Skip to main content
Top

BMC Medical Research Methodology

Issue 1/2016

Content (169 Articles)

Creating a literature database of low-calorie sweeteners and health studies: evidence mapping

  • Open Access
  • Research article

Ding Ding Wang, Marissa Shams-White, Oliver John M. Bright, J. Scott Parrott, Mei Chung

Estimating time-varying exposure-outcome associations using case-control data: logistic and case-cohort analyses

  • Open Access
  • Research article

Ruth H. Keogh, Punam Mangtani, Laura Rodrigues, Patrick Nguipdop Djomo

Early diagnosis of gestational trophoblastic neoplasia based on trajectory classification with compartment modeling

  • Open Access
  • Research article

Claire Burny, Muriel Rabilloud, François Golfier, Jérôme Massardier, Touria Hajri, Anne-Marie Schott, Fabien Subtil

Addressing challenges of validity and internal consistency of mental health measures in a 27- year longitudinal cohort study – the Northern Swedish Cohort study

  • Open Access
  • Research article

Anne Hammarström, Hugo Westerlund, Kaisa Kirves, Karina Nygren, Pekka Virtanen, Bruno Hägglöf

Crude incidence in two-phase designs in the presence of competing risks

  • Open Access
  • TECHNICAL ADVANCE

Paola Rebora, Laura Antolini, David V. Glidden, Maria Grazia Valsecchi

Assessing variability in results in systematic reviews of diagnostic studies

  • Open Access
  • Research article

Christiana A. Naaktgeboren, Eleanor A. Ochodo, Wynanda A. Van Enst, Joris A. H. de Groot, Lotty Hooft, Mariska M. G. Leeflang, Patrick M. Bossuyt, Karel G. M. Moons, Johannes B. Reitsma

Meta-analytic estimation of measurement variability and assessment of its impact on decision-making: the case of perioperative haemoglobin concentration monitoring

  • Open Access
  • Research Article

Emmanuel Charpentier, Vincent Looten, Björn Fahlgren, Alexandre Barna, Loïc Guillevin

Propensity score to detect baseline imbalance in cluster randomized trials: the role of the c-statistic

  • Open Access
  • Research Article

Clémence Leyrat, Agnès Caille, Yohann Foucher, Bruno Giraudeau

Patient responses to research recruitment and follow-up surveys: findings from a diverse multicultural health care setting in Qatar

  • Open Access
  • Research article

Amal Khidir, Humna Asad, Huda Abdelrahim, Maha Elnashar, Amal Killawi, Maya Hammoud, Abdul Latif Al-Khal, Pascale Haddad, Michael D. Fetters

Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

  • Open Access
  • Research article

Michael Walker, Carole Fureix, Rupert Palme, Jonathan A. Newman, Jamie Ahloy Dallaire, Georgia Mason

The quality and diagnostic value of open narratives in verbal autopsy: a mixed-methods analysis of partnered interviews from Malawi

  • Open Access
  • Research article

C. King, C. Zamawe, M. Banda, N. Bar-Zeev, J. Beard, J. Bird, A. Costello, P. Kazembe, D. Osrin, E. Fottrell

Eliciting parental support for the use of newborn blood spots for pediatric research

  • Open Access
  • Research article

Edwina H. Yeung, Germaine Buck Louis, David Lawrence, Kurunthachalam Kannan, Alexander C. McLain, Michele Caggana, Charlotte Druschel, Erin Bell

A scoping review on the conduct and reporting of scoping reviews

  • Open Access
  • Research article

Andrea C. Tricco, Erin Lillie, Wasifa Zarin, Kelly O’Brien, Heather Colquhoun, Monika Kastner, Danielle Levac, Carmen Ng, Jane Pearson Sharpe, Katherine Wilson, Meghan Kenny, Rachel Warren, Charlotte Wilson, Henry T. Stelfox, Sharon E. Straus

BMC Medical Research Methodology reviewer acknowledgement 2015

  • Open Access
  • Reviewer acknowledgement

Giulia Mangiameli

Applicable or non-applicable: investigations of clinical heterogeneity in systematic reviews

  • Open Access
  • Research article

Laura E. Chess, Joel J. Gagnier

Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes

  • Open Access
  • Research article

Julien Tanniou, Ingeborg van der Tweel, Steven Teerenstra, Kit C. B. Roes

Head to head comparison of the propensity score and the high-dimensional propensity score matching methods

  • Open Access
  • Research article

Jason R. Guertin, Elham Rahme, Colin R. Dormuth, Jacques LeLorier

Developing a system that can automatically detect health changes using transfer times of older adults

  • Open Access
  • Research Article

Greet Baldewijns, Stijn Luca, Bart Vanrumste, Tom Croonenborghs

Take the money and run? Redemption of a gift card incentive in a clinician survey

