1 / 2022
  2. 01-04-2020 | ICU-Acquired Weakness | ReviewPaper

    ICU-acquired weakness

    Critically ill patients often acquire neuropathy and/or myopathy labeled ICU-acquired weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk factors, short- and long-term consequences and management of ICU-acquired …

    Author:
    Ilse Vanhorebeek, Nicola Latronico, Greet Van den Berghe
    Published in:
    Intensive Care Medicine > Issue: 4 / 2020
  3. Open Access 01-12-2020 | ICU-Acquired Weakness | OriginalPaper

    ICU-acquired weakness, diaphragm dysfunction and long-term outcomes of critically ill patients

    Critically ill patients are likely to develop respiratory and limb muscle weakness [ 1 ]. It has been clearly established that intensive care unit (ICU)-acquired limb muscle weakness is a frequent condition, associated with poor prognosis [ 2 – 6 …

    Author:
    Clément Saccheri, Elise Morawiec, Julie Delemazure, Julien Mayaux, Bruno-Pierre Dubé, Thomas Similowski, Alexandre Demoule, Martin Dres
    Published in:
    Annals of Intensive Care > Issue: 1 / 2020
  4. Open Access 01-12-2020 | Cough | OriginalPaper

    Role of ICU-acquired weakness on extubation outcome among patients at high risk of reintubation

    The decision of extubation is a critical moment in the ICU because mortality is particularly high in case of extubation failure leading to reintubation [ 1 , 2 ]. The overall rate of reintubation after planned extubation is around 10% but may …

    Author:
    Arnaud W. Thille, Florence Boissier, Michel Muller, Albrice Levrat, Gaël Bourdin, Sylvène Rosselli, Jean-Pierre Frat, Rémi Coudroy, Emmanuel Vivier
    Published in:
    Critical Care > Issue: 1 / 2020
  5. Open Access 01-12-2018 | OriginalPaper

    ICU-acquired weakness: should medical sovereignty belong to any specialist?

    ICU-acquired weakness (ICUAW), including critical illness polyneuropathy, critical illness myopathy, and critical illness polyneuropathy and myopathy, is a frequent disabling disorder in ICU subjects. Research has predominantly been performed by …

    Author:
    Domenico Intiso
    Published in:
    Critical Care > Issue: 1 / 2018
  6. 01-12-2017 | BriefCommunication

    Mechanism of ICU-acquired weakness: skeletal muscle loss in critical illness
    Author:
    Jane Batt, Margaret Herridge, Claudia dos Santos
    Published in:
    Intensive Care Medicine > Issue: 12 / 2017
  7. 01-04-2017 | EditorialNotes

    Mechanism of ICU-acquired weakness: muscle contractility in critical illness
    Author:
    Jane Batt, Sunita Mathur, Hans D. Katzberg
    Published in:
    Intensive Care Medicine > Issue: 4 / 2017
  8. Open Access 01-12-2015 | OriginalPaper

    Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study

    After surviving critical illness, many patients suffer from its long-term consequences, which may consist of physical impairments, cognitive dysfunction, and mental health problems [ 1 ]. The relevance of physical impairments was described in acute …

    Author:
    Luuk Wieske, Daniela S Dettling-Ihnenfeldt, Camiel Verhamme, Frans Nollet, Ivo N van Schaik, Marcus J Schultz, Janneke Horn, Marike van der Schaaf
    Published in:
    Critical Care > Issue: 1 / 2015
  9. 01-05-2016 | OriginalPaper

    Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure

    Intensive care unit (ICU)-acquired weakness (ICUAW) is a complication observed in critically ill patients that combines myopathy and neuropathy [ 1 – 3 ]. Its incidence varies but may rise up to 100 % in patients with multiorgan failure [ 4 , 5 ].

    Author:
    Boris Jung, Pierre Henri Moury, Martin Mahul, Audrey de Jong, Fabrice Galia, Albert Prades, Pierre Albaladejo, Gerald Chanques, Nicolas Molinari, Samir Jaber
    Published in:
    Intensive Care Medicine > Issue: 5 / 2016
  10. Open Access 01-12-2015 | Abstract

    Increased early systemic inflammation in patients with ICU-acquired weakness

    Inflammation may be important in the pathogenesis of ICU-acquired weakness (ICU-AW) since SIRS, sepsis and multiple organ failure are the main risk factors. Local inflammation has been found in muscle and nerve tissue of patients with ICU-AW, but …

    Author:
    E Witteveen, L Wieske, C Verhamme, T Van der Poll, IN Van Schaik, MJ Schultz, J Horn
    Published in:
    Critical Care > Issue: Special Issue 1 / 2015
  11. 01-01-2009 | EditorialNotes

    Building consensus on ICU-acquired weakness
    Author:
    Margaret S. Herridge
    Published in:
    Intensive Care Medicine > Issue: 1 / 2009
  12. Open Access 01-12-2015 | ReviewPaper

    Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology

    Over the last 10 years we have significantly reduced hospital mortality from sepsis and critical illness. However, the evidence reveals that over the same period we have tripled the number of patients being sent to rehabilitation settings.

