Issue 1/2020
Content (40 Articles)
Immune cell extracellular vesicles and their mitochondrial content decline with ageing
Xin Zhang, Monica Jeanne Hubal, Virginia Byers Kraus
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Rachel Thomas, Weikan Wang, Dong-Ming Su
Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma
S. S. Jeske, P. J. Schuler, J. Doescher, M. N. Theodoraki, S. Laban, C. Brunner, T. K. Hoffmann, M. C. Wigand
A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation
Michiel G. H. Betjes, Anton W. Langerak, Mariska Klepper, Nicolle H. R. Litjens
“Inflammaging” and bone in the OsteoLaus cohort
Jessica Fischer, Didier Hans, Olivier Lamy, Pedro Marques-Vidal, Peter Vollenweider, Bérengère Aubry-Rozier
First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects – a cohort study
Lutz Hamann, Malgorzata Szwed, Malgorzata Mossakowska, Jerzy Chudek, Monika Puzianowska-Kuznicka
Can an effective SARS-CoV-2 vaccine be developed for the older population?
Graham Pawelec, Nan-ping Weng
The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route
Robert Edelman, Meagan E. Deming, Franklin R. Toapanta, Mark D. Heuser, Lisa Chrisley, Robin S. Barnes, Steven S. Wasserman, William C. Blackwelder, Barry S. Handwerger, Marcela Pasetti, Khan M. Siddiqui, Marcelo B. Sztein
The immune response to influenza in older humans: beyond immune senescence
Janet E. McElhaney, Chris P. Verschoor, Melissa K. Andrew, Laura Haynes, George A. Kuchel, Graham Pawelec
Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22
Arttu Autio, Tapio Nevalainen, Binisha H. Mishra, Marja Jylhä, Heini Flinck, Mikko Hurme
Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis
Sofia E. M. Andersson, Elvira Lange, Daniel Kucharski, Sara Svedlund, Karin Önnheim, Maria Bergquist, Elisabet Josefsson, Janet M. Lord, Inga-Lill Mårtensson, Kaisa Mannerkorpi, Inger Gjertsson
The lethal sex gap: COVID-19
Eladio J. Márquez, Jennifer Trowbridge, George A. Kuchel, Jacques Banchereau, Duygu Ucar
The impact of body mass index on adaptive immune cells in the human bone marrow
Luca Pangrazzi, Erin Naismith, Carina Miggitsch, Jose’ Antonio Carmona Arana, Michael Keller, Beatrix Grubeck-Loebenstein, Birgit Weinberger
Role of immune cells in the removal of deleterious senescent cells
Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez, Judith Campisi
Frontline treatments in extremely elderly patients with diffuse large B-cell lymphoma: a population-based study in Taiwan, 2010–2015
Huai-Hsuan Huang, Bor-Sheng Ko, Ho-Min Chen, Li-Ju Chen, Chen-Yu Wang, Fei-Yuan Hsiao
Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults
David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield, Moon H. Nahm
IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system
Zubin Zhou, Yiwei Lin, Chenhao Pan, Nan Wang, Lihui Zhou, Haojie Shan, Youshui Gao, Xiaowei Yu
In-depth immune cellular profiling reveals sex-specific associations with frailty
Leonard Daniël Samson, A. Mieke H. Boots, José A. Ferreira, H. Susan J. Picavet, Lia G. H. de Rond, Mary-lène de Zeeuw-Brouwer, W. M. Monique Verschuren, Anne-Marie Buisman, Peter Engelfriet
SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done?
