Issue 1/2022
Content (67 Articles)
Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study
Hui Zhang, Meng Hao, Zixin Hu, Yi Li, Xiaoyan Jiang, Jiucun Wang, Li Jin, Zuyun Liu, Xiaofeng Wang, Xuehui Sun
The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells
Yuma Sugiyama, Mitsuhiro Fujiwara, Akihiko Sakamoto, Hiromichi Tsushima, Akihiko Nishikimi, Mitsuo Maruyama
Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis
Min Chu, Yingchao Fan, Liting Wu, Xiaoyan Ma, Jinfeng Sao, Yonghua Yao, Wenfang Zhuang, Cui Zhang
The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study
Jingxian Chen, Kehmia Titanji, Anandi N. Sheth, Rajesh Gandhi, Deborah McMahon, Ighovwerha Ofotokun, M. Neale Weitzmann, Kristina De Paris, Julie B. Dumond
Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly
Leonard Daniël Samson, Peter Engelfriet, W. M. Monique Verschuren, H. Susan J. Picavet, José A. Ferreira, Mary-lène de Zeeuw-Brouwer, Anne-Marie Buisman, A. Mieke H. Boots
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?
Ludwig Englmeier, Julien Subburayalu
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis
Alicia Usategui, Cristina Municio, Elena G. Arias-Salgado, María Martín, Beatriz Fernández-Varas, Manuel J. Del Rey, Patricia Carreira, Antonio González, Gabriel Criado, Rosario Perona, José L. Pablos
Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation
Lily Wink, Richard A. Miller, Gonzalo G. Garcia
Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults
Juliana Ruiz Fernandes, Thalyta Nery Carvalho Pinto, Liã Barbara Arruda, Cibele Cristine Berto Marques da Silva, Celso Ricardo Fernandes de Carvalho, Regina Maria Carvalho Pinto, Alberto José da Silva Duarte, Gil Benard
High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study
Yen-Chun Fan, Chia-Chi Chou, Bagas Suryo Bintoro, Kuo-Liong Chien, Chyi-Huey Bai
CD161 expression defines new human γδ T cell subsets
Amali Karunathilaka, Samuel Halstrom, Patricia Price, Michael Holt, Viviana P. Lutzky, Denise L. Doolan, Andreas Kupz, Scott C. Bell, Rachel M. Thomson, John J. Miles, Champa N. Ratnatunga
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19
Xixi Jing, Min Xu, Deye Song, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq, Guangdi Li
Longitudinal association of cytokine-producing CMV-specific T cells with frailty in HIV-infected and -uninfected men who have sex with men
Weiying Zhang, Huifen Li, Jay H. Bream, Tricia L. Nilles, Sean X. Leng, Joseph B. Margolick
Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long bone critical-size defect model
Hirohito Hirata, Ning Zhang, Masaya Ueno, Danial Barati, Junichi Kushioka, Huaishuang Shen, Masanori Tsubosaka, Masakazu Toya, Tzuhua Lin, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang, Stuart B. Goodman
Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging
Arttu Autio, Jalmari Kettunen, Tapio Nevalainen, Bryn Kimura, Mikko Hurme
Telomerase deficiency reflects age-associated changes in CD4+ T cells
Diana M. Matthe, Oana-Maria Thoma, Tobias Sperka, Markus F. Neurath, Maximilian J. Waldner
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial
Grace M Niemiro, Adriana M Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M Brewster, Therese B Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C Gilchrist, Richard J. Simpson
NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing
Lucyna Kaszubowska, Jerzy Foerster, Zbigniew Kmieć
The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice
Camille Khairallah, Timothy H. Chu, Zhijuan Qiu, Jessica N. Imperato, Daniella Yang, Brian S. Sheridan
NF-κB, a culprit of both inflamm-ageing and declining immunity?