  • Open Access
  • Research article

Jane S. Chen, Brian L. Sprague, Carrie N. Klabunde, Anna N. A. Tosteson, Asaf Bitton, Tracy Onega, Charles D. MacLean, Kimberly Harris, Marilyn M. Schapira, Jennifer S. Haas

Comparison of predictive modeling approaches for 30-day all-cause non-elective readmission risk

  • Open Access
  • Research article

Liping Tong, Cole Erdmann, Marina Daldalian, Jing Li, Tina Esposito

Mechanisms and mediation in survival analysis: towards an integrated analytical framework

  • Open Access
  • Research article

Jonathan Pratschke, Trutz Haase, Harry Comber, Linda Sharp, Marianna de Camargo Cancela, Howard Johnson

A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle

  • Open Access
  • Research article

Eiliv Lund, Lars Holden, Hege Bøvelstad, Sandra Plancade, Nicolle Mode, Clara-Cecilie Günther, Gregory Nuel, Jean-Christophe Thalabard, Marit Holden

Can the buck always be passed to the highest level of clustering?

  • Open Access
  • Research Article

Christian Bottomley, Matthew J. Kirby, Steve W. Lindsay, Neal Alexander

Erratum to: The use of the Godin-Shephard Leisure-Time Physical Activity Questionnaire in oncology research: a systematic review

  • Open Access
  • Erratum

Steve Amireault, Gaston Godin, Jason Lacombe, Catherine M. Sabiston

Confidence intervals construction for difference of two means with incomplete correlated data

  • Open Access
  • Research Article

Hui-Qiong Li, Nian-Sheng Tang, Jie-Yi Yi

Methods for conducting systematic reviews of risk factors in low- and middle-income countries

  • Open Access
  • Research article

Yulia Shenderovich, Manuel Eisner, Christopher Mikton, Frances Gardner, Jianghong Liu, Joseph Murray

Comparing survival curves based on medians

  • Open Access
  • Technical advance

Zhongxue Chen, Guoyi Zhang

Young people’s views about consenting to data linkage: findings from the PEARL qualitative study

  • Open Access
  • Research article

Suzanne Audrey, Lindsey Brown, Rona Campbell, Andy Boyd, John Macleod

Meta-analyses including non-randomized studies of therapeutic interventions: a methodological review

  • Open Access
  • Research article

Timor Faber, Philippe Ravaud, Carolina Riveros, Elodie Perrodeau, Agnes Dechartres

Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis

  • Open Access
  • Research article

Béranger Lueza, Federico Rotolo, Julia Bonastre, Jean-Pierre Pignon, Stefan Michiels

Academic pediatric clinical research: factors associated with study implementation duration

  • Open Access
  • Research article

Delphine Meier-Girard, Annick Tibi, Hendy Abdoul, Sonia Prot-Labarthe, Françoise Brion, Olivier Bourdon, Corinne Alberti

On the use of propensity scores in case of rare exposure

  • Open Access
  • Research Article

David Hajage, Florence Tubach, Philippe Gabriel Steg, Deepak L. Bhatt, Yann De Rycke

Validation and reliability of a guideline appraisal mini-checklist for daily practice use

  • Open Access
  • Research article

Andrea Siebenhofer, Thomas Semlitsch, Thomas Herborn, Ulrich Siering, Ina Kopp, Johannes Hartig

Utilizing distributional analytics and electronic records to assess timeliness of inpatient blood glucose monitoring in non-critical care wards

  • Open Access
  • Research article

Ying Chen, Shih Ling Kao, E-Shyong Tai, Hwee Lin Wee, Eric Yin Hao Khoo, Yilin Ning, Mark Kevin Salloway, Xiaodong Deng, Chuen Seng Tan

Regression models for linking patterns of growth to a later outcome: infant growth and childhood overweight

  • Open Access
  • Research article

Andrew K. Wills, Bjørn Heine Strand, Kari Glavin, Richard J. Silverwood, Ragnhild Hovengen

A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

  • Open Access
  • Research article

Brennan C. Kahan, Helen Rushton, Tim P. Morris, Rhian M. Daniel

Exploring how individuals complete the choice tasks in a discrete choice experiment: an interview study

  • Open Access
  • Research article

Jorien Veldwijk, Domino Determann, Mattijs S. Lambooij, Janine A. van Til, Ida J. Korfage, Esther W. de Bekker-Grob, G. Ardine de Wit

Identification of risk factors for hospital admission using multiple-failure survival models: a toolkit for researchers

  • Open Access
  • Technical advance

Leo D. Westbury, Holly E. Syddall, Shirley J. Simmonds, Cyrus Cooper, Avan Aihie Sayer

A scoping review of indirect comparison methods and applications using individual patient data

  • Open Access
  • Research article

Areti Angeliki Veroniki, Sharon E. Straus, Charlene Soobiah, Meghan J. Elliott, Andrea C. Tricco