Caio Henrique Mazucanti, Josephine Mary Egan
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study
Aurora Jurado, María C. Martín, Cristina Abad-Molina, Antonio Orduña, Alba Martínez, Esther Ocaña, Oscar Yarce, Ana M. Navas, Antonio Trujillo, Luis Fernández, Esther Vergara, Beatriz Rodríguez, Bibiana Quirant, Eva Martínez-Cáceres, Manuel Hernández, Janire Perurena-Prieto, Juana Gil, Sergi Cantenys, Gema González-Martínez, María T. Martínez-Saavedra, Ricardo Rojo, Francisco M. Marco, Sergio Mora, Jesús Ontañón, Marcos López-Hoyos, Gonzalo Ocejo-Vinyals, Josefa Melero, Marta Aguilar, Delia Almeida, Silvia Medina, María C. Vegas, Yesenia Jiménez, Álvaro Prada, David Monzón, Francisco Boix, Vanesa Cunill, Juan Molina
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?
Arsun Bektas, Shepherd H. Schurman, Claudio Franceschi, Luigi Ferrucci
ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals
Michelle L. Ratliff, Joshua Garton, Judith A. James, Carol F. Webb
Alterations of monocyte NF-κB p65/RelA signaling in a cohort of older medical patients, age-matched controls, and healthy young adults
Juliette Tavenier, Line Jee Hartmann Rasmussen, Morten Baltzer Houlind, Aino Leegaard Andersen, Inge Panum, Ove Andersen, Janne Petersen, Anne Langkilde, Jan O. Nehlin
Genetic and environmental determinants of human TCR repertoire diversity
Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A. Chan
Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors
Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri, Susanna Mandruzzato
Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
Aaron Arvey, Michael Rowe, Joseph Barten Legutki, Gang An, Anantha Gollapudi, Anna Lei, Bill Colston, Chaim Putterman, David Smith, Janelle Stiles, Theodore Tarasow, Preveen Ramamoorthy
Reproducibility of serum cytokines in an elderly population
Jing Guo, Nicole Schupf, Richard P. Mayeux, Yian Gu
The correlation between the Th17/Treg cell balance and bone health
Lei Zhu, Fei Hua, Wenge Ding, Kai Ding, Yige Zhang, Chenyang Xu
Emergence of T cell immunosenescence in diabetic chronic kidney disease
Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu, Szu-Yu Pan, Feng-Jung Yang, Te-Tien Ting, Ju-Ying Jiang, Yu-Sen Peng, Yi-Fang Chuang
Effect of age and sex on immune checkpoint expression and kinetics in human T cells
Rosanne D. Reitsema, Rebeca Hid Cadena, Sander H. Nijhof, Wayel H. Abdulahad, Minke G. Huitema, Davy Paap, Elisabeth Brouwer, Annemieke M. H. Boots, Peter Heeringa
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing
Alistair V. W. Nunn, Geoffrey W. Guy, Wolfgang Brysch, Stanley W. Botchway, Wayne Frasch, Edward J. Calabrese, Jimmy D. Bell
An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients
Danay Saavedra, Ana Laura Añé-Kourí, Naivy Sánchez, Lázaro Manuel Filgueira, Julio Betancourt, Carlos Herrera, Leniel Manso, Elibet Chávez, Armando Caballero, Carlos Hidalgo, Geydi Lorenzo, Meylan Cepeda, Carmen Valenzuela, Mayra Ramos, Kalet León, Zaima Mazorra, Tania Crombet
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis
Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy, Heping Xu
Pathogen burden and leukocyte telomere length in the United States
Grace A. Noppert, Lydia Feinstein, Jennifer B. Dowd, Rebecca C. Stebbins, Emma Zang, Belinda L. Needham, Helen C. S. Meier, Amanda Simanek, Allison E. Aiello
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
Daniela Frasca, Bonnie B. Blomberg
Autoimmune hemolytic anemia: current knowledge and perspectives
Sylwia Sulimiera Michalak, Anna Olewicz-Gawlik, Joanna Rupa-Matysek, Edyta Wolny-Rokicka, Elżbieta Nowakowska, Lidia Gil
Correction to: Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors
Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri, Susanna Mandruzzato
T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II
Julia Sbierski-Kind, David Goldeck, Nikolaus Buchmann, Joachim Spranger, Hans-Dieter Volk, Elisabeth Steinhagen-Thiessen, Graham Pawelec, Ilja Demuth, Dominik Spira