Preeyaporn Songkiatisak, Shah Md Toufiqur Rahman, Mohammad Aqdas, Myong-Hee Sung
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study
Zhigao Sun, Jieqiong Lin, Yujie Zhang, Yao Yao, Zhenjun Huang, Yali Zhao, Pei Zhang, Shihui Fu
Poly-γ-glutamic acid/Alum adjuvanted pH1N1 vaccine-immunized aged mice exhibit a significant increase in vaccine efficacy with a decrease in age-associated CD8+ T cell proportion in splenocytes
Jihyun Yang, Jaemoo Kim, Chaewon Kwak, Haryoung Poo
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics
Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal Desai, Michael C. Honigberg, Shelly-Ann Love, Ana Barac, Kathleen M. Hayden, JoAnn E. Manson, Eric A. Whitsel, Charles Kooperberg, Pradeep Natarajan, Alexander P. Reiner, Jacob O. Kitzman
Neutralizing antibody and T cell responses against SARS-CoV-2 variants of concern following ChAdOx-1 or BNT162b2 boosting in the elderly previously immunized with CoronaVac vaccine
Chalerm Liwsrisakun, Supansa Pata, Witida Laopajon, Nuchjira Takheaw, Warawut Chaiwong, Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Kantinan Chuensirikulchai, Watchara Kasinrerk
Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155
Benjamin R. Cassidy, William E. Sonntag, Pieter J. M. Leenen, Douglas A. Drevets
Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells
Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney, Chris P. Verschoor
Altered transcriptional responses in the lungs of aged mice after influenza infection
Ana M. Hernandez, Jim A. Mossman, Franklin R. Toapanta, Dana M. Previte, Ted M. Ross, Gerard J. Nau
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp
Libo He, Xinyu Liang, Qian Wang, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study
Zongxue Cheng, Di He, Jun Li, Qiong Wu, Zuyun Liu, Yimin Zhu
Correction: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial
Grace M. Niemiro, Adriana M. Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M. Brewster, Therese B. Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C. Gilchrist, Richard J. Simpson
A subset of gut leukocytes has telomerase-dependent “hyper-long” telomeres and require telomerase for function in zebrafish
Pam S. Ellis, Raquel R. Martins, Emily J. Thompson, Asma Farhat, Stephen A. Renshaw, Catarina M. Henriques
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity
Bart N. Ford, Jonathan Savitz
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study
Ramya Ramasubramanian, Helen C. S. Meier, Sithara Vivek, Eric Klopack, Eileen M. Crimmins, Jessica Faul, Janko Nikolich-Žugich, Bharat Thyagarajan
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches
Xiaotao Zhang, Rui Wang, Haoran Chen, Chenghao Jin, Ziyang Jin, Jianan Lu, Liang Xu, Yunrong Lu, Jianmin Zhang, Ligen Shi
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
G. Provost, F. B. Lavoie, A. Larbi, TP. Ng, C. Tan Tze Ying, M. Chua, T. Fulop, A. A. Cohen
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases
Adeleh Sahebnasagh, Samira Eghbali, Fatemeh Saghafi, Antoni Sureda, Razieh Avan
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies
Gemma Manich, Elisabet Augé, Itsaso Cabezón, Mercè Pallàs, Jordi Vilaplana, Carme Pelegrí
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
Miriam Retuerto, Ana Lledó, Beatriz Fernandez-Varas, Rosa Guerrero-López, Alicia Usategui, Antonio Lalueza, Rocío García-García, Esther Mancebo, Estela Paz-Artal, Leandro Sastre, Rosario Perona, José L. Pablos
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons
Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney, George A. Kuchel
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
Bastian Robinson Baarz, Thea Laurentius, Jana Wolf, Inga Wessels, Leo Cornelius Bollheimer, Lothar Rink
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal
Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China
Wei Liu, Jie Xu, Qiyao Pu, Mingwei Lan, Xiaolu Zhang, Yufeng Gu, Ying Wang, Fan Zheng, Jingjing Qian, Chunxue Fan, Jun Sui, Yanli Xu, Yongchen Zhang, Jing Luo, Xiangyang Lin, Shaorui Shi, Liying Wang, Chengming Sun, Maohua Zhou, Baohong Yue, Feng Wang
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias
