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Anti-CD3 Antibody 

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  1. 01-05-2024 | Anti-CD3 Antibody | News

    Anti-CD3 monoclonal antibody/mipetresgene autoleucel/nivolumab

    Lack of efficacy
  2. Open Access 24-04-2024 | Type 1 Diabetes | Case Study

    Exogenous Insulin Antibody Syndrome (EIAS) Presenting in an Elderly, Long-Term Patient with Type 1 Diabetes Mellitus that Resolved with Low-Cost Outpatient Therapy with Mycophenolate Mofetil and Regular Insulin by Pump

    EIAS can cause hyperglycemia, hypoglycemia, and ketoacidosis in people with diabetes. This case in an older adult with type 1 diabetes shows how EIAS can be managed in an outpatient setting.

  3. Open Access 01-12-2024 | Antiphospholipid Syndrome | OriginalPaper

    The clinical relevance of different antiphospholipid antibody profiles in pediatric rheumatology patients

    Antiphospholipid syndrome (APS) is a systemic autoimmune disorder occurring due to antibodies against phospholipid-binding plasma proteins (antiphospholipid antibodies [aPL]), mainly lupus anticoagulant test (LA), anticardiolipin antibodies (aCL) …

  4. Open Access 01-12-2024 | Myopathy | OriginalPaper

    Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy

    Idiopathic inflammatory myopathies (IIMs) are a rare group of autoimmune diseases that can cause chronic inflammation of skeletal muscle and/or organs, including the skin, joints, lungs, gastrointestinal tract, and heart. Muscle involvement may …

  5. 06-05-2024 | Dermatomyositis | Online First

    Anti-TIF1-γ Antibody-Positive Dermatomyositis Leading to Identification of Diffuse Large B-Cell Lymphoma

    Older adults with dermatomyositis positive for anti-transcription intermediary factor 1-gamma (anti-TIF-1γ) antibodies have a high risk of malignancies, including hematologic malignancies such as lymphoma. Here, we present a case of …

  6. Open Access 01-12-2024 | Cancer Immunotherapy | OriginalPaper

    GNUV201, a novel human/mouse cross-reactive and low pH-selective anti-PD-1 monoclonal antibody for cancer immunotherapy

    The quality of the immune system is based on a precise balance between activating and inhibiting signals to maintain immune homeostasis. Immune checkpoints act as inhibiting signals whose role is to prevent the immune system from overactivation …

  7. Open Access 06-05-2024 | Online First

    IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice

    Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities, affecting approximately 60% of very low-birthweight infants needing oxygen therapy [ 1 , 2 ]. ROP is the leading …

  8. Open Access 08-05-2024 | Brentuximab vedotin | Online First

    Antibody–drug conjugates in the treatment of lymphoid neoplasms

    Antibody-drug conjugates (ADCs) are a new class of monoclonal antibodies with the characteritic to specifically target tumor cells and to deliver a cytotoxic drug directly to the target cell thereby minimising side effects and improving the …

  9. 24-04-2024 | COVID-19 | Online First

    Antineutrophil cytoplasmic antibody positivity incidence before and during COVID-19 pandemic

    There are many factors associated with the development of autoimmune diseases. It is known that viral infections can be the triggers of these diseases [ 1 , 2 ]. Since the end of 2019, the world has been faced with the global COVID19 pandemic …

  10. 30-04-2024 | Pathology | Online First

    Antibody-Mediated Rejection: Mechanisms, Pathology, and Therapeutics

    Lung transplantation is the definitive treatment for patients with end-stage lung disease. With advances in surgical techniques, early survival after lung transplantation has improved in recent years. Unfortunately, long-term outcomes continue to …

  11. Open Access 01-12-2024 | Systemic Sclerosis | OriginalPaper

    Clinical features of patients with systemic sclerosis positive for anti-SS-A antibody: a cohort study of 156 patients

    Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised by skin and internal organ fibrosis, microvascular dysfunction, and immune dysregulation [ 1 ]. The clinical phenotype of SSc is highly heterogeneous; thus …

  12. Open Access 25-04-2024 | Hemophagocytic Lymphohistiocytosis | Online First

    Population Pharmacokinetics of the Anti-Interferon-Gamma Monoclonal Antibody Emapalumab: An Updated Analysis

    Hemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive, and potentially fatal syndrome characterized by excessive, uncontrolled immune activation and systemic hyperinflammation [ 1 – 3 ]. Primary HLH is associated with genetic defects and …

  13. Open Access 01-12-2024 | Systemic Sclerosis | OriginalPaper

    Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model

    Systemic sclerosis (SSc) is a collagen disease that affects the skin and various internal organs. Of note, lung involvement in SSc represents a principal cause of mortality. SSc pathogenesis is characterized by vasculopathy, inflammation, and …

  14. Open Access 10-04-2024 | Cerebral Hemorrhage | Online First

    An anti-PF4 antibody-related disorder with cerebral venous sinus thrombosis and thrombocytopenia initially presenting as intracranial hemorrhage

    Anti-platelet factor (PF4) disorders are severe and diagnosis may be challenging. Intracranial hemorrhage could present first but usually develops secondary to cerebral venous sinus thrombosis.

  15. 14-05-2024 | Online First

    Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy

  16. Open Access 01-12-2024 | Radiotherapy | OriginalPaper

    Anti-PD-1 antibody in combination with radiotherapy as first-line therapy for unresectable intrahepatic cholangiocarcinoma

    Cholangiocarcinoma (CCA) is the second most common hepatic malignancy, and the incidence and mortality rates of CCA, especially the intrahepatic cholangiocarcinoma (iCCA) has increased over the last 10-20 years [ 1 – 3 ]. Surgery remains the …

  17. 18-04-2024 | Hemolytic Uremic Syndrome | Online First

    Managing anti-factor H antibody-associated hemolytic uremic syndrome: time for consensus

    This multicenter study provides information on clinical features, therapy, and outcome of 12 children with mild to moderate anti-FH associated aHUS, with 16% requiring transient dialytic therapy, and 8–25% with extrarenal manifestations at the …

  18. 08-05-2024 | Online First

    Therapeutic Potential of Antibody Targeting Neuronal Pentraxin Receptor in Esophageal Squamous Cell Carcinoma

  19. Open Access 01-12-2024 | Myopathy | OriginalPaper

    Pathological findings with vacuoles in anti-mitochondrial antibody-positive inflammatory myopathy

    Anti-mitochondrial antibody (AMA), a specific autoantibody of primary biliary cholangitis (PBC), can also be associated with inflammatory myopathy [ 1 ]. AMA is not considered to be associated with disease severity [ 2 ], and it has not been …

  20. Open Access 01-12-2024 | Neuropathic Pain | Erratum

    Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

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