Reliability and criterion validity of self-measured waist, hip, and neck circumferences

  • Open Access
  • Research article

Pamela Barrios, Jennifer Martin-Biggers, Virginia Quick, Carol Byrd-Bredbenner

Patient enrollment and logistical problems top the list of difficulties in clinical research: a cross-sectional survey

  • Open Access
  • Research article

Stéphane Cullati, Delphine S. Courvoisier, Angèle Gayet-Ageron, Guy Haller, Olivier Irion, Thomas Agoritsas, Sandrine Rudaz, Thomas V. Perneger

Complex intervention modelling should capture the dynamics of adaptation

  • Open Access
  • Debate

James Greenwood-Lee, Penelope Hawe, Alberto Nettel-Aguirre, Alan Shiell, Deborah A. Marshall

Implementing a complex rehabilitation intervention in a stroke trial: a qualitative process evaluation of AVERT

  • Open Access
  • Research article

Julie A Luker, Louise E Craig, Leanne Bennett, Fiona Ellery, Peter Langhorne, Olivia Wu, Julie Bernhardt

Factors relating to participation in follow-up to the 45 and up study in Aboriginal and non-Aboriginal individuals

  • Open Access
  • Research article

Lina Gubhaju, Emily Banks, Rona Macniven, Grace Joshy, Bridgette J. McNamara, Adrian Bauman, Sandra J. Eades

Cross-cultural adaptation of the drug-taking confidence questionnaire drug version for use in Brazil

  • Open Access
  • Research article

Selene Cordeiro Vasconcelos, Everton Botelho Sougey, Iracema da Silva Frazão, Nigel Ernest Turner, Vânia Pinheiro Ramos, Murilo Duarte da Costa Lima

Using the modified Delphi method to establish clinical consensus for the diagnosis and treatment of patients with rotator cuff pathology

  • Open Access
  • Research article

Breda H. Eubank, Nicholas G. Mohtadi, Mark R. Lafave, J. Preston Wiley, Aaron J. Bois, Richard S. Boorman, David M. Sheps

Comparison of non-parametric methods for ungrouping coarsely aggregated data

  • Open Access
  • Research Article

Silvia Rizzi, Mikael Thinggaard, Gerda Engholm, Niels Christensen, Tom Børge Johannesen, James W. Vaupel, Rune Lindahl-Jacobsen

Cochrane plain language summaries are highly heterogeneous with low adherence to the standards

  • Open Access
  • Research article

Antonia Jelicic Kadic, Mahir Fidahic, Milan Vujcic, Frano Saric, Ivana Propadalo, Ivana Marelja, Svjetlana Dosenovic, Livia Puljak

Minimal important differences for fatigue patient reported outcome measures—a systematic review

  • Open Access
  • Research article

Åsa Nordin, Charles Taft, Åsa Lundgren-Nilsson, Anna Dencker

Measurement and control of bias in patient reported outcomes using multidimensional item response theory

  • Open Access
  • Research Article

N. Maritza Dowling, Daniel M. Bolt, Sien Deng, Chenxi Li

ODMedit: uniform semantic annotation for data integration in medicine based on a public metadata repository

  • Open Access
  • Research article

Martin Dugas, Alexandra Meidt, Philipp Neuhaus, Michael Storck, Julian Varghese

Modeling the oxygen uptake kinetics during exercise testing of patients with chronic obstructive pulmonary diseases using nonlinear mixed models

  • Open Access
  • Research Article

Florent Baty, Christian Ritz, Arnoldus van Gestel, Martin Brutsche, Daniel Gerhard

Evaluation of a multi-arm multi-stage Bayesian design for phase II drug selection trials – an example in hemato-oncology

  • Open Access
  • Research article

Louis Jacob, Maria Uvarova, Sandrine Boulet, Inva Begaj, Sylvie Chevret

Time to publication among completed diagnostic accuracy studies: associated with reported accuracy estimates

  • Open Access
  • Research article

Daniël A. Korevaar, Nick van Es, Aeilko H. Zwinderman, Jérémie F. Cohen, Patrick M. M. Bossuyt

Stepped wedge cluster randomised trials: a review of the statistical methodology used and available

  • Open Access
  • Research article

D. Barker, P. McElduff, C. D’Este, M. J. Campbell

Should we embed randomized controlled trials within action research: arguing from a case study of telemonitoring

  • Open Access
  • Research article

Karen Day, Timothy W. Kenealy, Nicolette F. Sheridan

Erratum to: Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis

  • Open Access
  • Erratum

Béranger Lueza, Federico Rotolo, Julia Bonastre, Jean-Pierre Pignon, Stefan Michiels

Preparing linked population data for research: cohort study of prisoner perinatal health outcomes