    Author:
    Paul E Wischmeyer, Inigo San-Millan
    Published in:
    Critical Care > Issue: Special Issue 3 / 2015
  13. Open Access 01-12-2015 | OriginalPaper

    Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness

    Generalized inflammation and multi-organ failure in the acute phase of critical illness are accompanied by impairment of mitochondrial morphology [ 1 ] and function of skeletal muscle [ 2 – 5 ] and other organs [ 6 , 7 ]. The extent of …

    Author:
    Kateřina Jiroutková, Adéla Krajčová, Jakub Ziak, Michal Fric, Petr Waldauf, Valér Džupa, Jan Gojda, Vlasta Němcova-Fürstová, Jan Kovář, Moustafa Elkalaf, Jan Trnka, František Duška
    Published in:
    Critical Care > Issue: 1 / 2015
  14. Open Access 01-02-2014 | Abstract

    Early electrophysiological diagnosis of ICU-acquired weakness

    An early diagnosis of ICU-acquired weakness (ICU-AW) is difficult because disorders of consciousness preclude strength assessment [ 1 ]. Electrophysiological (EMG) studies may be an alternative approach [ 2 ]. In this study we investigated …

    Author:
    L Wieske, C Verhamme, E Witteveen, A Bouwes, MJ Schultz, IN Van Schaik, J Horn
    Published in:
    Critical Care > Issue: Special Issue 1 / 2014
  15. 01-08-2010 | Letter

    The role of inflammation in ICU-acquired weakness

    A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the …

    Author:
    Chris Winkelman
    Published in:
    Critical Care > Issue: 4 / 2010
  16. Open Access 01-04-2013 | Abstract

    Withholding parenteral nutrition for 1 week reduces ICU-acquired weakness

    ICU-acquired weakness (ICUAW) is a frequent and important complication of critical illness [ 1 ]. A large randomized controlled trial (EPaNIC: clinicaltrials.gov: NCT00512122) [ 2 ] showed that withholding parenteral nutrition during the first week …

    Author:
    G Hermans, B Clerckx, T Vanhullebusch, F Bruyninckx, M Casaer, P Meersseman, D Mesotten, S Vancromphaut, P Wouters, R Gosselink, A Wilmer, G Van den Berghe
    Published in:
    Critical Care > Issue: Special Issue 2 / 2013
  17. 01-09-2013 | OriginalPaper

    Autonomic dysfunction in ICU-acquired weakness: a prospective observational pilot study

    Intensive care unit-acquired weakness (ICU-AW) is a frequent and important neurological complication of critical illness [ 1 ]. In ICU-AW, critically ill patients develop severe weakness and sensory symptoms because of dysfunction of peripheral …

    Author:
    L. Wieske, D. R. P. P. Chan Pin Yin, C. Verhamme, M. J. Schultz, I. N. van Schaik, J. Horn
    Published in:
    Intensive Care Medicine > Issue: 9 / 2013
  18. 01-06-2015 | OriginalPaper

    Feasibility and Diagnostic Accuracy of Early Electrophysiological Recordings for ICU-Acquired Weakness: An Observational Cohort Study

    Intensive care unit-acquired weakness (ICU-AW) is a frequent and important complication of critical illness, occurring in approximately 50 % of critically ill patients [ 1 , 2 ]. ICU-AW can be caused by critical illness myopathy (CIM), critical …

    Author:
    Luuk Wieske, Camiel Verhamme, Esther Witteveen, Aline Bouwes, Daniela S. Dettling-Ihnenfeldt, Marike van der Schaaf, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn
    Published in:
    Neurocritical Care > Issue: 3 / 2015
  19. Open Access 01-10-2014 | Letter

    A promising new therapy may assist efforts to combat ICU-acquired weakness

    No abstract.

    Author:
    Sarah Bain, Meagan Littlepage
    Published in:
    Critical Care > Issue: 5 / 2014
  20. Open Access 01-12-2012 | ReviewPaper

    ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients?

    Intensive care unit-acquired weakness (ICUAW) has been recognized as an important and persistent complication in survivors of critical illness. The absence of a consistent nomenclature and diagnostic criteria for ICUAW has made research in this …

    Author:
    Christie M Lee, Eddy Fan
    Published in:
    BMC Medicine > Issue: 1 / 2012

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