Issue 1/2021
Content (45 Articles)
Obesity and COVID-19: what makes obese host so vulnerable?
Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani, Abderrezak Bouchama
Gut microbiota as the key controllers of “healthy” aging of elderly people
Emeline Ragonnaud, Arya Biragyn
Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice
Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter, Jae-Kyung Lee
Macrophage function in the elderly and impact on injury repair and cancer
L Duong, HG Radley, B Lee, DE Dye, FJ Pixley, MD Grounds, DJ Nelson, C Jackaman
Aging and CMV discordance are associated with increased immune diversity between monozygotic twins
Zheng Yan, Holden T. Maecker, Petter Brodin, Unni C. Nygaard, Shu Chen Lyu, Mark M. Davis, Kari C. Nadeau, Sandra Andorf
Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults
Stephanie M. Dillon, Tezha A. Thompson, Allison J. Christians, Martin D. McCarter, Cara C. Wilson
Unanticipated efficacy of SARS-CoV-2 vaccination in older adults
Graham Pawelec, Janet McElhaney
T cells accumulate in non-diabetic islets during ageing
Heather C. Denroche, Stéphanie Miard, Sandrine Sallé-Lefort, Frédéric Picard, C. Bruce Verchere
Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities
Daniela Frasca, Maria Romero, Denisse Garcia, Alain Diaz, Bonnie B. Blomberg
Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls
Pavel Borsky, Marcela Chmelarova, Zdenek Fiala, Kvetoslava Hamakova, Vladimir Palicka, Jan Krejsek, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Martin Beranek, Andrea Malkova, Tereza Svadlakova, Drahomira Holmannova, Lenka Borska
Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children
Katherine R. Dobbs, Paula Embury, Emmily Koech, Sidney Ogolla, Stephen Munga, James W. Kazura, Arlene E. Dent
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
Cecilia Söderberg-Nauclér
Improving seasonal influenza vaccination for older adults
Graham Pawelec, Janet McElhaney
Hypothetical COVID-19 protection mechanism: hints from centenarians
Franca Rosa Guerini, Matteo Cesari, Beatrice Arosio
Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals
Julia M. Scordo, Tucker J. Piergallini, Nicole Reuter, Colwyn A. Headley, Vida L. Hodara, Olga Gonzalez, Luis D. Giavedoni, James F. Papin, Joanne Turner
Analysis of the heterogeneity of the BCR H-CDR3 repertoire in the bone marrow and spleen of 3-, 12-, and 20-month old mice
Lina Ma, Xinxin Tao, Xiaoyan He, Peng Wang, Long Ma, Bin Shi, Xinsheng Yao
Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans
Jayaum S. Booth, Eric Goldberg, Seema A. Patil, Robin S. Barnes, Bruce D. Greenwald, Marcelo B. Sztein
High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges
Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch, Andreas Thiel
CMV infection, CD19+ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly
Liang-Yu Chen, An-Chun Hwang, Chung-Yu Huang, Liang-Kung Chen, Fu-Der Wang, Yu-Jiun Chan
Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges
Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch, Andreas Thiel
Functional conservation in genes and pathways linking ageing and immunity
Daniel K. Fabian, Matías Fuentealba, Handan Melike Dönertaş, Linda Partridge, Janet M. Thornton
The age again in the eye of the COVID-19 storm: evidence-based decision making
María C. Martín, Aurora Jurado, Cristina Abad-Molina, Antonio Orduña, Oscar Yarce, Ana M. Navas, Vanesa Cunill, Danilo Escobar, Francisco Boix, Sergio Burillo-Sanz, María C. Vegas-Sánchez, Yesenia Jiménez-de las Pozas, Josefa Melero, Marta Aguilar, Oana Irina Sobieschi, Marcos López-Hoyos, Gonzalo Ocejo-Vinyals, David San Segundo, Delia Almeida, Silvia Medina, Luis Fernández, Esther Vergara, Bibiana Quirant, Eva Martínez-Cáceres, Marc Boiges, Marta Alonso, Laura Esparcia-Pinedo, Celia López-Sanz, Javier Muñoz-Vico, Serafín López-Palmero, Antonio Trujillo, Paula Álvarez, Álvaro Prada, David Monzón, Jesús Ontañón, Francisco M. Marco, Sergio Mora, Ricardo Rojo, Gema González-Martínez, María T. Martínez-Saavedra, Juana Gil-Herrera, Sergi Cantenys-Molina, Manuel Hernández, Janire Perurena-Prieto, Beatriz Rodríguez-Bayona, Alba Martínez, Esther Ocaña, Juan Molina
A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases
Yuanyuan Wang, Shu-Chao Pang, Ying Yang
Is mechanical loading essential for exercise to preserve the aging immune system?
Richard J. Simpson, Graham Pawelec
Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing
Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber, Mitra Lavasani
miR-181a-regulated pathways in T-cell differentiation and aging
Chulwoo Kim, Zhongde Ye, Cornelia M. Weyand, Jörg J. Goronzy
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
Usma Munawara, Michael Catanzaro, Weili Xu, Crystal Tan, Katsuiku Hirokawa, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque, Charles Ramassamy, Annelise E. Barron, Stephen Cunnane, Pascale B. Beauregard, Jean-Pierre Bellenger, Serafim Rodrigues, Mathieu Desroches, Jacek M. Witkowski, Benoit Laurent, Eric H. Frost, Tamas Fulop
A description of the relationship in healthy longevity and aging-related disease: from gene to protein
Xiaolin Ni, Zhaoping Wang, Danni Gao, Huiping Yuan, Liang Sun, Xiaoquan Zhu, Qi Zhou, Ze Yang
Does immunosenescence drive organismal ageing via inflammageing?
Graham Pawelec
Correction to: Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults
David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield, Moon H. Nahm
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?
Ismael Dale Cotrim Guerreiro da Silva, Dirce Maria Lobo Marchioni, Antonio Augusto Ferreira Carioca, Valquiria Bueno, Gisele Wally Braga Colleoni
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people
Helen Parry, Rachel Bruton, Christine Stephens, Kevin Brown, Gayatri Amirthalingam, Ashley Otter, Bassam Hallis, Jianmin Zuo, Paul Moss
Metabolic phenotype of B cells from young and elderly HIV individuals
Daniela Frasca, Suresh Pallikkuth, Savita Pahwa
Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings
Nan-ping Weng, Graham Pawelec
A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age
Rachel H. McMahan, Kevin M. Najarro, Juliet E. Mullen, Madison T. Paul, David J. Orlicky, Holly J. Hulsebus, Elizabeth J. Kovacs
Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age
Rachel H. McMahan, Kevin M. Najarro, Juliet E. Mullen, Madison T. Paul, David J. Orlicky, Holly J. Hulsebus, Elizabeth J. Kovacs
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?
Alistair V.W. Nunn, Geoffrey W. Guy, Stanley W. Botchway, Jimmy D. Bell
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice
Huan Liu, Shujuan Chu, Zhilin Wu
Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
Lei Wang, Christien Rondaan, Anoek A. E. de Joode, Elisabeth Raveling-Eelsing, Nicolaas A. Bos, Johanna Westra
Quantification of dendritic cell subsets in human thymus tissues of various ages
Yan Li, Pei Chen, Hao Huang, Huiyu Feng, Hao Ran, Weibin Liu
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2
Guanghua Chen, Guizhi Huang, Han Lin, Xinyou Wu, Xiaoyan Tan, Zhoutao Chen