  • Open Access
  • Research article

Lisa Hilder, Jane R. Walker, Michael H. Levy, Elizabeth A. Sullivan

“A place at the table:” a qualitative analysis of community board members’ experiences with academic HIV/AIDS research

  • Open Access
  • Research article

Stella Safo, Chinazo Cunningham, Alice Beckman, Lorlette Haughton, Joanna L. Starrels

Exploring functional data analysis and wavelet principal component analysis on ecstasy (MDMA) wastewater data

  • Open Access
  • Research article

Stefania Salvatore, Jørgen G. Bramness, Jo Røislien

Evaluation of the effects of an offer of a monetary incentive on the rate of questionnaire return during follow-up of a clinical trial: a randomised study within a trial

  • Open Access
  • Research article

Pollyanna Hardy, Jennifer L. Bell, Peter Brocklehurst, Debra Bick, Annette Briley, Edmund Juszczak, Lynn Lynch, Christine MacArthur, Phillip Moore, Mary Nolan, Felicity Plaat, Julia Sanders, Andrew Shennan, Matt Wilson, Steve Hibbert, Elizabeth Howden, Sawretse Leslie, Amber Gibney, Claire Nelis

How to deal with missing longitudinal data in cost of illness analysis in Alzheimer’s disease—suggestions from the GERAS observational study

  • Open Access
  • Research article

Mark Belger, Josep Maria Haro, Catherine Reed, Michael Happich, Kristin Kahle-Wrobleski, Josep Maria Argimon, Giuseppe Bruno, Richard Dodel, Roy W Jones, Bruno Vellas, Anders Wimo

A virtual experimenter to increase standardization for the investigation of placebo effects

  • Open Access
  • Study protocol

Bjoern Horing, Nathan D. Newsome, Paul Enck, Sabarish V. Babu, Eric R. Muth

A comparison of two methods for expert elicitation in health technology assessments

  • Open Access
  • Research article

Bogdan Grigore, Jaime Peters, Christopher Hyde, Ken Stein

“I am yet to encounter any survey that actually reflects my life”: a qualitative study of inclusivity in sexual health research

  • Open Access
  • Research article

Elise R. Carrotte, Alyce M. Vella, Anna L. Bowring, Caitlin Douglass, Margaret E. Hellard, Megan S. C. Lim

Two new methods to fit models for network meta-analysis with random inconsistency effects

  • Open Access
  • Research Article

Martin Law, Dan Jackson, Rebecca Turner, Kirsty Rhodes, Wolfgang Viechtbauer

The development of PubMed search strategies for patient preferences for treatment outcomes

  • Open Access
  • Research article

Ralph van Hoorn, Wietske Kievit, Andrew Booth, Kati Mozygemba, Kristin Bakke Lysdahl, Pietro Refolo, Dario Sacchini, Ansgar Gerhardus, Gert Jan van der Wilt, Marcia Tummers

How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

  • Open Access
  • Research article

Angèle Gayet-Ageron, Anne-Sophie Jannot, Thomas Agoritsas, Sandrine Rudaz, Christophe Combescure, Thomas Perneger

Minimax and admissible adaptive two-stage designs in phase II clinical trials

  • Open Access
  • Research Article

Guogen Shan, Hua Zhang, Tao Jiang

Dose-response meta-analysis of differences in means

  • Open Access
  • Research Article

Alessio Crippa, Nicola Orsini

Testing for carryover effects after cessation of treatments: a design approach

  • Open Access
  • Research Article

S. Gwynn Sturdevant, Thomas Lumley

Measuring inter-rater reliability for nominal data – which coefficients and confidence intervals are appropriate?

  • Open Access
  • Research article

Antonia Zapf, Stefanie Castell, Lars Morawietz, André Karch

The effect of a monetary incentive for administrative assistants on the survey response rate: a randomized controlled trial

  • Open Access
  • Research article

Arnav Agarwal, Dany Raad, Victor Kairouz, John Fudyma, Anne B. Curtis, Holger J. Schünemann, Elie A. Akl

Modelling multiple thresholds in meta-analysis of diagnostic test accuracy studies

  • Open Access
  • Research Article

Susanne Steinhauser, Martin Schumacher, Gerta Rücker

Regional differences in the validity of self-reported use of health care in Belgium: selection versus reporting bias

  • Open Access
  • Research article

J. Van der Heyden, R. Charafeddine, D. De Bacquer, J. Tafforeau, K. Van Herck

A systematic review to investigate the measurement properties of goal attainment scaling, towards use in drug trials

  • Open Access
  • Research article

Charlotte M. W. Gaasterland, Marijke C. Jansen-van der Weide, Stephanie S. Weinreich, Johanna H. van der Lee

Network or regression-based methods for disease discrimination: a comparison study