Travis E. Hodges, Stephanie E. Lieblich, Rebecca K. Rechlin, Liisa A. M. Galea
Different phenotypes of microglia in animal models of Alzheimer disease
Yun Wei, Xianxiao Li
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging
Tapio Nevalainen, Arttu Autio, Mikko Hurme
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial
Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng, Haipeng Xiao
Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers
Hamed Zare, Hadis Rezapour, Alireza Fereidouni, Saboura Nikpour, Sara Mahmoudzadeh, Simon G Royce, Mohammad Fereidouni
Inflammation and cell-to-cell communication, two related aspects in frailty
Orietta Pansarasa, Maria Chiara Mimmi, Annalisa Davin, Marta Giannini, Antonio Guaita, Cristina Cereda
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis
Ti Zhang, Xin Liu, Yue Zhao, Xiaodong Xu, Yaoyang Liu, Xin Wu
Ageing-resembling phenotype of long-term allogeneic hematopoietic cells recipients compared to their donors
Michał Cezary Czarnogórski, Justyna Sakowska, Mateusz Maziewski, Maciej Zieliński, Agnieszka Piekarska, Igor Obuchowski, Mikołaj Młyński, Magdalena Dutka, Alicja Sadowska-Klasa, Ewa Zarzycka, Maria Bieniaszewska, Piotr Trzonkowski, Jacek M. Witkowski, Andrzej Hellmann, Katarzyna Ruckemann-Dziurdzińska, Jan M. Zaucha
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats
Tian-Ce Xu, Yan Lv, Quan-Ying Liu, Hui-Sheng Chen
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Anteneh Mehari Tizazu, Hylemariam Mihiretie Mengist, Gebreselassie Demeke
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults
Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi, Julia McKelvey, Alexei Sharov, Yu-Tsueng Liu, Jonathan Schneck, Nan-ping Weng
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium
Zheng Shen, Mickey V. Patel, Marta Rodriguez-Garcia, Charles R. Wira
Immunosenescence in Caenorhabditis elegans
Sieun S. Kim, Jooyeon Sohn, Seung-Jae V. Lee
The oldest unvaccinated Covid-19 survivors in South America
Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard, Jean-Laurent Casanova, Mauricio Quiñones-Vega, Patricia Sosa-Acosta, Jéssica de S. Guedes, Natália P. de Almeida, Fábio C. S. Nogueira, Gilberto B. Domont, Keity S. Santos, Mayana Zatz
The diseased kidney: aging and senescent immunology
Mingxuan Chi, Zijun Tian, Kuai Ma, Yunlong Li, Li Wang, Moussa Ide Nasser, Chi Liu
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis
Joshua A. Taylor, Mark A. Hutchinson, Patricia J. Gearhart, Robert W. Maul
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis
Mark A. Foster, Conor Bentley, Jon Hazeldine, Animesh Acharjee, Ornit Nahman, Shai S. Shen-Orr, Janet M. Lord, Niharika A. Duggal
Correction: The oldest unvaccinated Covid-19 survivors in South America
Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard, Jean-Laurent Casanova, Mauricio Quiñones-Vega, Patricia Sosa-Acosta, Jéssica de S. Guedes, Natália P. de Almeida, Fábio C. S. Nogueira, Gilberto B. Domont, Keity S. Santos, Mayana Zatz
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study
I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ling Chen, Pei-Fen Chen, Ray-Chin Wu, Chen-Wei Huang, Chao A. Hsiung, Chih-Cheng Hsu
Phenotypic and functional alterations of monocyte subsets with aging
Yu Cao, Yang Fan, Fangyuan Li, Yu Hao, Yaxian Kong, Chen Chen, Xing Hao, Dannuo Han, Guoli Li, Zengtao Wang, Chuan Song, Junyan Han, Hui Zeng
MicroRNAs: a crossroad that connects obesity to immunity and aging
Ahmed Rakib, Sonia Kiran, Mousumi Mandal, Udai P. Singh
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients
M. Cardelli, E. Pierpaoli, F. Marchegiani, F. Marcheselli, F. Piacenza, R. Giacconi, R. Recchioni, T. Casoli, P. Stripoli, M. Provinciali, G. Matacchione, A. Giuliani, D. Ramini, J. Sabbatinelli, M. Bonafè, M. Di Rosa, A. Cherubini, C. Di Pentima, F. Spannella, R. Antonicelli, A. R. Bonfigli, F. Olivieri, F. Lattanzio
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging
Min Sun Shin, Hong-Jai Park, Juan Young, Insoo Kang
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam M. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur, Eva L. Feldman