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Herpes Simplex Type 1 

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  1. 29-02-2024 | Hemophagocytic Lymphohistiocytosis | Online First

    Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review

    Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome that can be potentially life-threatening without appropriate treatment. Although viral infection is the most common trigger of hemophagocytic lymphohistiocytosis, cases of …

  2. 01-12-2023 | OriginalPaper

    Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid

    The use of biocides (antiseptics, disinfectants, and preservatives) has expanded worldwide, especially for applications that do not necessarily need them, including cleaning of households and offices. Excessive discharge of these compounds into …

  3. Open Access 01-12-2023 | Herpes Virus | OriginalPaper

    Seroprevalence of herpes simplex virus type 1 and type 2 among the migrant workers in Qatar

    Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections are life-long and common worldwide [ 1 ]. Infections with these viruses are typically latent and asymptomatic, but with frequent reactivations, subclinical shedding and sporadic …

  4. Open Access 01-12-2021 | Herpes Virus | OriginalPaper

    Herpes simplex virus type 1 related acute retinal necrosis following an encephalitis illness: a case report

    Acute retinal necrosis (ARN) is a serious and potential blinding viral ocular infection, and it rapidly develops and progresses in immunocompetent people, causing uveitis with necrotizing retinitis [ 1 ]. Varicella-zoster virus (VZV) and herpes

  5. 01-12-2021 | Herpes Virus | OriginalPaper

    The effects of photodynamic therapy on Vero cells and replication of herpes simplex type 1: an in vitro analysis

    The herpes simplex virus (HSV) is the etiologic agent that causes a latent and recurrent chronic infection that affects one third of the world population. Human herpesvirus 1 (HHV-1) and 2 (HHV-2) or herpes simplex virus 1 (HSV-1) and 2 (HSV-2) …

  6. 01-05-2023 | Herpes Virus | BriefCommunication

    Synthetic dibenzylideneketones as promising anti-herpes simplex virus type 1 agents

    New antiviral agents for the treatment of herpes simplex virus type 1 (HSV-1) infection, which causes a highly prevalent and incurable disease, are needed. Here, we report for the first time the in vitro anti-HSV-1 activity of two …

  7. 01-04-2023 | Herpes Virus | OriginalPaper

    An oncolytic herpes simplex virus type 1 strain expressing a single-chain variable region antibody fragment against PD-1 and a PI3K inhibitor synergize to elicit antitumor immunity in ovarian cancer

    Due to recurrence and resistance to chemotherapy, the current standard therapeutics are not fully effective against ovarian cancer. Therefore, we aimed to find an effective approach to improve the prognosis and therapy of ovarian cancer.

  8. Open Access 01-12-2019 | Herpes Virus | OriginalPaper

    Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions

    Herpes simplex virus type 1 (HSV-1) is a highly contagious and lifelong infection, with high prevalence and rapid acquisition during childhood [ 1 ]. It is estimated that there were 118 million new infections globally in 2012 [ 1 ], much higher …

  9. 08-08-2022 | Herpes Virus | Erratum

    Correction to: Inhibitory activity and mechanism of silver nanoparticles against herpes simplex virus type 1

    Author would like to revise the affiliation of author from “Xuanhe Pan 1 ” to “Xuanhe Pan 1,2 ”.

  10. 01-06-2022 | Herpes Virus | OriginalPaper

    Inhibitory activity and mechanism of silver nanoparticles against herpes simplex virus type 1

    Herpes simplex virus type 1 (HSV-1) is a common pathogen that infects 50–90% of the world’s population and causes a variety of diseases, some of which can be life-threatening. Silver nanoparticles (AgNPs) have been shown to have broad-spectrum …

  11. Open Access 01-03-2022 | Herpes Virus | OriginalPaper

    Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus

    Clinical reactivations of herpes simplex virus or varicella zoster virus occur frequently among patients with malignancies and manifest particularly as herpes simplex stomatitis in patients with acute leukaemia treated with intensive chemotherapy …

  12. Open Access 21-04-2022 | Herpes Virus | OriginalPaper

    Gastric herpes simplex virus type 1 infection is associated with functional gastrointestinal disorders in the presence and absence of comorbid fibromyalgia: a pilot case–control study

    Functional gastrointestinal disorders (FGIDs), a group of conditions characterized by chronic gastrointestinal (GI) symptoms, comprise a significant social and economic burden. With a worldwide prevalence of 40%, FGIDs account for a large …

  13. Open Access 01-12-2022 | Herpes Virus | OriginalPaper

    Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1

    Herpes Simplex Virus type 1 (HSV-1) is a prevalent and important human pathogen with a worldwide seroprevalence of more than 80% in adults. Despite considerable effort, there is still no cure and no vaccine for HSV-1 [ 1 ]. Oxidative stress-induced …

  14. 10-05-2022 | Herpes Virus | Letter

    Gastric herpes simplex virus type 1 infection is associated with functional gastrointestinal disorders in the presence and absence of comorbid fibromyalgia

  15. 01-12-2021 | Herpes Virus | OriginalPaper

    Antiviral activity of Phoenix dactylifera extracts against herpes simplex virus type 1: an animal study

    Herbal medicines have recently been developed for the treatment of infectious diseases. The aim of this study was to investigate the therapeutic potential of Phoenix dactylifera fruit and kernel extracts against herpes simplex virus type 1 (HSV-1) …

  16. 01-04-2020 | Herpes Virus | OriginalPaper

    Next-generation sequencing technology as a powerful detection and semi-quantitative method for herpes simplex virus type 1 in pediatric encephalitis

    This case report presents a 1-year-old boy from China, with sudden onset of fever, convulsion, and sleepiness, screened for viral DNA in blood and cerebrospinal fluid (CSF) sample using next-generation sequencing (NGS) to diagnose herpes simplex

  17. Open Access 01-12-2020 | Herpes Virus | OriginalPaper

    Comparative analysis of the tear protein profile in herpes simplex virus type 1 epithelial keratitis

    Herpes simplex virus type 1 (HSV-1) is the most important pathogen causing ocular diseases in the world [ 1 ]. More than 40,000 new cases caused by HSV-1 infection each year, which range from mild corneal epithelial inflammation to severe chronic …

  18. 01-12-2020 | Herpes Virus

    Seroprevalence of herpes simplex virus type 1 among people living with HIV in Mbeya, Tanzania

    In mainland Tanzania, the prevalence of human immunodeficiency virus (HIV) infection among adults aged 15–49 years is 4.7%, and the prevalence among females is twice that among males (6.2% vs. 3.1%). Although there is evidence of a significant …

  19. 01-10-2020 | Herpes Virus | OriginalPaper

    Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging

    Reporter gene-based molecular imaging, including positron emission tomography (PET) with the appropriate reporter probes, is a noninvasive and quantitative imaging tool for monitoring specific biological process, investigating protein-protein …

  20. 01-05-2019 | Herpes Virus | OriginalPaper

    Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1

    The long-term administration of acyclovir (ACV) for therapy against herpes simplex virus type 1 (HSV-1) infections can result in the emergence of ACV-resistant HSV strains. It is therefore urgent to develop new anti-herpetic compounds with …

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