  • Open Access
  • Research article

Xiaoshuai Zhang, Zhongshang Yuan, Jiadong Ji, Hongkai Li, Fuzhong Xue

Establishing the Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CHIWOS): Operationalizing Community-based Research in a Large National Quantitative Study

  • Open Access
  • Correspondence

Mona Loutfy, Saara Greene, V. Logan Kennedy, Johanna Lewis, Jamie Thomas-Pavanel, Tracey Conway, Alexandra de Pokomandy, Nadia O’Brien, Allison Carter, Wangari Tharao, Valerie Nicholson, Kerrigan Beaver, Danièle Dubuc, Jacqueline Gahagan, Karène Proulx-Boucher, Robert S. Hogg, Angela Kaida, Aranka Anema, Denise Becker, Lori Brotto, Allison Carter, Claudette Cardinal, Guillaume Colley, Erin Ding, Janice Duddy, Nada Gataric, Robert S. Hogg, Terry Howard, Shahab Jabbari, Evin Jones, Mary Kestler, Andrea Langlois, Viviane Lima, Elisa Lloyd-Smith, Melissa Medjuck, Cari Miller, Deborah Money, Valerie Nicholson, Gina Ogilvie, Sophie Patterson, Neora Pick, Eric Roth, Kate Salters, Margarite Sanchez, Jacquie Sas, Paul Sereda, Marcie Summers, Christina Tom, Clara Wang, Kath Webster, Wendy Zhang, Rahma Abdul-Noor, Jonathan Angel, Fatimatou Barry, Greta Bauer, Kerrigan Beaver, Anita Benoit, Breklyn Bertozzi, Sheila Borton, Tammy Bourque, Jason Brophy, Ann Burchell, Allison Carlson, Lynne Cioppa, Jeffrey Cohen, Tracey Conway, Curtis Cooper, Jasmine Cotnam, Janette Cousineau, Marisol Desbiens, Annette Fraleigh, Brenda Gagnier, Claudine Gasingirwa, Saara Greene, Trevor Hart, Shazia Islam, Charu Kaushic, Logan Kennedy, Desiree Kerr, Maxime Kiboyogo, Gladys Kwaramba, Lynne Leonard, Johanna Lewis, Carmen Logie, Shari Margolese, Marvelous Muchenje, Mary (Muthoni) Ndung’u, Kelly O’Brien, Charlene Ouellette, Jeff Powis, Corinna Quan, Janet Raboud, Anita Rachlis, Edward Ralph, Sean Rourke, Sergio Rueda, Roger Sandre, Fiona Smaill, Stephanie Smith, Tsitsi Tigere, Wangari Tharao, Sharon Walmsley, Wendy Wobeser, Jessica Yee, Mark Yudin, Dada Mamvula Bakombo, Jean-Guy Baril, Nora Butler Burke, Pierrette Clément, Janice Dayle, Danièle Dubuc, Mylène Fernet, Danielle Groleau, Aurélie Hot, Marina Klein, Carrie Martin, Lyne Massie, Brigitte Ménard, Nadia O’Brien, Joanne Otis, Doris Peltier, Alie Pierre, Karène Proulx-Boucher, Danielle Rouleau, Édénia Savoie, Cécile Tremblay, Benoit Trottier, Sylvie Trottier, Christos Tsoukas, Jacqueline Gahagan, Catherine Hankins, Renee Masching, Susanna Ogunnaike-Cooke

A simulation study on matched case-control designs in the perspective of causal diagrams

  • Open Access
  • Research article

Hongkai Li, Zhongshang Yuan, Ping Su, Tingting Wang, Yuanyuan Yu, Xiaoru Sun, Fuzhong Xue

The case-crossover design via penalized regression

  • Open Access
  • Research article

Sam Doerken, Maja Mockenhaupt, Luigi Naldi, Martin Schumacher, Peggy Sekula

Population cardiovascular health and urban environments: the Heart Healthy Hoods exploratory study in Madrid, Spain

  • Open Access
  • Research article

Usama Bilal, Julia Díez, Silvia Alfayate, Pedro Gullón, Isabel del Cura, Francisco Escobar, María Sandín, Manuel Franco

Rasch modelling to deal with changes in the questionnaires used during long-term follow-up of cohort studies: a simulation study

  • Open Access
  • Research article

Alexandra Rouquette, Sylvana M. Côté, Jean-Benoit Hardouin, Bruno Falissard

Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives

  • Open Access
  • Research article

Robert D. Beckett, Kathryn C. Loeser, Kathryn R. Bowman, Trent G. Towne

A computational approach to compare regression modelling strategies in prediction research

  • Open Access
  • Research article

Romin Pajouheshnia, Wiebe R. Pestman, Steven Teerenstra, Rolf H. H. Groenwold

The use of rapid review methods in health technology assessments: 3 case studies

  • Open Access
  • Research article

Eva Kaltenthaler, Katy Cooper, Abdullah Pandor, Marrissa Martyn-St. James, Robin Chatters, Ruth Wong

Adapting the nominal group technique for priority setting of evidence-practice gaps in implementation science

  • Open Access
  • Research article

Nicole M. Rankin, Deborah McGregor, Phyllis N. Butow, Kate White, Jane L. Phillips, Jane M. Young, Sallie A. Pearson, Sarah York, Tim Shaw

Resuming the discussion of AMSTAR: What can (should) be made better?

  • Open Access
  • Debate

Uta Wegewitz, Beate Weikert, Alba Fishta, Anja Jacobs, Dawid Pieper

Managing distance and covariate information with point-based clustering

  • Open Access
  • Research article

Peter A. Whigham, Brandon de Graaf, Rashmi Srivastava, Paul Glue

Multiple time scales in modeling the incidence of infections acquired in intensive care units

  • Open Access
  • Research Article

Martin Wolkewitz, Ben S. Cooper, Mercedes Palomar-Martinez, Francisco Alvarez-Lerma, Pedro Olaechea-Astigarraga, Adrian G. Barnett, Martin Schumacher

Joint modelling of time-to-event and multivariate longitudinal outcomes: recent developments and issues

  • Open Access
  • Research article

Graeme L. Hickey, Pete Philipson, Andrea Jorgensen, Ruwanthi Kolamunnage-Dona

IDGenerator: unique identifier generator for epidemiologic or clinical studies

  • Open Access
  • Software

Matthias Olden, Rolf Holle, Iris M. Heid, Klaus Stark

Combined models for pre- and post-treatment longitudinal biomarker data: an application to CD4 counts in HIV-patients

  • Open Access
  • Research Article

Oliver T. Stirrup, Abdel G. Babiker, Andrew J. Copas

Onset of persistent pseudomonas aeruginosa infection in children with cystic fibrosis with interval censored data

  • Open Access
  • Research Article

Wenjie Wang, Ming-Hui Chen, Sy Han Chiou, Hui-Chuan Lai, Xiaojing Wang, Jun Yan, Zhumin Zhang

Predictor characteristics necessary for building a clinically useful risk prediction model: a simulation study

  • Open Access
  • Research article

Laura Schummers, Katherine P. Himes, Lisa M. Bodnar, Jennifer A. Hutcheon

Description and initial evaluation of incorporating electronic follow-up of study participants in a longstanding multisite cohort study

  • Open Access
  • Research article

Kiarri N. Kershaw, Kiang Liu, David C. Goff Jr., Donald M. Lloyd-Jones, Laura J. Rasmussen-Torvik, Jared P. Reis, Pamela J. Schreiner, Daniel B. Garside, Stephen Sidney

The use of relative incidence ratios in self-controlled case series studies: an overview

  • Open Access
  • Research article

Steven Hawken, Beth K. Potter, Julian Little, Eric I. Benchimol, Salah Mahmud, Robin Ducharme, Kumanan Wilson

The contribution of databases to the results of systematic reviews: a cross-sectional study

  • Open Access
  • Research article

Lisa Hartling, Robin Featherstone, Megan Nuspl, Kassi Shave, Donna M. Dryden, Ben Vandermeer

Improving prediction models with new markers: a comparison of updating strategies

  • Open Access
  • Research article

D. Nieboer, Y. Vergouwe, Danna P. Ankerst, Monique J. Roobol, Ewout W. Steyerberg

Adjusting for overdispersion in piecewise exponential regression models to estimate excess mortality rate in population-based research

  • Open Access
  • Research Article

Miguel Angel Luque-Fernandez, Aurélien Belot, Manuela Quaresma, Camille Maringe, Michel P. Coleman, Bernard Rachet

Methods for network meta-analysis of continuous outcomes using individual patient data: a case study in acupuncture for chronic pain

  • Open Access
  • Research article

Pedro Saramago, Beth Woods, Helen Weatherly, Andrea Manca, Mark Sculpher, Kamran Khan, Andrew J. Vickers, Hugh MacPherson

Measurement of adherence in a randomised controlled trial of a complex intervention: supported self-management for adults with learning disability and type 2 diabetes

  • Open Access
  • Research article

Liz Graham, Judy Wright, Rebecca Walwyn, Amy M. Russell, Louise Bryant, Amanda Farrin, Allan House

Mechanisms and direction of allocation bias in randomised clinical trials

  • Open Access
  • Research article

Asger Paludan-Müller, David Ruben Teindl Laursen, Asbjørn Hróbjartsson

A consumer register: an acceptable and cost-effective alternative for accessing patient populations

  • Open Access
  • Research article

Jamie Bryant, Rob Sanson-Fisher, Elizabeth Fradgley, Breanne Hobden, Alison Zucca, Frans Henskens, Andrew Searles, Brad Webb, Christopher Oldmeadow

Impact of socioeconomic inequalities on geographic disparities in cancer incidence: comparison of methods for spatial disease mapping

  • Open Access
  • Research article

Juste Aristide Goungounga, Jean Gaudart, Marc Colonna, Roch Giorgi

Differences in reported sepsis incidence according to study design: a literature review

  • Open Access
  • Research article

Saga Elise Mariansdatter, Andreas Halgreen Eiset, Kirstine Kobberøe Søgaard, Christian Fynbo Christiansen

Abstracts reporting of HIV/AIDS randomized controlled trials in general medicine and infectious diseases journals: completeness to date and improvement in the quality since CONSORT extension for abstracts

  • Open Access
  • Research article

Jean Joel R. Bigna, Jean Jacques N. Noubiap, Serra Lem Asangbeh, Lewis N. Um, Paule Sandra D. Sime, Elvis Temfack, Mathurin Cyrille Tejiokem

A method for sensitivity analysis to assess the effects of measurement error in multiple exposure variables using external validation data

  • Open Access
  • Research article

George O. Agogo, Hilko van der Voet, Pieter van ’t Veer, Pietro Ferrari, David C. Muller, Emilio Sánchez-Cantalejo, Christina Bamia, Tonje Braaten, Sven Knüppel, Ingegerd Johansson, Fred A. van Eeuwijk, Hendriek C. Boshuizen

Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania

  • Open Access
  • Study protocol

Abel Makubi, Philip Sasi, Mariam Ngaeje, Enrico M. Novelli, Bruno P. Mmbando, Mark T. Gladwin, Julie Makani

Health Equity Assessment Toolkit (HEAT): software for exploring and comparing health inequalities in countries

  • Open Access
  • Software

Ahmad Reza Hosseinpoor, Devaki Nambiar, Anne Schlotheuber, Daniel Reidpath, Zev Ross

Assessment of predictive performance in incomplete data by combining internal validation and multiple imputation

  • Open Access
  • Research Article

Simone Wahl, Anne-Laure Boulesteix, Astrid Zierer, Barbara Thorand, Mark A. van de Wiel

Why sex and gender matter in implementation research

  • Open Access
  • Debate

Cara Tannenbaum, Lorraine Greaves, Ian D. Graham

Comparing two sampling methods to engage hard-to-reach communities in research priority setting

  • Open Access
  • Research article

Melissa A. Valerio, Natalia Rodriguez, Paula Winkler, Jaime Lopez, Meagen Dennison, Yuanyuan Liang, Barbara J. Turner

Statistical methodology for age-adjustment of the GH-2000 score detecting growth hormone misuse

  • Open Access
  • Research article

Dankmar Böhning, Walailuck Böhning, Nishan Guha, David A. Cowan, Peter H. Sönksen, Richard I. G. Holt

A comparison of time dependent Cox regression, pooled logistic regression and cross sectional pooling with simulations and an application to the Framingham Heart Study

  • Open Access
  • Research article

Julius S. Ngwa, Howard J. Cabral, Debbie M. Cheng, Michael J. Pencina, David R. Gagnon, Michael P. LaValley, L. Adrienne Cupples

Autoregressive transitional ordinal model to test for treatment effect in neurological trials with complex endpoints

  • Open Access
  • Research Article

Lorenzo G. Tanadini, John D. Steeves, Armin Curt, Torsten Hothorn

Inverse probability weighting to estimate causal effect of a singular phase in a multiphase randomized clinical trial for multiple myeloma

  • Open Access
  • Research article

Annalisa Pezzi, Michele Cavo, Annibale Biggeri, Elena Zamagni, Oriana Nanni

Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry

  • Open Access
  • Research article

Krystal Bergin, Elizabeth Moore, Zoe McQuilten, Erica Wood, Bradley Augustson, Hilary Blacklock, Joy Ho, Noemi Horvath, Tracy King, John McNeil, Peter Mollee, Hang Quach, Christopher M. Reid, Brian Rosengarten, Patricia Walker, Andrew Spencer

Defining the clinical pathway in cochrane diagnostic test accuracy reviews

  • Open Access
  • Research article

G. Gopalakrishna, Miranda W. Langendam, Rob J. P. M. Scholten, Patrick M. M. Bossuyt, Mariska M. G. Leeflang

Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

  • Open Access
  • Research article

Monica M. Vasquez, Chengcheng Hu, Denise J. Roe, Zhao Chen, Marilyn Halonen, Stefano Guerra

National weighting of data from the Behavioral Risk Factor Surveillance System (BRFSS)

  • Open Access
  • Research article

Ronaldo Iachan, Carol Pierannunzi, Kristie Healey, Kurt J. Greenlund, Machell Town

Does size really matter? A sensitivity analysis of number of seeds in a respondent-driven sampling study of gay, bisexual and other men who have sex with men in Vancouver, Canada

  • Open Access
  • Research article

Nathan John Lachowsky, Justin Tyler Sorge, Henry Fisher Raymond, Zishan Cui, Paul Sereda, Ashleigh Rich, Eric A. Roth, Robert S. Hogg, David M. Moore

Using cognitive pre-testing methods in the development of a new evidenced-based pressure ulcer risk assessment instrument

  • Open Access
  • Research article

S. Coleman, J. Nixon, J. Keen, D. Muir, L. Wilson, E. McGinnis, N. Stubbs, C. Dealey, E. A. Nelson

Common data elements for secondary use of electronic health record data for clinical trial execution and serious adverse event reporting

  • Open Access
  • Research article

Philipp Bruland, Mark McGilchrist, Eric Zapletal, Dionisio Acosta, Johann Proeve, Scott Askin, Thomas Ganslandt, Justin Doods, Martin Dugas

Predictors of in-hospital mortality following major lower extremity amputations in type 2 diabetic patients using artificial neural networks

  • Open Access
  • Research article

Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Roberto Lopez, Pablo Martin-Junco, Isabel Jimenez-Trujillo, Alejandro Alvaro-Meca, Miguel Angel Salinero-Fort, Rodrigo Jimenez-Garcia

Conducting a large, multi-site survey about patients’ views on broad consent: challenges and solutions

  • Open Access
  • Research article

Maureen E. Smith, Saskia C. Sanderson, Kyle B. Brothers, Melanie F. Myers, Jennifer McCormick, Sharon Aufox, Martha J. Shrubsole, Nanibaá A. Garrison, Nathaniel D. Mercaldo, Jonathan S. Schildcrout, Ellen Wright Clayton, Armand H. Matheny Antommaria, Melissa Basford, Murray Brilliant, John J. Connolly, Stephanie M. Fullerton, Carol R. Horowitz, Gail P. Jarvik, Dave Kaufman, Terri Kitchner, Rongling Li, Evette J. Ludman, Catherine McCarty, Valerie McManus, Sarah Stallings, Janet L. Williams, Ingrid A. Holm

No rationale for 1 variable per 10 events criterion for binary logistic regression analysis

  • Open Access
  • Research Article

Maarten van Smeden, Joris A. H. de Groot, Karel G. M. Moons, Gary S. Collins, Douglas G. Altman, Marinus J. C. Eijkemans, Johannes B. Reitsma

Erratum to: Statistical methodology for age-adjustment of the GH-2000 score detecting growth hormone misuse

  • Open Access
  • Publisher's Erratum

Dankmar Böhning, Walailuck Böhning, Nishan Guha, David A. Cowan, Peter H. Sönksen, Richard I. G. Holt

Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes

  • Open Access
  • Research Article

Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield, Stephen J. Walters

Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

  • Open Access
  • Research article

Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah, Sophia J. S. De Padua

ImpRess: an Implementation Readiness checklist developed using a systematic review of randomised controlled trials assessing cognitive stimulation for dementia

  • Open Access
  • Research article

Amy Streater, Aimee Spector, Elisa Aguirre, Jacki Stansfeld, Martin Orrell

Joint models for longitudinal and time-to-event data: a review of reporting quality with a view to meta-analysis

  • Open Access
  • Research article

Maria Sudell, Ruwanthi Kolamunnage-Dona, Catrin Tudur-Smith

Sexual Health questions included in the Health Behaviour in School-aged Children (HBSC) Study: an international methodological pilot investigation

  • Open Access
  • Research article

Honor Young, András Költő, Marta Reis, Elizabeth M. Saewyc, Nathalie Moreau, Lorraine Burke, Alina Cosma, Béat Windlin, Saoirse Nic Gabhainn, Emmanuelle Godeau

Erratum to: Assessment of predictive performance in incomplete data by combining internal validation and multiple imputation

  • Open Access
  • Erratum

Simone Wahl, Anne-Laure Boulesteix, Astrid Zierer, Barbara Thorand, Mark A. van de Wiel

Inter-rater reliability of the QuIS as an assessment of the quality of staff-inpatient interactions

  • Open Access
  • Research article

Ines Mesa-Eguiagaray, Dankmar Böhning, Chris McLean, Peter Griffiths, Jackie Bridges, Ruth M Pickering

Multiple and mixed methods in formative evaluation: Is more better? Reflections from a South African study

  • Open Access
  • Research article

Willem Odendaal, Salla Atkins, Simon Lewin

Can longitudinal generalized estimating equation models distinguish network influence and homophily? An agent-based modeling approach to measurement characteristics

  • Open Access
  • Research article

Kori Sauser Zachrison, Theodore J. Iwashyna, Achamyeleh Gebremariam, Meghan Hutchins, Joyce M Lee